Validation of cell culture models for the intestine and the blood-brain barrier and comparison of drug permeation

Altex

Volumn 21, Issue SUPPL. 3, 2004, Pages 57-64

  Bock, Udo ^a   Flötotto, Thomas ^a   Haltner, Eleonore ^a  

^a ACROSS BARRIERS GMBH   (Germany)

Author keywords

Biopharmaceutical classification; Blood brain barrier (BBB); Caco 2; Porcine brain endothelial cells (PBEC)

Indexed keywords

ATENOLOL; CAFFEINE; CARBAMAZEPINE; CITALOPRAM; CLONIDINE; DIGOXIN; FLUORESCEIN; FUROSEMIDE; KETOPROFEN; MACROGOL 400; MACROGOL 4000; MANNITOL; METOPROLOL; NAPROXEN; PHENAZONE; PROPRANOLOL; RHODAMINE 123; VERAPAMIL;

ACCURACY; ANIMAL TESTING REDUCTION; ARTICLE; BLOOD BRAIN BARRIER; CARCINOMA CELL; CELL CULTURE; CELL STRAIN; COLON CARCINOMA; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG PENETRATION; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; MOLECULAR MODEL; PERMEABILITY BARRIER; PREDICTION; REPRODUCIBILITY; SKIN ABSORPTION; VALIDATION PROCESS;

ANIMAL TESTING ALTERNATIVES; ANIMALS; BLOOD-BRAIN BARRIER; CACO-2 CELLS; CELL CULTURE TECHNIQUES; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; COST-BENEFIT ANALYSIS; DRUG EVALUATION, PRECLINICAL; HUMANS; INTESTINES; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 3242753525     PISSN: 09467785     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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