Strategies to in vitro assessment of major human CYP enzyme activities by using liquid chromatography tandem mass spectrometry

Current Drug Metabolism

Volumn 9, Issue 1, 2008, Pages 12-19

  Lahoz, Agustin ^a   Donato, M T ^b   Castell, J V ^b,c   Gomez Lechon M J ^c  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c CIBERHEPAD   (Spain)

Author keywords

ADME; CYP activities; HPLC MS MS; HTS; Mass spectrometry; Substrates cocktail

Indexed keywords

4 NITROPHENOL; AFLATOXIN B1; AMFEBUTAMONE; AMODIAQUINE; BUFURALOL; CAFFEINE; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450; DEBRISOQUINE; DEXAMETHASONE; DEXTROMETHORPHAN; DICLOFENAC; ETHOXYRESORUFIN; MELATONIN; MEPHENYTOIN; MIDAZOLAM; NICOTINE; NIFEDIPINE; OMEPRAZOLE; PACLITAXEL; PHENACETIN; PHENOBARBITAL; PROGESTERONE; RECOMBINANT ENZYME; RIFAMPICIN; TESTOSTERONE; TOLBUTAMIDE; UNINDEXED DRUG; WARFARIN;

DRUG METABOLISM; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; NONHUMAN; PHENOTYPE; QUANTITATIVE ANALYSIS; REVIEW; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INDUCTION; HEPATOCYTES; HUMANS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SUBSTRATE SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 38849153472     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008783331112     Document Type: Review

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