Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle

Journal of Clinical Investigation

Volumn 98, Issue 1, 1996, Pages 43-49

  Laville, M ^a   Auboeuf, D ^b   Khalfallah, Y ^b   Vega, N ^b   Riou, J P ^b   Vidal, H ^b  

^a INSERM   (France)

^b NONE

Author keywords

euglycemic hyperinsulinemic clamp; gene expression; reverse transcription competitive polymerase chain reaction

Indexed keywords

GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR; LIPOPROTEIN LIPASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ADULT; ARTICLE; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE METABOLISM; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MUSCLE BIOPSY; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE;

EID: 0030037364     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118775     Document Type: Article

References (39)

1. Cheatham, B., and R.C. Kahn. 1995. Insulin action and the insulin signaling network. Endocr. Rev. 16:117-142.
2. O'Brien, R.M., and D.K. Granner. 1991. Regulation of gene expression by insulin. Biochem. J. 278:609-619.
3. Lemaigre, F.P., and G.G. Rousseau. 1994. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver. Biochem. J. 303:1-14.
4. Vaulont, S., and A. Kahn. 1994. Transcriptional control of metabolic regulation genes by carbohydrates. FASEB J. 8:28-35.
5. DeFronzo, R.A. 1988. The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes. 37:667-687.
6. Reynet, C., and C.R. Kahn. 1993. Rad: a member of the Ras family over-expressed in muscle of type II diabetic humans. Science (Wash. DC). 262:1441-1444.
7. Vestergaard, H., C. Bjorbaek, T. Hansen, F.S. Larsen, D.K. Granner, and O. Pedersen. 1995. Impaired activity and gene expression of hexokinase II in muscle from non-insulin-dependent diabetes mellitus patients. J. Clin. Invest. 96:2639-2645.
8. Vestergaard, H., S. Lund, F.S. Larsen, O.J. Bjerrum, and O. Pedersen. 1993. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 91:2342-2350.
9. Garvey, T.W., L. Maianu, J.A. Hancock, A.M. Golichowski, and A. Baron. 1992. Gene expression of Glut 4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM and NIDDM. Diabetes. 41:465-475.
10. Vestergaard, H., P.H. Andersen, S. Lund, P. Vedel, and O. Pedersen. 1994. Expression of glycogen synthase and phosphofructokinase in muscle from type 1 (insulin-dependent) diabetic patients before and after intensive insulin treatment. Diabetologia. 37:82-90.
11. Mandarino, L.J., R.L. Printz, K.A. Cusi, P. Kinchington, R.M. O'Doherty, H. Osawa, C. Sewell, A. Consoli, D.K. Granner, and R.A. DeFronzo. 1995. Regulation of hexokinase II and glycogen synthase mRNA, protein, and activity in human muscle. Am. J. Physiol. 269:E701-E708.
12. Yki-Järvinen, H., H. Vuorinen-Markkola, L. Koranyi, R. Bourey, K. Tordjman, M. Mueckler, A.M. Permutt, and V.A. Koivisto. 1992. Defect in insulin action on expression of the muscle/adipose tissue glucose transporter gene in skeletal muscle of type 1 diabetic patients. J. Clin. Endocrinol & Metab. 75: 795-799.
13. Schalin-Jänti, C., H. Yki-Järvinen, L. Koranyi, R. Bourey, J. Lindström, P. Nikula-Ijäs, A. Franssila-Kallunki, and L.C. Groop. 1994. Effect of insulin on Glut 4 mRNA and protein concentrations in skeletal muscle of patients with NIDDM and their first-degree relatives. Diabetologia. 37:401.
14. Wang, A.M., M.V. Doyle, and D.F. Mark. 1989. Quantitation of mRNA by the polymerase chain reaction. Proc. Natl. Acad. Sci. USA. 86:9717-9721.
15. Bouaboula, M., P. Legoux, B. Pességué, B. Delpech, X. Dumont, M. Piechaczyk, P. Casellas, and D. Shire. 1992. Standardization of mRNA titration using polymerase chain reaction method involving co-amplification with multi-specific internal control. J. Biol. Chem. 267:21830-21838.
16. Rizza, R.A., L.J. Mandarino, and J.E. Gerich. 1981. Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am. J. Physiol. 240:E630-E639.
17. Laville, M., J.P. Riou, P.F. Bougnéres, B. Canivet, M. Beylot, R. Cohen, P. Serusclat, C. Dumontet, F. Berthezene, and R. Mornex. 1984. Glucose metabolism in experimental hyperthyroidism: intact in vivo sensitivity to insulin with abnormal binding and increased glucose turnover. J. Clin. Endocrinol. & Metab. 58:960-965.
18. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
19. Gilliland, G., S. Perrin, K. Blanchard, and H.F. Bunn. 1990. Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc. Natl. Acad. Sci. USA. 87:2725-2729.
20. Vidal, H., D. Auboeuf, M. Beylot, and J.P. Riou. 1995. Regulation of insulin receptor mRNA splicing in rat tissues: effect of fasting, aging and diabetes. Diabetes. 44:1196-1201.
21. Higuchi, R. 1989. Using PCR to engineer DNA. In PCR Technology: Principles and Application for DNA Amplification. H.A. Erlich, editor. Stockton Press, New York. 61-70.
22. Araki, E., X.J. Sun, B.L. Haag, L.M. Chuang, Y. Zhang, T.L. Yang-Feng, M.F. White, and C.R. Kahn. 1993. Human skeletal muscle insulin receptor substrate-1: characterization of the cDNA, gene, and chromosomal localization. Diabetes. 42:1041-1054.
23. Fukumoto, H., T. Kayano, J.B. Buse, Y. Edwards, P.F. Pilch, G.I. Bell, and S. Seino. 1989. Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. J. Biol. Chem. 264:7776-7779.
24. Lange, A.J., and S.J. Pilkis. 1990. Sequence of the human 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Nucleic Acids Res. 18:3652-3655.
25. Browner, M.F., K. Nakano, A.G. Bang, and R.J. Fletterick. 1989. Human muscle glycogen synthase cDNA sequence: a negatively charged protein with an asymmetric charge distribution. Proc. Natl. Acad. Sci. USA. 86:1443-1447.
26. Langin, D., H. Laurell, L. Stenson-Holst, P. Belfrage, and C. Holm. 1993. Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with the lipase of Moraxella TA 144, an antarctic bacterium. Proc. Natl. Acad. Sci. USA. 90:4897-4901.
27. Nakajima, H., T. Noguchi, T. Yamasaki, N. Kono, T. Tanaka, and S. Tarui. 1987. Cloning of human muscle phosphofructokinase cDNA. FEBS Lett. 223:113-116.
28. Guessow, D., R. Rein, I. Ginjaar, F. Hochstenbach, G. Seemann, A. Kottman, and H.L. Ploegh. 1987. The human beta-2-microglobulin gene: primary structure and definition of the transcription unit. J. Immunol. 139:3132-3138.
29. Skolnik, E.Y., B. Margolis, M. Mohammadi, E. Lowenstein, R. Fischer, A. Drepps, A. Ullrich, and J. Schlessinger. 1991. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. Cell. 65:83-90.
30. Riond, J., M.G. Mattei, M. Kaghad, X. Dumont, J.C. Guillemot, G. Le Fur, D. Caput, and P. Ferrara. 1991. Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. Eur. J. Biochem. 195:305-311.
31. Ebina, Y., L. Ellis, K. Jarnagin, M. Edery, L. Graf, E. Clauser, J. Ou, F. Massiarz, Y.W. Kan, I.D. Goldfine, et al. 1985. The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell. 40:747-758.
32. Wion, K.L., T.G. Kirchgessner, A.J. Lusls, M.C. Schotz, and R.M. Lawn. 1987. Human lipoprotein lipase complementary DNA sequence. Science Wash. DC 235:1638-1641.
33. Norgren, S., P. Arner, and H. Luthman. 1994. Insulin receptor ribonucleic acid levels and alternative splicing in human liver, muscle, and adipose tissue: tissue specificity and relation to insulin action. J. Clin. Endocrinol. & Metab. 78:757-762.
34. Kiens, B., H. Lithell, K.J. Mikines, and E.A. Richter. 1989. Effects of insulin and exercise on muscle lipoprotein lipase activity in man and its relation to insulin action. J. Clin. Invest. 84:1124-1129.
35. Norgren, S., J. Zierath, A. Wedell, H. Wallberg-Henriksson, and H. Luthman. 1994. Regulation of human insulin receptor RNA splicing in vivo. Proc. Natl. Acad. Sci. USA. 91:1465-1469.
36. Sell, S.M., D. Reese, and V.M. Ossowski. 1994. Insulin-inducible changes in insulin receptor mRNA splice variants. J. Biol. Chem. 269:30769-30772.
37. Granner, D.K., and S. Pilkis. 1990. The genes of hepatic glucose metabolism. J. Biol. Chem. 265:10173-10176.
38. Stephens, J.M., and P.F. Pilch. 1995. The metabolic regulation and vesicular transport of Glut 4, the major insulin-responsive glucose transporter. Endocr. Rev. 16:529-546.
39. O'Brien, R.M., and D.K. Granner. 1995. Why there is an IRS. J. Clin. Invest. 96:2546.