메뉴 건너뛰기




Volumn 16, Issue 3, 2007, Pages 286-294

Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE;

EID: 33847312358     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddl457     Document Type: Article
Times cited : (30)

References (47)
  • 1
    • 23844558266 scopus 로고    scopus 로고
    • A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
    • Wallace, D.C. (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Annu. Rev. Genet., 39, 359-407.
    • (2005) Annu. Rev. Genet. , vol.39 , pp. 359-407
    • Wallace, D.C.1
  • 2
    • 0037180245 scopus 로고    scopus 로고
    • Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: Is there a common mechanism?
    • Chinnery, P.F., Samuels, D.C., Elson, J. and Turnbull, D.M. (2002) Accumulation of mitochondrial DNA mutations in ageing, cancer, and mitochondrial disease: Is there a common mechanism? Lancet, 360, 1323-1325.
    • (2002) Lancet , vol.360 , pp. 1323-1325
    • Chinnery, P.F.1    Samuels, D.C.2    Elson, J.3    Turnbull, D.M.4
  • 3
    • 33745617384 scopus 로고    scopus 로고
    • Mitochondrial DNA and ageing
    • Trifunovic, A. (2006) Mitochondrial DNA and ageing. Biochim. Biophys. Acta, 1757, 611-617.
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 611-617
    • Trifunovic, A.1
  • 4
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harman, D. (1972) The biologic clock: The mitochondria? J. Am. Geriatr. Soc., 20, 145-147.
    • (1972) J. Am. Geriatr. Soc. , vol.20 , pp. 145-147
    • Harman, D.1
  • 5
    • 33744478401 scopus 로고    scopus 로고
    • Free radical theory of aging: An update: Increasing the functional life span
    • HarmaI, D. (2006) Free radical theory of aging: An update: increasing the functional life span. Ann. NY Acad. Sci., 1067, 10-21.
    • (2006) Ann. NY Acad. Sci. , vol.1067 , pp. 10-21
    • Harman, D.1
  • 6
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • Linnane, A.W., Marzuki, S., Ozawa, T. and Tanaka, M. (1989) Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet, 1, 642-645.
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 7
    • 30044434360 scopus 로고    scopus 로고
    • The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations
    • Loeb, L.A., Wallace, D.C. and Martin, G.M. (2005) The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations. Proc. Natl Acad. Sci. USA, 102, 18769-18770.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 18769-18770
    • Loeb, L.A.1    Wallace, D.C.2    Martin, G.M.3
  • 8
    • 0242321023 scopus 로고    scopus 로고
    • Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation
    • Lin, P.H., Lee, S.H., Su, C.P. and Wei, Y.H. (2003) Oxidative damage to mitochondrial DNA in atrial muscle of patients with atrial fibrillation. Free Radic. Biol. Med., 35, 1310-1318.
    • (2003) Free Radic. Biol. Med. , vol.35 , pp. 1310-1318
    • Lin, P.H.1    Lee, S.H.2    Su, C.P.3    Wei, Y.H.4
  • 9
    • 0042386022 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging
    • Pak, J.W., Herbst, A., Bua, E., Gokey, N., McKenzie, D. and Aiken, J.M. (2003) Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging. Aging Cell, 2, 1-7.
    • (2003) Aging Cell , vol.2 , pp. 1-7
    • Pak, J.W.1    Herbst, A.2    Bua, E.3    Gokey, N.4    McKenzie, D.5    Aiken, J.M.6
  • 10
    • 0042886929 scopus 로고    scopus 로고
    • The mitochondrial theory of aging: Dead or alive?
    • Jacobs, H.T. (2003) The mitochondrial theory of aging: Dead or alive? Aging Cell, 2, 11-17.
    • (2003) Aging Cell , vol.2 , pp. 11-17
    • Jacobs, H.T.1
  • 11
    • 33744494572 scopus 로고    scopus 로고
    • The free radical fantasy: A panoply of paradoxes
    • Howes, R.M. (2006) The free radical fantasy: A panoply of paradoxes. Ann. NY Acad. Sci., 1067, 22-26.
    • (2006) Ann. NY Acad. Sci. , vol.1067 , pp. 22-26
    • Howes, R.M.1
  • 15
    • 0034667349 scopus 로고    scopus 로고
    • Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis
    • Zhang, D., Mott, J.L., Chang, S.W., Denniger, G., Feng, Z. and Zassenhaus, H.P. (2000) Construction of transgenic mice with tissue-specific acceleration of mitochondrial DNA mutagenesis. Genomics, 69, 151-161.
    • (2000) Genomics , vol.69 , pp. 151-161
    • Zhang, D.1    Mott, J.L.2    Chang, S.W.3    Denniger, G.4    Feng, Z.5    Zassenhaus, H.P.6
  • 16
    • 0035283326 scopus 로고    scopus 로고
    • Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations
    • Mott, J.L., Zhang, D., Stevens, M., Chang, S., Denniger, G. and Zassenhaus, H.P. (2001) Oxidative stress is not an obligate mediator of disease provoked by mitochondrial DNA mutations. Mutat. Res., 474, 35-45.
    • (2001) Mutat. Res. , vol.474 , pp. 35-45
    • Mott, J.L.1    Zhang, D.2    Stevens, M.3    Chang, S.4    Denniger, G.5    Zassenhaus, H.P.6
  • 20
    • 33744458966 scopus 로고    scopus 로고
    • Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?
    • Khrapko, K., Kraytsberg, Y., de Grey, A.D., Vijg, J. and Schon, E.A. (2006) Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging? Aging Cell, 5, 279-282.
    • (2006) Aging Cell , vol.5 , pp. 279-282
    • Khrapko, K.1    Kraytsberg, Y.2    de Grey, A.D.3    Vijg, J.4    Schon, E.A.5
  • 21
    • 8844255456 scopus 로고    scopus 로고
    • What the papers say: Where is the somatic mutation that causes aging?
    • Driver, C. (2004) What the papers say: Where is the somatic mutation that causes aging? Bioessays, 26, 1160-1163.
    • (2004) Bioessays , vol.26 , pp. 1160-1163
    • Driver, C.1
  • 22
    • 6344269167 scopus 로고    scopus 로고
    • Mitochondrial mutations in mammalian aging: An over-hasty about-turn?
    • de Grey, A.D. (2004) Mitochondrial mutations in mammalian aging: An over-hasty about-turn? Rejuvenation Res., 7, 171-174.
    • (2004) Rejuvenation Res. , vol.7 , pp. 171-174
    • de Grey, A.D.1
  • 23
    • 33646448921 scopus 로고    scopus 로고
    • Biology of normal and acute myeloid leukemia stem cells
    • Dick, J.E. and Lapidot, T. (2005) Biology of normal and acute myeloid leukemia stem cells. Int. J. Hematol., 82, 389-396.
    • (2005) Int. J. Hematol. , vol.82 , pp. 389-396
    • Dick, J.E.1    Lapidot, T.2
  • 24
    • 0037974840 scopus 로고    scopus 로고
    • Genetic control of stem cells: Implications for aging
    • Van Zant, G. (2003) Genetic control of stem cells: Implications for aging. Int. J. Hematol., 77, 29-36.
    • (2003) Int. J. Hematol. , vol.77 , pp. 29-36
    • Van Zant, G.1
  • 25
    • 3343027273 scopus 로고    scopus 로고
    • Hematopoiesis in the elderly
    • Berkahn, L. and Keating, A. (2004) Hematopoiesis in the elderly. Hematology, 9, 159-163.
    • (2004) Hematology , vol.9 , pp. 159-163
    • Berkahn, L.1    Keating, A.2
  • 26
    • 0024380947 scopus 로고
    • Numbers and functions of transplantable primitive immunohematopoietic stem cells. Effects of age
    • Harrison, D.E., Astle, C.M. and Stone, M. (1989) Numbers and functions of transplantable primitive immunohematopoietic stem cells. Effects of age. J. Immunol., 142, 3833-3840.
    • (1989) J. Immunol. , vol.142 , pp. 3833-3840
    • Harrison, D.E.1    Astle, C.M.2    Stone, M.3
  • 28
    • 30444448896 scopus 로고    scopus 로고
    • Hematopoietic stem cells do not engraft with absolute efficiencies
    • Camargo, F.D., Chambers, S.M., Drew, E., McNagny, K.M. and Goodell, M.A. (2006) Hematopoietic stem cells do not engraft with absolute efficiencies. Blood, 107, 501-507.
    • (2006) Blood , vol.107 , pp. 501-507
    • Camargo, F.D.1    Chambers, S.M.2    Drew, E.3    McNagny, K.M.4    Goodell, M.A.5
  • 29
    • 0029796633 scopus 로고    scopus 로고
    • Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell
    • Osawa, M., Hanada, K., Hamada, H. and Nakauchi, H. (1996) Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science, 273, 242-245.
    • (1996) Science , vol.273 , pp. 242-245
    • Osawa, M.1    Hanada, K.2    Hamada, H.3    Nakauchi, H.4
  • 30
    • 0032920969 scopus 로고    scopus 로고
    • Development and aging of primitive hematopoietic stem cells in BALB/cBy mice
    • Chen, J., Astle, C.M. and Harrison, D.E. (1999) Development and aging of primitive hematopoietic stem cells in BALB/cBy mice. Exp. Hematol., 27, 928-935.
    • (1999) Exp. Hematol. , vol.27 , pp. 928-935
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3
  • 31
    • 0034008968 scopus 로고    scopus 로고
    • Genetic regulation of primitive hematopoietic stem cell senescence
    • Chen, J., Astle, C.M. and Harrison, D.E. (2000) Genetic regulation of primitive hematopoietic stem cell senescence. Exp. Hematol., 28, 442-450.
    • (2000) Exp. Hematol. , vol.28 , pp. 442-450
    • Chen, J.1    Astle, C.M.2    Harrison, D.E.3
  • 32
    • 0034613690 scopus 로고    scopus 로고
    • Age-associated characteristics of murine hematopoietic stem cells
    • Sudo, K., Ema, H., Morita, Y. and Nakauchi, H. (2000) Age-associated characteristics of murine hematopoietic stem cells. J. Exp. Med., 192, 1273-1280.
    • (2000) J. Exp. Med. , vol.192 , pp. 1273-1280
    • Sudo, K.1    Ema, H.2    Morita, Y.3    Nakauchi, H.4
  • 33
    • 23744439044 scopus 로고    scopus 로고
    • Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells
    • Liang, Y., Van Zant, G. and Szilvassy, S.J. (2005) Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood, 106, 1479-1487.
    • (2005) Blood , vol.106 , pp. 1479-1487
    • Liang, Y.1    Van Zant, G.2    Szilvassy, S.J.3
  • 35
    • 27644590570 scopus 로고    scopus 로고
    • Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytes
    • Ogasawara, Y., Nakayama, K., Tarnowka, M., McCoy, J.P., Jr., Kajigaya, S., Levin, B.C. and Young, N.S. (2005) Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytes. Blood, 106, 3271-3284.
    • (2005) Blood , vol.106 , pp. 3271-3284
    • Ogasawara, Y.1    Nakayama, K.2    Tarnowka, M.3    McCoy Jr., J.P.4    Kajigaya, S.5    Levin, B.C.6    Young, N.S.7
  • 36
    • 0942276848 scopus 로고    scopus 로고
    • Marked mitochondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow
    • Shin, M.G., Kajigaya, S., McCoy, J.P., Jr., Levin, B.C. and Young, N.S. (2004) Marked mitochondrial DNA sequence heterogeneity in single CD34+ cell clones from normal adult bone marrow. Blood, 103, 553-561.
    • (2004) Blood , vol.103 , pp. 553-561
    • Shin, M.G.1    Kajigaya, S.2    McCoy Jr., J.P.3    Levin, B.C.4    Young, N.S.5
  • 37
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G. and Attardi, G. (1999) Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science, 286, 774-779.
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 41
    • 0032401024 scopus 로고    scopus 로고
    • Ageing and mammalian mitochondrial genetics
    • Nagley, P. and Wei, Y.H. (1998) Ageing and mammalian mitochondrial genetics. Trends Genet., 14, 513-517.
    • (1998) Trends Genet. , vol.14 , pp. 513-517
    • Nagley, P.1    Wei, Y.H.2
  • 42
    • 0036086130 scopus 로고    scopus 로고
    • Free radicals in the physiological control of cell function
    • Droge, W. (2002) Free radicals in the physiological control of cell function. Physiol. Rev., 82, 47-95.
    • (2002) Physiol. Rev. , vol.82 , pp. 47-95
    • Droge, W.1
  • 43
    • 28844473846 scopus 로고    scopus 로고
    • Opinion: Radical medicine: Treating ageing to cure disease
    • Finkel, T. (T005) Opinion: Radical medicine: treating ageing to cure disease. Nat. Rev. Mol. Cell Biol., 6, 971-976.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 971-976
    • Finkel, T.1
  • 44
    • 33748643416 scopus 로고    scopus 로고
    • Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers
    • Bua, E., Johnson, J., Herbst, A., Delong, B., McKenzie, D., Salamat, S. and Aiken, J.M. (2006) Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am. J. Hum. Genet., 79, 469-480.
    • (2006) Am. J. Hum. Genet. , vol.79 , pp. 469-480
    • Bua, E.1    Johnson, J.2    Herbst, A.3    Delong, B.4    McKenzie, D.5    Salamat, S.6    Aiken, J.M.7
  • 45
    • 0029741431 scopus 로고    scopus 로고
    • Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging
    • Pallotti, F., Chen, X., Bonilla, E. and Schon, E.A. (1996) Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am. J. Hum. Genet., 59, 591-602.
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 591-602
    • Pallotti, F.1    Chen, X.2    Bonilla, E.3    Schon, E.A.4
  • 47
    • 19344375427 scopus 로고    scopus 로고
    • Specific point mutations may not accumulate with aging in the mouse mitochondrial DNA control region
    • Song, X., Deng, J.H., Liu, C.J. and Bai, Y. (2005) Specific point mutations may not accumulate with aging in the mouse mitochondrial DNA control region. Gene, 350, 193-199.
    • (2005) Gene , vol.350 , pp. 193-199
    • Song, X.1    Deng, J.H.2    Liu, C.J.3    Bai, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.