Thrombopoietin, but not erythropoietin promotes viability and inhibits apoptosis of multipotent murine hematopoietic progenitor cells in vitro

Blood

Volumn 88, Issue 8, 1996, Pages 2859-2870

  Borge, Ole J ^a   Ramsfjell, Veslemøy ^b   Veiby, Ole P ^b   Murphy Jr , Martin J ^b   Lok, Si ^b   Jacobsen, Sten E W ^b  

^a Cancer Prevention Institute Dayton   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1; STEM CELL FACTOR; THROMBOPOIETIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL SUBPOPULATION; CELL VIABILITY; ETIOLOGY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0029858989     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.8.2859.bloodjournal8882859     Document Type: Article

References (54)

1. Spangrude GJ, Smith L, Uchida N, Ikuta K, Heimfeld S, Friedman J, Weissman IL: Mouse hematopoietic stem cells. Blood 78:1395, 1991
2. Ogawa M: Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844, 1993
3. Metcalf D: Hematopoietic regulators: Redundancy or subtlety. Blood 82:3515, 1993
4. Moore MAS: Clinical implications of positive and negative hematopoietic stem cell regulators. Blood 78:1, 1991
5. Ikebuchi K, Clark S, Ihle J, Souza L, Ogawa M: Granulocyte colony stimulation factor enhances interleukin-3 dependent proliferation of multipotential of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 85:3445, 1988
6. Bodine D, Crosier P, Clark SC: Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture. Blood 78:914, 1991
7. Itoh Y, Ikebuchi K, Hirashima K: Interleukin-3 and granulocyte colony-stimulating factor as survival factors in murine hemopoietic stem cells in vitro. Int J Hematol 55:139, 1992
8. Leary AG, Zeng HQ, Clark SC, Ogawa M: Growth factor requirements for survival in GO and entry into the cell cycle of primitive human hemopoietic progenitors. Proc Natl Acad Sci USA 89:4013, 1992
9. Katayama N, Clark SC, Ogawa M: Growth factor requirement for survival in cell-cycle dormancy of primitive murine lymphohematopoietic progenitors. Blood 81:610, 1993
10. Sasaki H, Hirabayashi Y, Inoue T, Taniguchi S, Ikuta K, Matsuyama S: Promotion of survival and proliferation by interleukin 3, kit-ligand and erythropoietin on early and late appearing spleen colony forming units in culture. Stem Cells 11:555, 1993
11. Li CL, Johnson GR: Stem cell factor enhances the survival but not the self-renewal of murine hematopoietic long-term repopulating cells. Blood 84:408, 1994
12. Keller JR, Ortiz M, Ruscetti FW: Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division. Blood 86:1757, 1995
13. Williams DE, Broxmeyer HE: Interleukin-1 alpha enhances the in vitro survival of purified murine granulocyte-macrophage progenitor cells in the absence of colony-stimulating factors. Blood 72:1608, 1988
14. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR: Haematopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343:76, 1990
15. Bazan JF: Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934, 1990
16. Vigon I, Mornon JP, Cocault L, Mitjavila MT, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1992
17. Li B, Dai W: Thrombopoietin and neurotrophins share a common domain. Blood 86:1643, 1995
18. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
19. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
20. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gumey AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
21. Kuter DJ, Beeler DL, Rosenberg RD: The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc Natl Acad Sci USA 91:11104, 1994
22. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
23. Wendling F, Maraskovsky E, Debili N, Florindo C, Teepe M, Titeux M, Methia N, Breton-Gorius J, Cosman D, Vainchenker W: cMpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 369:571, 1994
24. Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419, 1995
25. Krantz SB: Erythropoietin. Blood 77:419, 1991
26. Koury MJ, Bondurant MC: Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science 248:378, 1990
27. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568, 1994
28. Broudy VC, Lin NL, Kaushansky K: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85:1719, 1995
29. Debili N, Wendung F, Katz A, Guichard J, Breton-Gorius J, Hunt P, Vainchenker W: The Mpl-ligand or thrombopoietin or megakaryocyte growth and differentiative factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 86:2516, 1995
30. Zeigler FC, de Sauvage F, Widmer HR, Keller GA, Donahue C, Schreiber RD, Malloy B, Hass P, Eaton D, Matthews W: In vitro megakaryocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 84:4045, 1994
31. Spangrude GJ, Heimfeld S, Weissman IL: Purification and characterization of mouse hematopoietic stem cells. Science 241:58, 1988
32. Spangrude GJ, Scollay R: A simplified method for enrichment of mouse hematopoietic stem cells. Exp Hematol 18:920, 1990
33. Jacobsen SEW, Okkenhaug C, Myklebust J, Veiby OP, Lyman SD: The FLT3 ligand potently and directly stimulates the growth and expansion of primitive murine bone marrow progenitor cells in vitro: Synergistic interactions with interleukin (IL) 11, IL-12, and other hematopoietic growth factors. J Exp Med 181:1357, 1995
34. Burstein SA, Boyd CN, Dale GL: Quantification of megakaryocytopoiesis in vitro by enzymatic determination of AchE. J Cell Physiol 122:159, 1985
35. Long MW, Williams N: Immature megakaryocytes in the mouse: Morphology and quantitation by acetylcholinesterase staining. Blood 58:1032, 1981
36. Veiby OP, Lyman SD, Jacobsen SEW: Combined signaling through IL-7 receptor and flt3 but not c-kit potently and selectively promotes B cell commitment and differentiation from uncommitted murine bone marrow progenitor cells. Blood (in press)
37. Jacobsen FW, Stokke T, Jacobsen SE: Transforming growth factor-β potently inhibits the viability-promoting activity of stem cell factor and other cytokines and induces apoptosis of primitive murine hematopoietic progenitor cells. Blood 86:2957, 1995
38. Gorczyca W, Gong J, Darzynkiewicz Z: Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53:1945, 1993
39. Brandt JE, Bhalla K, Hoffman R: Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells. Blood 83:1507, 1994
40. Smith LG, Weissman IL, Heimfeld S: Clonal analysis of hematopoietic stem-cell differentiation in vivo. Proc Natl Acad Sci USA 88:2788, 1991
41. Hirayama F, Shin JP, Awgulewitsch A, Warr GW, Clark SC, Ogawa M: Clonal proliferation of murine lymphohemopoietic progenitors in culture. Proc Natl Acad Sci USA 89:5907, 1992
42. Ikuta K, Weissman IL: Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA 89:1502, 1992
43. Li CL, Johnson GR: Murine hematopoietic stem and progenitor cells: I. Enrichment and biologic characterization. Blood 85:1472, 1995
44. Lotem J, Sachs L: Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells. Blood 80:1750, 1992
45. Sachs L, Lotem J: Control of programmed cell death in normal and leukemic cells: New implications for therapy. Blood 82:15, 1993
46. Dybedal I, Jacobsen SEW: Transforming growth factor beta (TGF-beta), a potent inhibitor of erythropoiesis: Neutralizing TGF-beta antibodies show erythropoietin as a potent stimulator of murine burst-forming unit erythroid colony formation in the absence of a burst-promoting activity. Blood 86:949, 1995
47. Spangrude GJ, Brooks DM, Tumas DB: Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: In vivo expansion of stem cell phenotype but not function. Blood 85:1006, 1995
48. Ramsfjell V, Borge OJ, Veiby OP, Cardier J, Murphy MJJ, Lyman SD, Lok S, Jacobsen SEW: Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: Distinct interactions with the ligands for c-kit and FLT3. Blood (in press)
49. Sawada K, Krantz SB, Kans JS, Dessypris EN, Sawyer S, Glick AD, Civin CI: Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin. J Clin Invest 80:357, 1987
50. Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF: Structure, function, and activation of the erythropoietin receptor. Blood 81:2223, 1993
51. Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Ren HP, Bailey MC, Papayannopoulou T, Forstrom JW, Sprugel KH: Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J Clin Invest 96:1683, 1995
52. Hokom MM, Lacey D, Kinstler OB, Choi E, Kaufman S, Faust J, Rowan C, Dwyer E, Nichol JL, Grasel T, Wilson J, Steinbrink R, Hecht R, Winters D, Boone T, Hunt P: Pegylated megakaryocyte growth and development factor abrogates the lethal trombocytopenia associated with carboplatin and irradiation in mice. Blood 86:4486, 1995
53. Warren SA, Roberts AW, Nicola NA, Li R, Metcalf D: Deficiencies in progentior cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-Mpl. Blood 87:2162, 1996
54. Uchida N, Fleming WH, Alpern EJ, Weissman IL: Heterogeneity of hematopoietic stem cells. Curr Opin Immunol 5:177, 1993