Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats

Diabetologia

Volumn 48, Issue 6, 2005, Pages 1229-1237

  Ouwens, D M ^a   Boer, C ^b   Fodor, M ^a,b   De Galan, P ^a   Heine, R J ^b   Maassen, J A ^a,b   Diamant, M ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Diabetes mellitus; Diabetic cardiomyopathy; Diet; Insulin; Phospholamban

Indexed keywords

CALCIUM ION; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FAT; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLAMBAN; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BODY WEIGHT; CARDIOMYOPATHY; CELL LYSATE; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; DIET RESTRICTION; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HEART FUNCTION; HEART MUSCLE; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HEART PAPILLARY MUSCLE; HEART WEIGHT; INSULIN METABOLISM; INSULIN RESISTANCE; LIPID DIET; LONG TERM EXPOSURE; LOW FAT DIET; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; WORKLOAD;

ANIMALS; DIET, FAT-RESTRICTED; DIETARY FATS; HEART; HEART VENTRICLES; INSULIN; MALE; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TRIGLYCERIDES;

EID: 21344455935     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1755-x     Document Type: Article

References (50)

1. Kannel WB, Hjortland M, Castelli WP (1974) Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol 34:29-34
2. Stander J, Vaccaro O, Neaton JD, Wentworth D (1993) Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 16:434-444
3. Vanninen E, Mustonen J, Vainio P, Lansimies E, Uusitupa M (1992) Left ventricular function and dimensions in newly diagnosed non-insulin-dependent diabetes mellitus. Am J Cardiol 70:371-378
4. Diamant M, Lamb HJ, Groeneveld Y et al (2003) Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus. J Am Coll Cardiol 42:328-335
5. Bell DS (1995) Diabetic cardiomyopathy. A unique entity or a complication of coronary artery disease? Diabetes Care 18:708-714
6. Taegtmeyer H, McNulty P, Young ME (2002) Adaptation and maladaptation of the heart in diabetes: part I. General concepts. Circulation 105:1727-1733
7. Unger RH (2002) Lipotoxic diseases. Annu Rev Med 53:319-336
8. Zhou YT, Grayburn P, Karim A et al (2000) Lipotoxic heart disease in obese rats: implications for human obesity. Proc Natl Acad Sci U S A 97:1784-1789
9. Kessler A, Uphues I, Ouwens DM, Till M, Eckel J (2001) Diversification of cardiac insulin signaling involves the p85 alpha/ beta subunits of phosphatidylinositol 3-kinase. Am J Physiol Endocrinol Metab 280:E65-E74
10. Lamberts RR, Van Rijen MH, Sipkema P, Fransen P, Sys SU, Westerhof N (2002) Coronary perfusion and muscle lengthening increase cardiac contraction: different stretch-triggered mechanisms. Am J Physiol Heart Circ Physiol 283:H1515-H1522
11. Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Med Sci 37:911-917
12. Withers DJ, Ouwens DM, Nave BT et al (1997) Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. Biochem Biophys Res Commun 241:704-709
13. Christoffersen C, Bollano E, Lindegaard MLS et al (2003) Cardiac lipid accumulation associated with diasystolic dysfunction in obese mice. Endocrinology 144:3483-3490
14. Perseghin G, Petersen K, Shulman GI (2003) Cellular mechanism of insulin resistance: potential links with inflammation. Int J Obes Relat Metab Disord 27(Suppl 3):S6-S11
15. Schaffer JE (2003) Lipotoxicity: when tissues overeat. Curr Opin Lipidol 14:281-287
16. Frey N, Katus HA, Olson EN, Hill JA (2004) Hypertrophy of the heart: a new therapeutic target? Circulation 109:1580-1589
17. Belke DD, Betuing S, Turtle MJ et al (2002) Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression. J Clin Invest 109:629-639
18. Murphy S, Frishman WH (2005) Protein kinase C in cardiac disease and as a potential therapeutic target. Cardiol Rev 13:3-12
19. Fitzgerald SM, Henegar JR, Brands MW, Henegar LK, Hall JE (2001) Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats. Am J Physiol Regul Integr Comp Physiol 281:R547-R552
20. Korvald C, Elvenes OP, Myrmel T (2000) Myocardial substrate metabolism influences left ventricular energetics in vivo. Am J Physiol Heart Circ Physiol 278:H1345-H1351
21. Borst P, Loos JA, Christ EJ, Slater EC (1962) Uncoupling activity of long-chain fatty acids. Biochim Biophys Acta 62:509-518
22. Myrmel T, Forsdahl K, Larsen TS (1992) Triacylglycerol metabolism in hypoxic, glucose-deprived rat cardiomyocytes. J Mol Cell Cardiol 24:855-868
23. 2+ permeability of cardiac sarcolemmal vesicles. J Biol Chem 260:9666-9671
24. Huang JM, Xian H, Bacaner M (1992) Long-chain fatty acids activate calcium channels in ventricular myocytes. Proc Natl Acad Sci U S A 89:6452-6456
25. Chiu HC, Kovacs A, Ford DA et al (2001) A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest 107:813-822
26. Finck BN, Lehman JJ, Leone TC et al (2002) The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. J Clin Invest 109:121-130
27. Young ME, Guthrie PH, Razeghi P et al (2002) Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. Diabetes 51:2587-2595
28. Abel ED, Kaulbach HC, Tian R et al (1999) Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Invest 104:1703-1714
29. Atkinson LL, Kozak R, Kelly SE, Onay BA, Russell JC, Lopaschuk GD (2003) Potential mechanisms and consequences of cardiac triacylglycerol accumulation in insulin-resistant rats. Am J Physiol Endocrinol Metab 284:E923-E930
30. Hu P, Zhang D, Swenson L, Chakrabarti G, Abel ED, Litwin SE (2003) Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload. Am J Physiol Heart Circ Physiol 285:H1261-H1269
31. Dutta K, Podolin DA, Davidson MB, Davidoff AJ (2001) Cardiomyocyte dysfunction in sucrose-fed rats is associated with insulin resistance. Diabetes 50:1186-1192
32. Fath-Ordoubadi F, Beatt KJ (1997) Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation 96:1152-1156
33. Ren J, Walsh MF, Hamaty M, Sowers JR, Brown RA (1999) Augmentation of the inotropic response to insulin in diabetic rat hearts. Life Sci 65:369-380
34. Ren J, Sowers JR, Walsh MF, Brown RA (2000) Reduced contractile response to insulin and IGF-I in ventricular myocytes from genetically obese Zucker rats. Am J Physiol Heart Circ Physiol 279:H1708-H1714
35. Allard MF, Wambolt RB, Longnus SL et al (2000) Hypertrophied rat hearts are less responsive to the metabolic and functional effects of insulin. Am J Physiol Endocrinol Metab 279:E487-E493
36. Doenst T, Goodwin GW, Cedars AM, Wang M, Stepkowski S, Taegtmeyer H (2001) Load-induced changes in vivo alter substrate fluxes and insulin responsiveness of rat heart in vitro. Metabolism 50:1083-1090
37. Sasso FC, Carbonara O, Cozzolino D et al (2000) Effects of insulin-glucose infusion on left ventricular function at rest and during dynamic exercise in healthy subjects and noninsulin dependent diabetic patients: a radionuclide ventriculographic study. J Am Coll Cardiol 36:219-226
38. 2+ -cycling proteins may underlie sarcoplasmic reticulum dysfunction in the diabetic heart. Diabetes 50:2133-2138
39. 2+ -ATPases in muscle and heart. J Biol Chem 272:23696-23702
40. Dutta K, Carmody MW, Cala SE, Davidoff AJ (2002) Depressed PKA activity contributes to impaired SERCA function and is linked to the pathogenesis of glucose-induced cardiomyopathy. J Mol Cell Cardiol 34:985-996
41. Belke DD, Swanson EA, Dillmann WH (2004) Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart. Diabetes 53:3201-3208
42. MacLennan DH, Kranias EG (2003) Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4:566-577
43. Zierath JR, Krook A, Wallberg-Henriksson H (2000) Insulin action and insulin resistance in human skeletal muscle. Diabetologia 43:821-835
44. Youngren JF, Paik J, Barnard RJ (2001) Impaired insulin-receptor autophosphorylation is an early defect in fat-fed, insulin-resistant rats. J Appl Physiol 91:2240-2247
45. Mazumder PK, O'Neill BT, Roberts MW et al (2004) Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. Diabetes 53:2366-2374
46. Carvalheira JB, Calegari VC, Zecchin HG et al (2003) The cross-talk between angiotensin and insulin differentially affects phosphatidylinositol 3-kinase- and mitogen-activated protein kinase-mediated signaling in rat heart: implications for insulin resistance. Endocrinology 144:5604-5614
47. Cazzolli R, Carpenter L, Biden TJ, Schmitz-Peiffer C (2001) A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate. Diabetes 50:2210-2218
48. Gergs U, Boknik P, Buchwalow I et al (2004) Overexpression of the catalytic subunit of protein phosphatase 2A impairs cardiac function. J Biol Chem 279:40827-40834
49. Gao F, Gao E, Yue TL et al (2002) Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 105:1497-1502
50. Accili D, Arden KC (2004) FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-426