Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice

Archives of Physiology and Biochemistry

Volumn 113, Issue 4-5, 2007, Pages 173-185

  Korsheninnikova, E ^a   Voshol, P J ^a   Baan, B ^a   Van Der Zon, G C M ^a   Havekes, L M ^a,b   Romijn, J A ^a   Maassen, J A ^a,c   Ouwens, D M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b TNO   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Hepatic glucose production; High fat diet; Insulin resistance; Insulin signalling; Liver

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; DRUG EFFECT; FAT INTAKE; GENE EXPRESSION REGULATION; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; LIVER; MALE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; DIETARY FATS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; HYPERINSULINISM; INSULIN; LIVER; MALE; MICE; MICE, INBRED C57BL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

MUS;

EID: 37548999797     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.1080/13813450701669084     Document Type: Article

References (35)

1. Accili D, Arden KC. 2004. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-26.
2. Anai M, Funaki M, Ogihara T, Kanda A, Onishi Y, Sakoda H, Inukai K, Nawano M, Fukushima Y, Yazaki Y, et al. 1999. Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat-fed rats. Diabetes 48:158-69.
3. Barthel A, Schmoll D, Unterman TG. 2005. FoxO proteins in insulin action and metabolism. Trends Endocrinol Metab 16:183-9.
4. den Boer MA, Voshol PJ, Schroder-van der Elst JP, Korsheninnikova E, Ouwens DM, Kuipers F, Havekes LM, Romijn JA. 2006. Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice. Endocrinology 147:4553-8.
5. Farese RV, Sajan MP, Standaert ML. 2005a. Atypical protein kinase C in insulin action and insulin resistance. Biochem Soc Trans 33:350-53.
6. Farese RV, Sajan MP, Standaert ML. 2005b. Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/ Akt): actions and defects in obesity and type II diabetes. Exp Biol Med (Maywood) 230:593-605.
7. Foufelle F, Ferre P. 2002. New perspectives in the regulation of hepatic glycolytic and lipogenic genes by insulin and glucose: a role for the transcription factor sterol regulatory element binding protein-1c. Biochem J 366:377-91.
8. Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC, Jr. 2006. mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin. EMBO J 25:1659-68.
9. Hotamisligil GS. 2005. Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 Suppl 2:S73-8.
10. Kessler A, Uphues I, Ouwens DM, Till M, Eckel J. 2001. Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase. Am J Physiol Endocrinol Metab 280:E65-E74.
11. Khamzina L, Veilleux A, Bergeron S, Marette A. 2005. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 146:1473-81.
12. Korsheninnikova E, van der Zon GC, Voshol PJ, Janssen GM, Havekes LM, Grefhorst A, Kuipers F, Reijngoud DJ, Romijn JA, Ouwens DM, et al. 2006. Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice. Diabetologia 49:3049-57.
13. Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, et al. 2005. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 120:261-73.
14. Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, et al. 2003. PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest 112: 935-44.
15. Nascimento EB, Fodor M, van der Zon GC, Jazet IM, Meinders AE, Voshol PJ, Vlasblom R, Baan B, Eckel J, Maassen JA, et al. 2006. Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats. Diabetes 55:3221-8.
16. Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. 1999. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 344 Pt 2:427-31.
17. Ouwens DM, Boer C, Fodor M, de Galan P, Heine RJ, Maassen JA, Diamant M. 2005. Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats. Diabetologia 48:1229-37.
18. Proud CG. 2006. Regulation of protein synthesis by insulin. Biochem Soc Trans 34:213-16.
19. Saltiel AR, Kahn CR. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806.
20. Sanders J, Brandsma M, Janssen GM, Dijk J, Moller W. 1996. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation facto-1 beta gamma delta in the endoplasmic reticulum. J Cell Sci 109 (Part 5):1113-17.
21. Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. 2000. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 6:77-86.
22. Solinas G, Naugler W, Galimi F, Lee MS, Karin M. 2006. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci U S A 103:16454-9.
23. Taniguchi CM, Emanuelli B, Kahn CR. 2006a. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96.
24. Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR. 2006b. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metab 3:343-3.
25. Taniguchi CM, Ueki K, Kahn R. 2005. Complementary roles of IRS-I and IRS-2 in the hepatic regulation of metabolism. J Clin Invest 115:718-27.
26. Traverse S, Gomez N, Paterson H, Marshall C, Cohen P. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem J 288 (Pt 2):351-5.
27. Tremblay F, Krebs M, Dombrowski L, Brehm A, Bernroider E, Roth E, Nowotny P, Waldhausl W, Marette A, Roden M. 2005. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 54:2674-84.
28. Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, et al. 2004. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200-05.
29. Voshol PJ, Haemmerle G, Ouwens DM, Zimmermann R, Zechner R, Teusink B, Maassen JA, Havekes LM, Romijn JA. 2003. Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice. Endocrinology 144:3456-62.
30. Wang H, Wollheim CB. 2005. Does chasing selected 'Fox' to the nucleus prevent diabetes? Trends Mol Med 11:262-5.
31. Werlen G, Hausmann B, Naeher D, Palmer E. 2003. Signaling life and death in the thymus: timing is everything. Science 299:1859-63.
32. Withers DJ, Ouwens DM, Nave BT, van der Zon GC, Alarcon CM, Cardenas ME, Heitman J, Maassen JA, Shepherd PR. 1997. Expression, enzyme activity, and sub-cellular localization of mammalian target of rapamycin in insulin-responsive cells. Biochem Biophys Res Commun 241:704-09.
33. Wojtaszewski JF, Hansen BF, Gade, Kiens B, Markuns JF, Goodyear LJ, Richter EA. 2000. Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes 49:325-31.
34. Wolfrum C, Asilmaz E, Luca E, Friedman JM, Stoffel M. 2004. Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature 432:1027-32.
35. Yan GZ, Ziff EB. 1995. NGF regulates the PC12 cell cycle machinery through specific inhibition of the Cdk kinases and induction of cyclin Dl. J Neurosci 15:6200-12.