-
1
-
-
0036468677
-
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
-
Lois C, Hong EJ, Pease S, Brown EJ, Baltimore D: Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295, 868-872 (2002).
-
(2002)
Science
, vol.295
, pp. 868-872
-
-
Lois, C.1
Hong, E.J.2
Pease, S.3
Brown, E.J.4
Baltimore, D.5
-
2
-
-
0036201592
-
Opportunities for the use of lentiviral vectors in human gene therapy
-
Galimi F, Verma IM: Opportunities for the use of lentiviral vectors in human gene therapy. Curr. Top. Microbiol. Immunol. 261, 245-254 (2002).
-
(2002)
Curr. Top. Microbiol. Immunol
, vol.261
, pp. 245-254
-
-
Galimi, F.1
Verma, I.M.2
-
3
-
-
0037370498
-
A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
-
Rubinson DA, Dillon CP, Kwiatkowski AV et al.: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet 33(3), 401-406 (2003).
-
(2003)
Nat. Genet
, vol.33
, Issue.3
, pp. 401-406
-
-
Rubinson, D.A.1
Dillon, C.P.2
Kwiatkowski, A.V.3
-
4
-
-
13644269779
-
Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells
-
Miyagishi M, Sumimoto H, Miyoshi H, Kawakami Y, Taira K: Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells. J. Gene Med. 6, 715-723, (2004).
-
(2004)
J. Gene Med
, vol.6
, pp. 715-723
-
-
Miyagishi, M.1
Sumimoto, H.2
Miyoshi, H.3
Kawakami, Y.4
Taira, K.5
-
5
-
-
0034737298
-
RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
-
Zamore P, Tushl T, Sharp P, Bartel D: RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101, 25-33 (2000).
-
(2000)
Cell
, vol.101
, pp. 25-33
-
-
Zamore, P.1
Tushl, T.2
Sharp, P.3
Bartel, D.4
-
6
-
-
0034673638
-
An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
-
Hammond SM, Bernstein E, Beach D, Hannon G: An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404, 293-296 (2000).
-
(2000)
Nature
, vol.404
, pp. 293-296
-
-
Hammond, S.M.1
Bernstein, E.2
Beach, D.3
Hannon, G.4
-
7
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montogeomery MK, Kostas SA, Driver SE, Mello CC: Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811 (1998).
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montogeomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
8
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
Yalcin, A.4
Weber, K.5
Tuschl, T.6
-
9
-
-
1642346273
-
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference
-
Ui-Tei K, Naito Y, Takahashi F et al.: Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res. 32, 936-948 (2004).
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 936-948
-
-
Ui-Tei, K.1
Naito, Y.2
Takahashi, F.3
-
10
-
-
1542336952
-
Rational siRNA design for RNA interference
-
Reynolds A, Leake D, Boese Q, Scaringe S, Marshall WS, Khvorova A: Rational siRNA design for RNA interference. Nature Biotech. 22, 326-330 (2004).
-
(2004)
Nature Biotech
, vol.22
, pp. 326-330
-
-
Reynolds, A.1
Leake, D.2
Boese, Q.3
Scaringe, S.4
Marshall, W.S.5
Khvorova, A.6
-
11
-
-
1642273831
-
An algorithm for selection of functional siRNA interference
-
Amarzuguioui M, Pryds H: An algorithm for selection of functional siRNA interference. Biochem. Biophys. Res. Commun. 316, 1050-1058 (2004).
-
(2004)
Biochem. Biophys. Res. Commun
, vol.316
, pp. 1050-1058
-
-
Amarzuguioui, M.1
Pryds, H.2
-
12
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp, TR, Bernards; R, Agami R: A system for stable expression of short interfering RNAs in mammalian cells. Science 296, 550-553 (2002).
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
13
-
-
0036245628
-
U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells
-
Miyagishi M, Taira K: U6 promoter-driven siRNAs with four uridine 3′ overhangs efficiently suppress targeted gene expression in mammalian cells. Nature Biotech. 20, 497-500 (2002).
-
(2002)
Nature Biotech
, vol.20
, pp. 497-500
-
-
Miyagishi, M.1
Taira, K.2
-
14
-
-
0036256430
-
Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells
-
Lee NS, Dohjima T, Bauer G et al.: Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells. Nature Biotech. 20, 500-505 (2002).
-
(2002)
Nature Biotech
, vol.20
, pp. 500-505
-
-
Lee, N.S.1
Dohjima, T.2
Bauer, G.3
-
15
-
-
0037089589
-
Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells
-
Paddison PJ, Candy AA, Bernstein E, Hannon GJ, Conklin DS: Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev. 16, 948-958 (2002).
-
(2002)
Genes Dev
, vol.16
, pp. 948-958
-
-
Paddison, P.J.1
Candy, A.A.2
Bernstein, E.3
Hannon, G.J.4
Conklin, D.S.5
-
16
-
-
0036251639
-
Effective expression of small interfering RNA in human cells
-
Paul CP, Good PD, Winer I, Engelke DR: Effective expression of small interfering RNA in human cells. Nature Biotech. 20, 505-508 (2002)
-
(2002)
Nature Biotech
, vol.20
, pp. 505-508
-
-
Paul, C.P.1
Good, P.D.2
Winer, I.3
Engelke, D.R.4
-
17
-
-
0036726313
-
Stable suppression of tumorigenicity by virus-mediated RNA interference
-
Burmmelkamp TR, Bernards R, Agami R: Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2, 243-247 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 243-247
-
-
Burmmelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
18
-
-
0037069417
-
-
Barton GM, Medzhitov R: Retroviral delivery of small interfering RNA into primary cells. Proc. Natl Acad. Sci. USA 99, 14943-14945 (2002).
-
Barton GM, Medzhitov R: Retroviral delivery of small interfering RNA into primary cells. Proc. Natl Acad. Sci. USA 99, 14943-14945 (2002).
-
-
-
-
19
-
-
0036976008
-
Lentiviral-mediated RNA interference
-
Abbas-Terki T, Blanco-Bose W, Deglon N, Pralong W, Aebischer P: Lentiviral-mediated RNA interference. Human Gene Therapy 13, 2197-2201 (2002).
-
(2002)
Human Gene Therapy
, vol.13
, pp. 2197-2201
-
-
Abbas-Terki, T.1
Blanco-Bose, W.2
Deglon, N.3
Pralong, W.4
Aebischer, P.5
-
20
-
-
22344454846
-
Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
-
Judge AD, Sood V, Shaw JR, Fang D, McClintock K, MacLachian I: Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA. Nature Biotech. 23, 457-462 (2005).
-
(2005)
Nature Biotech
, vol.23
, pp. 457-462
-
-
Judge, A.D.1
Sood, V.2
Shaw, J.R.3
Fang, D.4
McClintock, K.5
MacLachian, I.6
-
21
-
-
20144389695
-
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
-
Hornung V, Guenthner-Biller M, Bourquin C et al.: Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nature Med. 11, 263-270 (2005).
-
(2005)
Nature Med
, vol.11
, pp. 263-270
-
-
Hornung, V.1
Guenthner-Biller, M.2
Bourquin, C.3
-
22
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via roll-like receptor 7 and 8
-
Heil F, Hemmi H, Hochrein H et al.: Species-specific recognition of single-stranded RNA via roll-like receptor 7 and 8. Science 303, 1526-1529 (2004).
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
-
23
-
-
3242813113
-
The RNA helicase RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses
-
Yoneyama M, Kikuchi M, Natsukawa T et al.: The RNA helicase RIG-1 has an essential function in double-stranded RNA-induced innate antiviral responses. Nature Immunol. 5, 730-737 (2004).
-
(2004)
Nature Immunol
, vol.5
, pp. 730-737
-
-
Yoneyama, M.1
Kikuchi, M.2
Natsukawa, T.3
-
24
-
-
23844438864
-
Shared and unique functions of the DExD/H-box helicases; RIG-1, MDA5, and LGP2 in antiviral innate immunity
-
Yoneyama M, Kukuchi M, Matsumoto K et al.: Shared and unique functions of the DExD/H-box helicases; RIG-1, MDA5, and LGP2 in antiviral innate immunity. J. Immunol. 175, 2851-2858 (2005).
-
(2005)
J. Immunol
, vol.175
, pp. 2851-2858
-
-
Yoneyama, M.1
Kukuchi, M.2
Matsumoto, K.3
-
25
-
-
33646561864
-
A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells
-
Marques JT, Devosse T, Wang D et al.: A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells. Nature Biotech. 24, 559-565 (2006).
-
(2006)
Nature Biotech
, vol.24
, pp. 559-565
-
-
Marques, J.T.1
Devosse, T.2
Wang, D.3
-
26
-
-
4344651348
-
Self-inactivating lentiviral vectors resist proviral methylation but do not confer position-independent expression in hematopoietic stem cells
-
Mohamedali A, Moreau-Gaudry F, Richard E, Xia P, Nolta J, Malik P: Self-inactivating lentiviral vectors resist proviral methylation but do not confer position-independent expression in hematopoietic stem cells. Mol. Ther. 10, 249-259 (2004)
-
(2004)
Mol. Ther
, vol.10
, pp. 249-259
-
-
Mohamedali, A.1
Moreau-Gaudry, F.2
Richard, E.3
Xia, P.4
Nolta, J.5
Malik, P.6
-
27
-
-
0037685280
-
Expression profiling reveals off-target gene regulation by RNAi
-
Jackson AL, Bartz SR, Schelter J et al.: Expression profiling reveals off-target gene regulation by RNAi. Nature Biotech. 21, 635-637 (2003).
-
(2003)
Nature Biotech
, vol.21
, pp. 635-637
-
-
Jackson, A.L.1
Bartz, S.R.2
Schelter, J.3
-
28
-
-
33745299723
-
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
-
Grimm D, Streetz KL, Jopling CL et al.: Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441, 537-541 (2006).
-
(2006)
Nature
, vol.441
, pp. 537-541
-
-
Grimm, D.1
Streetz, K.L.2
Jopling, C.L.3
-
29
-
-
0031666744
-
Development of a self-inactivating lentivirus vector
-
Miyoshi H, Blömer U, Takahashi M, Gage FH, Verma IM: Development of a self-inactivating lentivirus vector. J. Virol. 72(10), 8150-8157 (1998).
-
(1998)
J. Virol
, vol.72
, Issue.10
, pp. 8150-8157
-
-
Miyoshi, H.1
Blömer, U.2
Takahashi, M.3
Gage, F.H.4
Verma, I.M.5
-
30
-
-
0043210428
-
Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference
-
Wiznerowicz M, Trono D: Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference. J. Virol. 77, 8957-8961 (2003).
-
(2003)
J. Virol
, vol.77
, pp. 8957-8961
-
-
Wiznerowicz, M.1
Trono, D.2
-
31
-
-
28844433551
-
Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi
-
Sumimoto H, Hirata K, Yamagata S et al.: Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi. Int. J. Cancer 118, 472-476 (2006).
-
(2006)
Int. J. Cancer
, vol.118
, pp. 472-476
-
-
Sumimoto, H.1
Hirata, K.2
Yamagata, S.3
-
32
-
-
33745859743
-
The BRAF-MAPK signaling pathway is essential for cancer immune evasion in human melanoma cells
-
Sumimoto H, Imabayashi F, Iwata. T, Kawakami Y: The BRAF-MAPK signaling pathway is essential for cancer immune evasion in human melanoma cells. J. Exp. Med. 203, 1651-1656 (2006).
-
(2006)
J. Exp. Med
, vol.203
, pp. 1651-1656
-
-
Sumimoto, H.1
Imabayashi, F.2
Iwata, T.3
Kawakami, Y.4
-
33
-
-
0034646513
-
Genome nuclear import is mediated by a central DNA flap
-
Zennou V, Petit C, Guetard D, Nerhbass U, Montagnier L, Charneau P: Genome nuclear import is mediated by a central DNA flap. Cell 101 (2), 173-185 (2000).
-
(2000)
Cell
, vol.101
, Issue.2
, pp. 173-185
-
-
Zennou, V.1
Petit, C.2
Guetard, D.3
Nerhbass, U.4
Montagnier, L.5
Charneau, P.6
-
34
-
-
0032978712
-
Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors
-
Zufferey R, Donello JE, Trono D, Hope TJ: Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73, 2886-2892 (1999).
-
(1999)
J. Virol
, vol.73
, pp. 2886-2892
-
-
Zufferey, R.1
Donello, J.E.2
Trono, D.3
Hope, T.J.4
-
35
-
-
34249111217
-
Lentiviral vectors for cancer immunotherapy: Transforming infectious particles into therapeutics
-
Breckpot K, Aerts JL, Thielemans K: Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics. Gene Therapy 14, 847-862 (2007).
-
(2007)
Gene Therapy
, vol.14
, pp. 847-862
-
-
Breckpot, K.1
Aerts, J.L.2
Thielemans, K.3
-
36
-
-
0036787671
-
siRNA-mediated gene silencing in vitro and in vivo
-
Xia H, Mao Q, Paulson H, Davidson BL: siRNA-mediated gene silencing in vitro and in vivo. Nature Biotech. 20, 1006-1010 (2002).
-
(2002)
Nature Biotech
, vol.20
, pp. 1006-1010
-
-
Xia, H.1
Mao, Q.2
Paulson, H.3
Davidson, B.L.4
-
37
-
-
2342627912
-
Control of siRNA expression using the Cre-loxP recombination system
-
Kasim V, Miyagishi M, Taira K: Control of siRNA expression using the Cre-loxP recombination system. Nucleic Acids Res. 32, E66 (2004).
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Kasim, V.1
Miyagishi, M.2
Taira, K.3
-
38
-
-
34547629188
-
Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference
-
Hitz C, Worst W, Kühn R: Conditional brain-specific knockdown of MAPK using Cre/loxP regulated RNA interference. Nucleic Acids Res. 35, E90 (2007).
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Hitz, C.1
Worst, W.2
Kühn, R.3
-
39
-
-
18144453718
-
Inducible suppression of Fgr2 and Survivin in ES cells using combination of the RNA inteference (RNAi) and the Cre-LoxP sytem
-
Coumoul X, Li W, Wang RH, Deng C: Inducible suppression of Fgr2 and Survivin in ES cells using combination of the RNA inteference (RNAi) and the Cre-LoxP sytem. Nucleic Acids Res. 32, E85 (2004).
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Coumoul, X.1
Li, W.2
Wang, R.H.3
Deng, C.4
-
40
-
-
33746833330
-
Targeting lentiviral vectors to specific cell types in vivo
-
Lili Y, Bailey L, Baltimore D, Wang P: Targeting lentiviral vectors to specific cell types in vivo. Proc. Natl Acad. Sci. USA 103, 11479-11484 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 11479-11484
-
-
Lili, Y.1
Bailey, L.2
Baltimore, D.3
Wang, P.4
-
41
-
-
7244240716
-
+ hematopoietic cells using novel ligand display technology
-
+ hematopoietic cells using novel ligand display technology. Blood 104, 2697-2703 (2004).
-
(2004)
Blood
, vol.104
, pp. 2697-2703
-
-
Chandrashekran, A.1
Gordon, M.Y.2
Casimir, C.3
-
42
-
-
33645167401
-
Prospects of RNA interference therapy for cancer
-
Pai SI, Lin YY, Macaes B, Meneshian A, Hung CF, Wu TC: Prospects of RNA interference therapy for cancer. Gene Therapy, 13, 464-477 (2006).
-
(2006)
Gene Therapy
, vol.13
, pp. 464-477
-
-
Pai, S.I.1
Lin, Y.Y.2
Macaes, B.3
Meneshian, A.4
Hung, C.F.5
Wu, T.C.6
-
43
-
-
0141816881
-
Suppression of BRAF(V599E) in human melanoma abrogates transformation
-
Hingorani SR, Jacobetz MA, Robertson GP, Herlyn M, Tuveson DA: Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer Res. 63, 5198-5202 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 5198-5202
-
-
Hingorani, S.R.1
Jacobetz, M.A.2
Robertson, G.P.3
Herlyn, M.4
Tuveson, D.A.5
-
44
-
-
4444240325
-
Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference
-
Sumimoto H, Miyagishi M, Miyoshi H et al.: Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 23, 6031-6039 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 6031-6039
-
-
Sumimoto, H.1
Miyagishi, M.2
Miyoshi, H.3
-
45
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
Soutschek J, Akinc A, Bramlage B et al.: Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004).
-
(2004)
Nature
, vol.432
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
-
46
-
-
23844474160
-
Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
-
Song E, Zhu P, Lee SK et al.: Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nature Biotech. 23, 709-717 (2005).
-
(2005)
Nature Biotech
, vol.23
, pp. 709-717
-
-
Song, E.1
Zhu, P.2
Lee, S.K.3
-
47
-
-
33847720312
-
In vivo imaging of siRNA delivery and silencing in tumors
-
Medarova Z, Pham W, Farrar C, Petkova V, Moore A. In vivo imaging of siRNA delivery and silencing in tumors. Nature Med. 13, 372-377 (2007).
-
(2007)
Nature Med
, vol.13
, pp. 372-377
-
-
Medarova, Z.1
Pham, W.2
Farrar, C.3
Petkova, V.4
Moore, A.5
-
48
-
-
34447114618
-
Transvascular delivery of small interfering RNA to the central nervous system
-
Kumar P, Wu H, McBride JL et al.: Transvascular delivery of small interfering RNA to the central nervous system. Nature 448, 39-43 (2007).
-
(2007)
Nature
, vol.448
, pp. 39-43
-
-
Kumar, P.1
Wu, H.2
McBride, J.L.3
-
49
-
-
0038610713
-
Caspase 8 small interfering RNA prevents acute liver failure in mice
-
Zender L, Hütker S, Liedtke C et al.: Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc. Natl Acad. Sci. USA 100, 7797-7802 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 7797-7802
-
-
Zender, L.1
Hütker, S.2
Liedtke, C.3
|