Alveolar macrophage-mediated elastolysis: Roles of matrix metalloproteinases, cysteine, and serine proteases

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 283, Issue 4 27-4, 2002, Pages

  Russell, Richard E K ^a   Thorley, Andrew ^b   Culpitt, Sarah V ^a   Dodd, Sara ^a   Donnelly, Louise E ^a   Demattos, Carmen ^a   Fitzgerald, Mary ^b   Barnes, Peter J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b Bayer Pharmaceuticals   (United Kingdom)

Author keywords

Chronic obstructive pulmonary disease

Indexed keywords

CYSTEINE; ELASTIN; MATRIX METALLOPROTEINASE; SERINE PROTEINASE;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CLINICAL ARTICLE; CONTROLLED STUDY; ELASTOLYSIS; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; ISOTOPE LABELING; LUNG ALVEOLUS MACROPHAGE; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; WESTERN BLOTTING; ZYMOGRAPHY;

EID: 0036783727     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00020.2002     Document Type: Article

References (49)

1. Relationship of alveolar macrophage plasminogen activator and elastase activities to lung function and CT evidence of emphysema
2. Relationship of alveolar macrophage plasminogen activator and elastase activities to lung function and CT evidence of emphysema
3. Chronic obstructive pulmonary disease: New opportunities for drug development
4. E-64 [L-transepoxysuccinyl-leucyl-amido(4-guanidino)butanel and related epoxides as inhibitors of cysteine proteinases
5. Stimulation of cyclic AMP production in human alveolar macrophages induced by inflammatory mediators and beta-sympathicomimetics
6. Endothelial-leukocyte adhesion molecules in human disease
7. The matrix metalloproteinase inhibitor BB-94 limits expansion of experimental abdominal aortic aneurysms
8. Doxycycline inhibits elastin degradation and reduces metalloproteinase activity in a model of aneurysmal disease
9. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
10. Clinical features and history of the destructive lung disease associated with alpha-1-antitrypsin deficiency of adults with pulmonary symptoms
11. Matrix metalloproteinase inhibitors: A novel class of anticancer agents
12. Human leukocyte elastase, cathepsin G, and lactoferrin: Family of neutrophil granule glycoproteins that bind to an alveolar macrophage receptor
13. Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases
14. Free-radical chemistry of cigarette smoke and its toxicological implications
15. Matrix metalloproteinases generate angiostatin: Effects on neovascularization
16. Biochemistry and turnover of lung interstitium
17. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts
18. Elastin and collagen remodeling in emphysema. A scanning electron microscopy study
19. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
20. Inactivation of tissue inhibitor of metalloproteinase-1 by peroxynitrite
21. Characterization of matrix metalloproteinases produced by rat alveolar macrophages
22. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
23. The bronchial epithelium as a key regulator of airway inflammation and remodelling in asthma
24. Elastin fragments attract macrophage precursors to diseased sites in pulmonary emphysema
25. Cellular profiles in asthmatic airways: A comparison of induced sputum, bronchial washings, and bronchoalveolar lavage fluid
26. Identification of the 72-kDa (MMP-2) and 92-kDa (MMP-9) gelatinase/type IV collagenase in preparations of laminin and Matrigel
27. Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease
28. The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage
29. Smoke extract stimulates lung epithelial cells to release neutrophil and monocyte chemotactic activity
30. Altered cytokine regulation in the lungs of cigarette smokers
31. Mechanisms of airway obstruction
32. Elastinolytic activity of alveolar macrophages in smoking-associated pulmonary emphysema
33. Time course of neutrophil and macrophage elastinolytic activities in cigarette smoke-induced emphysema
34. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
35. Systemic oxidative stress in asthma, COPD, and smokers
36. Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages
37. Inflammation and repair processes in chronic obstructive pulmonary disease
38. CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease
39. Elastin degradation by human alveolar macrophages. A prominent role of metalloproteinase activity
40. Proteinases secreted by human mononuclear phagocytes
41. Elastin degradation by mononuclear phagocytes
42. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease
43. Comparison of elastolytic activity in lung lavage from current, ex- and non-smokers
44. Putative role of neutrophil elastase in the pathogenesis of emphysema
45. Elastin and the lung
46. Tests of a model of pulmonary elasticity
47. Nonpeptidic inhibitors of human leukocyte elastase. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one containing trifluoromethyl ketones
48. Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages
49. Elastases and elastin degradation