Inhibition of CYP3A4 in a rapid microtiter plate assay using recombinant enzyme and in human liver microsomes using conventional substrates

Drug Metabolism and Disposition

Volumn 29, Issue 5, 2001, Pages 748-753

  Nomeir, Amin A ^a   Ruegg, Charles ^b   Shoemaker, Matthew ^b   Favreau, Leonard V ^a   Palamanda, Jairam R ^a   Silber, Paul ^b   Lin, Chin Chung ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b In Vitro Technologies Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; DEXTROMETHORPHAN; KETOCONAZOLE; MIDAZOLAM; RECOMBINANT ENZYME; RESORUFIN DERIVATIVE; TESTOSTERONE;

ARTICLE; DRUG HYDROXYLATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IC 50; LIVER MICROSOME; PRIORITY JOURNAL; RELIABILITY;

CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0035039894     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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