The cannabinoid CB1 receptor antagonist SR 141716A induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats

Behavioural Brain Research

Volumn 169, Issue 2, 2006, Pages 274-281

  Succu, Salvatora ^a   Mascia, Maria Stefania ^a   Sanna, Fabrizio ^a   Melis, Tiziana ^a   Argiolas, Antonio ^a   Melis, Maria Rosaria ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Cannabinoid CB1 receptor agonists and antagonists; GABA; Glutamic acid; Oxytocin; Paraventricular nucleus; Penile erection; Rat

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; AMINO ACID RECEPTOR; BACLOFEN; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; DEXANABINOL; DIZOCILPINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR ANTAGONIST; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID; RIMONABANT; SODIUM CHANNEL BLOCKING AGENT; SR 14116A; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DRUG MECHANISM; ELECTRIC POTENTIAL; MALE; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; THALAMUS MIDLINE NUCLEUS;

ANESTHETICS, LOCAL; ANIMALS; BACLOFEN; BEHAVIOR, ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; GABA AGONISTS; GLUTAMIC ACID; MALE; MICRODIALYSIS; MICROINJECTIONS; MODELS, BIOLOGICAL; MUSCIMOL; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PENILE ERECTION; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CANNABINOID; TETRODOTOXIN;

EID: 33645063448     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2006.01.017     Document Type: Article

References (40)

1. K.E. Andersson Pharmacology of penile erection Pharmacol Rev 53 2001 417 450
2. A. Argiolas, and M.R. Melis Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides Prog Neurobiol 47 1995 235 255
3. A. Argiolas, and M.R. Melis The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals Physiol Behav 83 2004 309 317
4. A. Argiolas, and M.R. Melis Central control of penile erection: role of the paraventricular nucleus of the hypothalamus Prog Neurobiol 76 2005 1 21
5. G.W. Bisset, H.S. Chowdrey, K.M. Fairhall, and L.K. Gunn Central inhibition by gamma-aminobutyric acid and muscimol of the release of vasopressin and oxytocin by an osmotic stimulus in the rat Br J Pharmacol 99 1990 529 535
6. C. Boubada, K. Szabò, and G. Tasker Physiological mapping of local inhibitory inputs to the hypothalamic paraventricular nucleus J Neurosci 15 1996 7151 7160
7. C.S. Breivogel, J.M. Walker, S.M. Huang, M.B. Roy, and S.R. Childers Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids Neuropharmacology 47 2004 81 91
8. T.M. Brown, J.M. Brotchie, and S.M. Fitzjohn Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake J Neurosci 23 2003 11073 11077
9. G.E. da Silva, M.S. Fernandes, and R.N. Takahashi Potentiation of penile erection and yawning responses to apomorphine by cannabinoid receptor antagonists in rats Neurosci Lett 349 2003 49 52
10. R. De Miguel, J. Romero, R.M. Munoz, L. Garcia-Gil, S. Gonzalez, and M.A. Villanua Effects of cannabinoids on prolactin and gonadotropin secretion: involvement of changes in hypothalamic gamma-amino-butyric acid (GABA) inputs Biochem Pharmacol 56 1998 1331 1338
11. F. Ferrari, A. Ottani, and D. Giuliani Inhibitory effects of the cannabinoid agonist HU 210 on rat sexual behaviour Physiol Behav 69 2000 547 554
12. T.F. Freund, I. Katona, and D. Piomelli Role of endogenous cannabinoids in synaptic signalling Physiol Rev 83 2003 1017 1066
13. F. Giuliano, and O. Rampin Central neural control of penile erection Neurosci Biobehav Rev 24 2000 517 533
14. M. Herkenham, A.B. Lynn, M.R. Johnson, L.S. Melvin, B.R. de Costa, and K.C. Rice Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study J Neurosci 11 1991 563 583
15. A.C. Howlett, C.S. Breivogel, S.R. Childers, S.A. Deadwyler, R.E. Hampson, and L.J. Porrino Cannabinoid physiology and pharmacology: 30 years of progress Neuropharmacology 47 Suppl. 1 2004 345 358
16. E.M. Hull, R.L. Meisel, and B.D. Sachs Male sexual behavior D.W. Pfaff A.P. Arnold A.M. Etgen S.E. Fahrbach R.T. Rubin Hormones, brain and behavior 2002 Academic Press New York 3 137
17. P. Jourdain, B. Dupouy, R. Bonhomme, D.A. Poulain, J.M. Israel, and D.T. Theodosis Visualization of local afferent inputs to magnocellular oxytocin neurons in vitro Eur J Neurosci 11 1999 1960 1972
18. M. Maccarrone, and A. Finazzi-Agrò Endocannabinoids and their actions Vitam Horm 65 2002 225 255
19. K.E. McKenna Some proposals regarding the organization of the central nervous system control of penile erection Neurosci Biobehav Rev 24 2000 535 540
20. A receptors in the paraventricular nucleus: involvement of nitric oxide Eur J Neurosci 15 2002 852 860
21. M.R. Melis, and A. Argiolas Central oxytocinergic neurotransmission: a drug target for the therapy of psycogenic erectile dysfunction Curr Drug Targets 4 2003 55 66
22. M.R. Melis, S. Succu, and A. Argiolas Dopamine agonists increase nitric oxide production in the paraventricular nucleus of the hypothalamus: correlation with penile erection and yawning Eur J Neurosci 8 1996 2056 2063
23. M.R. Melis, S. Succu, U. Iannucci, and A. Argiolas N-Methyl-d-aspartic acid-induced penile erection and yawning: role of hypothalamic paraventricular nitric oxide Eur J Pharmacol 328 1997 115 123
24. M.R. Melis, S. Succu, A. Mauri, and A. Argiolas Nitric oxide production is increased in the paraventricular nucleus of the hypothalamus of male rats during non-contact penile erections and copulation Eur J Neurosci 10 1998 1968 1974
25. M.R. Melis, S. Succu, M.S. Spano, and A. Argiolas Effect of excitatory amino acid, dopamine and oxytocin receptor antagonists on non-contact penile erections and paraventricular nitric oxide production in male rats Behav Neurosci 114 2000 849 857
26. M.R. Melis, S. Succu, M.S. Mascia, and A. Argiolas Antagonism of cannabinoid CB1 receptors in the paraventricular nucleus of male rats induces penile erection Neurosci Lett 359 2004 17 20
27. M.R. Melis, S. Succu, M.S. Mascia, L. Cortis, and A. Argiolas Extra-cellular excitatory amino acids increase in the paraventricular nucleus of male rats during sexual activity: main role of NMDA receptors in erectile function Eur J Neurosci 17 2004 1266 1272
28. M.R. Melis, S. Succu, M.S. Mascia, T. Melis, F. Sanna, and M.P. Castelli The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide Neuropharmacology 50 2006 219 228
29. G.G. Muccioli, and D.M. Lambert Current knowledge on the antagonists and inverse agonists of cannabinoid receptors Curr Med Chem 12 2005 1361 1394
30. L.J. Pellegrino, and A.J. Cushman A stereotaxic atlas of the rat brain 1971 Meredith New York
31. M. Pistis, A.L. Muntoni, G. Pillola, and G.L. Gessa Cannabinoids inhibit excitatory inputs to neurons in the shell of the nucleus accumbens: an in vivo electrophysiological study Eur J Neurosci 15 2002 1795 1802
32. W.S. Powell, J.M. Dominguez, and E.M. Hull An NMDA antagonist impairs copulation and the experience-induced enhancement of male sexual behavior in the rat Behav Neurosci 117 2003 69 75
33. M. Rinaldi-Carmona, F. Barth, M. Heaulme, D. Shire, B. Calandra, and S. Cong Martinez SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor FEBS Lett 350 2004 240 244
34. M. Rinaldi-Carmona, F. Barth, J. Millan, J.M. Derocq, P. Casellas, and C. Congy SR 144528 the first potent and selective antagonist of the CB2 cannabinoid receptor J Pharmacol Exp Ther 284 1998 644 650
35. D. Robbe, G. Alonso, F. Duchamp, J. Bockaert, and O.J. Manzoni Localization and mechanisms of action of cannabinoid receptors at the glutamatergic synapses of the mouse nucleus accumbens J Neurosci 21 2001 109 116
36. B.L. Roland, and P.E. Sawchenko Local origin of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat J Comp Neurol 332 1983 123 143
37. D. Saphier, and S. Feldman Effects of septal and hippocampal stimuli on paraventricular nucleus neurons Neuroscience 20 1987 749 755
38. 9-THC is not dependent on changes in plasma testosterone or hypothalamic dopamine or serotonin content Pharmacol Biochem Behav 22 1985 415 420
39. A. van den Pool Glutamate and aspartate immunoreactivity in hypothalamic presynaptic axons J Neurosci 11 1991 2087 2101
40. L.D. Voisin, A.E. Herbison, and D.A. Poulain Central inhibitory effect of muscimol and bicuculline on the milk ejection reflex in the anaesthetized rat J Physiol (Lond) 483 1995 211 224