Down-regulation of cannabinoid-1 (CB-1) receptors in specific extrahypothalamic regions of rats with dietary obesity: A role for endogenous cannabinoids in driving appetite for palatable food?

Brain Research

Volumn 952, Issue 2, 2002, Pages 232-238

  Harrold, Joanne A ^a   Elliott, Joanne C ^a   King, Peter J ^a   Widdowson, Peter S ^b   Williams, Gareth ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Cannabinoid; CB 1 receptor; Dietary obesity; Palatable diet; Reward

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 1 RECEPTOR; RIMONABANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CALORIC INTAKE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENTOPEDUNCULAR NUCLEUS; FEEDING; FOOD INTAKE; FOREBRAIN; HIPPOCAMPUS; HYPOTHALAMUS; MALE; NONHUMAN; NUCLEUS ACCUMBENS; OBESITY; PALATABILITY; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RECEPTOR BINDING; RECEPTOR DENSITY; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE;

ANIMALS; APPETITE; APPETITE REGULATION; DOWN-REGULATION; ENDOCANNABINOIDS; ENERGY INTAKE; FATTY ACIDS, UNSATURATED; HYPOTHALAMUS; MALE; OBESITY; RATS; RATS, WISTAR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0037131098     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03245-6     Document Type: Article

References (31)

1. Abel E.L. Cannabis: Effects on hunger and thirst. Behav. Biol. 15:1975;255-281.
2. Arnone M., Maruani J., Chaperon F., Thiébot M.H., Poncelet M., Soubrié P., Le Fur G. Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist at central cannabinoid (CB1) receptors. Psychopharmcology. 132:1997;104-106.
3. Berger A., Crozier G., Bisogno T., Cavaliere P., Innis S., Di Marzo V. Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. Proc. Natl. Acad. Sci. USA. 98:2001;6402-6406.
4. Breivogel C.S., Sim L.J., Childers S.R. Regional differences in cannabinoid receptor/G-protein coupling in rat brain. J. Pharmacol. Exp. Ther. 282:1997;1632-1642.
5. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:1995;546-549.
6. Chaperon F., Thiébot M.H. Behavioural effects of cannabinoid agents in animals. Crit. Rev. Neurobiol. 13:1999;243-281.
7. Clark J.T., Kalra P.S., Crowley W.R., Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behaviour in rats. Endocrinology. 115:1984;427-429.
8. Columbo G., Agabio R., Diaz G., Lobina C., Reali R., Gessa G.L. Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci. 63:1998;PL113-117.
9. Corp E.S., Melville L.D., Greenberg D., Gibbs J., Smith G.P. Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviors. Am. J. Physiol. 259:1990;R317-R323.
10. 9-tetrahydrocannabinol-tolerant rats. J. Neurochem. 74:2000;1627-1635.
11. Di Marzo V., Goparaju S.K., Wang L., Liu J., Bátkai S., Járai Z., Fezza F., Liura G.I., Palmiter R.D., Sugiura T., Kunos G. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature. 410:2001;822-825.
12. Finkelstein D.I., Reeves A.K., Horne M.K. An electron microscopic tracer study of the projections from entopeduncular nucleus to the ventrolateral nucleus of the rat. Neurosci. Lett. 211:1996;33-36.
13. Glass M., Dragunow M., Faull R.L.M. Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in fetal, neonatal and adult human brains. Neuroscience. 77:1997;299-318.
14. Gorbachevskaia A.L. Projections of the substantia nigra, ventral tegmental area and amygdala to the pallidum in dog brain. Morfologiia. 115:1999;11-14.
15. Halaas J.L., Boozer C., Blair-West J., Fidahusein N., Denton D.A., Friedman J.M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA. 94:1997;8878-8883.
16. Hao S., Avraham Y., Mechoulam R., Berry E.M. Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice. Eur. J. Pharmcol. 392:2000;147-156.
17. Harrold J.A., Williams G., Widdowson P.S. Early leptin response to a palatable diet predicts dietary obesity in rats: key role of melanocortin-4 receptors in the ventromedial hypothalamic nucleus. J. Neurochem. 74:2000;1224-1228.
18. Leshner A.I., Koob G.F. Drugs of abuse and the brain. Proc. Assoc. Am. Phys. 111:1999;99-108.
19. Lynch W.C., Hart P., Babcock A.M. Neuropeptide Y attenuates satiety: evidence from a detailed analysis of ingestive patterns. Brain Res. 636:1994;28-34.
20. Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 346:1990;561-564.
21. Mechoulam R., Ben-Shabat S., Hanus L., Liqumsky M., Kaminski N.E., Schatz A.R., Gopher A., Almog S., Martin B.R., Compton D.R. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 50:1995;83-90.
22. Pecina S., Berridge K.C. Opioid sites in nucleus accumbens shell mediate eating and hedonic 'liking' for food: map based on microinjection Fos plumes. Brain Res. 863:2000;71-86.
23. Rubino T., Tizzoni L., Vigano D., Massi P., Paloro D. Modulation of rat brain cannabinoid receptors after chronic morphine treatment. Neuroreport. 8:1997;3219-3243.
24. Shockley M.S., Burford N.T., Sadee W., Lameh J. Residues specifically involved in down-regulation but not internalization of the mu muscarinic acetylcholine receptor. J. Neurochem. 68:1997;601-609.
25. Tanda G., Pontiere F.E., DiChiara G. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common μ 1 opioid receptor mechanism. Science. 276:1997;2048-2050.
26. Widdowson P.S., Upton R., Henderson L., Buckingham R., Wilson S., Williams G. Reciprocal regional changes in brain NPY receptor density during dietary restriction and dietary-induced obesity in the rat. Brain Res. 774:1997;1-10.
27. Widdowson P.S., Upton R., Buckingham R., Arch J., Williams G. Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity. Diabetes. 46:1997;1782-1785.
28. Wilding J.P.H., Gilbey S.G., Mannan M., Aslam N., Ghatei M.A., Bloom S.R. Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA in diet-induced obesity in rats. J. Endocrinol. 132:1992;299-304.
29. Williams C.M., Rogers P.J., Kirkham T.C. Hyperphagia in pre-fed rats following oral delta9-THC. Physiol. Behav. 15:1998;343-346.
30. Williams C.M., Kirkham T.C. Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors. Psychopharmacology. 143:1999;315-317.
31. Williams G., Harrold J.A., Cutler D.J. The hypothalamus and the regulation of energy homeostasis: lifting the lid on a black box. Proc. Nutr. Soc. 59:2000;385-396.