Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase - Increased expression with reduced muscle damage

Gene Therapy

Volumn 8, Issue 16, 2001, Pages 1264-1270

  McMahon, J M ^a   Signori, E ^b,c   Wells, K E ^a   Fazio, V M ^c,d   Wells, D J ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b CNR   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^d UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

Electroporation; Fibres; Gene therapy; Muscular dystrophy; Plasmid; Skeletal muscle

Indexed keywords

APOLIPOPROTEIN E; BETA GALACTOSIDASE; BLOOD CLOTTING FACTOR 9; COLLAGEN; ERYTHROPOIETIN; HYALURONIC ACID; HYALURONIDASE; PLASMID DNA; SODIUM CHLORIDE; SUCROSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DRUG EFFICACY; ELECTRIC FIELD; ELECTRIC INJURY; ELECTRIC POTENTIAL; ELECTRICAL EQUIPMENT; GENE EXPRESSION; GENE TRANSFER; MOUSE; MUSCLE CELL; MUSCLE INJURY; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE;

ANIMALS; BETA-GALACTOSIDASE; ELECTROPORATION; GENE EXPRESSION; GENE THERAPY; HYALURONOGLUCOSAMINIDASE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; PLASMIDS;

EID: 0034893580     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301522     Document Type: Article

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