Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects: Biochemical and molecular mechanisms

Journal of Clinical Investigation

Volumn 98, Issue 5, 1996, Pages 1231-1236

  Henry, Robert R ^a,b,c   Ciaraldi, Theodore P ^b   Abrams Carter, Leslie ^a,b   Mudaliar, Sunder ^a   Park, Kyong Soo ^a   Nikoulina, Svetlana E ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

diabetes mellitus, non insulin dependent; enzyme activation; glycogen synthase; insulin resistance; muscle, skeletal

Indexed keywords

GLYCOGEN SYNTHASE; INSULIN; URIDINE DIPHOSPHATE GLUCOSE;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME KINETICS; GLYCOGEN SYNTHESIS; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MUSCLE FIBER CULTURE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SKELETAL MUSCLE;

EID: 0029739976     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118906     Document Type: Article

References (36)

1. Mandarino, L.J., K.S. Wright, L.S. Verity, J. Nichols, J.M. Bell, O.G. Kolterman, and H. Beck-Nielsen. 1987. Effect of insulin infusion on human skeletal muscle pyruvate dehydrogenase, phosphofructokinase, and glycogen synthase. Evidence for their role in oxidative and nonoxidative glucose metabolism. J. Clin. Invest. 80:655-663.
2. Bak, J.F., N. Moller, A. Saack, and O. Pedersen. 1992. In vivo insulin action and muscle glycogen synthase activity in Type 2 (non-insulin-dependent) diabetes mellitus: effects of diet treatment. Diabetologia. 35:777-784.
3. 13C nuclear magnetic resonance spectroscopy. N. Engl. J. Med. 322:223-228.
4. Thorburn, A.W., B. Gumbiner, F. Bulacan, P. Wallace, and R.R. Henry. 1990. Intracellular glucose oxidation and glycogen synthase activity are reduced in non-insulin-dependent (type II) diabetes independent of impaired glucose uptake. J. Clin. Invest. 85:522-529.
5. Thorburn, A.W., B. Gumbiner, F. Bulacan, G. Brechtel, and R.R. Henry. 1991. Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. J. Clin. Invest. 87:489-495.
6. Schalin-Jantti, C., M. Harkonen, and L.C. Groop. 1992. Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes. 41:598-604.
7. Vaag, A., J.E. Henriksen, and H. Beck-Nielsen. 1992. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 89:782-788.
8. Eriksson, J., A. Franssila-Kallunki, A. Ekstrand, C. Saloranta, E. Widen, C. Schalin, and L. Groop. 1989. Early metabolic defects in persons at increased risk for non-insulin dependent diabetes mellitus. N. Engl. J. Med. 321:337-341.
9. Ghosh, S., and N.J. Schork. 1996. Pespectives in diabetes. Genetic analysis of NIDDM. The study of quantitative traits. Diabetes. 45:1-14.
10. DeFronzo, R.A., and E. Ferrannini. 1991. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 14:173-194.
11. Beck-Nielsen, H., A. Vaag, P. Damsbo, A. Handberg, O.H. Nielsen, J.E. Henriksen, and P. Thye-Ronn. 1992. Insulin resistance in skeletal muscle of patients with NIDDM. Diabetes Care. 15:418-429.
12. Henry, R.R., L. Abrams, S. Nikoulina, and T.P. Ciaraldi. 1995. Insulin action and glucose metabolism in non-diabetic control and NIDDM subjects: comparison using human skeletal muscle cell cultures. Diabetes. 44:936-946.
13. Henry, R.R., T.P. Ciaraldi, S. Mudaliar, L. Abrams, and S.E. Nikoulina. 1996. Acquired defects or glycogen synthase activity in cultured human skeletal muscle cells: influence of high glucose and insulin levels. Diabetes. 45:400-407.
14. Wells, A.M., I.C. Sutcliffe, A.B. Johnson, and R. Taylor. 1993. Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism. Diabetes. 42:583-589.
15. National Diabetes Data Group. 1979. Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes. 28:1039-1057.
16. Blau, H.M., and C. Webster. 1981. Isolation and characterization of human muscle cells. Proc. Natl. Acad. Sci. USA. 78:5623-5627.
17. Sarabia, V., L. Lam, E. Burdett, L.A. Leiter, and A. Klip. 1992. Glucose transport in human skeletal muscle cells in culture. Stimulation by insulin and metformin. J. Clin. Invest. 90:1386-1395.
18. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 71:248-254.
19. Burnette, W.N. 1981. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitro-cellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112:195-203.
20. Henderson, P.J.F. 1992. Statistical analysis of enzyme kinetic data. In Enzyme Assays. A practical approach. R. Eisenthal and M.J. Danson, editors. Oxford University Press Inc., New York. 277-316.
21. Vestergaard, H., C. Bjorbaek, P.H. Andersen, J.F. Bak, and O. Pedersen. 1991. Impaired expression of glycogen synthase mRNA in skeletal muscle of NIDDM patients. Diabetes. 40:1740-1745.
22. Vestergaard, H., S. Lund, F.S. Larsen, O.J. Bjerrum, and O. Pedersen. 1993. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 91:2342-2350.
23. Bogardus, C., S. Lillioja, K. Stone, and D. Mott. 1984. Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J. Clin. Invest. 73:1185-1190.
24. Chen, Y.H., L. Hansen, M.X. Chen, C. Bjorbaek, H. Vestergaard, T. Hansen, P.T.W. Cohen, and O. Pedersen. 1994. Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM. Diabetes. 43:1234-1241.
25. Orho, M., P. Nikula-Ijas, C. Schalin-Jantti, M.A. Permutt, and L.C. Groop. 1995. Isolation and characterization of the human muscle glycogen synthase gene. Diabetes. 44:1099-1105.
26. Majer, M., D.M. Mott, H. Mochizuki, J.C. Rowles, O. Pedersen, W.C. Knowler, C. Bogardus, and M. Prochazka. 1996. Association of the glycogen synthase locus on 19q13 with NIDDM in Pima Indians. Diabetologia. 39:314-321.
27. Groop, L.C., M. Kankuri, C. Schalin-Jantti, A. Ekstrand, P. Nikula-Ijas, E. Widen, E. Kuismanen, J. Eriksson, A. Franssila-Kallunki, C. Saloranta, and S. Koskimies. 1993. Association between polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 328: 10-14.
28. Zouali, H., G. Velho, and P. Froguel. 1993. Polymorphism of the glycogen synthase gene and non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 328:1568.
29. Kuroyama, H., T. Sanke, S. Ohangi, M. Furanta, H. Furata, and K. Nanjo. 1994. Single tandem repeat DNA polymorphism in the human glycogen synthase gene is associated with NIDDM in Japanese subjects. Diabetologia. 37:536-539.
30. Seldin, M.F., D. Mott, D. Bhat, A. Petro, C.M. Kuhn, S.F. Kingsmore, C. Bogardus, E. Opara, M.N. Feinglos, and R.S. Surwit. 1994. Glycogen synthase: a putative locus for diet-induced hyperglycemia. J. Clin. Invest. 94:269-276.
31. Ciaraldi, T.P., L. Abrams, S. Nikoulina, S. Mudaliar, and R.R. Henry. 1995. Glucose transport in cultured human skeletal muscle cells: regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects. J. Clin. Invest. 96:2820-2827.
32. Lofman, M., H. Yki-Jarvinen, M. Parkkonen, J. Lindstrom, L. Koranyi, C. Schalin-Jantti, and L. Groop. 1995. Increased concentrations of glycogen synthase protein in skeletal muscle of patients with NIDDM. Am. J. Physiol. 269:27-32.
33. Roach, P.J., and J. Larner. 1977. Covalent phosphorylation in the regulation of glycogen synthase activity. Mol. Cell. Biochem. 15:179-200.
34. Dent, P., A. Lavoinne, S. Nakielny, F.B. Caudwell, P. Watt, and P. Cohen. 1990. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature (Lond.). 348:302-308.
35. Skurat, A.V., Y. Wang, and P.J. Roach. 1994. Rabbit skeletal muscle glycogen synthase expressed in COS cells. Identification of regulatory phosphorylation sites. J. Biol. Chem. 269:25534-25542.
36. Zhang, W.A., A. DePaoli-Roach, and P. Roach. 1943. Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase. Arch. Biochem. Biophys. 304:219-225.