Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 9, 2001, Pages 4307-4314

  Nikoulina, Svetlana E ^b   Ciaraldi, Theodore P ^b   Carter, Leslie ^b   Mudaliar, Sunder ^b   Park, Kyong Soo ^b   Henry, Robert R ^a  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; GLYCOGEN; GLYCOGEN SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; S6 KINASE; WORTMANNIN;

ADULT; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0034841515     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.86.9.7872     Document Type: Article

References (52)

1. Insulin-stimulated entry of glucose into muscle in vivo as a major factor in the regulation of blood glucose
2. Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans
3. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
4. Interaction of insulin and exercise on glucose transport in muscle
5. Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle
6. Correlation between muscle glycogen synthase activity and in vivo insulin action in man
7. Glycogen synthase: Characteristics and putative role in insulin insensitivity
8. Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake
9. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms
10. Stimulation of protein phosphatase-1 activity by insulin in rat adipocytes. Evaluation of the role of mitogen-activated protein kinase pathway
11. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue
12. Control of glycogen synthesis in cultures human muscle cells
13. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)
14. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle
15. The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro
16. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
17. Dissection of the protein phosphorylation cascades involved in insulin and growth factor action
18. Upstream mechanisms of glycogen synthase activation by insulin and insulin growth factor-I. Glycogen synthase activation is antagonized by wortmannin or LY294002 but not by rapamycin or by inhibiting p21ras
19. Studies with wortmannin suggest a role for phosphatidylinositol 3-kinase in the activation of glycogen synthase and mitogen-activated protein kinase by insulin in rat adipocytes: Comparison of insulin and protein kinase C modulators
20. Multiple signaling pathways involved in stimulation of fatty acid and glycogen synthesis by insulin in rat epididimal fat cells
21. Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: Evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase
22. Insulin action in cultured human myoblasts: Contribution of different signalling pathways to regulation of glycogen synthesis
23. Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
24. Regulation of both glycogen synthase and PHAS-I by insulin in rat skeletal muscle involves mitogen-activated protein kinase-independent and rapamycin-sensitive pathways
25. Activation of ribosomal protein S6 kinases does not increase glycogen synthesis or glucose transport in rat adipocytes
26. Insulin stimulation of mitogen-activated protein kinase, p90rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant mice. Implications for the regulation of glycogen synthase
27. Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism
28. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures
29. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
30. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
31. Characterisation of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
32. Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects
33. Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus
34. Report of the expert committee on the diagnosis and classification of diabetes mellitus
35. TOR signaling and control of cell growth
36. Regulation of glycogen synthase activity in cultured skeletal muscle cells from subjects with type II diabetes: Role of chronic hyperinsulinemia and hyperglycemia
37. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
38. Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle
39. "Western blotting": Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A
40. Protein kinase B (c-Akt) in phosphatydilinositol-3-OH kinase signal transduction
41. Insulin activates glycogen synthase by a novel PI 3-kinase/p70s6k dependent pathway in 3T3-L1 adipocytes
42. Involvement of phosphoinositide 3-kinase in insulin stimulation of MAP-kinase and phosphorylation of protein kinase-B in human skeletal muscle: Implications for glucose metabolism
43. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
44. New insights into the role and mechanism of glycogen synthase activation by insulin
45. Multiple roles of Phosphatidylinositol 3-kinase in regulation of glucose transport, amino acid transport, and glucose transporters in L6 skeletal muscle cells
46. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
47. Jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo
48. Identification of a common amino acid polymorphism in the p85α regulatory subunit of phosphatidylinositol 3-kinase
49. Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus
50. Gene encoding the catalytic subunit p110β of human phosphatidylinositol 3-kinase
51. Spatial determinants of specificity in insulin action
52. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects