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Volumn 2, Issue 3, 2005, Pages 341-353

The role of airway secretions in COPD: Pathophysiology, epidemiology and pharmacotherapeutic options

Author keywords

Airway inflammation; Chronic obstructive pulmonary disease; Erythromycin; Goblet cell; MUC gene; Mucin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (4 HYDROXYPHENYL) 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ACETYLCYSTEINE; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ANTISENSE OLIGONUCLEOTIDE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BEZAFIBRATE; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLARITHROMYCIN; CORTICOSTEROID; DIQUAFOSOL; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERDOSTEINE; ERYTHROMYCIN; EXPECTORANT AGENT; FLURITHROMYCIN; GEFITINIB; GLUCOCORTICOID; GW 273629; IODINATED GLYCEROL; LAPATINIB; MACROLIDE; MARCKS PROTEIN; METHYLXANTHINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MSI 1956; MUCOLYTIC AGENT; MUNC18 PROTEIN; PELITINIB; PROTEIN BCL 2; PROTEIN INHIBITOR; PURINERGIC RECEPTOR BLOCKING AGENT; TACHYKININ RECEPTOR ANTAGONIST; THIOL DERIVATIVE; UNINDEXED DRUG; UO 126;

EID: 33645507720     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.1080/15412550500218098     Document Type: Review
Times cited : (37)

References (126)
  • 1
    • 0017402583 scopus 로고
    • The natural history of chronic airflow obstruction
    • Fletcher C, Peto R. The natural history of chronic airflow obstruction. Br Med J 1977; 1:1645-1648.
    • (1977) Br Med J , vol.1 , pp. 1645-1648
    • Fletcher, C.1    Peto, R.2
  • 3
    • 0021358910 scopus 로고
    • Definitions of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 Years on from the Ciba symposium
    • Fletcher CM, Pride NB. Definitions of emphysema, chronic bronchitis, asthma, and airflow obstruction: 25 years on from the Ciba symposium. Thorax 1984; 39:81-85.
    • (1984) Thorax , vol.39 , pp. 81-85
    • Fletcher, C.M.1    Pride, N.B.2
  • 4
    • 0023567409 scopus 로고
    • Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma
    • American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987; 136:225-244.
    • (1987) Am Rev Respir Dis , vol.136 , pp. 225-244
  • 5
    • 0003736031 scopus 로고    scopus 로고
    • Publication No. 2701, National Institutes of Health
    • National Heart Lung and Blood Institute/WHO. Global Initiative for Chronic Obstructive Lung Disease. Publication No. 2701, National Institutes of Health, 2001.
    • (2001) Global Initiative for Chronic Obstructive Lung Disease
  • 6
    • 1542405163 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease: National clinical guideline on management of chronic obstructive pulmonary disease in adults in primary and secondary care
    • National Institute for Clinical Excellence (NICE). Chronic obstructive pulmonary disease: national clinical guideline on management of chronic obstructive pulmonary disease in adults in primary and secondary care. Thorax 2004; 59.
    • (2004) Thorax , vol.59
  • 7
    • 4344675455 scopus 로고    scopus 로고
    • Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
    • Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet 2004; 364:709-721.
    • (2004) Lancet , vol.364 , pp. 709-721
    • Hogg, J.C.1
  • 8
    • 0029150812 scopus 로고
    • Chronic mucus hypersecretion in COPD and death from pulmonary infection
    • Prescott E, Lange P, Vestbo J. Chronic mucus hypersecretion in COPD and death from pulmonary infection. Eur Respir J 1995; 8:1333-1338.
    • (1995) Eur Respir J , vol.8 , pp. 1333-1338
    • Prescott, E.1    Lange, P.2    Vestbo, J.3
  • 9
    • 0036194724 scopus 로고    scopus 로고
    • Mucus clearance as a primary innate defense mechanism for mammalian airways
    • Knowles MR, Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 2002; 109:571-577.
    • (2002) J Clin Invest , vol.109 , pp. 571-577
    • Knowles, M.R.1    Boucher, R.C.2
  • 10
    • 0021867292 scopus 로고
    • Morphological features of the interaction between mucus and surfactant on the bronchial mucosa
    • Morgenroth K, Bolz J. Morphological features of the interaction between mucus and surfactant on the bronchial mucosa. Respiration 1985; 47:225-231.
    • (1985) Respiration , vol.47 , pp. 225-231
    • Morgenroth, K.1    Bolz, J.2
  • 11
    • 0025307779 scopus 로고
    • Surfactant displaces particles toward the epithelium in airways and alveoli
    • Schurch S, Gehr P, Im Hof V, Geiser M, Green F. Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol 1990; 80:17-32.
    • (1990) Respir Physiol , vol.80 , pp. 17-32
    • Schurch, S.1    Gehr, P.2    Im Hof, V.3    Geiser, M.4    Green, F.5
  • 14
    • 0032751413 scopus 로고    scopus 로고
    • Physiology and pathology of tracheobronchial glands
    • Finkbeiner WE. Physiology and pathology of tracheobronchial glands. Respir Physiol 1999; 118:77-83.
    • (1999) Respir Physiol , vol.118 , pp. 77-83
    • Finkbeiner, W.E.1
  • 15
    • 1242324931 scopus 로고
    • Molecular biophysics of mucin secretion
    • Takishima T, Shimura S, eds. New York: Marcel Dekker
    • Verdugo P. Molecular biophysics of mucin secretion. In: Takishima T, Shimura S, eds. Airway Secretion. New York: Marcel Dekker, 1994:101-121.
    • (1994) Airway Secretion , pp. 101-121
    • Verdugo, P.1
  • 19
    • 0035861196 scopus 로고    scopus 로고
    • Isolation and characterization of the major form of human MUC18 cDNA gene and correlation of MUC18 over-expression in prostate cancer cell lines and tissues with malignant progression
    • Wu GJ, Wu MW, Wang SW, Liu Z, Qu P, Peng Q, Yang H, Varma VA, Sun QC, Petros JA, Lim SD, Amin MB. Isolation and characterization of the major form of human MUC18 cDNA gene and correlation of MUC18 over-expression in prostate cancer cell lines and tissues with malignant progression. Gene 2001; 279:17-31.
    • (2001) Gene , vol.279 , pp. 17-31
    • Wu, G.J.1    Wu, M.W.2    Wang, S.W.3    Liu, Z.4    Qu, P.5    Peng, Q.6    Yang, H.7    Varma, V.A.8    Sun, Q.C.9    Petros, J.A.10    Lim, S.D.11    Amin, M.B.12
  • 22
    • 0033772671 scopus 로고    scopus 로고
    • Mucus pathophysiology in COPD: Differences to asthma, and pharmacotherapy
    • Rogers DF. Mucus pathophysiology in COPD: differences to asthma, and pharmacotherapy. Monaldi Arch Chest Dis 2000; 55:324-332.
    • (2000) Monaldi Arch Chest Dis , vol.55 , pp. 324-332
    • Rogers, D.F.1
  • 23
    • 0034032761 scopus 로고    scopus 로고
    • Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley Lecture
    • Jeffery PK. Comparison of the structural and inflammatory features of COPD and asthma. Giles F. Filley Lecture. Chest 2000; 117:251S-260S.
    • (2000) Chest , vol.117
    • Jeffery, P.K.1
  • 24
    • 10644266789 scopus 로고    scopus 로고
    • Mediators of chronic obstructive pulmonary disease
    • Barnes PJ. Mediators of chronic obstructive pulmonary disease. Pharmacol Rev 2004; 56:515-548.
    • (2004) Pharmacol Rev , vol.56 , pp. 515-548
    • Barnes, P.J.1
  • 25
    • 0000226036 scopus 로고
    • Pathology of chronic bronchitis
    • Reid L. Pathology of chronic bronchitis. Lancet 1954; i:275-278.
    • (1954) Lancet , vol.1 , pp. 275-278
    • Reid, L.1
  • 26
    • 0024469645 scopus 로고
    • Morphometric analysis of intraluminal mucus in airways in chronic obstructive pulmonary disease
    • Aikawa T, Shimura S, Sasaki H, Takishima T, Yaegashi H, Takahashi T. Morphometric analysis of intraluminal mucus in airways in chronic obstructive pulmonary disease. Am Rev Respir Dis 1989; 140:477-482.
    • (1989) Am Rev Respir Dis , vol.140 , pp. 477-482
    • Aikawa, T.1    Shimura, S.2    Sasaki, H.3    Takishima, T.4    Yaegashi, H.5    Takahashi, T.6
  • 27
    • 0028437272 scopus 로고
    • Use of mucin antibodies and cDNA probes to quantify hypersecretion in vivo in human airways
    • Steiger D, Fahy J, Boushey H, Finkbeiner WE, Basbaum C. Use of mucin antibodies and cDNA probes to quantify hypersecretion in vivo in human airways. Am J Respir Cell Mol Biol 1994; 10:538-545.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 538-545
    • Steiger, D.1    Fahy, J.2    Boushey, H.3    Finkbeiner, W.E.4    Basbaum, C.5
  • 28
    • 0023636536 scopus 로고
    • Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: Relationship to lung function
    • Mullen JB, Wright JL, Wiggs BR, Pare PD, Hogg JC. Structure of central airways in current smokers and ex-smokers with and without mucus hypersecretion: relationship to lung function. Thorax 1987; 42:843-848.
    • (1987) Thorax , vol.42 , pp. 843-848
    • Mullen, J.B.1    Wright, J.L.2    Wiggs, B.R.3    Pare, P.D.4    Hogg, J.C.5
  • 29
    • 0000385474 scopus 로고
    • Measurement of the bronchial mucous gland layer: A diagnostic yardstick in chronic bronchitis
    • Reid L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax 1960; 15:132-141.
    • (1960) Thorax , vol.15 , pp. 132-141
    • Reid, L.1
  • 30
    • 0001545745 scopus 로고
    • The size of the bronchial glands in chronic bronchitis
    • Restrepo G, Heard BE. The size of the bronchial glands in chronic bronchitis. J Pathol Bacteriol 1963; 85:305-310.
    • (1963) J Pathol Bacteriol , vol.85 , pp. 305-310
    • Restrepo, G.1    Heard, B.E.2
  • 31
    • 72849172137 scopus 로고
    • Bronchial biopsy in chronic bronchitis and asthma
    • Glynn AA, Michaels L. Bronchial biopsy in chronic bronchitis and asthma. Thorax 1960; 15:142-153.
    • (1960) Thorax , vol.15 , pp. 142-153
    • Glynn, A.A.1    Michaels, L.2
  • 32
    • 0021261611 scopus 로고
    • Chronic bronchitis. Correlation of morphologic findings to sputum production and flow rates
    • Jamal K, Cooney TP, Fleetham JA, Thurlbeck WM. Chronic bronchitis. Correlation of morphologic findings to sputum production and flow rates. Am Rev Respir Dis 1984; 129:719-722.
    • (1984) Am Rev Respir Dis , vol.129 , pp. 719-722
    • Jamal, K.1    Cooney, T.P.2    Fleetham, J.A.3    Thurlbeck, W.M.4
  • 33
    • 0014573235 scopus 로고
    • Distribution of bronchial gland measurement in a Jamaican population
    • Hayes JA. Distribution of bronchial gland measurement in a Jamaican population. Thorax 1960; 24:619-622.
    • (1960) Thorax , vol.24 , pp. 619-622
    • Hayes, J.A.1
  • 34
    • 0001799111 scopus 로고
    • Mucous gland hypertrophy in chronic bronchitis, and its occurrence in smokers
    • Thurlbeck WM, Angus CW, Paré JAP. Mucous gland hypertrophy in chronic bronchitis, and its occurrence in smokers. Br J Dis Chest 1963; 57:73-78.
    • (1963) Br J Dis Chest , vol.57 , pp. 73-78
    • Thurlbeck, W.M.1    Angus, C.W.2    Paré, J.A.P.3
  • 35
    • 0000295735 scopus 로고
    • A distribution curve for chronic bronchitis
    • Thurlbeck WM, Angus GE. A distribution curve for chronic bronchitis. Thorax 1964; 19:436-442.
    • (1964) Thorax , vol.19 , pp. 436-442
    • Thurlbeck, W.M.1    Angus, G.E.2
  • 39
    • 0032531083 scopus 로고    scopus 로고
    • MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: Identification of glycoforms and C-terminal cleavage
    • Wickstrom C, Davies JR, Eriksen GV, Veerman EC, Carlstedt I. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J 1998; 334:685-693.
    • (1998) Biochem J , vol.334 , pp. 685-693
    • Wickstrom, C.1    Davies, J.R.2    Eriksen, G.V.3    Veerman, E.C.4    Carlstedt, I.5
  • 40
    • 0033105846 scopus 로고    scopus 로고
    • Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug
    • Sheehan JK, Howard M, Richardson PS, Longwill T, Thornton DJ. Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug. Biochem J 1999; 338:507-513.
    • (1999) Biochem J , vol.338 , pp. 507-513
    • Sheehan, J.K.1    Howard, M.2    Richardson, P.S.3    Longwill, T.4    Thornton, D.J.5
  • 41
    • 0036471129 scopus 로고    scopus 로고
    • Heterogeneity of airways mucus: Variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B
    • Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J 2002; 361:537-546.
    • (2002) Biochem J , vol.361 , pp. 537-546
    • Kirkham, S.1    Sheehan, J.K.2    Knight, D.3    Richardson, P.S.4    Thornton, D.J.5
  • 43
    • 0035190107 scopus 로고    scopus 로고
    • Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5′-flanking region
    • Chen Y, Zhao YH, Di YP, Wu R. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5′-flanking region. Am J Respir Cell Mol Biol 2001; 25:542-553.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 542-553
    • Chen, Y.1    Zhao, Y.H.2    Di, Y.P.3    Wu, R.4
  • 46
    • 0033406611 scopus 로고    scopus 로고
    • Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions
    • Davies JR, Svitacheva N, Lannefors L, Kornfalt R, Carlstedt I. Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions. Biochem J 1999; 344(Pt 2):321-330.
    • (1999) Biochem J , vol.344 , Issue.2 PART , pp. 321-330
    • Davies, J.R.1    Svitacheva, N.2    Lannefors, L.3    Kornfalt, R.4    Carlstedt, I.5
  • 47
    • 0017517706 scopus 로고
    • Clinical aspects of mucociliary transport
    • Wanner A. Clinical aspects of mucociliary transport. Am Rev Respir Dis 1977; 116:73-125.
    • (1977) Am Rev Respir Dis , vol.116 , pp. 73-125
    • Wanner, A.1
  • 51
    • 0031018434 scopus 로고    scopus 로고
    • Relationship between bronchial reversibility and tracheobronchial clearance in patients with chronic bronchitis
    • Moretti M, Lopez-Vidriero MT, Pavia D, Clarke SW. Relationship between bronchial reversibility and tracheobronchial clearance in patients with chronic bronchitis. Thorax 1997; 52:176-180.
    • (1997) Thorax , vol.52 , pp. 176-180
    • Moretti, M.1    Lopez-Vidriero, M.T.2    Pavia, D.3    Clarke, S.W.4
  • 52
    • 0017854521 scopus 로고
    • Relationship of smoking history and pulmonary function tests to tracheal mucous velocity in nonsmokers, young smokers, ex-smokers, and patients with chronic bronchitis
    • Goodman RM, Yergin BM, Landa JF, Golivanux MH, Sackner MA. Relationship of smoking history and pulmonary function tests to tracheal mucous velocity in nonsmokers, young smokers, ex-smokers, and patients with chronic bronchitis. Am Rev Respir Dis 1978; 117:205-214.
    • (1978) Am Rev Respir Dis , vol.117 , pp. 205-214
    • Goodman, R.M.1    Yergin, B.M.2    Landa, J.F.3    Golivanux, M.H.4    Sackner, M.A.5
  • 53
    • 0020055924 scopus 로고
    • Mucus clearance from the airways in chronic bronchitis - Smokers and ex-smokers
    • Agnew JE, Little F, Pavia D, Clarke SW. Mucus clearance from the airways in chronic bronchitis - smokers and ex-smokers. Bull Eur Physiopathol Respir 1982; 18:473-484.
    • (1982) Bull Eur Physiopathol Respir , vol.18 , pp. 473-484
    • Agnew, J.E.1    Little, F.2    Pavia, D.3    Clarke, S.W.4
  • 54
    • 0025078842 scopus 로고
    • Effect of forced expirations on mucus clearance in patients with chronic airflow obstruction: Effect of lung recoil pressure
    • van der Schans CP, Piers DA, Beekhuis H, Koeter GH, van der Mark TW, Postma DS. Effect of forced expirations on mucus clearance in patients with chronic airflow obstruction: effect of lung recoil pressure. Thorax 1990; 45:623-627.
    • (1990) Thorax , vol.45 , pp. 623-627
    • Van Der Schans, C.P.1    Piers, D.A.2    Beekhuis, H.3    Koeter, G.H.4    Van Der Mark, T.W.5    Postma, D.S.6
  • 56
    • 0037674024 scopus 로고    scopus 로고
    • Epidemiological studies in mucus hypersecretion
    • Vestbo J. Epidemiological studies in mucus hypersecretion. Novartis Found Symp 2002; 248:3-12.
    • (2002) Novartis Found Symp , vol.248 , pp. 3-12
    • Vestbo, J.1
  • 59
    • 0023836635 scopus 로고
    • Respiratory symptoms and pulmonary function as predictors of 10-year mortality from respiratory disease, cardiovascular disease, and all causes in the Whitehall Study
    • Ebi-Kryston KL. Respiratory symptoms and pulmonary function as predictors of 10-year mortality from respiratory disease, cardiovascular disease, and all causes in the Whitehall Study. J Clin Epidemiol 1988; 41:251-260.
    • (1988) J Clin Epidemiol , vol.41 , pp. 251-260
    • Ebi-Kryston, K.L.1
  • 60
    • 0025978140 scopus 로고
    • Relevance of airflow obstruction and mucus hypersecretion to mortality
    • Wiles FJ, Hnizdo E. Relevance of airflow obstruction and mucus hypersecretion to mortality. Respir Med 1991; 85:27-35.
    • (1991) Respir Med , vol.85 , pp. 27-35
    • Wiles, F.J.1    Hnizdo, E.2
  • 61
    • 0014424329 scopus 로고
    • Site and nature of airway obstruction in chronic obstructive lung disease
    • Hogg JC, Macklem PT, Thurlbeck WM. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med 1968; 278:1355-1360.
    • (1968) N Engl J Med , vol.278 , pp. 1355-1360
    • Hogg, J.C.1    Macklem, P.T.2    Thurlbeck, W.M.3
  • 62
    • 0022453116 scopus 로고
    • Is respiratory mucus hypersecretion really an innocent disorder? A 22-year mortality survey of 1,061 working men
    • Annesi I, Kauffmann F. Is respiratory mucus hypersecretion really an innocent disorder? A 22-year mortality survey of 1,061 working men. Am Rev Respir Dis 1986; 134:688-693.
    • (1986) Am Rev Respir Dis , vol.134 , pp. 688-693
    • Annesi, I.1    Kauffmann, F.2
  • 63
    • 0024394821 scopus 로고
    • Respiratory symptoms, lung function, and mortality in a screening center cohort
    • Vollmer WM, McCamant LE, Johnson LR, Buist AS. Respiratory symptoms, lung function, and mortality in a screening center cohort. Am J Epidemiol 1989; 129:1157-1169.
    • (1989) Am J Epidemiol , vol.129 , pp. 1157-1169
    • Vollmer, W.M.1    McCamant, L.E.2    Johnson, L.R.3    Buist, A.S.4
  • 65
    • 0024724145 scopus 로고
    • Respiratory symptoms and FEV1 as predictors of hospitalization and medication in the following 12 years due to respiratory disease
    • Vestbo J, Rasmussen FV. Respiratory symptoms and FEV1 as predictors of hospitalization and medication in the following 12 years due to respiratory disease. Eur Respir J 1989; 2:710-715.
    • (1989) Eur Respir J , vol.2 , pp. 710-715
    • Vestbo, J.1    Rasmussen, F.V.2
  • 66
    • 0024382070 scopus 로고
    • The value of mucus hypersecretion as a predictor of mortality and hospitalization. An 11-year register based follow-up study of a random population sample of 876 men
    • Vestbo J, Knudsen KM, Rasmussen FV. The value of mucus hypersecretion as a predictor of mortality and hospitalization. An 11-year register based follow-up study of a random population sample of 876 men. Respir Med 1989; 83:207-211.
    • (1989) Respir Med , vol.83 , pp. 207-211
    • Vestbo, J.1    Knudsen, K.M.2    Rasmussen, F.V.3
  • 67
    • 0025033561 scopus 로고
    • Relation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease and from all causes
    • Lange P, Nyboe J, Appleyard M, Jensen G, Schnohr P. Relation of ventilatory impairment and of chronic mucus hypersecretion to mortality from obstructive lung disease and from all causes. Thorax 1990; 45:579-585.
    • (1990) Thorax , vol.45 , pp. 579-585
    • Lange, P.1    Nyboe, J.2    Appleyard, M.3    Jensen, G.4    Schnohr, P.5
  • 69
    • 0029947193 scopus 로고    scopus 로고
    • Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity
    • Copenhagen City Heart Study Group
    • Vestbo J, Prescott E, Lange P. Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group. Am J Respir Crit Care Med 1996; 153:1530-1535.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1530-1535
    • Vestbo, J.1    Prescott, E.2    Lange, P.3
  • 70
    • 0033781008 scopus 로고    scopus 로고
    • Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: A multiple logistic regression analysis
    • The EOLO Study Group
    • Miravitlles M, Guerrero T, Mayordomo C, Sanchez-Agudo L, Nicolau F, Segu JL. Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis. The EOLO Study Group. Respiration 2000; 67:495-501.
    • (2000) Respiration , vol.67 , pp. 495-501
    • Miravitlles, M.1    Guerrero, T.2    Mayordomo, C.3    Sanchez-Agudo, L.4    Nicolau, F.5    Segu, J.L.6
  • 71
    • 0035422691 scopus 로고    scopus 로고
    • Lower respiratory illnesses promote FEV(1) decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: Results from the lung health study
    • Kanner RE, Anthonisen NR, Connett JE. Lower respiratory illnesses promote FEV(1) decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: results from the lung health study. Am J Respir Crit Care Med 2001; 164:358-364.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 358-364
    • Kanner, R.E.1    Anthonisen, N.R.2    Connett, J.E.3
  • 72
    • 10644240946 scopus 로고    scopus 로고
    • Mucociliary dysfunction in COPD: Effect of current pharmacotherapeutic options
    • Rogers DF. Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulm Pharmacol Ther 2005; 18:1-8.
    • (2005) Pulm Pharmacol Ther , vol.18 , pp. 1-8
    • Rogers, D.F.1
  • 73
    • 0027956153 scopus 로고
    • Airway goblet cells: Responsive and adaptable front-line defenders
    • Rogers DF. Airway goblet cells: responsive and adaptable front-line defenders. Eur Respir J 1994; 7:1690-1706.
    • (1994) Eur Respir J , vol.7 , pp. 1690-1706
    • Rogers, D.F.1
  • 74
    • 0004163344 scopus 로고    scopus 로고
    • Bethesda: National Institutes of Health, National Heart, Lung and Blood Institute, vol. Publication no. 02-3659
    • National Institutes of Health. Global Initiative for Asthma: Pocket Guide for Asthma Management and Prevention. Bethesda: National Institutes of Health, National Heart, Lung and Blood Institute, 2002, vol. Publication no. 02-3659.
    • (2002) Global Initiative for Asthma: Pocket Guide for Asthma Management and Prevention
  • 75
    • 0034231457 scopus 로고    scopus 로고
    • Evaluation of current pharmacotherapy of chronic obstructive pulmonary disease
    • Culpitt SV, Rogers DF. Evaluation of current pharmacotherapy of chronic obstructive pulmonary disease. Expert Opin Pharmacother 2000; 1:1007-1020.
    • (2000) Expert Opin Pharmacother , vol.1 , pp. 1007-1020
    • Culpitt, S.V.1    Rogers, D.F.2
  • 76
    • 1542301591 scopus 로고    scopus 로고
    • Corticosteroid resistance in chronic obstructive pulmonary disease: Inactivation of histone deacetylase
    • Barnes PJ, Ito K, Adcock IM. Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 2004; 363:731-733.
    • (2004) Lancet , vol.363 , pp. 731-733
    • Barnes, P.J.1    Ito, K.2    Adcock, I.M.3
  • 77
    • 0036142111 scopus 로고    scopus 로고
    • Mucoactive drugs for asthma and COPD: Any place in therapy?
    • Rogers DF. Mucoactive drugs for asthma and COPD: any place in therapy? Expert Opin Investig Drugs 2002; 11:15-35.
    • (2002) Expert Opin Investig Drugs , vol.11 , pp. 15-35
    • Rogers, D.F.1
  • 78
    • 0034023927 scopus 로고    scopus 로고
    • Efficacy of oral long-term N-acetylcysteine in chronic broncho-pulmonary disease: A meta-analysis of published double-blind, placebo-controlled clinical trials
    • Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic broncho-pulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Ther 2000; 22:209-221.
    • (2000) Clin Ther , vol.22 , pp. 209-221
    • Grandjean, E.M.1    Berthet, P.2    Ruffmann, R.3    Leuenberger, P.4
  • 79
    • 0033898870 scopus 로고    scopus 로고
    • The effect of oral N-acetylcysteine in chronic bronchitis: A quantitative systematic review
    • Stey C, Steurer J, Bachmann S, Medici TC, Tramer MR. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur Respir J 2000; 16:253-262.
    • (2000) Eur Respir J , vol.16 , pp. 253-262
    • Stey, C.1    Steurer, J.2    Bachmann, S.3    Medici, T.C.4    Tramer, M.R.5
  • 80
    • 0035954121 scopus 로고    scopus 로고
    • Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: Systematic review
    • Poole PJ, Black PN. Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review. Br Med J 2001; 322:1271-1274.
    • (2001) Br Med J , vol.322 , pp. 1271-1274
    • Poole, P.J.1    Black, P.N.2
  • 81
    • 0033849631 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of oral N-acetylcysteine as a preventive treatment in chronic bronchitis
    • Grandjean EM, Berthet PH, Ruffmann R, Leuenberger P. Cost-effectiveness analysis of oral N-acetylcysteine as a preventive treatment in chronic bronchitis. Pharmacol Res 2000; 42:39-50.
    • (2000) Pharmacol Res , vol.42 , pp. 39-50
    • Grandjean, E.M.1    Berthet, P.H.2    Ruffmann, R.3    Leuenberger, P.4
  • 82
    • 1842481121 scopus 로고    scopus 로고
    • Antioxidant properties of N-acetylcysteine: Their relevance in relation to chronic obstructive pulmonary disease
    • Dekhuijzen PN. Antioxidant properties of N-acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J 2004; 23:629-636.
    • (2004) Eur Respir J , vol.23 , pp. 629-636
    • Dekhuijzen, P.N.1
  • 84
    • 0035840849 scopus 로고    scopus 로고
    • Oxidative stress and lung inflammation in airways disease
    • MacNee W. Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol 2001; 429:195-207.
    • (2001) Eur J Pharmacol , vol.429 , pp. 195-207
    • MacNee, W.1
  • 85
    • 0034827652 scopus 로고    scopus 로고
    • Exhaled carbon monoxide and nitric oxide in COPD
    • Montuschi P, Kharitonov SA, Barnes PJ. Exhaled carbon monoxide and nitric oxide in COPD. Chest 2001; 120:496-501.
    • (2001) Chest , vol.120 , pp. 496-501
    • Montuschi, P.1    Kharitonov, S.A.2    Barnes, P.J.3
  • 86
    • 0029853916 scopus 로고    scopus 로고
    • Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism
    • Wright DT, Fischer BM, Li C, Rochelle LG, Akley NJ, Adler KB. Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism. Am J Physiol 1996; 271:L854-L861.
    • (1996) Am J Physiol , vol.271
    • Wright, D.T.1    Fischer, B.M.2    Li, C.3    Rochelle, L.G.4    Akley, N.J.5    Adler, K.B.6
  • 87
    • 8544250584 scopus 로고    scopus 로고
    • Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium
    • Burgel PR, Nadel JA. Roles of epidermal growth factor receptor activation in epithelial cell repair and mucin production in airway epithelium. Thorax 2004; 59:992-996.
    • (2004) Thorax , vol.59 , pp. 992-996
    • Burgel, P.R.1    Nadel, J.A.2
  • 89
    • 0022596795 scopus 로고
    • Excessive accumulation of mucus in children with asthma: A potential role for erythromycin? A case discussion
    • Suez D, Szefler SJ. Excessive accumulation of mucus in children with asthma: a potential role for erythromycin? A case discussion. J Allergy Clin Immunol 1986; 77:330-334.
    • (1986) J Allergy Clin Immunol , vol.77 , pp. 330-334
    • Suez, D.1    Szefler, S.J.2
  • 90
    • 0025766950 scopus 로고
    • Respiratory mucus hypersecretion (bronchorrhea): A case discussion - Possible mechanisms(s) and treatment
    • Marom ZM, Goswami SK. Respiratory mucus hypersecretion (bronchorrhea): a case discussion - possible mechanisms(s) and treatment. J Allergy Clin Immunol 1991; 87:1050-1055.
    • (1991) J Allergy Clin Immunol , vol.87 , pp. 1050-1055
    • Marom, Z.M.1    Goswami, S.K.2
  • 91
    • 0035688845 scopus 로고    scopus 로고
    • The effect of erythromycin on mucociliary transportability and rheology of cystic fibrosis and bronchiectasis sputum
    • Shibuya Y, Wills PJ, Cole PJ. The effect of erythromycin on mucociliary transportability and rheology of cystic fibrosis and bronchiectasis sputum. Respiration 2001; 68:615-619.
    • (2001) Respiration , vol.68 , pp. 615-619
    • Shibuya, Y.1    Wills, P.J.2    Cole, P.J.3
  • 93
    • 0041874952 scopus 로고    scopus 로고
    • In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells
    • Shimizu T, Shimizu S, Hattori R, Gabazza EC, Majima Y. In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Am J Respir Crit Care Med 2003; 168:581-587.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 581-587
    • Shimizu, T.1    Shimizu, S.2    Hattori, R.3    Gabazza, E.C.4    Majima, Y.5
  • 94
    • 0037674016 scopus 로고    scopus 로고
    • Current and future therapies for airway mucus hypersecretion
    • Barnes PJ. Current and future therapies for airway mucus hypersecretion. Novartis Found Symp 2002; 248:237-249.
    • (2002) Novartis Found Symp , vol.248 , pp. 237-249
    • Barnes, P.J.1
  • 95
    • 0141961518 scopus 로고    scopus 로고
    • Therapy for chronic obstructive pulmonary disease in the 21st century
    • Donnelly LE, Rogers DF. Therapy for chronic obstructive pulmonary disease in the 21st century. Drugs 2003; 63:1973-1998.
    • (2003) Drugs , vol.63 , pp. 1973-1998
    • Donnelly, L.E.1    Rogers, D.F.2
  • 97
    • 3042570458 scopus 로고    scopus 로고
    • Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): A rational therapeutic to enhance apoptosis in therapy of lung cancer
    • Herbst RS, Frankel SR. Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): a rational therapeutic to enhance apoptosis in therapy of lung cancer. Clin Cancer Res 2004; 10:4245s-4248s.
    • (2004) Clin Cancer Res , vol.10
    • Herbst, R.S.1    Frankel, S.R.2
  • 98
    • 0038350458 scopus 로고    scopus 로고
    • Clinical studies with non-iressa EGFR tyrosine kinase inhibitors
    • Bonomi P. Clinical studies with non-iressa EGFR tyrosine kinase inhibitors. Lung Cancer 2003; 41(suppl 1):S43-S48.
    • (2003) Lung Cancer , vol.41 , Issue.1 SUPPL.
    • Bonomi, P.1
  • 99
    • 0025186606 scopus 로고
    • Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism
    • Adler KB, Holden-Stauffer WJ, Repine JE. Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism. J Clin Invest 1990; 85:75-85.
    • (1990) J Clin Invest , vol.85 , pp. 75-85
    • Adler, K.B.1    Holden-Stauffer, W.J.2    Repine, J.E.3
  • 100
    • 0035126934 scopus 로고    scopus 로고
    • Motor control of airway goblet cells and glands
    • Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol 2001; 125:129-144.
    • (2001) Respir Physiol , vol.125 , pp. 129-144
    • Rogers, D.F.1
  • 101
    • 0036605457 scopus 로고    scopus 로고
    • Pharmacological regulation of the neuronal control of airway mucus secretion
    • Rogers DF. Pharmacological regulation of the neuronal control of airway mucus secretion. Curr Opin Pharmacol 2002; 2:249-255.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 249-255
    • Rogers, D.F.1
  • 102
    • 0034937042 scopus 로고    scopus 로고
    • Tachykinin receptor antagonists for asthma and COPD
    • Rogers DF. Tachykinin receptor antagonists for asthma and COPD. Expert Opin Ther Pat 2001; 11:1097-1121.
    • (2001) Expert Opin Ther Pat , vol.11 , pp. 1097-1121
    • Rogers, D.F.1
  • 103
    • 0034926291 scopus 로고    scopus 로고
    • The vanilloid receptor: A molecular gateway to the pain pathway
    • Caterina MJ, Julius D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu Rev Neurosci 2001; 24:487-517.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 487-517
    • Caterina, M.J.1    Julius, D.2
  • 104
    • 0035965327 scopus 로고    scopus 로고
    • Epoxygenase pathways of arachidonic acid metabolism
    • Zeldin DC. Epoxygenase pathways of arachidonic acid metabolism. J Biol Chem 2001; 276:36059-36062.
    • (2001) J Biol Chem , vol.276 , pp. 36059-36062
    • Zeldin, D.C.1
  • 105
    • 0034892724 scopus 로고    scopus 로고
    • Clinical and cellular effects of cytochrome P-450 modulators
    • Tesfaigzi Y, Kluger M, Kozak W. Clinical and cellular effects of cytochrome P-450 modulators. Respir Physiol 2001; 128:79-87.
    • (2001) Respir Physiol , vol.128 , pp. 79-87
    • Tesfaigzi, Y.1    Kluger, M.2    Kozak, W.3
  • 106
    • 0035798685 scopus 로고    scopus 로고
    • MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro
    • Li Y, Martin LD, Spizz G, Adler KB. MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro. J Biol Chem 2001; 276:40982-40990.
    • (2001) J Biol Chem , vol.276 , pp. 40982-40990
    • Li, Y.1    Martin, L.D.2    Spizz, G.3    Adler, K.B.4
  • 112
    • 0037059829 scopus 로고    scopus 로고
    • Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway
    • Wang B, Lim DJ, Han J, Kim YS, Basbaum CB, Li JD. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. J Biol Chem 2002; 277:949-957.
    • (2002) J Biol Chem , vol.277 , pp. 949-957
    • Wang, B.1    Lim, D.J.2    Han, J.3    Kim, Y.S.4    Basbaum, C.B.5    Li, J.D.6
  • 113
    • 0043011579 scopus 로고    scopus 로고
    • IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation
    • Atherton HC, Jones G, Danahay H. IL-13-induced changes in the goblet cell density of human bronchial epithelial cell cultures: MAP kinase and phosphatidylinositol 3-kinase regulation. Am J Physiol, Lung Cell Mol Physiol 2003; 285:L730-L739.
    • (2003) Am J Physiol, Lung Cell Mol Physiol , vol.285
    • Atherton, H.C.1    Jones, G.2    Danahay, H.3
  • 116
  • 117
    • 0141851910 scopus 로고    scopus 로고
    • Antiproteases and retinoids for treatment of chronic obstructive pulmonary disease
    • Donnelly LE, Rogers DF. Antiproteases and retinoids for treatment of chronic obstructive pulmonary disease. Expert Opin Ther Pat 2003; 13:1345-1372.
    • (2003) Expert Opin Ther Pat , vol.13 , pp. 1345-1372
    • Donnelly, L.E.1    Rogers, D.F.2
  • 118
    • 0030462812 scopus 로고    scopus 로고
    • Quantitation of mucin RNA by PCR reveals induction of both MUC2 and MUC5AC mRNA levels by retinoids
    • Guzman K, Gray TE, Yoon JH, Nettesheim P. Quantitation of mucin RNA by PCR reveals induction of both MUC2 and MUC5AC mRNA levels by retinoids. Am J Physiol 1996; 271:L1023-L1028.
    • (1996) Am J Physiol , vol.271
    • Guzman, K.1    Gray, T.E.2    Yoon, J.H.3    Nettesheim, P.4
  • 119
    • 0031159337 scopus 로고    scopus 로고
    • Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracellular matrix
    • Yoon JH, Gray T, Guzman K, Koo JS, Nettesheim P. Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracellular matrix. Am J Respir Cell Mol Biol 1997; 16:724-731.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 724-731
    • Yoon, J.H.1    Gray, T.2    Guzman, K.3    Koo, J.S.4    Nettesheim, P.5
  • 120
    • 0033104859 scopus 로고    scopus 로고
    • Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells
    • Koo JS, Jetten AM, Belloni P, Yoon JH, Kim YD, Nettesheim P. Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells. Biochem J 1999; 338:351-357.
    • (1999) Biochem J , vol.338 , pp. 351-357
    • Koo, J.S.1    Jetten, A.M.2    Belloni, P.3    Yoon, J.H.4    Kim, Y.D.5    Nettesheim, P.6
  • 122
    • 0031976326 scopus 로고    scopus 로고
    • Smoke-induced inhalation injury: Effects of retinoic acid and antisense oligodeoxynucleotide on stability and differentiated state of the mucociliary epithelium
    • Bhattacharyya SN, Manna B, Smiley R, Ashbaugh P, Coutinho R, Kaufman B. Smoke-induced inhalation injury: effects of retinoic acid and antisense oligodeoxynucleotide on stability and differentiated state of the mucociliary epithelium. Inflammation 1998; 22:203-214.
    • (1998) Inflammation , vol.22 , pp. 203-214
    • Bhattacharyya, S.N.1    Manna, B.2    Smiley, R.3    Ashbaugh, P.4    Coutinho, R.5    Kaufman, B.6
  • 123
  • 124
    • 0036260974 scopus 로고    scopus 로고
    • P2Y(2) receptor agonists: A new class of medication targeted at improved mucociliary clearance
    • Kellerman DJ. P2Y(2) receptor agonists: a new class of medication targeted at improved mucociliary clearance. Chest 2002; 121:2015-2055.
    • (2002) Chest , vol.121 , pp. 2015-2055
    • Kellerman, D.J.1
  • 126
    • 0035153026 scopus 로고    scopus 로고
    • Airway goblet-cell mucus secretion
    • Jackson AD. Airway goblet-cell mucus secretion. Trends Pharmacol Sci 2001; 22:39-45.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 39-45
    • Jackson, A.D.1


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