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Volumn 19, Issue 5, 2007, Pages 331-340

Impact of niche aging on thymic regeneration and immune reconstitution

Author keywords

Aging; Involution; Regeneration; Sex steroids; Thymus

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DEXAMETHASONE; FLT3 LIGAND; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GRANULOCYTE COLONY STIMULATING FACTOR; GROWTH FACTOR; GROWTH HORMONE; HEPATITIS B VACCINE; INTERLEUKIN 7; KERATINOCYTE GROWTH FACTOR; PARATHYROID HORMONE; RECOMBINANT INTERLEUKIN 7; SOMATOMEDIN C; T LYMPHOCYTE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 36549062401     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2007.10.006     Document Type: Review
Times cited : (86)

References (106)
  • 1
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    • Gray D.H., Seach N., Ueno T., Milton M.K., Liston A., Lew A.M., et al. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108 (2006) 3777-3785
    • (2006) Blood , vol.108 , pp. 3777-3785
    • Gray, D.H.1    Seach, N.2    Ueno, T.3    Milton, M.K.4    Liston, A.5    Lew, A.M.6
  • 5
    • 0016746976 scopus 로고
    • Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos
    • Le Lievre C.S., and Le Douarin N.M. Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos. J Embryol Exp Morphol 34 (1975) 125-154
    • (1975) J Embryol Exp Morphol , vol.34 , pp. 125-154
    • Le Lievre, C.S.1    Le Douarin, N.M.2
  • 6
    • 1842631137 scopus 로고    scopus 로고
    • Developing a new paradigm for thymus organogenesis
    • Blackburn C.C., and Manley N.R. Developing a new paradigm for thymus organogenesis. Nat Rev Immunol 4 (2004) 278-289
    • (2004) Nat Rev Immunol , vol.4 , pp. 278-289
    • Blackburn, C.C.1    Manley, N.R.2
  • 7
    • 0037375743 scopus 로고    scopus 로고
    • A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?
    • Manley N.R., and Blackburn C.C. A developmental look at thymus organogenesis: where do the non-hematopoietic cells in the thymus come from?. Curr Opin Immunol 15 (2003) 225-232
    • (2003) Curr Opin Immunol , vol.15 , pp. 225-232
    • Manley, N.R.1    Blackburn, C.C.2
  • 8
    • 33846255080 scopus 로고    scopus 로고
    • Thymic epithelial progenitor cells and thymus regeneration: an update
    • Zhang L., Sun L., and Zhao Y. Thymic epithelial progenitor cells and thymus regeneration: an update. Cell Res 17 (2007) 50-55
    • (2007) Cell Res , vol.17 , pp. 50-55
    • Zhang, L.1    Sun, L.2    Zhao, Y.3
  • 9
    • 0034802258 scopus 로고    scopus 로고
    • Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage
    • Itoi M., Kawamoto H., Katsura Y., and Amagai T. Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage. Int Immunol 13 (2001) 1203-1211
    • (2001) Int Immunol , vol.13 , pp. 1203-1211
    • Itoi, M.1    Kawamoto, H.2    Katsura, Y.3    Amagai, T.4
  • 10
    • 33745516115 scopus 로고    scopus 로고
    • Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium
    • Rossi S.W., Jenkinson W.E., Anderson G., and Jenkinson E.J. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 441 (2006) 988-991
    • (2006) Nature , vol.441 , pp. 988-991
    • Rossi, S.W.1    Jenkinson, W.E.2    Anderson, G.3    Jenkinson, E.J.4
  • 11
    • 0037105620 scopus 로고    scopus 로고
    • Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus
    • Klug D.B., Carter C., Gimenez-Conti I.B., and Richie E.R. Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus. J Immunol 169 (2002) 2842-2845
    • (2002) J Immunol , vol.169 , pp. 2842-2845
    • Klug, D.B.1    Carter, C.2    Gimenez-Conti, I.B.3    Richie, E.R.4
  • 12
    • 0021334469 scopus 로고
    • Dependence of thymus development on derivatives of the neural crest
    • Bockman D.E., and Kirby M.L. Dependence of thymus development on derivatives of the neural crest. Science 223 (1984) 498-500
    • (1984) Science , vol.223 , pp. 498-500
    • Bockman, D.E.1    Kirby, M.L.2
  • 13
    • 0025074562 scopus 로고
    • Impaired development of the thymic primordium after neural crest ablation
    • Kuratani S., and Bockman D.E. Impaired development of the thymic primordium after neural crest ablation. Anat Rec 228 (1990) 185-190
    • (1990) Anat Rec , vol.228 , pp. 185-190
    • Kuratani, S.1    Bockman, D.E.2
  • 14
    • 0042662851 scopus 로고    scopus 로고
    • Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors
    • Jenkinson W.E., Jenkinson E.J., and Anderson G. Differential requirement for mesenchyme in the proliferation and maturation of thymic epithelial progenitors. J Exp Med 198 (2003) 325-332
    • (2003) J Exp Med , vol.198 , pp. 325-332
    • Jenkinson, W.E.1    Jenkinson, E.J.2    Anderson, G.3
  • 15
    • 0034597752 scopus 로고    scopus 로고
    • FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development
    • Ohuchi H., Hori Y., Yamasaki M., Harada H., Sekine K., Kato S., et al. FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun 277 (2000) 643-649
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 643-649
    • Ohuchi, H.1    Hori, Y.2    Yamasaki, M.3    Harada, H.4    Sekine, K.5    Kato, S.6
  • 16
    • 0035281514 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4
    • Revest J.M., Spencer-Dene B., Kerr K., De Moerlooze L., Rosewell I., and Dickson C. Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol 231 (2001) 47-62
    • (2001) Dev Biol , vol.231 , pp. 47-62
    • Revest, J.M.1    Spencer-Dene, B.2    Kerr, K.3    De Moerlooze, L.4    Rosewell, I.5    Dickson, C.6
  • 17
    • 0035881543 scopus 로고    scopus 로고
    • Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb
    • Revest J.M., Suniara R.K., Kerr K., Owen J.J., and Dickson C. Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb. J Immunol 167 (2001) 1954-1961
    • (2001) J Immunol , vol.167 , pp. 1954-1961
    • Revest, J.M.1    Suniara, R.K.2    Kerr, K.3    Owen, J.J.4    Dickson, C.5
  • 18
    • 33846867492 scopus 로고    scopus 로고
    • PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches
    • Jenkinson W.E., Rossi S.W., Parnell S.M., Jenkinson E.J., and Anderson G. PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches. Blood 109 (2007) 954-960
    • (2007) Blood , vol.109 , pp. 954-960
    • Jenkinson, W.E.1    Rossi, S.W.2    Parnell, S.M.3    Jenkinson, E.J.4    Anderson, G.5
  • 20
    • 25844526684 scopus 로고    scopus 로고
    • Central tolerance: learning self-control in the thymus
    • Hogquist K.A., Baldwin T.A., and Jameson S.C. Central tolerance: learning self-control in the thymus. Nat Rev Immunol 5 (2005) 772-782
    • (2005) Nat Rev Immunol , vol.5 , pp. 772-782
    • Hogquist, K.A.1    Baldwin, T.A.2    Jameson, S.C.3
  • 21
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • Kyewski B., and Klein L. A central role for central tolerance. Annu Rev Immunol 24 (2006) 571-606
    • (2006) Annu Rev Immunol , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 22
    • 0041884736 scopus 로고    scopus 로고
    • Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial crosstalk via LTbetaR
    • Boehm T., Scheu S., Pfeffer K., and Bleul C.C. Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial crosstalk via LTbetaR. J Exp Med 198 (2003) 757-769
    • (2003) J Exp Med , vol.198 , pp. 757-769
    • Boehm, T.1    Scheu, S.2    Pfeffer, K.3    Bleul, C.C.4
  • 24
    • 34250336454 scopus 로고    scopus 로고
    • RANK signals from CD4+3- inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla
    • Rossi S.W., Kim M.Y., Leibbrandt A., Parnell S.M., Jenkinson W.E., Glanville S.H., et al. RANK signals from CD4+3- inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. J Exp Med 204 (2007) 1267-1272
    • (2007) J Exp Med , vol.204 , pp. 1267-1272
    • Rossi, S.W.1    Kim, M.Y.2    Leibbrandt, A.3    Parnell, S.M.4    Jenkinson, W.E.5    Glanville, S.H.6
  • 27
    • 20344371900 scopus 로고    scopus 로고
    • Insights into thymic aging and regeneration
    • Taub D.D., and Longo D.L. Insights into thymic aging and regeneration. Immunol Rev 205 (2005) 72-93
    • (2005) Immunol Rev , vol.205 , pp. 72-93
    • Taub, D.D.1    Longo, D.L.2
  • 28
  • 29
    • 34147099672 scopus 로고    scopus 로고
    • Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging
    • Pearce D.J., Anjos-Afonso F., Ridler C.M., Eddaoudi A., and Bonnet D. Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging. Stem Cells 25 (2007) 828-835
    • (2007) Stem Cells , vol.25 , pp. 828-835
    • Pearce, D.J.1    Anjos-Afonso, F.2    Ridler, C.M.3    Eddaoudi, A.4    Bonnet, D.5
  • 31
    • 0034613690 scopus 로고    scopus 로고
    • Age-associated characteristics of murine hematopoietic stem cells
    • Sudo K., Ema H., Morita Y., and Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 192 (2000) 1273-1280
    • (2000) J Exp Med , vol.192 , pp. 1273-1280
    • Sudo, K.1    Ema, H.2    Morita, Y.3    Nakauchi, H.4
  • 32
    • 23744439044 scopus 로고    scopus 로고
    • Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells
    • Liang Y., Van Zant G., and Szilvassy S.J. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 106 (2005) 1479-1487
    • (2005) Blood , vol.106 , pp. 1479-1487
    • Liang, Y.1    Van Zant, G.2    Szilvassy, S.J.3
  • 34
    • 0042931219 scopus 로고    scopus 로고
    • The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors
    • Miller J.P., and Allman D. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J Immunol 171 (2003) 2326-2330
    • (2003) J Immunol , vol.171 , pp. 2326-2330
    • Miller, J.P.1    Allman, D.2
  • 35
    • 30744451406 scopus 로고    scopus 로고
    • Effects of aging on the common lymphoid progenitor to pro-B cell transition
    • Min H., Montecino-Rodriguez E., and Dorshkind K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J Immunol 176 (2006) 1007-1012
    • (2006) J Immunol , vol.176 , pp. 1007-1012
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 36
    • 2542473275 scopus 로고    scopus 로고
    • Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness
    • Muller-Sieburg C.E., Cho R.H., Karlsson L., Huang J.F., and Sieburg H.B. Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. Blood 103 (2004) 4111-4118
    • (2004) Blood , vol.103 , pp. 4111-4118
    • Muller-Sieburg, C.E.1    Cho, R.H.2    Karlsson, L.3    Huang, J.F.4    Sieburg, H.B.5
  • 37
    • 5444271778 scopus 로고    scopus 로고
    • Stem cells, aging, and cancer: inevitabilities and outcomes
    • Bell D.R., and Van Zant G. Stem cells, aging, and cancer: inevitabilities and outcomes. Oncogene 23 (2004) 7290-7296
    • (2004) Oncogene , vol.23 , pp. 7290-7296
    • Bell, D.R.1    Van Zant, G.2
  • 38
    • 32844459373 scopus 로고    scopus 로고
    • Hypothesis: myeloid-restricted hematopoietic stem cells with self-renewal capacity may be the transformation site in acute myeloid leukemia
    • Satoh C., and Ogata K. Hypothesis: myeloid-restricted hematopoietic stem cells with self-renewal capacity may be the transformation site in acute myeloid leukemia. Leuk Res 30 (2006) 491-495
    • (2006) Leuk Res , vol.30 , pp. 491-495
    • Satoh, C.1    Ogata, K.2
  • 39
    • 33846921755 scopus 로고    scopus 로고
    • The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
    • Dumble M., Moore L., Chambers S.M., Geiger H., Van Zant G., Goodell M.A., et al. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109 (2007) 1736-1742
    • (2007) Blood , vol.109 , pp. 1736-1742
    • Dumble, M.1    Moore, L.2    Chambers, S.M.3    Geiger, H.4    Van Zant, G.5    Goodell, M.A.6
  • 40
    • 33847312358 scopus 로고    scopus 로고
    • Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background
    • Yao Y.G., Ellison F.M., McCoy J.P., Chen J., and Young N.S. Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background. Hum Mol Genet 16 (2007) 286-294
    • (2007) Hum Mol Genet , vol.16 , pp. 286-294
    • Yao, Y.G.1    Ellison, F.M.2    McCoy, J.P.3    Chen, J.4    Young, N.S.5
  • 41
    • 33645086366 scopus 로고    scopus 로고
    • Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus-bone marrow feedback loop
    • Goldschneider I. Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus-bone marrow feedback loop. Immunol Rev 209 (2006) 58-75
    • (2006) Immunol Rev , vol.209 , pp. 58-75
    • Goldschneider, I.1
  • 42
    • 0035808785 scopus 로고    scopus 로고
    • The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice
    • Foss D.L., Donskoy E., and Goldschneider I. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J Exp Med 193 (2001) 365-374
    • (2001) J Exp Med , vol.193 , pp. 365-374
    • Foss, D.L.1    Donskoy, E.2    Goldschneider, I.3
  • 43
    • 0036200874 scopus 로고    scopus 로고
    • Functional demonstration of intrathymic binding sites and microvascular gates for prothymocytes in irradiated mice
    • Foss D.L., Donskoy E., and Goldschneider I. Functional demonstration of intrathymic binding sites and microvascular gates for prothymocytes in irradiated mice. Int Immunol 14 (2002) 331-338
    • (2002) Int Immunol , vol.14 , pp. 331-338
    • Foss, D.L.1    Donskoy, E.2    Goldschneider, I.3
  • 44
    • 3242747324 scopus 로고    scopus 로고
    • Regulation of thymus size by competition for stromal niches among early T cell progenitors
    • Prockop S.E., and Petrie H.T. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J Immunol 173 (2004) 1604-1611
    • (2004) J Immunol , vol.173 , pp. 1604-1611
    • Prockop, S.E.1    Petrie, H.T.2
  • 45
    • 0027458058 scopus 로고
    • The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate
    • Wu L., Kincade P.W., and Shortman K. The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate. Immunol Lett 38 (1993) 69-75
    • (1993) Immunol Lett , vol.38 , pp. 69-75
    • Wu, L.1    Kincade, P.W.2    Shortman, K.3
  • 46
    • 22344450253 scopus 로고    scopus 로고
    • A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision
    • Benz C., and Bleul C.C. A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision. J Exp Med 202 (2005) 21-31
    • (2005) J Exp Med , vol.202 , pp. 21-31
    • Benz, C.1    Bleul, C.C.2
  • 49
    • 22144487402 scopus 로고    scopus 로고
    • Notch signaling controls the generation and differentiation of early T lineage progenitors
    • Sambandam A., Maillard I., Zediak V.P., Xu L., Gerstein R.M., Aster J.C., et al. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nat Immunol 6 (2005) 663-670
    • (2005) Nat Immunol , vol.6 , pp. 663-670
    • Sambandam, A.1    Maillard, I.2    Zediak, V.P.3    Xu, L.4    Gerstein, R.M.5    Aster, J.C.6
  • 50
    • 23044433011 scopus 로고    scopus 로고
    • Aging and T cell development: interplay between progenitors and their environment
    • Zediak V.P., and Bhandoola A. Aging and T cell development: interplay between progenitors and their environment. Semin Immunol 17 (2005) 337-346
    • (2005) Semin Immunol , vol.17 , pp. 337-346
    • Zediak, V.P.1    Bhandoola, A.2
  • 51
    • 20644462119 scopus 로고    scopus 로고
    • Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1
    • Rossi F.M., Corbel S.Y., Merzaban J.S., Carlow D.A., Gossens K., Duenas J., et al. Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1. Nat Immunol 6 (2005) 626-634
    • (2005) Nat Immunol , vol.6 , pp. 626-634
    • Rossi, F.M.1    Corbel, S.Y.2    Merzaban, J.S.3    Carlow, D.A.4    Gossens, K.5    Duenas, J.6
  • 52
    • 0030604540 scopus 로고    scopus 로고
    • Differential requirements for alpha4 integrins during fetal and adult hematopoiesis
    • Arroyo A.G., Yang J.T., Rayburn H., and Hynes R.O. Differential requirements for alpha4 integrins during fetal and adult hematopoiesis. Cell 85 (1996) 997-1008
    • (1996) Cell , vol.85 , pp. 997-1008
    • Arroyo, A.G.1    Yang, J.T.2    Rayburn, H.3    Hynes, R.O.4
  • 53
    • 33644827383 scopus 로고    scopus 로고
    • Bone-marrow haematopoietic-stem-cell niches
    • Wilson A., and Trumpp A. Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol 6 (2006) 93-106
    • (2006) Nat Rev Immunol , vol.6 , pp. 93-106
    • Wilson, A.1    Trumpp, A.2
  • 55
    • 20944440068 scopus 로고    scopus 로고
    • Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
    • Broxmeyer H.E., Orschell C.M., Clapp D.W., Hangoc G., Cooper S., Plett P.A., et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med 201 (2005) 1307-1318
    • (2005) J Exp Med , vol.201 , pp. 1307-1318
    • Broxmeyer, H.E.1    Orschell, C.M.2    Clapp, D.W.3    Hangoc, G.4    Cooper, S.5    Plett, P.A.6
  • 56
    • 0037237648 scopus 로고    scopus 로고
    • Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide
    • Levesque J.P., Hendy J., Takamatsu Y., Simmons P.J., and Bendall L.J. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest 111 (2003) 187-196
    • (2003) J Clin Invest , vol.111 , pp. 187-196
    • Levesque, J.P.1    Hendy, J.2    Takamatsu, Y.3    Simmons, P.J.4    Bendall, L.J.5
  • 57
    • 0037317025 scopus 로고    scopus 로고
    • Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells
    • Levesque J.P., Hendy J., Winkler I.G., Takamatsu Y., and Simmons P.J. Granulocyte colony-stimulating factor induces the release in the bone marrow of proteases that cleave c-KIT receptor (CD117) from the surface of hematopoietic progenitor cells. Exp Hematol 31 (2003) 109-117
    • (2003) Exp Hematol , vol.31 , pp. 109-117
    • Levesque, J.P.1    Hendy, J.2    Winkler, I.G.3    Takamatsu, Y.4    Simmons, P.J.5
  • 58
    • 33749365721 scopus 로고    scopus 로고
    • Increased hematopoietic stem cell mobilization in aged mice
    • Xing Z., Ryan M.A., Daria D., Nattamai K.J., Van Zant G., Wang L., et al. Increased hematopoietic stem cell mobilization in aged mice. Blood 108 (2006) 2190-2197
    • (2006) Blood , vol.108 , pp. 2190-2197
    • Xing, Z.1    Ryan, M.A.2    Daria, D.3    Nattamai, K.J.4    Van Zant, G.5    Wang, L.6
  • 59
    • 0037791913 scopus 로고    scopus 로고
    • Mesenchymal stem cells and hematopoietic stem cell transplantation
    • Fibbe W.E., and Noort W.A. Mesenchymal stem cells and hematopoietic stem cell transplantation. Ann NY Acad Sci 996 (2003) 235-244
    • (2003) Ann NY Acad Sci , vol.996 , pp. 235-244
    • Fibbe, W.E.1    Noort, W.A.2
  • 60
    • 18444374992 scopus 로고    scopus 로고
    • Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice
    • Noort W.A., Kruisselbrink A.B., in't Anker P.S., Kruger M., van Bezooijen R.L., de Paus R.A., et al. Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34(+) cells in NOD/SCID mice. Exp Hematol 30 (2002) 870-878
    • (2002) Exp Hematol , vol.30 , pp. 870-878
    • Noort, W.A.1    Kruisselbrink, A.B.2    in't Anker, P.S.3    Kruger, M.4    van Bezooijen, R.L.5    de Paus, R.A.6
  • 61
    • 0035104210 scopus 로고    scopus 로고
    • Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice
    • Li F., Jin F., Freitas A., Szabo P., and Weksler M.E. Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. Eur J Immunol 31 (2001) 500-505
    • (2001) Eur J Immunol , vol.31 , pp. 500-505
    • Li, F.1    Jin, F.2    Freitas, A.3    Szabo, P.4    Weksler, M.E.5
  • 62
    • 0031985281 scopus 로고    scopus 로고
    • Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age
    • Stephan R.P., Reilly C.R., and Witte P.L. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 91 (1998) 75-88
    • (1998) Blood , vol.91 , pp. 75-88
    • Stephan, R.P.1    Reilly, C.R.2    Witte, P.L.3
  • 63
    • 0031568406 scopus 로고    scopus 로고
    • Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors
    • Stephan R.P., Lill-Elghanian D.A., and Witte P.L. Development of B cells in aged mice: decline in the ability of pro-B cells to respond to IL-7 but not to other growth factors. J Immunol 158 (1997) 1598-1609
    • (1997) J Immunol , vol.158 , pp. 1598-1609
    • Stephan, R.P.1    Lill-Elghanian, D.A.2    Witte, P.L.3
  • 64
    • 23944509562 scopus 로고    scopus 로고
    • B cell development and receptor diversity during aging
    • Allman D., and Miller J.P. B cell development and receptor diversity during aging. Curr Opin Immunol 17 (2005) 463-467
    • (2005) Curr Opin Immunol , vol.17 , pp. 463-467
    • Allman, D.1    Miller, J.P.2
  • 65
  • 66
    • 0033854211 scopus 로고    scopus 로고
    • The effect of age on the B-cell repertoire
    • Weksler M.E., and Szabo P. The effect of age on the B-cell repertoire. J Clin Immunol 20 (2000) 240-249
    • (2000) J Clin Immunol , vol.20 , pp. 240-249
    • Weksler, M.E.1    Szabo, P.2
  • 67
    • 0035075040 scopus 로고    scopus 로고
    • Hepatitis B immunization of healthy elderly adults: relationship between naive CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvant
    • Looney R.J., Hasan M.S., Coffin D., Campbell D., Falsey A.R., Kolassa J., et al. Hepatitis B immunization of healthy elderly adults: relationship between naive CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvant. J Clin Immunol 21 (2001) 30-36
    • (2001) J Clin Immunol , vol.21 , pp. 30-36
    • Looney, R.J.1    Hasan, M.S.2    Coffin, D.3    Campbell, D.4    Falsey, A.R.5    Kolassa, J.6
  • 68
    • 33749993411 scopus 로고    scopus 로고
    • Chemotherapy disrupts activity of translational regulatory proteins in bone marrow stromal cells
    • Clutter S.D., Fortney J.E., and Gibson L.F. Chemotherapy disrupts activity of translational regulatory proteins in bone marrow stromal cells. Exp Hematol 34 (2006) 1522-1531
    • (2006) Exp Hematol , vol.34 , pp. 1522-1531
    • Clutter, S.D.1    Fortney, J.E.2    Gibson, L.F.3
  • 69
    • 35348835595 scopus 로고    scopus 로고
    • Reduced supportive capacity of bone marrow stroma upon chemotherapy is mediated via changes in glycosaminoglycan profile
    • Zweegman S., Kessler F.L., Kerkhoven R.M., Heimerikx M., Celie J.W., Janssen J.J., et al. Reduced supportive capacity of bone marrow stroma upon chemotherapy is mediated via changes in glycosaminoglycan profile. Matrix Biol 26 (2007) 561-571
    • (2007) Matrix Biol , vol.26 , pp. 561-571
    • Zweegman, S.1    Kessler, F.L.2    Kerkhoven, R.M.3    Heimerikx, M.4    Celie, J.W.5    Janssen, J.J.6
  • 70
    • 25444443392 scopus 로고    scopus 로고
    • Activation of transforming growth factor-beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage
    • Wang L., Clutter S., Benincosa J., Fortney J., and Gibson L.F. Activation of transforming growth factor-beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage. Stem Cells 23 (2005) 1122-1134
    • (2005) Stem Cells , vol.23 , pp. 1122-1134
    • Wang, L.1    Clutter, S.2    Benincosa, J.3    Fortney, J.4    Gibson, L.F.5
  • 71
    • 34247573902 scopus 로고    scopus 로고
    • Graft-versus-host disease
    • Shlomchik W.D. Graft-versus-host disease. Nat Rev Immunol 7 (2007) 340-352
    • (2007) Nat Rev Immunol , vol.7 , pp. 340-352
    • Shlomchik, W.D.1
  • 72
    • 34247392402 scopus 로고    scopus 로고
    • Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation
    • Hauri-Hohl M.M., Keller M.P., Gill J., Hafen K., Pachlatko E., Boulay T., et al. Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation. Blood 109 (2007) 4080-4088
    • (2007) Blood , vol.109 , pp. 4080-4088
    • Hauri-Hohl, M.M.1    Keller, M.P.2    Gill, J.3    Hafen, K.4    Pachlatko, E.5    Boulay, T.6
  • 73
    • 0028020494 scopus 로고
    • Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution
    • Ben-Yehuda A., Szabo P., Dyall R., and Weksler M.E. Bone marrow declines as a site of B-cell precursor differentiation with age: relationship to thymus involution. Proc Natl Acad Sci USA 91 (1994) 11988-11992
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11988-11992
    • Ben-Yehuda, A.1    Szabo, P.2    Dyall, R.3    Weksler, M.E.4
  • 74
    • 2942700206 scopus 로고    scopus 로고
    • Reduction in the developmental potential of intrathymic T cell progenitors with age
    • Min H., Montecino-Rodriguez E., and Dorshkind K. Reduction in the developmental potential of intrathymic T cell progenitors with age. J Immunol 173 (2004) 245-250
    • (2004) J Immunol , vol.173 , pp. 245-250
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 75
    • 0033003685 scopus 로고    scopus 로고
    • Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy
    • Offner F., Kerre T., De Smedt M., and Plum J. Bone marrow CD34 cells generate fewer T cells in vitro with increasing age and following chemotherapy. Br J Haematol 104 (1999) 801-808
    • (1999) Br J Haematol , vol.104 , pp. 801-808
    • Offner, F.1    Kerre, T.2    De Smedt, M.3    Plum, J.4
  • 76
    • 31344443618 scopus 로고    scopus 로고
    • Donor age and degree of HLA matching have a major impact on the outcome of unrelated donor haematopoietic cell transplantation for chronic myeloid leukaemia
    • Carreras E., Jimenez M., Gomez-Garcia V., de la Camara R., Martin C., Martinez F., et al. Donor age and degree of HLA matching have a major impact on the outcome of unrelated donor haematopoietic cell transplantation for chronic myeloid leukaemia. Bone Marrow Transplant 37 (2006) 33-40
    • (2006) Bone Marrow Transplant , vol.37 , pp. 33-40
    • Carreras, E.1    Jimenez, M.2    Gomez-Garcia, V.3    de la Camara, R.4    Martin, C.5    Martinez, F.6
  • 78
    • 1942457308 scopus 로고    scopus 로고
    • Hematopoiesis is severely altered in mice with an induced osteoblast deficiency
    • Visnjic D., Kalajzic Z., Rowe D.W., Katavic V., Lorenzo J., and Aguila H.L. Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood 103 (2004) 3258-3264
    • (2004) Blood , vol.103 , pp. 3258-3264
    • Visnjic, D.1    Kalajzic, Z.2    Rowe, D.W.3    Katavic, V.4    Lorenzo, J.5    Aguila, H.L.6
  • 79
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang J., Niu C., Ye L., Huang H., He X., Tong W.G., et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 425 (2003) 836-841
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1    Niu, C.2    Ye, L.3    Huang, H.4    He, X.5    Tong, W.G.6
  • 80
    • 34248577022 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of the anabolic effect of intermittent PTH
    • Jilka R.L. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone 40 (2007) 1434-1446
    • (2007) Bone , vol.40 , pp. 1434-1446
    • Jilka, R.L.1
  • 82
    • 33645765679 scopus 로고    scopus 로고
    • Parathyroid hormone: a novel tool for treating bone marrow depletion in cancer patients caused by chemotherapeutic drugs and ionizing radiation
    • Whitfield J.F. Parathyroid hormone: a novel tool for treating bone marrow depletion in cancer patients caused by chemotherapeutic drugs and ionizing radiation. Cancer Lett 244 (2006) 8-15
    • (2006) Cancer Lett , vol.244 , pp. 8-15
    • Whitfield, J.F.1
  • 83
    • 29344458032 scopus 로고    scopus 로고
    • Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation
    • Goldberg G.L., Sutherland J.S., Hammet M.V., Milton M.K., Heng T.S., Chidgey A.P., et al. Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation. Transplantation 80 (2005) 1604-1613
    • (2005) Transplantation , vol.80 , pp. 1604-1613
    • Goldberg, G.L.1    Sutherland, J.S.2    Hammet, M.V.3    Milton, M.K.4    Heng, T.S.5    Chidgey, A.P.6
  • 84
    • 23844486206 scopus 로고    scopus 로고
    • Effects of castration on thymocyte development in two different models of thymic involution
    • Heng T.S., Goldberg G.L., Gray D.H., Sutherland J.S., Chidgey A.P., and Boyd R.L. Effects of castration on thymocyte development in two different models of thymic involution. J Immunol 175 (2005) 2982-2993
    • (2005) J Immunol , vol.175 , pp. 2982-2993
    • Heng, T.S.1    Goldberg, G.L.2    Gray, D.H.3    Sutherland, J.S.4    Chidgey, A.P.5    Boyd, R.L.6
  • 85
    • 33644768024 scopus 로고    scopus 로고
    • Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration
    • Alpdogan O., Hubbard V.M., Smith O.M., Patel N., Lu S., Goldberg G.L., et al. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood 107 (2006) 2453-2460
    • (2006) Blood , vol.107 , pp. 2453-2460
    • Alpdogan, O.1    Hubbard, V.M.2    Smith, O.M.3    Patel, N.4    Lu, S.5    Goldberg, G.L.6
  • 86
    • 33947192136 scopus 로고    scopus 로고
    • Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
    • Min D., Panoskaltsis-Mortari A., Kuro O.M., Hollander G.A., Blazar B.R., and Weinberg K.I. Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood 109 (2007) 2529-2537
    • (2007) Blood , vol.109 , pp. 2529-2537
    • Min, D.1    Panoskaltsis-Mortari, A.2    Kuro, O.M.3    Hollander, G.A.4    Blazar, B.R.5    Weinberg, K.I.6
  • 87
    • 0037100314 scopus 로고    scopus 로고
    • Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease
    • Rossi S., Blazar B.R., Farrell C.L., Danilenko D.M., Lacey D.L., Weinberg K.I., et al. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood 100 (2002) 682-691
    • (2002) Blood , vol.100 , pp. 682-691
    • Rossi, S.1    Blazar, B.R.2    Farrell, C.L.3    Danilenko, D.M.4    Lacey, D.L.5    Weinberg, K.I.6
  • 88
    • 34247328577 scopus 로고    scopus 로고
    • Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
    • Rossi S.W., Jeker L.T., Ueno T., Kuse S., Keller M.P., Zuklys S., et al. Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells. Blood 109 (2007) 3803-3811
    • (2007) Blood , vol.109 , pp. 3803-3811
    • Rossi, S.W.1    Jeker, L.T.2    Ueno, T.3    Kuse, S.4    Keller, M.P.5    Zuklys, S.6
  • 89
    • 34347400589 scopus 로고    scopus 로고
    • Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques
    • Seggewiss R., Lore K., Guenaga F.J., Pittaluga S., Mattapallil J., Chow C.K., et al. Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques. Blood 110 (2007) 441-449
    • (2007) Blood , vol.110 , pp. 441-449
    • Seggewiss, R.1    Lore, K.2    Guenaga, F.J.3    Pittaluga, S.4    Mattapallil, J.5    Chow, C.K.6
  • 90
    • 0037165910 scopus 로고    scopus 로고
    • Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone
    • Napolitano L.A., Lo J.C., Gotway M.B., Mulligan K., Barbour J.D., Schmidt D., et al. Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone. AIDS 16 (2002) 1103-1111
    • (2002) AIDS , vol.16 , pp. 1103-1111
    • Napolitano, L.A.1    Lo, J.C.2    Gotway, M.B.3    Mulligan, K.4    Barbour, J.D.5    Schmidt, D.6
  • 91
    • 0036916440 scopus 로고    scopus 로고
    • Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro
    • Schmitt T.M., and Zuniga-Pflucker J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17 (2002) 749-756
    • (2002) Immunity , vol.17 , pp. 749-756
    • Schmitt, T.M.1    Zuniga-Pflucker, J.C.2
  • 92
    • 0036305567 scopus 로고    scopus 로고
    • Generation of a complete thymic microenvironment by MTS24 (+) thymic epithelial cells
    • Gill J., Malin M., Hollander G.A., and Boyd R. Generation of a complete thymic microenvironment by MTS24 (+) thymic epithelial cells. Nat Immunol 3 (2002) 635-642
    • (2002) Nat Immunol , vol.3 , pp. 635-642
    • Gill, J.1    Malin, M.2    Hollander, G.A.3    Boyd, R.4
  • 93
    • 33745532385 scopus 로고    scopus 로고
    • Formation of a functional thymus initiated by a postnatal epithelial progenitor cell
    • Bleul C.C., Corbeaux T., Reuter A., Fisch P., Monting J.S., and Boehm T. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 441 (2006) 992-996
    • (2006) Nature , vol.441 , pp. 992-996
    • Bleul, C.C.1    Corbeaux, T.2    Reuter, A.3    Fisch, P.4    Monting, J.S.5    Boehm, T.6
  • 95
    • 27644465295 scopus 로고    scopus 로고
    • Human skin cells support thymus-independent T cell development
    • Clark R.A., Yamanaka K., Bai M., Dowgiert R., and Kupper T.S. Human skin cells support thymus-independent T cell development. J Clin Invest 115 (2005) 3239-3249
    • (2005) J Clin Invest , vol.115 , pp. 3239-3249
    • Clark, R.A.1    Yamanaka, K.2    Bai, M.3    Dowgiert, R.4    Kupper, T.S.5
  • 96
    • 0035496939 scopus 로고    scopus 로고
    • Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease
    • Alpdogan O., Schmaltz C., Muriglan S.J., Kappel B.J., Perales M.A., Rotolo J.A., et al. Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease. Blood 98 (2001) 2256-2265
    • (2001) Blood , vol.98 , pp. 2256-2265
    • Alpdogan, O.1    Schmaltz, C.2    Muriglan, S.J.3    Kappel, B.J.4    Perales, M.A.5    Rotolo, J.A.6
  • 97
    • 0242348786 scopus 로고    scopus 로고
    • IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation
    • Alpdogan O., Muriglan S.J., Eng J.M., Willis L.M., Greenberg A.S., Kappel B.J., et al. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J Clin Invest 112 (2003) 1095-1107
    • (2003) J Clin Invest , vol.112 , pp. 1095-1107
    • Alpdogan, O.1    Muriglan, S.J.2    Eng, J.M.3    Willis, L.M.4    Greenberg, A.S.5    Kappel, B.J.6
  • 98
    • 10444254555 scopus 로고    scopus 로고
    • Interleukin-7 improves reconstitution of antiviral CD4 T cells
    • Lu H., Zhao Z., Kalina T., Gillespy III T., Liggitt D., et al. Interleukin-7 improves reconstitution of antiviral CD4 T cells. Clin Immunol 114 (2005) 30-41
    • (2005) Clin Immunol , vol.114 , pp. 30-41
    • Lu, H.1    Zhao, Z.2    Kalina, T.3    Gillespy III, T.4    Liggitt, D.5
  • 99
    • 0035138982 scopus 로고    scopus 로고
    • Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis
    • Napolitano L.A., Grant R.M., Deeks S.G., Schmidt D., De Rosa S.C., Herzenberg L.A., et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7 (2001) 73-79
    • (2001) Nat Med , vol.7 , pp. 73-79
    • Napolitano, L.A.1    Grant, R.M.2    Deeks, S.G.3    Schmidt, D.4    De Rosa, S.C.5    Herzenberg, L.A.6
  • 100
    • 34247156743 scopus 로고    scopus 로고
    • Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection
    • Fluur C., De Milito A., Fry T.J., Vivar N., Eidsmo L., Atlas A., et al. Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection. J Immunol 178 (2007) 5340-5350
    • (2007) J Immunol , vol.178 , pp. 5340-5350
    • Fluur, C.1    De Milito, A.2    Fry, T.J.3    Vivar, N.4    Eidsmo, L.5    Atlas, A.6
  • 101
    • 7244251615 scopus 로고    scopus 로고
    • Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
    • Fry T.J., Sinha M., Milliron M., Chu Y.W., Kapoor V., Gress R.E., et al. Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution. Blood 104 (2004) 2794-2800
    • (2004) Blood , vol.104 , pp. 2794-2800
    • Fry, T.J.1    Sinha, M.2    Milliron, M.3    Chu, Y.W.4    Kapoor, V.5    Gress, R.E.6
  • 102
    • 33947214395 scopus 로고    scopus 로고
    • Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation
    • Wils E.J., Braakman E., Verjans G.M., Rombouts E.J., Broers A.E., Niesters H.G., et al. Flt3 ligand expands lymphoid progenitors prior to recovery of thymopoiesis and accelerates T cell reconstitution after bone marrow transplantation. J Immunol 178 (2007) 3551-3557
    • (2007) J Immunol , vol.178 , pp. 3551-3557
    • Wils, E.J.1    Braakman, E.2    Verjans, G.M.3    Rombouts, E.J.4    Broers, A.E.5    Niesters, H.G.6
  • 103
    • 22544451234 scopus 로고    scopus 로고
    • A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential
    • Balciunaite G., Ceredig R., Massa S., and Rolink A.G. A B220+ CD117+ CD19- hematopoietic progenitor with potent lymphoid and myeloid developmental potential. Eur J Immunol 35 (2005) 2019-2030
    • (2005) Eur J Immunol , vol.35 , pp. 2019-2030
    • Balciunaite, G.1    Ceredig, R.2    Massa, S.3    Rolink, A.G.4
  • 104
    • 33747190606 scopus 로고    scopus 로고
    • Increasing Flt3L availability alters composition of a novel bone marrow lymphoid progenitor compartment
    • Ceredig R., Rauch M., Balciunaite G., and Rolink A.G. Increasing Flt3L availability alters composition of a novel bone marrow lymphoid progenitor compartment. Blood 108 (2006) 1216-1222
    • (2006) Blood , vol.108 , pp. 1216-1222
    • Ceredig, R.1    Rauch, M.2    Balciunaite, G.3    Rolink, A.G.4
  • 105
    • 33748459567 scopus 로고    scopus 로고
    • Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation
    • Zakrzewski J.L., Kochman A.A., Lu S.X., Terwey T.H., Kim T.D., Hubbard V.M., et al. Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nat Med 12 (2006) 1039-1047
    • (2006) Nat Med , vol.12 , pp. 1039-1047
    • Zakrzewski, J.L.1    Kochman, A.A.2    Lu, S.X.3    Terwey, T.H.4    Kim, T.D.5    Hubbard, V.M.6


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