Macrophages and the pathogenesis of COPD

Chest

Volumn 121, Issue 5 SUPPL., 2002, Pages 156S-159S

  Tetley, Teresa D ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Cigarette smoke; COPD; Elastase; Emphysema; Macrophage; Matrix metalloproteinase; Neutrophil

Indexed keywords

MATRIX METALLOPROTEINASE; PROTEINASE;

APOPTOSIS; CELL COUNT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFERENCE PAPER; EFFECTOR CELL; EMPHYSEMA; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; EPITHELIUM CELL; FIBROBLAST; HUMAN; LUNG PARENCHYMA; MACROPHAGE; MEDIATOR; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RESPIRATORY AIRFLOW; SMOKING; TISSUE INJURY;

EID: 0036257599     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.121.5_suppl.156S     Document Type: Conference Paper

References (21)

1. Structural and inflammatory changes in COPD: A comparison with asthma
2. Alveolar inflammation and its relationship to emphysema in smokers
3. Emphysema: The first two centuries; part II
4. 1 in smokers are associated with increased levels of sputum neutrophils
5. Granulocyte activation markers in induced sputum: Comparison between chronic obstructive pulmonary disease, asthma, and normal subjects
6. Neutrophil traffic and COPD
7. Proteinase imbalance: Its role in lung disease
8. Activation mechanisms of matrix metalloproteinases
9. Tobacco smoke-induced lung emphysema in guinea pigs is associated with increased interstitial collagenase
10. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
11. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
12. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
13. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD
14. Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema
15. The macrophage in chronic obstructive pulmonary disease
16. Emerging roles for cysteine proteases in human biology
17. Compromised inhibition of human lung lavage cell elastases
18. Receptor-mediated binding and internalization of leukocyte elastase by alveolar macrophages in vitro
19. Altered cytokine regulation in the lungs of cigarette smokers
20. 2
21. Cigarette smoking decreases interleukin-8 secretion by human alveolar macrophages