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Volumn 17, Issue 1, 2008, Pages 1-10

Role of the endocannabinoid system in metabolic control

Author keywords

Cannabinoid receptor; Endocannabinoid; N oleoylethanolamine; Obesity; Rimonabant

Indexed keywords

2 ARACHIDONOYLGLYCEROL; AM 1387; ANANDAMIDE; CANNABINOID 1 RECEPTOR ANTAGONIST; ENDOCANNABINOID; G PROTEIN COUPLED RECEPTOR; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LH 21; N OLEOYLETHANOLAMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RIMONABANT; TARANABANT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 37349023167     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e3282f29071     Document Type: Review
Times cited : (20)

References (105)
  • 1
    • 33947489961 scopus 로고
    • Isolation, structure, and partial synthesis of an active constituent of hashish
    • Gaoni Y, Mechoulam R. Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964; 86:1646-1647.
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 2
  • 3
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Brownstein MJ, et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990; 346:561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3
  • 4
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993; 365:61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 5
    • 85047690626 scopus 로고    scopus 로고
    • The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    • Cota D, Marsicano G, Tschöp M, et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 2003; 112:423-431.
    • (2003) J Clin Invest , vol.112 , pp. 423-431
    • Cota, D.1    Marsicano, G.2    Tschöp, M.3
  • 6
    • 33845296428 scopus 로고    scopus 로고
    • Spoto B, Fezza F, Parlongo G, et al. Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. Biochimie 2006; 88:1889-1897. • This is the first report of functional analysis of anandamide and 2-AG in human adipose tissue.
    • Spoto B, Fezza F, Parlongo G, et al. Human adipose tissue binds and metabolizes the endocannabinoids anandamide and 2-arachidonoylglycerol. Biochimie 2006; 88:1889-1897. • This is the first report of functional analysis of anandamide and 2-AG in human adipose tissue.
  • 7
    • 20944436157 scopus 로고    scopus 로고
    • Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    • Osei-Hyiaman D, DePetrillo M, Pacher P, et al. Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. J Clin Invest 2005; 115:1298-1305.
    • (2005) J Clin Invest , vol.115 , pp. 1298-1305
    • Osei-Hyiaman, D.1    DePetrillo, M.2    Pacher, P.3
  • 8
    • 29544435299 scopus 로고    scopus 로고
    • 2+ signals and insulin secretion in pancreatic β-cell. Cell Calcium 2006; 39:155-162. • This is the first report of both CB1 and CB2 expression in endocrine pancreatic cells.
    • 2+ signals and insulin secretion in pancreatic β-cell. Cell Calcium 2006; 39:155-162. • This is the first report of both CB1 and CB2 expression in endocrine pancreatic cells.
  • 9
    • 0033626501 scopus 로고    scopus 로고
    • Localization of CB1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system
    • Kulkarni-Narla A, Brown DR. Localization of CB1-cannabinoid receptor immunoreactivity in the porcine enteric nervous system. Cell Tissue Res 2000; 302:73-80.
    • (2000) Cell Tissue Res , vol.302 , pp. 73-80
    • Kulkarni-Narla, A.1    Brown, D.R.2
  • 11
    • 32844465920 scopus 로고    scopus 로고
    • Gong JP, Onaivi ES, Ishiguro H, et al. Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res 2006; 1071:10-23. • This article reported a wide distribution of CB2 in mouse brain, which suggested reevaluation of possible roles of CB2 in CNS.
    • Gong JP, Onaivi ES, Ishiguro H, et al. Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res 2006; 1071:10-23. • This article reported a wide distribution of CB2 in mouse brain, which suggested reevaluation of possible roles of CB2 in CNS.
  • 12
    • 18144385088 scopus 로고    scopus 로고
    • Evidence for novel cannabinoid receptors
    • Begg M, Pacher P, Bátkai S, et al. Evidence for novel cannabinoid receptors. Pharmacol Ther 2005; 106:133-145.
    • (2005) Pharmacol Ther , vol.106 , pp. 133-145
    • Begg, M.1    Pacher, P.2    Bátkai, S.3
  • 14
    • 33646814424 scopus 로고    scopus 로고
    • Mackie K, Stella N. Cannabinoid receptors and endocannabinoids: evidence for new players. AAPS J 2006; 8:E298-E306. • This review article supplied several lines of evidence that suggested the existence of additional cannabinoid receptors distinct from CB1 and CB2.
    • Mackie K, Stella N. Cannabinoid receptors and endocannabinoids: evidence for new players. AAPS J 2006; 8:E298-E306. • This review article supplied several lines of evidence that suggested the existence of additional cannabinoid receptors distinct from CB1 and CB2.
  • 15
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992; 258:1946-1949.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3
  • 16
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R, Ben-Shabat S, Hanus L, et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995; 50:83-90.
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3
  • 17
    • 0028970517 scopus 로고
    • 2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
    • Sugiura T, Kondo S, Sukagawa A, et al. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun 1995; 215:89-97.
    • (1995) Biochem Biophys Res Commun , vol.215 , pp. 89-97
    • Sugiura, T.1    Kondo, S.2    Sukagawa, A.3
  • 18
    • 32444440208 scopus 로고    scopus 로고
    • The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    • •• This is an intensive review of the role of endocannabinoids in the regulation of food intake and peripheral metabolism. The experimental results in this field are summarized
    • Pagotto U, Marsicano G, Cota D, et al. The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev 2006; 27:73-100. •• This is an intensive review of the role of endocannabinoids in the regulation of food intake and peripheral metabolism. The experimental results in this field are summarized.
    • (2006) Endocr Rev , vol.27 , pp. 73-100
    • Pagotto, U.1    Marsicano, G.2    Cota, D.3
  • 19
    • 33645796477 scopus 로고    scopus 로고
    • Cannabinoid receptor signaling
    • Howlett AC. Cannabinoid receptor signaling. Handb Exp Pharmacol 2005; 168:53-79.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 53-79
    • Howlett, A.C.1
  • 20
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signaling
    • Piomelli D. The molecular logic of endocannabinoid signaling. Nat Rev Neurosci 2003; 4:873-884.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 873-884
    • Piomelli, D.1
  • 21
    • 33745487912 scopus 로고    scopus 로고
    • Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance
    • • This article reviewed not only strong evidence for a major role of the ECS in the control of energy balance, but also recent findings on alteration of the endocannabinoid tone by unbalanced energy homeostasis
    • Matias I, Di Marzo V. Endocannabinoid synthesis and degradation, and their regulation in the framework of energy balance. J Endocrinol Invest 2006; 29:15-26. • This article reviewed not only strong evidence for a major role of the ECS in the control of energy balance, but also recent findings on alteration of the endocannabinoid tone by unbalanced energy homeostasis.
    • (2006) J Endocrinol Invest , vol.29 , pp. 15-26
    • Matias, I.1    Di Marzo, V.2
  • 22
    • 33947532254 scopus 로고    scopus 로고
    • 2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. J Biol Chem 2007; 282:3614-3623. •• This article reports discovery of a calcium-independent N-acyltransferase in animal tissues.
    • 2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. J Biol Chem 2007; 282:3614-3623. •• This article reports discovery of a calcium-independent N-acyltransferase in animal tissues.
  • 23
    • 1242294480 scopus 로고    scopus 로고
    • Molecular characterization of a phospholipase D generating anandamide and its congeners
    • Okamoto Y, Morishita J, Tsuboi K, et al. Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem 2004; 279:5298-5305.
    • (2004) J Biol Chem , vol.279 , pp. 5298-5305
    • Okamoto, Y.1    Morishita, J.2    Tsuboi, K.3
  • 24
    • 33744962965 scopus 로고    scopus 로고
    • Wang J, Okamoto Y, Morishita J, et al. Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family. J Biol Chem 2006; 281:12325-12335. • NAPE-PLD was extensively characterized as a member of the metallo-β- lactamase family with a highly purified recombinant enzyme from E.coli.
    • Wang J, Okamoto Y, Morishita J, et al. Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-β-lactamase family. J Biol Chem 2006; 281:12325-12335. • NAPE-PLD was extensively characterized as a member of the metallo-β- lactamase family with a highly purified recombinant enzyme from E.coli.
  • 26
    • 33645935391 scopus 로고    scopus 로고
    • Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids
    • • The study revealed the existence of NAPE-PLD-independent pathways for the formation of anandamide by the analysis of NAPE-PLD-deficient mice
    • Leung D, Saghatelian A, Simon GM, Cravatt BF. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry 2006; 45:4720-4726. • The study revealed the existence of NAPE-PLD-independent pathways for the formation of anandamide by the analysis of NAPE-PLD-deficient mice.
    • (2006) Biochemistry , vol.45 , pp. 4720-4726
    • Leung, D.1    Saghatelian, A.2    Simon, G.M.3    Cravatt, B.F.4
  • 28
    • 33748608009 scopus 로고    scopus 로고
    • Liu J, Wang L, Harvey-White J, et al. A biosynthetic pathway for anandamide. Proc Natl Acad Sci U S A 2006; 103:13345-13350. • This article reported a novel NAPE-PLD-independent pathway for the anandamide formation in lipopolysaccharide-stimulated RAW264.7 macrophage cells and mouse brain.
    • Liu J, Wang L, Harvey-White J, et al. A biosynthetic pathway for anandamide. Proc Natl Acad Sci U S A 2006; 103:13345-13350. • This article reported a novel NAPE-PLD-independent pathway for the anandamide formation in lipopolysaccharide-stimulated RAW264.7 macrophage cells and mouse brain.
  • 29
    • 22244484464 scopus 로고    scopus 로고
    • Structure and function of fatty acid amide hydrolase
    • McKinney MK, Cravatt BF. Structure and function of fatty acid amide hydrolase. Annu Rev Biochem 2005; 74:411-432.
    • (2005) Annu Rev Biochem , vol.74 , pp. 411-432
    • McKinney, M.K.1    Cravatt, B.F.2
  • 30
    • 33845981826 scopus 로고    scopus 로고
    • A second fatty acid amide hydrolase with variable distribution among placental mammals
    • Wei BQ, Mikkelsen TS, McKinney MK, et al. A second fatty acid amide hydrolase with variable distribution among placental mammals. J Biol Chem 2006; 281:36569-36578.
    • (2006) J Biol Chem , vol.281 , pp. 36569-36578
    • Wei, B.Q.1    Mikkelsen, T.S.2    McKinney, M.K.3
  • 31
    • 15744378565 scopus 로고    scopus 로고
    • Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase
    • Tsuboi K, Sun Y-X, Okamoto Y, et al. Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J Biol Chem 2005; 280:11082-11092.
    • (2005) J Biol Chem , vol.280 , pp. 11082-11092
    • Tsuboi, K.1    Sun, Y.-X.2    Okamoto, Y.3
  • 32
    • 34247585700 scopus 로고    scopus 로고
    • Tsuboi K, Zhao L-Y, Okamoto Y, et al. Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies. Biochim Biophys Acta 2007; 1771:623-632. • The article reported for the first time immunochemical studies on NAAA and revealed its predominant expression in macrophage cells.
    • Tsuboi K, Zhao L-Y, Okamoto Y, et al. Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies. Biochim Biophys Acta 2007; 1771:623-632. • The article reported for the first time immunochemical studies on NAAA and revealed its predominant expression in macrophage cells.
  • 33
    • 0020659765 scopus 로고
    • Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate
    • Prescott SM, Majerus PW. Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J Biol Chem 1983; 258:764-769.
    • (1983) J Biol Chem , vol.258 , pp. 764-769
    • Prescott, S.M.1    Majerus, P.W.2
  • 34
    • 10744229235 scopus 로고    scopus 로고
    • Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
    • Bisogno T, Howell F, Williams G, et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol 2003; 163:463-468.
    • (2003) J Cell Biol , vol.163 , pp. 463-468
    • Bisogno, T.1    Howell, F.2    Williams, G.3
  • 36
    • 33646472897 scopus 로고    scopus 로고
    • Bisogno T, Cascio MG, Saha B, et al. Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochim Biophys Acta 2006; 1761:205-212. • The first potent and specific inhibitors of DAGL were reported in this article.
    • Bisogno T, Cascio MG, Saha B, et al. Development of the first potent and specific inhibitors of endocannabinoid biosynthesis. Biochim Biophys Acta 2006; 1761:205-212. • The first potent and specific inhibitors of DAGL were reported in this article.
  • 37
    • 34147145848 scopus 로고    scopus 로고
    • Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum
    • Uchigashima M, Narushima M, Fukaya M, et al. Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J Neurosci 2007; 27:3663-3676.
    • (2007) J Neurosci , vol.27 , pp. 3663-3676
    • Uchigashima, M.1    Narushima, M.2    Fukaya, M.3
  • 38
    • 33745195042 scopus 로고    scopus 로고
    • Sugiura T, Kishimoto S, Oka S, Gokoh M. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog Lipid Res 2006; 45:405-446. •• This is a comprehensive review article on 2-AG. Its physiological significance as endocannabinoid is discussed.
    • Sugiura T, Kishimoto S, Oka S, Gokoh M. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog Lipid Res 2006; 45:405-446. •• This is a comprehensive review article on 2-AG. Its physiological significance as endocannabinoid is discussed.
  • 39
    • 6944247598 scopus 로고    scopus 로고
    • RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol
    • Dinh TP, Kathuria S, Piomelli D. RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Mol Pharmacol 2004; 66:1260-1264.
    • (2004) Mol Pharmacol , vol.66 , pp. 1260-1264
    • Dinh, T.P.1    Kathuria, S.2    Piomelli, D.3
  • 40
    • 33846795915 scopus 로고    scopus 로고
    • Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus
    • • The article revealed the important role of MAGL in determining basal endocannabinoid tone and terminating retrograde endocannabinoid signaling in hippocampus
    • Hashimotodani Y, Ohno-Shosaku T, Kano M. Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus. J Neurosci 2007; 27:1211-1219. • The article revealed the important role of MAGL in determining basal endocannabinoid tone and terminating retrograde endocannabinoid signaling in hippocampus.
    • (2007) J Neurosci , vol.27 , pp. 1211-1219
    • Hashimotodani, Y.1    Ohno-Shosaku, T.2    Kano, M.3
  • 41
    • 0037131098 scopus 로고    scopus 로고
    • Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: A role for endogenous cannabinoids in driving appetite for palatable food?
    • Harrold JA, Elliott JC, King PJ, et al. Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: a role for endogenous cannabinoids in driving appetite for palatable food? Brain Res 2002; 952:232-238.
    • (2002) Brain Res , vol.952 , pp. 232-238
    • Harrold, J.A.1    Elliott, J.C.2    King, P.J.3
  • 42
    • 1642298863 scopus 로고    scopus 로고
    • Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin
    • Burdyga G, Lal S, Varro A, et al. Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin. J Neurosci 2004; 24:2708-2715.
    • (2004) J Neurosci , vol.24 , pp. 2708-2715
    • Burdyga, G.1    Lal, S.2    Varro, A.3
  • 43
    • 33646856625 scopus 로고    scopus 로고
    • Ghrelin receptors in rat and human nodose ganglia: Putative role in regulating CB-1 and MCH receptor abundance
    • Burdyga G, Varro A, Dimaline R, et al. Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance. Am J Physiol Gastrointest Liver Physiol 2006; 290:G1289-G1297.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Burdyga, G.1    Varro, A.2    Dimaline, R.3
  • 44
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated endocannabinoids are involved in maintaining food intake
    • Di Marzo V, Goparaju SK, Wang L, et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Naure 2001; 410:822-825.
    • (2001) Naure , vol.410 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3
  • 45
    • 33745768460 scopus 로고    scopus 로고
    • Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release
    • Malcher-Lopes R, Di S, Marcheselli VS, et al. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci 2006; 26:6643-6650.
    • (2006) J Neurosci , vol.26 , pp. 6643-6650
    • Malcher-Lopes, R.1    Di, S.2    Marcheselli, V.S.3
  • 46
    • 0035984946 scopus 로고    scopus 로고
    • Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: Stimulation of eating by 2-arachidonoyl glycerol
    • Kirkham TC, Williams CM, Fezza F, Di Marzo V. Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 2002; 136:550-557.
    • (2002) Br J Pharmacol , vol.136 , pp. 550-557
    • Kirkham, T.C.1    Williams, C.M.2    Fezza, F.3    Di Marzo, V.4
  • 47
    • 8744249918 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin
    • Tucci SA, Rogers EK, Korbonits M, Kirkham TC. The cannabinoid CB1 receptor antagonist SR141716 blocks the orexigenic effects of intrahypothalamic ghrelin. Br J Pharmacol 2004; 143:520-523.
    • (2004) Br J Pharmacol , vol.143 , pp. 520-523
    • Tucci, S.A.1    Rogers, E.K.2    Korbonits, M.3    Kirkham, T.C.4
  • 49
    • 33748703859 scopus 로고    scopus 로고
    • The endocannabinoid system as an emerging target of pharmacotherapy
    • •• This is a comprehensive overview on the current knowledge of the ECS as a target of pharmacotherapy
    • Pacher P, Bátkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 2006; 58:389-462. •• This is a comprehensive overview on the current knowledge of the ECS as a target of pharmacotherapy.
    • (2006) Pharmacol Rev , vol.58 , pp. 389-462
    • Pacher, P.1    Bátkai, S.2    Kunos, G.3
  • 50
    • 33846827125 scopus 로고    scopus 로고
    • The endocannabinoid system: Mechanisms behind metabolic homeostasis and imbalance
    • • This article is an intensive review of the role of ECS in the metabolic homeostasis and imbalance
    • Woods SC. The endocannabinoid system: mechanisms behind metabolic homeostasis and imbalance. Am J Med 2007; 120:S9-S17. • This article is an intensive review of the role of ECS in the metabolic homeostasis and imbalance.
    • (2007) Am J Med , vol.120
    • Woods, S.C.1
  • 51
    • 33746541662 scopus 로고    scopus 로고
    • Solinas M, Justinova Z, Goldberg SR, Tanda G. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. J Neurochem 2006; 98:408-419. • This article reported for the first time that anandamide administration potentiates neurotransmission in the mesolimbic dopamine reward system.
    • Solinas M, Justinova Z, Goldberg SR, Tanda G. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. J Neurochem 2006; 98:408-419. • This article reported for the first time that anandamide administration potentiates neurotransmission in the mesolimbic dopamine reward system.
  • 52
    • 34248551106 scopus 로고    scopus 로고
    • The cannabinoid antagonist SR141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food
    • Melis T, Succu S, Sanna F, et al. The cannabinoid antagonist SR141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food. Neurosci Lett 2007; 419:231-235.
    • (2007) Neurosci Lett , vol.419 , pp. 231-235
    • Melis, T.1    Succu, S.2    Sanna, F.3
  • 53
    • 33747644061 scopus 로고    scopus 로고
    • Matias I, Gonthier M-P, Orlando P, et al. Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia. J Clin Endocr Metab 2006; 91:3171-3180. • This is the first report to show overactivity of the ECS in several peripheral cells and organs during obesity and hyperglycaemia, and in the adipose tissue of obese patients.
    • Matias I, Gonthier M-P, Orlando P, et al. Regulation, function, and dysregulation of endocannabinoids in models of adipose and β-pancreatic cells and in obesity and hyperglycemia. J Clin Endocr Metab 2006; 91:3171-3180. • This is the first report to show overactivity of the ECS in several peripheral cells and organs during obesity and hyperglycaemia, and in the adipose tissue of obese patients.
  • 54
    • 33845318626 scopus 로고    scopus 로고
    • Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes
    • • This is a report revealing the functional expression of CB receptors in human adipocytes
    • Roche R, Hoareau L, Bes-Houtmann S, et al. Presence of the cannabinoid receptors, CB1 and CB2, in human omental and subcutaneous adipocytes. Histochem Cell Biol 2006; 126:177-187. • This is a report revealing the functional expression of CB receptors in human adipocytes.
    • (2006) Histochem Cell Biol , vol.126 , pp. 177-187
    • Roche, R.1    Hoareau, L.2    Bes-Houtmann, S.3
  • 55
    • 13244249625 scopus 로고    scopus 로고
    • Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice
    • Liu YL, Connoley IP, Wilson CA, Stock MJ. Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lep(ob)/Lep(ob) mice. Int J Obesity 2005; 29:183-187.
    • (2005) Int J Obesity , vol.29 , pp. 183-187
    • Liu, Y.L.1    Connoley, I.P.2    Wilson, C.A.3    Stock, M.J.4
  • 56
    • 0036849961 scopus 로고    scopus 로고
    • A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding
    • Gómez R, Navarro M, Ferrer B, et al. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 2002; 22:9612-9617.
    • (2002) J Neurosci , vol.22 , pp. 9612-9617
    • Gómez, R.1    Navarro, M.2    Ferrer, B.3
  • 57
    • 24644500204 scopus 로고    scopus 로고
    • The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance
    • Jbilo O, Ravinet-Trillou C, Arnone M, et al. The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB J 2005; 19:1567-1569.
    • (2005) FASEB J , vol.19 , pp. 1567-1569
    • Jbilo, O.1    Ravinet-Trillou, C.2    Arnone, M.3
  • 58
    • 25844460609 scopus 로고    scopus 로고
    • Activation of the peripheral endocannabinoid system in human obesity
    • Engeli S, Böhnke J, Feldpausch M, et al. Activation of the peripheral endocannabinoid system in human obesity. Diabetes 2005; 54:2838-2843.
    • (2005) Diabetes , vol.54 , pp. 2838-2843
    • Engeli, S.1    Böhnke, J.2    Feldpausch, M.3
  • 59
    • 33845522074 scopus 로고    scopus 로고
    • Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    • • This paper showed the close relationship between abdominal obesity and dysregulation of the peripheral ECS in human
    • Blüher M, Engeli S, Klöting N, et al. Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes 2006; 55:3053-3060. • This paper showed the close relationship between abdominal obesity and dysregulation of the peripheral ECS in human.
    • (2006) Diabetes , vol.55 , pp. 3053-3060
    • Blüher, M.1    Engeli, S.2    Klöting, N.3
  • 60
    • 33846569044 scopus 로고    scopus 로고
    • Yan ZC, Liu DY, Zhang LL, et al. Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ. Biochem Biophys Res Commun 2007; 354:427-433. • The article indicated that high-fat diet-induced hypertrophy of adipocytes is associated with increased CB1 expression, which is directly regulated by PPAR-δ.
    • Yan ZC, Liu DY, Zhang LL, et al. Exercise reduces adipose tissue via cannabinoid receptor type 1 which is regulated by peroxisome proliferator-activated receptor-δ. Biochem Biophys Res Commun 2007; 354:427-433. • The article indicated that high-fat diet-induced hypertrophy of adipocytes is associated with increased CB1 expression, which is directly regulated by PPAR-δ.
  • 61
    • 0034890103 scopus 로고    scopus 로고
    • Physiological role of adipose tissue: White adipose tissue as an endocrine and secretory organ
    • Trayhurn P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001; 60:329-339.
    • (2001) Proc Nutr Soc , vol.60 , pp. 329-339
    • Trayhurn, P.1    Beattie, J.H.2
  • 62
    • 0037374766 scopus 로고    scopus 로고
    • 1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells
    • 1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol 2003; 63:908-914.
    • (2003) Mol Pharmacol , vol.63 , pp. 908-914
    • Bensaid, M.1    Gary-Bobo, M.2    Esclangon, A.3
  • 63
    • 31044456243 scopus 로고    scopus 로고
    • Gary-Bobo M, Elachouri G, Scatton B, et al. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes. Mol Pharmacol 2006; 69:471-478. • In this paper rimonabant was reported to inhibit the proliferation of preadipocyte cells and to induce adipocyte late maturation without fat accumulation
    • Gary-Bobo M, Elachouri G, Scatton B, et al. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes. Mol Pharmacol 2006; 69:471-478. • In this paper rimonabant was reported to inhibit the proliferation of preadipocyte cells and to induce adipocyte late maturation without fat accumulation.
  • 64
    • 34547423962 scopus 로고    scopus 로고
    • Rimonabant reduces obesityassociated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats
    • • This article reported the hepatoprotective role of rimonabant which reversed and prevented steatohepatitis and metabolic syndrome-related features
    • Gary-Bobo M, Elachouri G, Gallas JF, et al. Rimonabant reduces obesityassociated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats. Hepatology 2007; 46:122-129. • This article reported the hepatoprotective role of rimonabant which reversed and prevented steatohepatitis and metabolic syndrome-related features.
    • (2007) Hepatology , vol.46 , pp. 122-129
    • Gary-Bobo, M.1    Elachouri, G.2    Gallas, J.F.3
  • 65
    • 33847306530 scopus 로고    scopus 로고
    • Effects of cannabinoid receptors on skeletal muscle oxidative pathways
    • • This study examined the effects of endocannabinoids on the expression of genes regulating energy metabolism in human skeletal muscle
    • Cavuoto P, McAinch AJ, Hatzinikolas G, et al. Effects of cannabinoid receptors on skeletal muscle oxidative pathways. Mol Cell Endocrinol 2007; 267:63-69. • This study examined the effects of endocannabinoids on the expression of genes regulating energy metabolism in human skeletal muscle.
    • (2007) Mol Cell Endocrinol , vol.267 , pp. 63-69
    • Cavuoto, P.1    McAinch, A.J.2    Hatzinikolas, G.3
  • 66
    • 32044464960 scopus 로고    scopus 로고
    • Bermúdez-Silva FJ, Serrano A, Diaz-Molina FJ, et al. Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. Eur J Pharmacol 2006; 531:282-284. • This study showed that CB1 receptor activation reduces insulin sensitivity in rats.
    • Bermúdez-Silva FJ, Serrano A, Diaz-Molina FJ, et al. Activation of cannabinoid CB1 receptors induces glucose intolerance in rats. Eur J Pharmacol 2006; 531:282-284. • This study showed that CB1 receptor activation reduces insulin sensitivity in rats.
  • 67
    • 34249097103 scopus 로고    scopus 로고
    • 2 receptors in glucose homeostasis in rats. Eur J Pharmacol 2007; 565:207-211. • This article reported an in-vivo study on the role of CB2 in glucose homeostasis.
    • 2 receptors in glucose homeostasis in rats. Eur J Pharmacol 2007; 565:207-211. • This article reported an in-vivo study on the role of CB2 in glucose homeostasis.
  • 68
    • 0038070321 scopus 로고    scopus 로고
    • Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
    • Vickers SP, Webster LJ, Wyatt A, et al. Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats. Psychopharmacology 2003; 167:103-111.
    • (2003) Psychopharmacology , vol.167 , pp. 103-111
    • Vickers, S.P.1    Webster, L.J.2    Wyatt, A.3
  • 69
    • 33748344924 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks
    • Gadde KM, Allison DB. Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks. Circulation 2006; 114:974-984.
    • (2006) Circulation , vol.114 , pp. 974-984
    • Gadde, K.M.1    Allison, D.B.2
  • 70
    • 34247891784 scopus 로고    scopus 로고
    • Drug treatment of the overweight patient
    • Bray GA, Ryan DH. Drug treatment of the overweight patient. Gastroenterology 2007; 132:2239-2252.
    • (2007) Gastroenterology , vol.132 , pp. 2239-2252
    • Bray, G.A.1    Ryan, D.H.2
  • 71
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • Van Gaal LF, Rissanen AM, Scheen AJ, et al. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 2005; 365:1389-1397.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3
  • 72
    • 27844463517 scopus 로고    scopus 로고
    • Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    • Després J-P, Golay A, Sjöström L. Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. New Engl J Med 2005; 353:2121-2134.
    • (2005) New Engl J Med , vol.353 , pp. 2121-2134
    • Després, J.-P.1    Golay, A.2    Sjöström, L.3
  • 73
    • 85136371338 scopus 로고    scopus 로고
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, et al. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 2006; 295:761-775. •• This is the first report on a 2-year clinical trial of rimonabant. The efficacy and safety of rimonabant were described.
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, et al. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 2006; 295:761-775. •• This is the first report on a 2-year clinical trial of rimonabant. The efficacy and safety of rimonabant were described.
  • 74
    • 33751001942 scopus 로고    scopus 로고
    • Scheen AJ, Finer N, Hollander P, et al. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 2006; 368:1660-1672. •• This important clinical study showed the effectiveness of rimonabant not only on weight loss but also on improvement of HbA1c levels in obese patients with type 2 diabetes.
    • Scheen AJ, Finer N, Hollander P, et al. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 2006; 368:1660-1672. •• This important clinical study showed the effectiveness of rimonabant not only on weight loss but also on improvement of HbA1c levels in obese patients with type 2 diabetes.
  • 75
    • 33846815271 scopus 로고    scopus 로고
    • Endocannabinoid blockade for improving glycemic control and lipids in patients with type 2 diabetes mellitus
    • Hollander P. Endocannabinoid blockade for improving glycemic control and lipids in patients with type 2 diabetes mellitus. Am J Med 2007; 120:S18-S28.
    • (2007) Am J Med , vol.120
    • Hollander, P.1
  • 76
    • 37349059601 scopus 로고    scopus 로고
    • Acomplia: Summary of product characteristics
    • European Medicines Agency, July 14, Accessed August 10
    • European Medicines Agency. Acomplia: summary of product characteristics. London: European Medicines Agency; July 14, 2006. http://www.emea.eu.int/ humandocs/PDFs/EPAR/acomplia/H-666-Pl-en%20.pdf. [Accessed August 10, 2006]
    • (2006) London: European Medicines Agency
  • 77
    • 34347336599 scopus 로고    scopus 로고
    • Rimonabant: Just an antiobesity drug? Current evidence on its pleiotropic effects
    • • This article reviewed the pleiotropic effects of rimonabant from both preclinical and clinical research works
    • Bifulco M, Grimaldi C, Gazzerro P, et al. Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects. Mol Pharmacol 2007; 71:1445-1456. • This article reviewed the pleiotropic effects of rimonabant from both preclinical and clinical research works.
    • (2007) Mol Pharmacol , vol.71 , pp. 1445-1456
    • Bifulco, M.1    Grimaldi, C.2    Gazzerro, P.3
  • 78
    • 33847666405 scopus 로고    scopus 로고
    • Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats
    • Croci T, Zarini E. Effect of the cannabinoid CB1 receptor antagonist rimonabant on nociceptive responses and adjuvant-induced arthritis in obese and lean rats. Br J Pharmacol 2007; 150:559-566.
    • (2007) Br J Pharmacol , vol.150 , pp. 559-566
    • Croci, T.1    Zarini, E.2
  • 79
    • 33745003240 scopus 로고    scopus 로고
    • CB1 cannabinoid receptor antagonism: A new strategy for the treatment of liver fibrosis
    • Teixeira-Clerc F, Julien B, Grenard P, et al. CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis. Nat Med 2006; 12:671-676.
    • (2006) Nat Med , vol.12 , pp. 671-676
    • Teixeira-Clerc, F.1    Julien, B.2    Grenard, P.3
  • 80
    • 33748933891 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism
    • Sarnataro D, Pisanti S, Santoro A, et al. The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism. Mol Pharmacol 2006; 70:1298-1306.
    • (2006) Mol Pharmacol , vol.70 , pp. 1298-1306
    • Sarnataro, D.1    Pisanti, S.2    Santoro, A.3
  • 81
    • 30744455029 scopus 로고    scopus 로고
    • The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: Involvement of paraventricular glutamic acid and nitric oxide
    • Melis MR, Succu S, Mascia MS, et al. The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide. Neuropharmacology 2006; 50:219-228.
    • (2006) Neuropharmacology , vol.50 , pp. 219-228
    • Melis, M.R.1    Succu, S.2    Mascia, M.S.3
  • 82
    • 33645063448 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716 induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats
    • Succu S, Mascia MS, Sanna F, et al. The cannabinoid CB1 receptor antagonist SR141716 induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats. Behav Brain Res 2006; 169:274-281.
    • (2006) Behav Brain Res , vol.169 , pp. 274-281
    • Succu, S.1    Mascia, M.S.2    Sanna, F.3
  • 83
    • 33746110406 scopus 로고    scopus 로고
    • Pavon FJ, Bilbao A, Hernández-Folgado L, et al. Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole - LH 21. Neuropharmacology 2006; 51:358-366. • This article showed that a new CB1 antagonist, LH 21, offered a potential advantage for the treatment of obesity due to its reduced unwanted side effects.
    • Pavon FJ, Bilbao A, Hernández-Folgado L, et al. Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole - LH 21. Neuropharmacology 2006; 51:358-366. • This article showed that a new CB1 antagonist, LH 21, offered a potential advantage for the treatment of obesity due to its reduced unwanted side effects.
  • 84
    • 34248532300 scopus 로고    scopus 로고
    • Fong TM, Guan X-M, Marsh DJ, et al. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4- chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl) pyridin-2-yl]oxy}propanamide (MK-0364), in rodents. J Pharmacol Exp Ther 2007; 321:1013-1022. • This article revealed that a novel highly potent and selective CB1 inverse agonist, MK-0364, is orally active in rodent models and has the potential to be a new agent for the treatment of obesity.
    • Fong TM, Guan X-M, Marsh DJ, et al. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4- chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl) pyridin-2-yl]oxy}propanamide (MK-0364), in rodents. J Pharmacol Exp Ther 2007; 321:1013-1022. • This article revealed that a novel highly potent and selective CB1 inverse agonist, MK-0364, is orally active in rodent models and has the potential to be a new agent for the treatment of obesity.
  • 85
    • 33646683613 scopus 로고    scopus 로고
    • Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387
    • McLaughlin PJ, Qian L, Wood JT, et al. Suppression of food intake and food-reinforced behavior produced by the novel CB1 receptor antagonist/inverse agonist AM 1387. Pharmacol Biochem Behav 2006; 83:396-402.
    • (2006) Pharmacol Biochem Behav , vol.83 , pp. 396-402
    • McLaughlin, P.J.1    Qian, L.2    Wood, J.T.3
  • 86
    • 24044539957 scopus 로고    scopus 로고
    • Allosteric modulation of the cannabinoid CB1 receptor
    • Price MR, Baillie GL, Thomas A, et al. Allosteric modulation of the cannabinoid CB1 receptor. Mol Pharmacol 2005; 68:1484-1495.
    • (2005) Mol Pharmacol , vol.68 , pp. 1484-1495
    • Price, M.R.1    Baillie, G.L.2    Thomas, A.3
  • 87
    • 35648985647 scopus 로고    scopus 로고
    • PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats
    • 25 Jun; [Epub ahead of print
    • Horswill JG, Bali U, Shaaban S, et al. PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats. Br J Pharmacol 2007; 25 Jun; [Epub ahead of print].
    • (2007) Br J Pharmacol
    • Horswill, J.G.1    Bali, U.2    Shaaban, S.3
  • 88
    • 17044393107 scopus 로고    scopus 로고
    • Regulation of food intake by oleoylethanolamide
    • Lo Verme J, Gaetani S, Fu J, et al. Regulation of food intake by oleoylethanolamide. Cell Mol Life Sci 2005; 62:708-716.
    • (2005) Cell Mol Life Sci , vol.62 , pp. 708-716
    • Lo Verme, J.1    Gaetani, S.2    Fu, J.3
  • 89
    • 0035829625 scopus 로고    scopus 로고
    • An anorexic lipid mediator regulated by feeding
    • Rodríguez de Fonseca F, Navarro M, Gómez R, et al. An anorexic lipid mediator regulated by feeding. Nature 2001; 414:209-212.
    • (2001) Nature , vol.414 , pp. 209-212
    • Rodríguez de Fonseca, F.1    Navarro, M.2    Gómez, R.3
  • 91
    • 0041321275 scopus 로고    scopus 로고
    • Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α
    • Fu J, Gaetani S, Oveisi F, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α. Nature 2003; 425:90-93.
    • (2003) Nature , vol.425 , pp. 90-93
    • Fu, J.1    Gaetani, S.2    Oveisi, F.3
  • 92
    • 19444372260 scopus 로고    scopus 로고
    • Oleoylethanolamide, an endogenous PPAR-α agonist, lowers body weight and hyperlipidemia in obese rats
    • Fu J, Oveisi F, Gaetani S, et al. Oleoylethanolamide, an endogenous PPAR-α agonist, lowers body weight and hyperlipidemia in obese rats. Neuropharmacology 2005; 48:1147-1153.
    • (2005) Neuropharmacology , vol.48 , pp. 1147-1153
    • Fu, J.1    Oveisi, F.2    Gaetani, S.3
  • 93
    • 3142583174 scopus 로고    scopus 로고
    • Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPAR-α)
    • Guzmán M, Lo Verme J, Fu J, et al. Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPAR-α). J Biol Chem 2004; 279:27849-27854.
    • (2004) J Biol Chem , vol.279 , pp. 27849-27854
    • Guzmán, M.1    Lo Verme, J.2    Fu, J.3
  • 94
    • 33846177900 scopus 로고    scopus 로고
    • Mechanism of oleoylethanolamide on fatty acid uptake in small intestine after food intake and body weight reduction
    • Yang Y, Chen M, Georgeson KE, Harmon CM. Mechanism of oleoylethanolamide on fatty acid uptake in small intestine after food intake and body weight reduction. Am J Physiol Regul Integr Comp Physiol 2007; 292:R235-R241.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Yang, Y.1    Chen, M.2    Georgeson, K.E.3    Harmon, C.M.4
  • 95
    • 27144462551 scopus 로고    scopus 로고
    • Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways
    • González-Yanes C, Serrano A, Bermúdez-Silva FJ, et al. Oleylethanolamide impairs glucose tolerance and inhibits insulin-stimulated glucose uptake in rat adipocytes through p38 and JNK MAPK pathways. Am J Physiol Endocrinol Metab 2005; 289:E923-E929.
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • González-Yanes, C.1    Serrano, A.2    Bermúdez-Silva, F.J.3
  • 96
    • 30944458055 scopus 로고    scopus 로고
    • Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure
    • Su H-F, Samsamshariat A, Fu J, et al. Oleylethanolamide activates Ras-Erk pathway and improves myocardial function in doxorubicin-induced heart failure. Endocrinology 2006; 147:827-834.
    • (2006) Endocrinology , vol.147 , pp. 827-834
    • Su, H.-F.1    Samsamshariat, A.2    Fu, J.3
  • 97
    • 33745967940 scopus 로고    scopus 로고
    • Astarita G, Di Giacomo B, Gaetani S, et al. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J Pharmacol Exp Ther 2006; 318:563-570. • This article described that the hydrolysis-resistant analogs of N-oleoylethanolamine, through PPAR-α activation, persistently reduced feeding in rodents, which provided a starting point for the development of novel anti-obesity drugs.
    • Astarita G, Di Giacomo B, Gaetani S, et al. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J Pharmacol Exp Ther 2006; 318:563-570. • This article described that the hydrolysis-resistant analogs of N-oleoylethanolamine, through PPAR-α activation, persistently reduced feeding in rodents, which provided a starting point for the development of novel anti-obesity drugs.
  • 98
    • 37349004756 scopus 로고    scopus 로고
    • Serrano A, del Arco I, Javier Pavón F, et al. The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats. Neuropharmacology 2007; 24 Mar [Epub ahead of print]. • The study examined the metabolic effect of a combination of rimonabant and N-oleoylethanolamine on obese Zucker rats.
    • Serrano A, del Arco I, Javier Pavón F, et al. The cannabinoid CB1 receptor antagonist SR141716A (Rimonabant) enhances the metabolic benefits of long-term treatment with oleoylethanolamide in Zucker rats. Neuropharmacology 2007; 24 Mar [Epub ahead of print]. • The study examined the metabolic effect of a combination of rimonabant and N-oleoylethanolamine on obese Zucker rats.
  • 99
    • 0042734414 scopus 로고    scopus 로고
    • Activation of TRPV1 by the satiety factor oleoylethanolamide
    • Ahern GP. Activation of TRPV1 by the satiety factor oleoylethanolamide. J Biol Chem 2003; 278:30429-30434.
    • (2003) J Biol Chem , vol.278 , pp. 30429-30434
    • Ahern, G.P.1
  • 101
    • 33644627958 scopus 로고    scopus 로고
    • Overton HA, Babbs AJ, Doel SM, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 2006; 3:167-175. •• This study revealed that N-oleoylethanolamine is an agonist of the GPR119 receptor, and its selective agonist was shown to suppress feeding and reduce body weight gain and adiposity in rat models.
    • Overton HA, Babbs AJ, Doel SM, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab 2006; 3:167-175. •• This study revealed that N-oleoylethanolamine is an agonist of the GPR119 receptor, and its selective agonist was shown to suppress feeding and reduce body weight gain and adiposity in rat models.
  • 102
    • 33646486532 scopus 로고    scopus 로고
    • Petersen G, Sørensen C, Schmid PC, et al. Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. Biochim Biophys Acta 2006; 1761:143-150. • The authors offer evidence that endogenous levels of anandamide and N-oleoylethanolamine in rat intestine depend on the relative abundance of their biosynthetic precursors.
    • Petersen G, Sørensen C, Schmid PC, et al. Intestinal levels of anandamide and oleoylethanolamide in food-deprived rats are regulated through their precursors. Biochim Biophys Acta 2006; 1761:143-150. • The authors offer evidence that endogenous levels of anandamide and N-oleoylethanolamine in rat intestine depend on the relative abundance of their biosynthetic precursors.
  • 103
    • 33847734027 scopus 로고    scopus 로고
    • Fu J, Astarita G, Gaetani S, et al. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem 2007; 282:1518-1528. • This article revealed that food intake promoted N-oleoylethanolamine mobilization in the mucosal layer of the rodent proximal small intestine through the concerted regulation of its biosynthesis and degradation.
    • Fu J, Astarita G, Gaetani S, et al. Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem 2007; 282:1518-1528. • This article revealed that food intake promoted N-oleoylethanolamine mobilization in the mucosal layer of the rodent proximal small intestine through the concerted regulation of its biosynthesis and degradation.
  • 104
    • 33747373845 scopus 로고    scopus 로고
    • Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue
    • LoVerme J, Guzmán M, Gaetani S, Piomelli D. Cold exposure stimulates synthesis of the bioactive lipid oleoylethanolamide in rat adipose tissue. J Biol Chem 2006; 281:22815-22818.
    • (2006) J Biol Chem , vol.281 , pp. 22815-22818
    • LoVerme, J.1    Guzmán, M.2    Gaetani, S.3    Piomelli, D.4
  • 105
    • 34250658035 scopus 로고    scopus 로고
    • Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol
    • Rubio M, McHugh D, Fernández-Ruiz J, et al. Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. Neurosci Lett 2007; 421:270-274.
    • (2007) Neurosci Lett , vol.421 , pp. 270-274
    • Rubio, M.1    McHugh, D.2    Fernández-Ruiz, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.