Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases

Human Gene Therapy

Volumn 10, Issue 18, 1999, Pages 2961-2972

  Dow, Steven W ^a,b   Elmslie, Robyn E ^c   Fradkin, Lee G ^d   Liggitt, Denny H ^d   Heath, Timothy D ^e   Willson, Andrew P ^a   Potter, Terry A ^a,f  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c Veterinary Referral Center of Colorado   (United States)

^d Urigen Pharmaceuticals Inc   (United States)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

^f UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; GENE THERAPY; LUNG METASTASIS; MOUSE; NONHUMAN; TREATMENT OUTCOME;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; CYTOTOXICITY, IMMUNOLOGIC; DNA; GENETIC VECTORS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; KILLER CELLS, NATURAL; LIPIDS; LUNG; LUNG NEOPLASMS; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED STRAINS;

ANIMALIA;

EID: 0033544946     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950016375     Document Type: Article

References (37)

1. BALLAS, Z.K., RASMUSSEN, W.L., and KRIEG, A.M. (1996). Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157, 1840-1845.
2. BLEZINGER, P., FREIMARK, B.D., MATAR, M., WILSON, E., SINGHAL, A., MIN, W., NORDSTROM, J.L., and PERICLE, F. (1999). Intratracheal administration of interluekin-12 plasmid cationic lipid complexes inhibits murine lung metastases. Hum. Gene Ther. 10, 723-731.
3. BRUNDA, M.J., LUISTRO, L., WARRIER, R.R., WRIGHT, R.B., HUBBARD, B.R., MURPHY, M., WOLF, S.F., and GATELY, M.K. (1993). Antitumor and antimetastatic activity of interleukin-12 against murine tumors. J. Exp. Med. 178, 1223-1230.
4. CHACE, J.H., HOOKER, N.A., MILDENSTEIN, K.L., KRIEG, A.M., and COWDERY, J.S. (1997). Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84, 185-193.
5. COUGHLIN, C.M., SALHANY, K.E., GEE, M.S., LATEMPLE, D.C., KOTENKO, S., MA, X., GRI, G., WYSOCKA, M., KIM, I.E., LIU, L., LIAO, F., FARBER, J.M., PESTKA, S., TRINCHIERI, G., and LEE, W.M. (1998a). Tumor cell responses to IFN-γ affect tumorigenicity and response to IL-12 therapy and antiangiogenesis. Immunity 9, 25-34.
6. COUGHLIN, C.M., SALHANY, K.E., WYSOCKA, M., ARUGA, E., KURZAWA, H., CHANG, A.E., HUNTER, C.A., FOX, J.C., TRINCHIERIA, G., and LEE, W.M.F. (1998b). Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J. Clin. Invest. 101, 1441-1452.
7. DOW, S.W., FRADKIN, L.G., LIGGITT, D.H., WILLSON, A.P., HEATH, T.D., and POTTER, T.A. (1999). Lipid-DNA complexes induce potent activation of innate immunity and antitumor activity when administered intravenously. J. Immunol. 163, 1552-1561.
8. DRANOFF, G., JAFFEE, E., LAZENBY, A., GOLUMBEK, P., LEVITSKY, H., BROSE, K., JACKSON, V., HAMADA, H., PARDOLL, D., and MULLIGAN, R. (1993). Vaccination with irradiated tumor cells engineered to secrete granulocyte-macrophage colony stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. U.S.A. 90, 3539-3543.
9. FEARON, E.R., PARDOLL, D.M., ITAYA, T., GOLUMBEK, P., LEVITSKY, H.I., SIMONS, J.W., KARASUYAMA, H., VOGELSTEIN, B., and FROST, P. (1990). Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 60, 397-403.
10. FERNANDEZ, N.C., LEVRAUD, J.P., HADDADA, H., PERRICAUDET, M., and KOURILSKY, P. (1999). High frequency of specific CD8+ T cells in the tumor and blood is associated with efficient local IL-12 gene therapy of cancer. J. Immunol. 162, 6609-6617.
11. FOGLER, W.E., VOLKER, K., WATANABE, M., WIGGINTON, J.M., ROESSLER, P., BRUNDA, M.J., ORTALDO, J.R., and WILTROUT, R.H. (1998). Recruitment of hepatic NK cells by IL-12 is dependent on IFN-gamma and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas. J. Immunol. 161, 6014-6021.
12. FYFE, G.A., FISHER, R.J., ROSENBERG, S.A., SZNOL, M., PARKINSON, D.R., and LOUIE, A.C. (1996). Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy. J. Clin. Oncol. 14, 2410-2411.
13. GANSBACHER, B., ZIER, K., DANIELS, B., CRONIN, K., BANNERJI, R., and GILBOA, E. (1990). Interleukin-2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J. Exp. Med. 172, 1217-1224.
14. IRVINE, K.R., ROA, J.B., ROSENBERG, S.A., and RESTIFO, N.P. (1996). Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J. Immunol. 156, 238-245.
15. KHATRI, V.P., FEHNIGER, T.A., BAIOCCHI, R.A., YU, F., SHAH, M.H., SCHILLER, D.S., GOULD, M., GAZZINELLI, R.T., BERNSTEIN, Z.P., and CALIGIURI, M.A. (1998). Ultra low dose interleukin-2 therapy promotes a type 1 cytokine profile in vivo in patients with AIDS and AIDS-associated malignancies. J. Clin. Invest. 101, 1373-1378.
16. KLINMAN, D.M., YI, A., BEAUCAGE, S.J., CONOVER, J., and KRIEG, A.M. (1996). CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin-6, interleukin-12, and interferon γ. Proc. Natl. Acad. Sci. U.S.A. 93, 2879-2883.
17. KRIEG, A.M., YI, A.K., MATSON, S., WALDSCHMIDT, T.J., BISHOP, G.A., TEASDALE, R., KORETZHY, G.A., and KLINMAN, D.M. (1995). CpG motifs in bacterial DNA trigger direct B-cell activation. Nature (London) 374, 546-549.
18. LESOON-WOOD, L.A., KIM, W.H., KLEINMAN, H.K., WEINTRAUB, B.D., and MIXSON, A.J. (1995). Systemic gene therapy with p53 reduces growth and metastases of a malignant human breast cancer in nude mice. Hum. Gene Ther. 6, 395-405.
19. LIU, Y., LIGGITT, D., TU, G., ZHONG, W., GAENSLER, K., and DEBS, R. (1995). Cationic liposome-mediated intravenous gene delivery in mice. J. Biol. Chem. 270, 24864-24870.
20. LIU, Y., MOUNKES, L.C., LIGGITT, H.D., BORWN, C.S., SOLODIN, I., HEATH, T.D., and DEBS, R.J. (1997). Factors influencing the efficiency of cationic liposome-mediated intravenous gene delivery. Nature Biotechnol. 15, 167-173.
21. LIU, Y., THOR, A., SHTIVELMAN. E., CAO, Y., TU, G., HEATH, T.D., and DEBS, R.J. (1999). Systemic gene delivery expands the repertoire of effective antiangiogenic agents. J. Biol. Chem. 274, 13338-13344.
22. LODE, H.N., DREIER, T., XIANG, R., VARKIN, M., KANG, A.S., and RESIFELD, R.A. (1998). Gene therapy with a single chain interleukin-12 fusion protein induces T cell-dependent protective immunity if a syngeneic model of murine neuroblastoma. Proc. Natl. Acad. Sci. U.S.A. 95, 2475-2480.
23. McLEAN, J.W., FOX, E.A., BALUK, P., BOLTON, P.B., HASKELL, A., PEARLMAN, R., THURSTON, G., UMEMOTO, E.Y., and McDONALD, D.M. (1997). Organ-specific endothelial cell uptake of cationic liposome-DNA complexes. Am. J. Physiol. 273, H387-H404.
24. NABEL, G.J., NABEL, E.G., YANG, Z., FOX, B.A., PLAUTZ, G.E., GAO, X., HUANG, L., SHU, S., GORDON, D., and CHANG, A.E. (1993). Direct gene transfer with DNA-liposome complexes in melanoma: Expression, biologic activity, and lack of toxicity in humans. Proc. Natl. Acad. Sci. U.S.A. 90, 11307-11311.
25. PARKER, S.E., KHATIBI, S., MARGALITH, M., ANDERSON, D., YANKAUCKAS, M., GROMKOWSKI, S.H., LATIMER, T., LEW, D., MARQUET, M., MANTHORPE, M., HOBART, P., HERSH, E., STOPECK, A.T., and NORMAN, J. (1996). Plasmid DNA gene therapy: Studies with the human interleukin-2 gene in tumor cells in vitro and in the murine B16 melanoma model in vivo. Cancer Gene Ther. 3, 175-185.
26. PISETSKY, D.S. (1996). Immune activation by bacterial DNA: A new genetic code. Immunity 5, 303-310.
27. PLAUTZ, G.E., YANG, Z., WU, B., GOA, X., HUANG, L., and NABEL, G. (1993). Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc. Natl. Acad. Sci. U.S.A. 90, 4645-4649.
28. ROSENBERG, S.A., YANG, J.C., TOPALIAN, S.L., WEBER, D.J., PARKINSON, D.R., et al. (1994). Treatment of 283 consecutive patients with metastatic melanoma or renal cell carcinoma using high-dose bolus interleukin-2. J. Am. Med. Assoc. 271, 907-913.
29. ROTH, J.A., NGUYEN, D., LAWRENCE, D.D., KEMP, B.L., CARRASCO, C.H., FERSON, D.Z., HONG, W.K., KOMAKI, R., LEE, J.J., NESBITT, J.C., PISTERS, K.M., PUTNAM, J.B., SCHEA, R., SHIN, D.M., WALSH, G.L., DOLORMENTE, M.M., HAN, C.I., MARTIN, F.D., YEN, N., XU, K., STEPHENS, L.C., McDONNELL, T.J., MUKHOPADHYAY, T., and CAI, D. (1996). Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nature Med. 2, 985-991.
30. SONG, Y.K., FENG, L., SHAOYOU, C., and DEXI, L. (1997). Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Hum. Gene Ther. 8, 1585-1594.
31. SUN, Y., JURGOVSKY, K., MOLLER, P., ALIJAGIC, S., DORBIC, T., GEORGIEVA, J., WITTIG, B., and SCHADENDORF, D. (1998). Vaccination with IL-12 gene-modified autologous melanoma cells: Preclinical results and a first clinical phase I study. Gene Ther. 5, 481-490.
32. TEMPLETON, N., LASIC, D., FREDERIK, P., STREY, H., ROBERTS, D., and PAVLAKIS, G. (1997). Improved DNA: Liposome complexes for increased systemic delivery and gene expression. Nature Biotechnol. 15, 647-652.
33. TOKUNAGA, T., YAMAMOTO, H., SHIMADA, S., ABE, H., FUKUDA, T., FUJISAWA, Y., FURUTANI, Y., YANO, O., KATAOKA, T., and SUDO, T. (1984). Antitumor activity of deoxyribonucleic acid fraction from Mycobacrerium bovis BCG. I. Isolation, physiochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72, 955-962.
34. WEXLER, H. (1966). Accurate identification of experimental pulmonary metastases. J. Natl. Cancer Inst. 36, 641-645.
35. WHITESIDE, T.L., VUJANOVIC, N.L., and HERBERMANN, R.B. (1998). Natural killer cells and tumor therapy. Curr. Top. Microb. Immunol. 230, 221-244.
36. YOKOYAMA, W.M., and SEAMAN, W.E. (1993). The Ly-49 and NKR-P1 gene gamilies encoding lectin-like receptors on natural killer cells: The NK gene complex. Annu. Rev. Immunol. 11, 613-635.
37. ZHU, N., LIGGITT, D., LIU, Y., and DEBS, R. (1993). Systemic gene expression after i.v. delivery of DNA into adult mice. Science 261, 209-211.