Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-α-converting enzyme in human airway epithelial (NCI-H292) cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 287, Issue 2 31-2, 2004, Pages

  Shao, Matt X G ^a   Nakanaga, Takashi ^a   Nadel, Jay A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chronic obstructive pulmonary disease; Ectodomain shedding; Epidermal growth factor receptor; Protease; Transforming growth factor

Indexed keywords

CIGARETTE SMOKE; EPIDERMAL GROWTH FACTOR RECEPTOR; ILOMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE; MUCIN 5AC; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA PROTEASE INHIBITOR 1; UNCLASSIFIED DRUG;

ARTICLE; BRONCHUS MUCUS; CELL SURFACE; CELLULAR DISTRIBUTION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MUCUS SECRETION; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RESPIRATORY EPITHELIUM;

ADAM PROTEINS; CARCINOMA, MUCOEPIDERMOID; CELL LINE, TUMOR; GENE EXPRESSION; HUMANS; LIGANDS; LUNG NEOPLASMS; METALLOENDOPEPTIDASES; MUCINS; PHOSPHORYLATION; PROTEIN PRECURSORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RESPIRATORY MUCOSA; SMOKING; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 3242706027     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00019.2004     Document Type: Article

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