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Volumn 5, Issue 1, 2008, Pages 11-24

Liposome-nucleic acid immunotherapeutics

Author keywords

Adjuvants; Innate immune; Interferons; Toll like receptors

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ALUMINUM HYDROXIDE; ANTIGEN; CANCER VACCINE; CD8 ANTIGEN; CPG OLIGODEOXYNUCLEOTIDE; CYTOKINE; CYTOPLASMIC RECEPTOR; FREUND ADJUVANT; GAMMA INTERFERON; IMIDAZOLE DERIVATIVE; IMIDAZOQUINOLINE DERIVATIVE; IMIQUIMOD; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; LIPOSOME; MPL; MURAMYL DIPEPTIDE; MURAMYL TRIPEPTIDE; NUCLEIC ACID; PATTERN RECOGNITION RECEPTOR; PHOSPHATIDYLETHANOLAMINE; PLASMID DNA; POLYINOSINIC POLYCYTIDYLIC ACID; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 39049165612     PISSN: 17425247     EISSN: None     Source Type: Journal    
DOI: 10.1517/17425247.5.1.11     Document Type: Review
Times cited : (46)

References (116)
  • 1
    • 0037232254 scopus 로고    scopus 로고
    • Toll-like receptors and their function in innate and adaptive immunity
    • Heine H, Lien E. Toll-like receptors and their function in innate and adaptive immunity. Int Arch Allergy Immunol 2003;130:180-92
    • (2003) Int Arch Allergy Immunol , vol.130 , pp. 180-192
    • Heine, H.1    Lien, E.2
  • 3
    • 0032191163 scopus 로고    scopus 로고
    • Innate immune recognition and control of adaptive immune responses
    • Medzhitov R, Janeway CA Jr. Innate immune recognition and control of adaptive immune responses. Semin Immunol 1998;10:351-3
    • (1998) Semin Immunol , vol.10 , pp. 351-353
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 4
    • 34249677845 scopus 로고    scopus 로고
    • Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
    • Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists. Nat Med 2007;13:552-9
    • (2007) Nat Med , vol.13 , pp. 552-559
    • Kanzler, H.1    Barrat, F.J.2    Hessel, E.M.3    Coffman, R.L.4
  • 5
  • 6
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg AM. Therapeutic potential of Toll-like receptor 9 activation. Nat Rev Drug Discov 2006;5:471-84
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 7
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation
    • Mariathasan S, Monack DM. Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev 2007;7:31-40
    • (2007) Nat Rev , vol.7 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 8
    • 33846136089 scopus 로고    scopus 로고
    • Innate recognition of intracellular bacteria
    • Delbridge LM, O'Riordan MX. Innate recognition of intracellular bacteria. Curr Opin Immunol 2007;19:10-16
    • (2007) Curr Opin Immunol , vol.19 , pp. 10-16
    • Delbridge, L.M.1    O'Riordan, M.X.2
  • 10
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev 2004;4:499-511
    • (2004) Nat Rev , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 12
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol 2001;2:675-80
    • (2001) Nat Immunol , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 13
    • 33947667884 scopus 로고    scopus 로고
    • Innate control of adaptive immunity: Dendritic cells and beyond
    • Lee HK, Iwasaki A. Innate control of adaptive immunity: dendritic cells and beyond. Semin Immunol 2007;19:48-55
    • (2007) Semin Immunol , vol.19 , pp. 48-55
    • Lee, H.K.1    Iwasaki, A.2
  • 14
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004;5:987-95
    • (2004) Nat Immunol , vol.5 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 15
    • 33244472793 scopus 로고    scopus 로고
    • Signalling pathways and molecular interactions of NOD1 and NOD2
    • Strober W, Murray PJ, Kitani A, Watanabe T. Signalling pathways and molecular interactions of NOD1 and NOD2. Nat Rev 2006;6:9-20
    • (2006) Nat Rev , vol.6 , pp. 9-20
    • Strober, W.1    Murray, P.J.2    Kitani, A.3    Watanabe, T.4
  • 17
    • 20444459502 scopus 로고    scopus 로고
    • NOD2 and Crohn's disease: Loss or gain of function?
    • Eckmann L, Karin M. NOD2 and Crohn's disease: loss or gain of function? Immunity 2005;22:661-7
    • (2005) Immunity , vol.22 , pp. 661-667
    • Eckmann, L.1    Karin, M.2
  • 18
    • 33846469538 scopus 로고    scopus 로고
    • The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
    • Hsu YM, Zhang Y, You Y, et al. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 2007;8:198-205
    • (2007) Nat Immunol , vol.8 , pp. 198-205
    • Hsu, Y.M.1    Zhang, Y.2    You, Y.3
  • 20
    • 0038824980 scopus 로고    scopus 로고
    • An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid
    • Chamaillard M, Hashimoto M, Horie Y, et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 2003;4:702-7
    • (2003) Nat Immunol , vol.4 , pp. 702-707
    • Chamaillard, M.1    Hashimoto, M.2    Horie, Y.3
  • 21
    • 29244471275 scopus 로고    scopus 로고
    • A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    • Ishii KJ, Coban C, Kato H, et al. A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 2006;7:40-8
    • (2006) Nat Immunol , vol.7 , pp. 40-48
    • Ishii, K.J.1    Coban, C.2    Kato, H.3
  • 22
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato H, Takeuchi O, Sato S, et al. Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 2006;441:101-5
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3
  • 23
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama M, Kikuchi M, Natsukawa T, et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol 2004;5:730-7
    • (2004) Nat Immunol , vol.5 , pp. 730-737
    • Yoneyama, M.1    Kikuchi, M.2    Natsukawa, T.3
  • 24
    • 34547143110 scopus 로고    scopus 로고
    • DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    • Takaoka A, Wang Z, Choi MK, et al. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 2007;448:501-5
    • (2007) Nature , vol.448 , pp. 501-505
    • Takaoka, A.1    Wang, Z.2    Choi, M.K.3
  • 25
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson DB, Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006;24:93-103
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 26
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda K, Ohba Y, Yanai H, et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 2005;434:1035-40
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1    Ohba, Y.2    Yanai, H.3
  • 27
    • 3142779901 scopus 로고    scopus 로고
    • Therapeutics targeting the innate immune system
    • Ulevitch RJ. Therapeutics targeting the innate immune system. Nat Rev 2004;4:512-20
    • (2004) Nat Rev , vol.4 , pp. 512-520
    • Ulevitch, R.J.1
  • 28
    • 34248169629 scopus 로고    scopus 로고
    • Development of TLR9 agonists for cancer therapy
    • Krieg AM. Development of TLR9 agonists for cancer therapy. J Clin Invest 2007;117:1184-94
    • (2007) J Clin Invest , vol.117 , pp. 1184-1194
    • Krieg, A.M.1
  • 29
    • 7944219649 scopus 로고    scopus 로고
    • Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides
    • Ishii KJ, Gursel I, Gursel M, Klinman DM. Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides. Curr Opin Mol Ther 2004;6:166-74
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 166-174
    • Ishii, K.J.1    Gursel, I.2    Gursel, M.3    Klinman, D.M.4
  • 31
    • 0029125936 scopus 로고
    • Biologic therapy for osteosarcoma using liposome-encapsulated muramyl tripeptide
    • Kleinerman ES. Biologic therapy for osteosarcoma using liposome-encapsulated muramyl tripeptide. Hematol Oncol Clin North Am 1995;9:927-38
    • (1995) Hematol Oncol Clin North Am , vol.9 , pp. 927-938
    • Kleinerman, E.S.1
  • 32
    • 0027347270 scopus 로고
    • Liposome-encapsulated muramyl tripeptide: A new biologic response modifier for the treatment of osteosarcoma
    • Kleinerman ES, Maeda M, Jaffe N. Liposome-encapsulated muramyl tripeptide: a new biologic response modifier for the treatment of osteosarcoma. Cancer Treat Res 1993;62:101-7
    • (1993) Cancer Treat Res , vol.62 , pp. 101-107
    • Kleinerman, E.S.1    Maeda, M.2    Jaffe, N.3
  • 33
    • 0032408130 scopus 로고    scopus 로고
    • Liposomal muramyl tripeptide (CGP 19835A lipid) therapy for resectable melanoma in patients who were at high risk for relapse: An update
    • Gianan MA, Kleinerman ES. Liposomal muramyl tripeptide (CGP 19835A lipid) therapy for resectable melanoma in patients who were at high risk for relapse: an update. Cancer Biother Radiopharm 1998;13:363-8
    • (1998) Cancer Biother Radiopharm , vol.13 , pp. 363-368
    • Gianan, M.A.1    Kleinerman, E.S.2
  • 34
    • 17144461583 scopus 로고    scopus 로고
    • Adjuvant therapy for melanoma in dogs: Results of randomized clinical trials using surgery, liposome-encapsulated muramyl tripeptide, and granulocyte macrophage colony-stimulating factor
    • MacEwen EG, Kurzman ID, Vail DM, et al. Adjuvant therapy for melanoma in dogs: results of randomized clinical trials using surgery, liposome-encapsulated muramyl tripeptide, and granulocyte macrophage colony-stimulating factor. Clin Cancer Res 1999;5:4249-58
    • (1999) Clin Cancer Res , vol.5 , pp. 4249-4258
    • MacEwen, E.G.1    Kurzman, I.D.2    Vail, D.M.3
  • 35
    • 0028825882 scopus 로고
    • Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine adjuvant immunotherapy for splenic hemangiosarcoma in the dog: A randomized multi-institutional clinical trial
    • Vail DM, MacEwen EG, Kurzman ID, et al. Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine adjuvant immunotherapy for splenic hemangiosarcoma in the dog: a randomized multi-institutional clinical trial. Clin Cancer Res 1995;1:1165-70
    • (1995) Clin Cancer Res , vol.1 , pp. 1165-1170
    • Vail, D.M.1    MacEwen, E.G.2    Kurzman, I.D.3
  • 36
    • 0024789583 scopus 로고
    • Phase I trial of liposomal muramyl tripeptide phosphatidylethanolamine in cancer patients
    • Murray JL, Kleinerman ES, Cunningham JE, et al. Phase I trial of liposomal muramyl tripeptide phosphatidylethanolamine in cancer patients. J Clin Oncol 1989;7:1915-25
    • (1989) J Clin Oncol , vol.7 , pp. 1915-1925
    • Murray, J.L.1    Kleinerman, E.S.2    Cunningham, J.E.3
  • 37
    • 0027939443 scopus 로고
    • In vivo modulation of macrophage tumoricidal activity by oral administration of the liposome-encapsulated macrophage activator CGP 19835A
    • Tanguay S, Bucana CD, Wilson MR, Fidler IJ, von Eschenbach AC, Killion JJ. In vivo modulation of macrophage tumoricidal activity by oral administration of the liposome-encapsulated macrophage activator CGP 19835A. Cancer Res 1994;54:5882-8
    • (1994) Cancer Res , vol.54 , pp. 5882-5888
    • Tanguay, S.1    Bucana, C.D.2    Wilson, M.R.3    Fidler, I.J.4    von Eschenbach, A.C.5    Killion, J.J.6
  • 39
    • 0031049765 scopus 로고    scopus 로고
    • Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery
    • Liu Y, Mounkes LC, Liggitt HD, et al. Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nat Biotechnol 1997;15:167-73
    • (1997) Nat Biotechnol , vol.15 , pp. 167-173
    • Liu, Y.1    Mounkes, L.C.2    Liggitt, H.D.3
  • 40
    • 0010276632 scopus 로고    scopus 로고
    • Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously
    • Dow SW, Fradkin LG, Liggitt DH, Willson AP, Heath TD, Potter TA. Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously. J Immunol 1999;163:1552-61
    • (1999) J Immunol , vol.163 , pp. 1552-1561
    • Dow, S.W.1    Fradkin, L.G.2    Liggitt, D.H.3    Willson, A.P.4    Heath, T.D.5    Potter, T.A.6
  • 41
    • 0032732516 scopus 로고    scopus 로고
    • LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth
    • Whitmore M, Li S, Huang L. LPD lipopolyplex initiates a potent cytokine response and inhibits tumor growth. Gene Ther 1999;6:1867-75
    • (1999) Gene Ther , vol.6 , pp. 1867-1875
    • Whitmore, M.1    Li, S.2    Huang, L.3
  • 42
    • 0035668040 scopus 로고    scopus 로고
    • Systemic administration of LPD prepared with CpG oligonucleotides inhibits the growth of established pulmonary metastases by stimulating innate and acquired antitumor immune responses
    • Whitmore MM, Li S, Falo L Jr, Huang L. Systemic administration of LPD prepared with CpG oligonucleotides inhibits the growth of established pulmonary metastases by stimulating innate and acquired antitumor immune responses. Cancer Immunol Immunother 2001;50:503-14
    • (2001) Cancer Immunol Immunother , vol.50 , pp. 503-514
    • Whitmore, M.M.1    Li, S.2    Falo Jr, L.3    Huang, L.4
  • 43
    • 18344398322 scopus 로고    scopus 로고
    • Cationic lipid: Bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models
    • Lanuti M, Rudginsky S, Force SD, et al. Cationic lipid: bacterial DNA complexes elicit adaptive cellular immunity in murine intraperitoneal tumor models. Cancer Res 2000;60:2955-63
    • (2000) Cancer Res , vol.60 , pp. 2955-2963
    • Lanuti, M.1    Rudginsky, S.2    Force, S.D.3
  • 44
    • 0036555074 scopus 로고    scopus 로고
    • Complex roles of CpG in liposomal delivery of DNA and oligonucleotides
    • Wilson A, Pitt B, Li S. Complex roles of CpG in liposomal delivery of DNA and oligonucleotides. Biosci Rep 2002;22:309-22
    • (2002) Biosci Rep , vol.22 , pp. 309-322
    • Wilson, A.1    Pitt, B.2    Li, S.3
  • 45
    • 0035885126 scopus 로고    scopus 로고
    • Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides
    • Gursel I, Gursel M, Ishii KJ, Klinman DM. Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides. J Immunol 2001;167:3324-8
    • (2001) J Immunol , vol.167 , pp. 3324-3328
    • Gursel, I.1    Gursel, M.2    Ishii, K.J.3    Klinman, D.M.4
  • 46
    • 33747865175 scopus 로고    scopus 로고
    • Lipoplexes prepared from cationic liposomes and mammalian DNA induce CpG-independent, direct cytotoxic effects in cell cultures and in mice
    • Khazanov E, Simberg D, Barenholz Y. Lipoplexes prepared from cationic liposomes and mammalian DNA induce CpG-independent, direct cytotoxic effects in cell cultures and in mice. J Gene Med 2006;8:998-1007
    • (2006) J Gene Med , vol.8 , pp. 998-1007
    • Khazanov, E.1    Simberg, D.2    Barenholz, Y.3
  • 47
    • 33744903928 scopus 로고    scopus 로고
    • Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes
    • Zaks K, Jordan M, Guth A, et al. Efficient immunization and cross-priming by vaccine adjuvants containing TLR3 or TLR9 agonists complexed to cationic liposomes. J Immunol 2006;176:7335-45
    • (2006) J Immunol , vol.176 , pp. 7335-7345
    • Zaks, K.1    Jordan, M.2    Guth, A.3
  • 48
    • 0345003929 scopus 로고    scopus 로고
    • Liposome-mediated immunotherapy against respiratory influenza virus infection using double-stranded RNA poly ICLC
    • Wong JP, Yang H, Nagata L, et al. Liposome-mediated immunotherapy against respiratory influenza virus infection using double-stranded RNA poly ICLC. Vaccine 1999;17:1788-95
    • (1999) Vaccine , vol.17 , pp. 1788-1795
    • Wong, J.P.1    Yang, H.2    Nagata, L.3
  • 49
    • 0141676278 scopus 로고    scopus 로고
    • Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: Poly C in a murine lung metastasis model
    • Sakurai F, Terada T, Maruyama M, et al. Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model. Cancer Gene Ther 2003;10:661-8
    • (2003) Cancer Gene Ther , vol.10 , pp. 661-668
    • Sakurai, F.1    Terada, T.2    Maruyama, M.3
  • 50
    • 33847342938 scopus 로고    scopus 로고
    • Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo
    • Hamm S, Heit A, Koffler M, et al. Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo. Int Immunol 2007;19:297-304
    • (2007) Int Immunol , vol.19 , pp. 297-304
    • Hamm, S.1    Heit, A.2    Koffler, M.3
  • 51
    • 23844478428 scopus 로고    scopus 로고
    • Type I interferons potently suppress gene expression following gene delivery using liposome(-)DNA complexes
    • Sellins K, Fradkin L, Liggitt D, Dow S. Type I interferons potently suppress gene expression following gene delivery using liposome(-)DNA complexes. Mol Ther 2005;12:451-9
    • (2005) Mol Ther , vol.12 , pp. 451-459
    • Sellins, K.1    Fradkin, L.2    Liggitt, D.3    Dow, S.4
  • 52
    • 32644463737 scopus 로고    scopus 로고
    • Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes
    • Gowen BB, Fairman J, Smee DF, et al. Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes. Antiviral Res 2006;69:165-72
    • (2006) Antiviral Res , vol.69 , pp. 165-172
    • Gowen, B.B.1    Fairman, J.2    Smee, D.F.3
  • 53
    • 0042691403 scopus 로고    scopus 로고
    • Small-interfering RNAs in the radar of the interferon system
    • Moss EG, Taylor JM. Small-interfering RNAs in the radar of the interferon system. Nat Cell Biol 2003;5:771-2
    • (2003) Nat Cell Biol , vol.5 , pp. 771-772
    • Moss, E.G.1    Taylor, J.M.2
  • 56
    • 33644593889 scopus 로고    scopus 로고
    • Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery
    • Khalil IA, Kogure K, Akita H, Harashima H. Uptake pathways and subsequent intracellular trafficking in nonviral gene delivery. Pharmacol Rev 2006;58:32-45
    • (2006) Pharmacol Rev , vol.58 , pp. 32-45
    • Khalil, I.A.1    Kogure, K.2    Akita, H.3    Harashima, H.4
  • 57
    • 0028097638 scopus 로고
    • DNA transfection mediated by cationic liposomes containing lipopolylysine: Characterization and mechanism of action
    • Zhou X, Huang L. DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action. Biochim Biophys Acta 1994;1189:195-203
    • (1994) Biochim Biophys Acta , vol.1189 , pp. 195-203
    • Zhou, X.1    Huang, L.2
  • 58
    • 0029019120 scopus 로고
    • Fusion of cationic liposomes with mammalian cells occurs after endocytosis
    • Wrobel I, Collins D. Fusion of cationic liposomes with mammalian cells occurs after endocytosis. Biochim Biophys Acta 1995;1235:296-304
    • (1995) Biochim Biophys Acta , vol.1235 , pp. 296-304
    • Wrobel, I.1    Collins, D.2
  • 59
    • 0037124051 scopus 로고    scopus 로고
    • Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis
    • Zuhorn IS, Kalicharan R, Hoekstra D. Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis. J Biol Chem 2002;277:18021-8
    • (2002) J Biol Chem , vol.277 , pp. 18021-18028
    • Zuhorn, I.S.1    Kalicharan, R.2    Hoekstra, D.3
  • 60
    • 33947168829 scopus 로고    scopus 로고
    • Signaling pathways activated by microorganisms
    • Takeuchi O, Akira S. Signaling pathways activated by microorganisms. Curr Opin Cell Biol 2007;19:185-91
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 185-191
    • Takeuchi, O.1    Akira, S.2
  • 61
    • 0029964866 scopus 로고    scopus 로고
    • Mechanism of oligonucleotide release from cationic liposomes
    • Zelphati O, Szoka FC Jr. Mechanism of oligonucleotide release from cationic liposomes. Proc Natl Acad Sci USA 1996;93:11493-8
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11493-11498
    • Zelphati, O.1    Szoka Jr., F.C.2
  • 62
    • 33746884630 scopus 로고    scopus 로고
    • Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
    • Guiducci C, Ott G, Chan JH, et al. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J Exp Med 2006;203:1999-2008
    • (2006) J Exp Med , vol.203 , pp. 1999-2008
    • Guiducci, C.1    Ott, G.2    Chan, J.H.3
  • 63
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferon-dependent immune responses
    • Honda K, Yanai H, Negishi H, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005;434:772-7
    • (2005) Nature , vol.434 , pp. 772-777
    • Honda, K.1    Yanai, H.2    Negishi, H.3
  • 64
    • 14644400451 scopus 로고    scopus 로고
    • Immunostimulation mechanism of LPD nanoparticle as a vaccine carrier
    • Cui Z, Han SJ, Vangasseri DP, Huang L. Immunostimulation mechanism of LPD nanoparticle as a vaccine carrier. Mol Pharm 2005;2:22-8
    • (2005) Mol Pharm , vol.2 , pp. 22-28
    • Cui, Z.1    Han, S.J.2    Vangasseri, D.P.3    Huang, L.4
  • 65
    • 0031765906 scopus 로고    scopus 로고
    • Biodistribution of radiolabeled lipid-DNA complexes and DNA in mice
    • Niven R, Pearlman R, Wedeking T, et al. Biodistribution of radiolabeled lipid-DNA complexes and DNA in mice. J Pharm Sci 1998;87:1292-9
    • (1998) J Pharm Sci , vol.87 , pp. 1292-1299
    • Niven, R.1    Pearlman, R.2    Wedeking, T.3
  • 66
    • 0034601885 scopus 로고    scopus 로고
    • Characteristics and biodistribution of cationic liposomes and their DNA complexes
    • Ishiwata H, Suzuki N, Ando S, Kikuchi H, Kitagawa T. Characteristics and biodistribution of cationic liposomes and their DNA complexes. J Control Rel 2000;69:139-48
    • (2000) J Control Rel , vol.69 , pp. 139-148
    • Ishiwata, H.1    Suzuki, N.2    Ando, S.3    Kikuchi, H.4    Kitagawa, T.5
  • 67
    • 9244233163 scopus 로고    scopus 로고
    • Pharmacodynamic behavior of liposomal antisense oligonucleotides targeting Her-2/neu and vascular endothelial growth factor in an ascitic MDA435/LCC6 human breast cancer model
    • Waterhouse DN, Dragowska WH, Gelmon KA, Mayer LD, Bally MB. Pharmacodynamic behavior of liposomal antisense oligonucleotides targeting Her-2/neu and vascular endothelial growth factor in an ascitic MDA435/LCC6 human breast cancer model. Cancer Biol Ther 2004;3:197-204
    • (2004) Cancer Biol Ther , vol.3 , pp. 197-204
    • Waterhouse, D.N.1    Dragowska, W.H.2    Gelmon, K.A.3    Mayer, L.D.4    Bally, M.B.5
  • 68
    • 14644412792 scopus 로고    scopus 로고
    • Biodistribution study of phosphonolipids: A class of non-viral vectors efficient in mice lung-directed gene transfer
    • Delepine P, Guillaume C, Montier T, et al. Biodistribution study of phosphonolipids: a class of non-viral vectors efficient in mice lung-directed gene transfer. J Gene Med 2003;5:600-8
    • (2003) J Gene Med , vol.5 , pp. 600-608
    • Delepine, P.1    Guillaume, C.2    Montier, T.3
  • 69
  • 70
    • 34447128388 scopus 로고    scopus 로고
    • Antiinfective applications of toll-like receptor 9 agonists
    • Krieg AM. Antiinfective applications of toll-like receptor 9 agonists. Proc Am Thorac Soc 2007;4:289-94
    • (2007) Proc Am Thorac Soc , vol.4 , pp. 289-294
    • Krieg, A.M.1
  • 71
    • 33747879641 scopus 로고    scopus 로고
    • CpG 7909: PF 3512676, PF-3512676. Drugs R D 2006;7:312-16
    • CpG 7909: PF 3512676, PF-3512676. Drugs R D 2006;7:312-16
  • 72
    • 0033544946 scopus 로고    scopus 로고
    • Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases
    • Dow SW, Elmslie RE, Fradkin LG, et al. Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases. Hum Gene Ther 1999;10:2961-72
    • (1999) Hum Gene Ther , vol.10 , pp. 2961-2972
    • Dow, S.W.1    Elmslie, R.E.2    Fradkin, L.G.3
  • 73
    • 0034653709 scopus 로고    scopus 로고
    • Eradication of disseminated lymphomas with CpG-DNA activated T helper type 1 cells from nontransgenic mice
    • Egeter O, Mocikat R, Ghoreschi K, Dieckmann A, Rocken M. Eradication of disseminated lymphomas with CpG-DNA activated T helper type 1 cells from nontransgenic mice. Cancer Res 2000;60:1515-20
    • (2000) Cancer Res , vol.60 , pp. 1515-1520
    • Egeter, O.1    Mocikat, R.2    Ghoreschi, K.3    Dieckmann, A.4    Rocken, M.5
  • 74
    • 0034114810 scopus 로고    scopus 로고
    • Bacterial DNA is implicated in the inflammatory response to delivery of DNA/DOTAP to mouse lungs
    • McLachlan G, Stevenson BJ, Davidson DJ, Porteous DJ. Bacterial DNA is implicated in the inflammatory response to delivery of DNA/DOTAP to mouse lungs. Gene Ther 2000;7:384-92
    • (2000) Gene Ther , vol.7 , pp. 384-392
    • McLachlan, G.1    Stevenson, B.J.2    Davidson, D.J.3    Porteous, D.J.4
  • 75
    • 0033586318 scopus 로고    scopus 로고
    • Intratracheal administration of interleukin 12 plasmid-cationic lipid complexes inhibits murine lung metastases
    • Blezinger P, Freimark BD, Matar M, et al. Intratracheal administration of interleukin 12 plasmid-cationic lipid complexes inhibits murine lung metastases. Hum Gene Ther 1999;10:723-31
    • (1999) Hum Gene Ther , vol.10 , pp. 723-731
    • Blezinger, P.1    Freimark, B.D.2    Matar, M.3
  • 76
    • 0033902946 scopus 로고    scopus 로고
    • Structure and function of lipid-DNA complexes for gene delivery
    • Chesnoy S, Huang L. Structure and function of lipid-DNA complexes for gene delivery. Ann Rev Biophys Biomol Struct 2000;29:27-47
    • (2000) Ann Rev Biophys Biomol Struct , vol.29 , pp. 27-47
    • Chesnoy, S.1    Huang, L.2
  • 77
    • 9444289263 scopus 로고    scopus 로고
    • Non-immunostimulatory nonviral vectors
    • Liu F, Shollenberger LM, Huang L. Non-immunostimulatory nonviral vectors. FASEB J 2004;18:1779-81
    • (2004) FASEB J , vol.18 , pp. 1779-1781
    • Liu, F.1    Shollenberger, L.M.2    Huang, L.3
  • 78
    • 0036954247 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Nonviral vectors
    • Niidome T, Huang L. Gene therapy progress and prospects: nonviral vectors. Gene Ther 2002;9:1647-52
    • (2002) Gene Ther , vol.9 , pp. 1647-1652
    • Niidome, T.1    Huang, L.2
  • 79
    • 0033671255 scopus 로고    scopus 로고
    • Spontaneously occurring tumors of companion animals as models for human cancer
    • Vail DM, MacEwen EG. Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest 2000;18:781-92
    • (2000) Cancer Invest , vol.18 , pp. 781-792
    • Vail, D.M.1    MacEwen, E.G.2
  • 81
    • 23844478541 scopus 로고    scopus 로고
    • Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases
    • Dow S, Elmslie R, Kurzman I, MacEwen G, Pericle F, Liggitt D. Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases. Hum Gene Ther 2005;16:937-46
    • (2005) Hum Gene Ther , vol.16 , pp. 937-946
    • Dow, S.1    Elmslie, R.2    Kurzman, I.3    MacEwen, G.4    Pericle, F.5    Liggitt, D.6
  • 82
    • 33645262322 scopus 로고    scopus 로고
    • Liposome-DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma
    • Kamstock D, Guth A, Elmslie R, et al. Liposome-DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma. Cancer Gene Ther 2005
    • (2005) Cancer Gene Ther
    • Kamstock, D.1    Guth, A.2    Elmslie, R.3
  • 83
    • 33750611959 scopus 로고    scopus 로고
    • Evaluation of a novel mmunotherapy for treatment of chronic rhinitis in cats
    • Veir JK, Lappin MR, Dow SW. Evaluation of a novel mmunotherapy for treatment of chronic rhinitis in cats. J Feline Med Surg 2006;8:400-11
    • (2006) J Feline Med Surg , vol.8 , pp. 400-411
    • Veir, J.K.1    Lappin, M.R.2    Dow, S.W.3
  • 84
    • 20444378530 scopus 로고    scopus 로고
    • Feline herpesvirus type-1 transcription is associated with increased nasal cytokine gene transcription in cats
    • Johnson LR, Maggs DJ. Feline herpesvirus type-1 transcription is associated with increased nasal cytokine gene transcription in cats. Vet Microbiol 2005;108:225-33
    • (2005) Vet Microbiol , vol.108 , pp. 225-233
    • Johnson, L.R.1    Maggs, D.J.2
  • 85
    • 0025478516 scopus 로고
    • Adjuvant formulations and their mode of action
    • Allison AC, Byars NE. Adjuvant formulations and their mode of action. Semin Immunol 1990;2:369-74
    • (1990) Semin Immunol , vol.2 , pp. 369-374
    • Allison, A.C.1    Byars, N.E.2
  • 86
    • 26244465082 scopus 로고    scopus 로고
    • Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: Therapeutic effect against cervical cancer
    • Cui Z, Huang L. Liposome-polycation-DNA (LPD) particle as a carrier and adjuvant for protein-based vaccines: therapeutic effect against cervical cancer. Cancer Immunol Immunother 2005;54:1180-90
    • (2005) Cancer Immunol Immunother , vol.54 , pp. 1180-1190
    • Cui, Z.1    Huang, L.2
  • 87
    • 0035575703 scopus 로고    scopus 로고
    • Efficient delivery of Antennapedia homeodomain fused to CTL epitope with liposomes into dendritic cells results in the activation of CD8+ T cells
    • Chikh GG, Kong S, Bally MB, Meunier JC, Schutze-Redelmeier MP. Efficient delivery of Antennapedia homeodomain fused to CTL epitope with liposomes into dendritic cells results in the activation of CD8+ T cells. J Immunol 2001;167:6462-70
    • (2001) J Immunol , vol.167 , pp. 6462-6470
    • Chikh, G.G.1    Kong, S.2    Bally, M.B.3    Meunier, J.C.4    Schutze-Redelmeier, M.P.5
  • 88
    • 0037529140 scopus 로고    scopus 로고
    • Effective induction of CD8+ T-cell response using CpG oligodeoxynucleotides and HER-2/neu-derived peptide co-encapsulated in liposomes
    • Li WM, Dragowska WH, Bally MB, Schutze-Redelmeier MP. Effective induction of CD8+ T-cell response using CpG oligodeoxynucleotides and HER-2/neu-derived peptide co-encapsulated in liposomes. Vaccine 2003;21:3319-29
    • (2003) Vaccine , vol.21 , pp. 3319-3329
    • Li, W.M.1    Dragowska, W.H.2    Bally, M.B.3    Schutze-Redelmeier, M.P.4
  • 90
    • 0021255726 scopus 로고
    • The effect of surface charges of liposomes in immunopotentiation
    • Latif N, Bachhawat BK. The effect of surface charges of liposomes in immunopotentiation. Biosci Rep 1984;4:99-107
    • (1984) Biosci Rep , vol.4 , pp. 99-107
    • Latif, N.1    Bachhawat, B.K.2
  • 91
    • 0023176326 scopus 로고
    • The effect of surface-coupled antigen of liposomes in immunopotentiation
    • Latif NA, Bachhawat BK. The effect of surface-coupled antigen of liposomes in immunopotentiation, Immunol Lett 1987;15:45-51
    • (1987) Immunol Lett , vol.15 , pp. 45-51
    • Latif, N.A.1    Bachhawat, B.K.2
  • 92
    • 23844462026 scopus 로고    scopus 로고
    • Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes
    • Rejman J, Bragonzi A, Conese M. Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes. Mol Ther 2005;12:468-74
    • (2005) Mol Ther , vol.12 , pp. 468-474
    • Rejman, J.1    Bragonzi, A.2    Conese, M.3
  • 93
    • 0036781643 scopus 로고    scopus 로고
    • On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: Is that the question?
    • Zuhorn IS, Hoekstra D. On the mechanism of cationic amphiphile-mediated transfection. To fuse or not to fuse: is that the question? J Membr Biol 2002;189:167-79
    • (2002) J Membr Biol , vol.189 , pp. 167-179
    • Zuhorn, I.S.1    Hoekstra, D.2
  • 94
    • 1942443062 scopus 로고    scopus 로고
    • Liposome-mediated DNA immunisation via the subcutaneous route
    • Perrie Y, McNeil S, Vangala A. Liposome-mediated DNA immunisation via the subcutaneous route. J Drug Target 2003;11:555-63
    • (2003) J Drug Target , vol.11 , pp. 555-563
    • Perrie, Y.1    McNeil, S.2    Vangala, A.3
  • 95
    • 0035971971 scopus 로고    scopus 로고
    • Liposome-mediated DNA vaccination: The effect of vesicle composition
    • Perrie Y, Frederik PM, Gregoriadis G. Liposome-mediated DNA vaccination: the effect of vesicle composition. Vaccine 2001;19:3301-10
    • (2001) Vaccine , vol.19 , pp. 3301-3310
    • Perrie, Y.1    Frederik, P.M.2    Gregoriadis, G.3
  • 96
    • 0031587422 scopus 로고    scopus 로고
    • Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins
    • Nakanishi T, Kunisawa J, Hayashi A, et al. Positively charged liposome functions as an efficient immunoadjuvant in inducing immune responses to soluble proteins. Biochem Biophys Res Commun 1997;240:793-97
    • (1997) Biochem Biophys Res Commun , vol.240 , pp. 793-797
    • Nakanishi, T.1    Kunisawa, J.2    Hayashi, A.3
  • 98
    • 2342625401 scopus 로고    scopus 로고
    • Interaction of dendritic cells with antigen-containing liposomes: Effect of bilayer composition
    • Foged C, Arigita C, Sundblad A, Jiskoot W, Storm G, Frokjaer S. Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition. Vaccine 2004;22:1903-13
    • (2004) Vaccine , vol.22 , pp. 1903-1913
    • Foged, C.1    Arigita, C.2    Sundblad, A.3    Jiskoot, W.4    Storm, G.5    Frokjaer, S.6
  • 99
    • 34247517688 scopus 로고    scopus 로고
    • The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes
    • Korsholm KS, Agger EM, Foged C, et al. The adjuvant mechanism of cationic dimethyldioctadecylammonium liposomes. Immunology 2007;121:216-26
    • (2007) Immunology , vol.121 , pp. 216-226
    • Korsholm, K.S.1    Agger, E.M.2    Foged, C.3
  • 100
    • 0035825581 scopus 로고    scopus 로고
    • Design, characterization and preclinical efficacy of a cationic lipid adjuvant for influenza split vaccine
    • Guy B, Pascal N, Francon A, et al. Design, characterization and preclinical efficacy of a cationic lipid adjuvant for influenza split vaccine. Vaccine 2001;19:1794-805
    • (2001) Vaccine , vol.19 , pp. 1794-1805
    • Guy, B.1    Pascal, N.2    Francon, A.3
  • 101
    • 1942451887 scopus 로고    scopus 로고
    • Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice
    • Hattori Y, Kawakami S, Suzuki S, Yamashita F, Hashida M. Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice. Biochem Biophys Res Commun 2004;317:992-9
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 992-999
    • Hattori, Y.1    Kawakami, S.2    Suzuki, S.3    Yamashita, F.4    Hashida, M.5
  • 103
    • 0036716966 scopus 로고    scopus 로고
    • Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients
    • Conry RM, Curiel DT, Strong TV, et al. Safety and immunogenicity of a DNA vaccine encoding carcinoembryonic antigen and hepatitis B surface antigen in colorectal carcinoma patients. Clin Cancer Res 2002;8:2782-7
    • (2002) Clin Cancer Res , vol.8 , pp. 2782-2787
    • Conry, R.M.1    Curiel, D.T.2    Strong, T.V.3
  • 104
    • 0034687696 scopus 로고    scopus 로고
    • Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses
    • Shi Y, Zheng W, Rock KL. Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses. Proc Natl Acad Sci USA 2000;97:14590-5
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 14590-14595
    • Shi, Y.1    Zheng, W.2    Rock, K.L.3
  • 105
    • 0034037160 scopus 로고    scopus 로고
    • Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway
    • Nakanishi T, Hayashi A, Kunisawa J, et al. Fusogenic liposomes efficiently deliver exogenous antigen through the cytoplasm into the MHC class I processing pathway. Eur J Immunol 2000;30:1740-7
    • (2000) Eur J Immunol , vol.30 , pp. 1740-1747
    • Nakanishi, T.1    Hayashi, A.2    Kunisawa, J.3
  • 106
    • 0026732781 scopus 로고
    • Cationic lipids direct a viral glycoprotein into the class I major histocompatibility complex antigen-presentation pathway
    • Walker C, Selby M, Erickson A, Cataldo D, Valensi JP, Van Nest GV. Cationic lipids direct a viral glycoprotein into the class I major histocompatibility complex antigen-presentation pathway. Proc Natl Acad Sci USA 1992;89:7915-18
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7915-7918
    • Walker, C.1    Selby, M.2    Erickson, A.3    Cataldo, D.4    Valensi, J.P.5    Van Nest, G.V.6
  • 107
    • 33947304311 scopus 로고    scopus 로고
    • TLR9 agonists as adjuvants for prophylactic and therapeutic vaccines
    • Daubenberger CA. TLR9 agonists as adjuvants for prophylactic and therapeutic vaccines. Curr Opin Mol Ther 2007;9:45-52
    • (2007) Curr Opin Mol Ther , vol.9 , pp. 45-52
    • Daubenberger, C.A.1
  • 108
    • 33750961667 scopus 로고    scopus 로고
    • Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA
    • McCluskie MJ, Krieg AM. Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA. Curr Top Microbiol Immunol 2006;311:155-78
    • (2006) Curr Top Microbiol Immunol , vol.311 , pp. 155-178
    • McCluskie, M.J.1    Krieg, A.M.2
  • 109
    • 33745851536 scopus 로고    scopus 로고
    • Adjuvant activity of CpG oligodeoxynucleotides
    • Klinman DM. Adjuvant activity of CpG oligodeoxynucleotides, Int Rev Immunol 2006;25:135-54
    • (2006) Int Rev Immunol , vol.25 , pp. 135-154
    • Klinman, D.M.1
  • 110
    • 15244360555 scopus 로고    scopus 로고
    • Current vaccine adjuvants: An overview of a diverse class
    • Kensil CR, Mo AX, Truneh A. Current vaccine adjuvants: an overview of a diverse class. Front Biosci 2004;9:2972-88
    • (2004) Front Biosci , vol.9 , pp. 2972-2988
    • Kensil, C.R.1    Mo, A.X.2    Truneh, A.3
  • 111
    • 0036803563 scopus 로고    scopus 로고
    • Immunopharmacology of CpG DNA
    • Dalpke A, Zimmermann S, Heeg K. Immunopharmacology of CpG DNA. Biol Chem 2002;383:1491-500
    • (2002) Biol Chem , vol.383 , pp. 1491-1500
    • Dalpke, A.1    Zimmermann, S.2    Heeg, K.3
  • 112
    • 2942631177 scopus 로고    scopus 로고
    • Enhanced hepatitis C virus NS3 specific Th1 immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes
    • Jiao X, Wang RY, Qiu Q, Alter HJ, Shih JW. Enhanced hepatitis C virus NS3 specific Th1 immune responses induced by co-delivery of protein antigen and CpG with cationic liposomes. J Gen Virol 2004;85:1545-53
    • (2004) J Gen Virol , vol.85 , pp. 1545-1553
    • Jiao, X.1    Wang, R.Y.2    Qiu, Q.3    Alter, H.J.4    Shih, J.W.5
  • 113
    • 33744521498 scopus 로고    scopus 로고
    • The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu
    • Salem ML, El-Naggar SA, Kadima A, Gillanders WE, Cole DJ. The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu. Vaccine 2006;24:5119-32
    • (2006) Vaccine , vol.24 , pp. 5119-5132
    • Salem, M.L.1    El-Naggar, S.A.2    Kadima, A.3    Gillanders, W.E.4    Cole, D.J.5
  • 114
    • 33845568917 scopus 로고    scopus 로고
    • Inhibitory effect of the polyinosinic-polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma
    • Fujimura T, Nakagawa S, Ohtani T, Ito Y, Aiba S. Inhibitory effect of the polyinosinic-polycytidylic acid/cationic liposome on the progression of murine B16F10 melanoma. Eur J Immunol 2006;36:3371-80
    • (2006) Eur J Immunol , vol.36 , pp. 3371-3380
    • Fujimura, T.1    Nakagawa, S.2    Ohtani, T.3    Ito, Y.4    Aiba, S.5


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