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Volumn 201, Issue 8, 1998, Pages 1243-1254

Mechanism and evolution of hypoxia-tolerance in humans

Author keywords

Endurance performance; Evolutionary physiology; High altitude; Hypoxia tolerance; Quechua; Sherpa

Indexed keywords

ADAPTATION; ANOXIA; ARTICLE; EVOLUTION; GENETICS; HUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PHYLOGENY; PHYSIOLOGY;

EID: 0032053158     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (112)

References (73)
  • 1
    • 21844515682 scopus 로고
    • Mechanism of oxygen sensing in the carotid body in comparison with other oxygen sensing cells
    • ACKER, H. AND XUE, D. (1995). Mechanism of oxygen sensing in the carotid body in comparison with other oxygen sensing cells. News physiol. Sci. 10, 211-216.
    • (1995) News Physiol. Sci. , vol.10 , pp. 211-216
    • Acker, H.1    Xue, D.2
  • 6
    • 0013694710 scopus 로고
    • What's past is prologue. A 'White Paper' on the future of physiology and the role of the APS in it
    • APS LRPC REPORT (1990). What's past is prologue. A 'White Paper' on the future of physiology and the role of the APS in it. Physiologist 33, 161-180.
    • (1990) Physiologist , vol.33 , pp. 161-180
  • 7
    • 0040321981 scopus 로고    scopus 로고
    • The sun breaks through: A bright future for physiology
    • APS LRPC REPORT (1996). The sun breaks through: A bright future for physiology. Physiologist 39, 375-388.
    • (1996) Physiologist , vol.39 , pp. 375-388
  • 8
    • 0001841679 scopus 로고
    • The accomplishments of ecological physiology
    • (ed. M. E. Feder, A. F. Bennett, W. W. Burggren and R. B. Huey), Cambridge: Cambridge University Press
    • BENNETT, A. F. (1987). The accomplishments of ecological physiology. In New Directions in Ecological Physiology (ed. M. E. Feder, A. F. Bennett, W. W. Burggren and R. B. Huey), pp. 1-8. Cambridge: Cambridge University Press.
    • (1987) New Directions in Ecological Physiology , pp. 1-8
    • Bennett, A.F.1
  • 9
  • 10
    • 0005693719 scopus 로고    scopus 로고
    • Mammalian fuel preferences during exercise
    • in press
    • BROOKS, G. A. (1998). Mammalian fuel preferences during exercise. Comp. Biochem. Physiol. (in press).
    • (1998) Comp. Biochem. Physiol.
    • Brooks, G.A.1
  • 13
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • BUNN, H. F. AND ANDPOYTON, R. O. (1996). Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76, 839-885.
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.F.1    Andpoyton, R.O.2
  • 17
    • 0031057091 scopus 로고    scopus 로고
    • Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptor in human skin
    • DETMAR, M., BROWN, L. F., BERSE, B., JACKMAN, R. W., ELICKER, B. M., DVORAK, H. F. AND CLAFFEY, K. P. (1996). Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptor in human skin. J. invest. Dermatol. 108, 263-268.
    • (1996) J. Invest. Dermatol. , vol.108 , pp. 263-268
    • Detmar, M.1    Brown, L.F.2    Berse, B.3    Jackman, R.W.4    Elicker, B.M.5    Dvorak, H.F.6    Claffey, K.P.7
  • 18
    • 0026086005 scopus 로고
    • Heritability of aerobic power and anaerobic energy generation during exercise
    • FAGARD, R., BIELEN, E. AND AMERY, A. (1991). Heritability of aerobic power and anaerobic energy generation during exercise. J. appl. Physiol. 70, 357-362.
    • (1991) J. Appl. Physiol. , vol.70 , pp. 357-362
    • Fagard, R.1    Bielen, E.2    Amery, A.3
  • 20
    • 0001927963 scopus 로고
    • The analysis of physiological diversity: The prospects for pattern documentation and general questions in ecological physiology
    • (ed. M. E. Feder, A. F. Bennett, W. W. Burggren and R. B. Huey), Cambridge: Cambridge University Press
    • FEDER, M. E. (1987). The analysis of physiological diversity: the prospects for pattern documentation and general questions in ecological physiology. In New Directions in Ecological Physiology (ed. M. E. Feder, A. F. Bennett, W. W. Burggren and R. B. Huey), pp. 38-70. Cambridge: Cambridge University Press.
    • (1987) New Directions in Ecological Physiology , pp. 38-70
    • Feder, M.E.1
  • 21
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • FORSYTHE, J. S., HANG, B. H., IYER, N. V., AGANI, F., LEUNG, S. W., KOOS, R. D. AND SEMENZA, G. L. (1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Molec. cell. Biol. 16, 4604-4613.
    • (1996) Molec. Cell. Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.S.1    Hang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 22
    • 0024273450 scopus 로고
    • Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
    • GOLDBERG, M. A., DUNNING, S. P. AND BUNN, H. F. (1988). Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein. Science 242, 1412-1415.
    • (1988) Science , vol.242 , pp. 1412-1415
    • Goldberg, M.A.1    Dunning, S.P.2    Bunn, H.F.3
  • 23
    • 0026445945 scopus 로고
    • Muscular adaptations at extreme altitude: Metabolic implications during exercise
    • GREEN, H. G. (1992). Muscular adaptations at extreme altitude: metabolic implications during exercise. Int. J. Sports Med. 13, S163-S165.
    • (1992) Int. J. Sports Med. , vol.13
    • Green, H.G.1
  • 26
    • 0030597075 scopus 로고    scopus 로고
    • Time-course and reversibility of the hypoxia induced alterations in cerebral vascularity and cerebral capillary glucose transporter density
    • HARIK, N., HARIK, S. I., KUO, N. T., SAKAI, K., PRZYBYLSKI, R. J. AND LAMANNA, J. C. (1996). Time-course and reversibility of the hypoxia induced alterations in cerebral vascularity and cerebral capillary glucose transporter density. Brain Res. 737, 335-338.
    • (1996) Brain Res. , vol.737 , pp. 335-338
    • Harik, N.1    Harik, S.I.2    Kuo, N.T.3    Sakai, K.4    Przybylski, R.J.5    Lamanna, J.C.6
  • 28
    • 0026474076 scopus 로고
    • Muscle enzymatic composition and metabolic regulation in high altitude adapted natives
    • HOCHACHKA, P. W. (1992). Muscle enzymatic composition and metabolic regulation in high altitude adapted natives. Int. J. Sports Med. 13, S89-S91.
    • (1992) Int. J. Sports Med. , vol.13
    • Hochachka, P.W.1
  • 31
    • 0029796904 scopus 로고    scopus 로고
    • Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack
    • HOCHACHKA, P. W., BUCK, L. T., DOLL, C. AND LAND, S. C. (1996a). Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc. natn. Acad. Sci. U.S.A. 93, 9493-9498.
    • (1996) Proc. Natn. Acad. Sci. U.S.A. , vol.93 , pp. 9493-9498
    • Hochachka, P.W.1    Buck, L.T.2    Doll, C.3    Land, S.C.4
  • 35
    • 0032539713 scopus 로고    scopus 로고
    • Our ancestral physiological phenotype: An adaptation for hypoxia tolerance and for endurance performance?
    • HOCHACHKA, P. W., GUNGA, H. C. AND KIRSCH, K. (1997). Our ancestral physiological phenotype: An adaptation for hypoxia tolerance and for endurance performance? Proc. natn. Acad. Sci. U.S.A. 95, 1915-1920.
    • (1997) Proc. Natn. Acad. Sci. U.S.A. , vol.95 , pp. 1915-1920
    • Hochachka, P.W.1    Gunga, H.C.2    Kirsch, K.3
  • 36
    • 0030939284 scopus 로고    scopus 로고
    • Cellular metabolic homeostasis during large scale change in ATP turnover rates in muscles
    • HOCHACHKA, P. W. AND MCCLELLAND, G. (1997). Cellular metabolic homeostasis during large scale change in ATP turnover rates in muscles. J. exp. Biol. 200, 381-386.
    • (1997) J. Exp. Biol. , vol.200 , pp. 381-386
    • Hochachka, P.W.1    Mcclelland, G.2
  • 37
    • 2642593601 scopus 로고    scopus 로고
    • Evolution and adaptation of the diving response: Phocids and otariids
    • in press
    • HOCHACHKA, P. W. AND MOTTISHAW, P. D. (1997). Evolution and adaptation of the diving response: phocids and otariids. Soc. exp. Biol. Symp. Ser. (in press).
    • (1997) Soc. Exp. Biol. Symp. Ser.
    • Hochachka, P.W.1    Mottishaw, P.D.2
  • 40
    • 0026437425 scopus 로고
    • Enzyme mechanisms for pyruvate-to-lactate flux attentuation: A study of Sherpas, Quechuas and hummingbirds
    • HOCHACHKA, P. W., STANLEY, C., MCKENZIE, D. C., VILLENA, A. AND MONGE, C. (1992). Enzyme mechanisms for pyruvate-to-lactate flux attentuation: A study of Sherpas, Quechuas and hummingbirds. Int. J. Sports Med. 13, S119-S123.
    • (1992) Int. J. Sports Med. , vol.13
    • Hochachka, P.W.1    Stanley, C.2    Mckenzie, D.C.3    Villena, A.4    Monge, C.5
  • 41
    • 0029151795 scopus 로고
    • Enhanced cardiac metabolism of plasma glucose in high altitude natives. Adaptations against chronic hypoxia
    • HOLDEN, J. E., STONE, C., BROWN, W. D., NICKLES, R. J., STANLEY, C., CLARK, C. M. AND HOCHACHKA, P. W. (1995). Enhanced cardiac metabolism of plasma glucose in high altitude natives. Adaptations against chronic hypoxia. J. appl. Physiol. 79, 222-228.
    • (1995) J. Appl. Physiol. , vol.79 , pp. 222-228
    • Holden, J.E.1    Stone, C.2    Brown, W.D.3    Nickles, R.J.4    Stanley, C.5    Clark, C.M.6    Hochachka, P.W.7
  • 42
    • 0004199488 scopus 로고
    • Cambridge: Cambridge University Press
    • JONES, S. (1995). (ed.) Human Evolution. Cambridge: Cambridge University Press. 506pp.
    • (1995) Human Evolution
    • Jones, S.1
  • 43
    • 0025796615 scopus 로고
    • Muscle structure and performance capacity of Himalayan Sherpas
    • KAYSER, B., HOPPELER, H., CLAASSEN, H. AND CERRETELLI, P. (1991). Muscle structure and performance capacity of Himalayan Sherpas. J. appl. Physiol. 70, 1938-1942.
    • (1991) J. Appl. Physiol. , vol.70 , pp. 1938-1942
    • Kayser, B.1    Hoppeler, H.2    Claassen, H.3    Cerretelli, P.4
  • 46
    • 0027328476 scopus 로고
    • Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart
    • LADOUX, A. AND FELIN, C. (1993). Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart. Biochem. biophys. Res. Commun. 195, 1005-1010.
    • (1993) Biochem. Biophys. Res. Commun. , vol.195 , pp. 1005-1010
    • Ladoux, A.1    Felin, C.2
  • 47
    • 0000610202 scopus 로고    scopus 로고
    • Peripheral chemoreceptors and their sensory neurons in chronic states of hypo- and hyperoxygenation
    • LAHIRI, S. (1996). Peripheral chemoreceptors and their sensory neurons in chronic states of hypo- and hyperoxygenation. Handbook Physiol. 2, 1183-1206.
    • (1996) Handbook Physiol. , vol.2 , pp. 1183-1206
    • Lahiri, S.1
  • 49
    • 0026478562 scopus 로고
    • A practical approach to altitude training: Where to live and train for optimal performance enhancement
    • LEVINE, B. D. AND STRAY-GUNDERSON, J. (1992). A practical approach to altitude training: Where to live and train for optimal performance enhancement. Int. J. Sports Med. 13, S209-212.
    • (1992) Int. J. Sports Med. , vol.13
    • Levine, B.D.1    Stray-Gunderson, J.2
  • 50
    • 0030848144 scopus 로고    scopus 로고
    • Living high -training low: The effect of high altitude acclimatization with low altitude training on sea level performance
    • LEVINE, B. D. AND STRAY-GUNDERSON, J. (1997). Living high -training low: the effect of high altitude acclimatization with low altitude training on sea level performance. J. appl. Physiol. 82, 102-112.
    • (1997) J. Appl. Physiol. , vol.82 , pp. 102-112
    • Levine, B.D.1    Stray-Gunderson, J.2
  • 52
    • 0032168540 scopus 로고    scopus 로고
    • New directions in comparative biochemistry and physiology: Mechanism, adaptation and evolution
    • in press
    • MANGUM, C. P. AND HOCHACHKA, P. W. (1998). New directions in comparative biochemistry and physiology: mechanism, adaptation and evolution. Physiol. Zool. (in press).
    • (1998) Physiol. Zool.
    • Mangum, C.P.1    Hochachka, P.W.2
  • 53
    • 0027523629 scopus 로고
    • O2max of trained and untrained subjects
    • O2max of trained and untrained subjects. J. Sports Sci. 11, 37-42.
    • (1992) J. Sports Sci. , vol.11 , pp. 37-42
    • Martin, D.1    O'Kroy, J.2
  • 55
    • 0027461553 scopus 로고
    • Inducible operation of the erythropoitin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen sensing mechanism
    • MAXWELL, P. H., PUGH, C. W. AND RATCLIFFE, P. J. (1993). Inducible operation of the erythropoitin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism. Proc. natn. Acad. Sci. U.S.A. 90, 2423-2427.
    • (1993) Proc. Natn. Acad. Sci. U.S.A. , vol.90 , pp. 2423-2427
    • Maxwell, P.H.1    Pugh, C.W.2    Ratcliffe, P.J.3
  • 58
    • 0028051712 scopus 로고
    • Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart
    • OGITA, H. E., NAKAOKA, T., MATSUOKA, R., TAKAO, A. AND KIRA, Y. (1994). Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am. J. Physiol. 267, H1948-H1954.
    • (1994) Am. J. Physiol. , vol.267
    • Ogita, H.E.1    Nakaoka, T.2    Matsuoka, R.3    Takao, A.4    Kira, Y.5
  • 59
    • 0029933004 scopus 로고    scopus 로고
    • Involvement of protein kinase C in hypoxia induced deserialization of the beta-adrenergic system in human endothelial cells
    • RESINK, T., BURAVKOVA, L., MIRZAPOYAZOVA KOHLER, E., ERNE, P. AND TKACHUK, V. (1996). Involvement of protein kinase C in hypoxia induced deserialization of the beta-adrenergic system in human endothelial cells: Biochem. biophys. Res. Commun. 222, 753-758.
    • (1996) Biochem. Biophys. Res. Commun. , vol.222 , pp. 753-758
    • Resink, T.1    Buravkova, L.2    Mirzapoyazova Kohler, E.3    Erne, P.4    Tkachuk, V.5
  • 60
    • 0027772359 scopus 로고
    • Metabolic capacity of muscle fibers from high-altitude natives
    • ROSSER, B. W. C. AND HOCHACHKA, P. W. (1994). Metabolic capacity of muscle fibers from high-altitude natives. Eur. J. appl. Physiol. 67, 513-517.
    • (1994) Eur. J. Appl. Physiol. , vol.67 , pp. 513-517
    • Rosser, B.W.C.1    Hochachka, P.W.2
  • 61
    • 0029351339 scopus 로고
    • Morphology, enzyme activities and buffer capacity in leg muscles of Kenyan and Scandinavian runners
    • SALTIN, B., KIM, C. K., TERRADOS, N., LARSEN, H., SVEDENHAG, J. AND ROLF, C. J. (1995a). Morphology, enzyme activities and buffer capacity in leg muscles of Kenyan and Scandinavian runners. Scand. J. Med. Sci. Sports 5, 222-230.
    • (1995) Scand. J. Med. Sci. Sports , vol.5 , pp. 222-230
    • Saltin, B.1    Kim, C.K.2    Terrados, N.3    Larsen, H.4    Svedenhag, J.5    Rolf, C.J.6
  • 62
    • 0029355787 scopus 로고
    • Aerobic exercise capacity at sea level and at altitude in Kenyan boys, junior and senior runners compared with Scandinavian runners
    • SALTIN, B., LARSEN, H., TORRADOS, N., BANGSBO, J., BAK, T., KIM, C. K., SVEDENHAG, J. AND ROLF, C. J. (1995b). Aerobic exercise capacity at sea level and at altitude in Kenyan boys, junior and senior runners compared with Scandinavian runners. Scand. J. Med. Sci. Sports 5, 209-221.
    • (1995) Scand. J. Med. Sci. Sports , vol.5 , pp. 209-221
    • Saltin, B.1    Larsen, H.2    Torrados, N.3    Bangsbo, J.4    Bak, T.5    Kim, C.K.6    Svedenhag, J.7    Rolf, C.J.8
  • 65
    • 0005692661 scopus 로고    scopus 로고
    • Ventilatory response to experimental hypoxia in adult male and female natives of the Tibetan and Andean plateaus
    • (ed. C. Houston). (in press)
    • STROHL, K. P. AND BEALL, C. M. (1997). Ventilatory response to experimental hypoxia in adult male and female natives of the Tibetan and Andean plateaus. In Women at Altitude (ed. C. Houston). (in press).
    • (1997) Women at Altitude
    • Strohl, K.P.1    Beall, C.M.2
  • 66
    • 0026437434 scopus 로고
    • Altitude training and muscular metabolism
    • TERRADOS, N. (1992). Altitude training and muscular metabolism. Int. J. Sports Med. 13, S206-S209.
    • (1992) Int. J. Sports Med. , vol.13
    • Terrados, N.1
  • 67
    • 0003501996 scopus 로고
    • New Haven, CT: Yale University Press
    • VRBA, E. S. (1994). (ed.) Paleoclimate and Evolution. New Haven, CT: Yale University Press. 547pp.
    • (1994) Paleoclimate and Evolution
    • Vrba, E.S.1
  • 68
    • 0029051439 scopus 로고
    • Hypoxia inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular oxygen tension
    • WANG, G. L., JIAN, B. H., RUE, E. A. AND SEMENZA, G. L. (1995). Hypoxia inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular oxygen tension. Proc. natn. Acad. Sci. U.S.A. 92, 5510-5514.
    • (1995) Proc. Natn. Acad. Sci. U.S.A. , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jian, B.H.2    Rue, E.A.3    Semenza, G.L.4
  • 69
    • 0028916976 scopus 로고
    • The mechanism of acute hypoxic pulmonary vasoconstriction: A tale of two channels
    • WEIR, E. K. AND ARCHER, S. L. (1955). The mechanism of acute hypoxic pulmonary vasoconstriction: a tale of two channels. FASEB J. 9, 183-189.
    • (1955) FASEB J. , vol.9 , pp. 183-189
    • Weir, E.K.1    Archer, S.L.2
  • 70
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor 1
    • WENGER, R. H. AND GASSMANN, M. (1997). Oxygen(es) and the hypoxia-inducible factor 1. Biol. Chem. 378, 609-616.
    • (1997) Biol. Chem. , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 71
    • 0022900777 scopus 로고
    • Lactate during exercise at extreme altitudes
    • WEST, J. B. (1986). Lactate during exercise at extreme altitudes. Fedn Proc. Fedn Am. Socs exp. Biol. 45, 2953-2957.
    • (1986) Fedn Proc. Fedn Am. Socs Exp. Biol. , vol.45 , pp. 2953-2957
    • West, J.B.1
  • 73
    • 0027327956 scopus 로고
    • Oxygen sensing in airway chemoreceptors
    • YOUNGSON, C. NURSE, C., YEGER, H. AND CUTZ, E. (1993). Oxygen sensing in airway chemoreceptors. Nature 365, 153-155.
    • (1993) Nature , vol.365 , pp. 153-155
    • Youngson, C.1    Nurse, C.2    Yeger, H.3    Cutz, E.4


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