Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation

Nature Medicine

Volumn 12, Issue 9, 2006, Pages 1039-1047

  Zakrzewski, Johannes L ^a   Kochman, Adam A ^a   Lu, Sydney X ^a   Terwey, Theis H ^a   Kim, Theo D ^a   Hubbard, Vanessa M ^a   Muriglan, Stephanie J ^a   Suh, David ^a   Smith, Odette M ^a   Grubin, Jeremy ^a   Patel, Neel ^a   Chow, Andrew ^a   Cabrera Perez, Javier ^a   Radhakrishnan, Radhika ^a   Diab, Adi ^a   Perales, Miguel Angel ^a   Rizzuto, Gabrielle ^a   Menet, Ewa ^a   Pamer, Eric G ^a   Heller, Glen ^b   Zúñiga Pflücker, Juan Carlos ^c   Alpdogan, Önder ^a   Van Den Brink, Marcel R M ^a   more..

^a Department of Medicine   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; T LYMPHOCYTE ANTIGEN;

ADOPTIVE TRANSFER; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ARTICLE; BONE MARROW; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL PROLIFERATION; CHIMERA; CONTROLLED STUDY; CYTOKINE RELEASE; GRAFT VERSUS HOST REACTION; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ADOPTIVE TRANSFER; ANIMALS; COCULTURE TECHNIQUES; FIBROBLAST GROWTH FACTOR 7; GRAFT VS HOST DISEASE; GRAFT VS TUMOR EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LISTERIA INFECTIONS; LISTERIOSIS; LYMPHOCYTE DEPLETION; MICE; REGENERATION; STEM CELLS; T-LYMPHOCYTES;

LISTERIA MONOCYTOGENES;

EID: 33748459567     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1463     Document Type: Article

References (41)

1. Kernan, N.A. et al. Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N. Engl. J. Med. 328, 593-602 (1993).
2. Ochs, L. et al. Late infections after allogeneic bone marrow transplantations: comparison of incidence in related and unrelated donor transplant recipients. Blood 86, 3979-3986 (1995).
3. Hongeng, S. et al. Outcomes of transplantation with matched-sibling and unrelated-donor bone marrow in children with leukaemia. Lancet 350, 767-771 (1997).
4. Hansen, J.A. et al. Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia. N. Engl. J. Med. 338, 962-968 (1998).
5. Small, T.N. et al. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood 93, 467-480 (1999).
6. van den Brink, M.R., Alpdogan, O. & Boyd, R.L. Strategies to enhance T-cell reconstitution in immunocompromised patients. Nat. Rev. Immunol. 4, 856-867 (2004).
7. Keever, C.A. et al. Immune reconstitution following bone marrow transplantation: comparison of recipients of T-cell depleted marrow with recipients of conventional marrow grafts. Blood 73, 1340-1350 (1989).
8. Storek, J., Witherspoon, R.P. & Storb, R. T-cell reconstitution after bone marrow transplantation into adult patients does not resemble T-cell development in early life. Bone Marrow Transplant. 16, 413-425 (1995).
9. Radtke, F. et al. Notch regulation of lymphocyte development and function. Nat. Immunol. 5, 247-253 (2004).
10. Harman, B.C., Jenkinson, E.J. & Anderson, G. Microenvironmental regulation of Notch signalling in T-cell development. Semin. Immunol. 15, 91-97 (2003).
11. Schmitt, T.M. & Zuniga-Pflucker, J.C. Induction of T-cell development from hematopoietic progenitor cells by Delta-like-1 in vitro. Immunity 17, 749-756 (2002).
12. Zuniga-Pflucker, J.C. T-cell development made simple. Nat. Rev. Immunol. 4, 67-72 (2004).
13. Schmitt, T.M. et al. Induction of T-cell development and establishment of T-cell competence from embryonic stem cells differentiated in vitro. Nat. Immunol. 5, 410-417 (2004).
14. La Motte-Mohs, R.N., Herer, E. & Zuniga-Pflucker, J.C. Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 105, 1431-1439 (2005).
15. + progenitor cells mature to T-cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells Mol. Dis. 33, 227-232 (2004).
16. Balciunaite, G., Ceredig, R., Fehling, H.J., Zuniga-Pflucker, J.C. & Rolink, A.G. The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. Eur. J. Immunol. 35, 1292-1300 (2005).
17. Huang, J. et al. Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation. J. Immunol. 175, 4858-4865 (2005).
18. Ikawa, T., Kawamoto, H., Fujimoto, S. & Katsura, Y. Commitment of common T/natural killer (NK) progenitors to unipotent T and NK progenitors in the mouse fetal thymus revealed by a single progenitor assay. J. Exp. Med. 190, 1617-1626 (1999).
19. Schmitt, T.M., Ciofani, M., Petrie, H.T. & Zuniga-Pflucker, J.C. Maintenance of T-cell specification and differentiation requires recurrent Notch receptor-ligand interactions. J. Exp. Med. 200, 469-479 (2004).
20. Danilenko, D.M. Preclinical and early clinical development of keratinocyte growth factor, an epithelial-specific tissue growth factor. Toxicol. Pathol. 27, 64-71 (1999).
21. Danilenko, D.M. et al. Keratinocyte growth factor alters thymocyte development via stimulation of thymic epithelial cells. FASEB J. 10, A1148 (1996).
22. Perales, M.A. et al. DNA immunization against melanoma antigens enhances tumor immunity after allogeneic hematopoietic stem cell transplantation. J. Immunol. (in the press).
23. Cooke, K.R. et al. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood 88, 3230-3239 (1996).
24. Foss, D.L., Donskoy, E. & Goldschneider, I. The importation of hematogenous precursors by the thymus is a gated phenomenon in normal adult mice. J. Exp. Med. 193, 365-374 (2001).
25. Prockop, S.E. & Petrie, H.T. Regulation of thymus size by competition for stromal niches among early T-cell progenitors. J. Immunol. 173, 1604-1611 (2004).
26. Min, D. et al. Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood 99, 4592-4600 (2002).
27. Rossi, S. et al. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Blood 100, 682-691 (2002).
28. Alpdogan, O. et al. Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration. Blood 107, 2453-2460 (2006).
29. Guy-Grand, D. et al. Extrathymic T-cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice. J. Exp. Med. 197, 333-341 (2003).
30. Lambolez, F. et al. The thymus exports long-lived fully committed T-cell precursors that can colonize primary lymphoid organs. Nat. Immunol. 7, 76-82 (2006).
31. Terszowski, G. et al. Evidence for a functional second thymus in mice. Science 312, 284-287 (2006).
32. Porter, D.L. & Antin, J.H. The graft-versus-leukemia effects of allogeneic cell therapy. Annu. Rev. Med. 50, 369-386 (1999).
33. Yang, Y.G., Qi, J., Wang, M.G. & Sykes, M. Donor-derived interferon γ separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T-cells. Blood 99, 4207-4215 (2002).
34. Chen, B.J., Cui, X., Sempowski, G.D., Domen, J. & Chao, N.J. Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood 103, 4344-4352 (2004).
35. BitMansour, A. et al. Myeloid progenitors protect against invasive aspergillosis and Pseudomonas aeruginosa infection following hematopoietic stem cell transplantation. Blood 100, 4660-4667 (2002).
36. Arber, C. et al. Common lymphoid progenitors rapidly engraft and protect against lethal mouse cytomegalovirus infection after hematopoietic stem cell transplantation. Blood 102, 421-428 (2003).
37. Delaney, C., Varnum-Finney, B., Aoyama, K., Brashem-Stein, C. & Bernstein, I.D. Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood 106, 2693-2699 (2005).
38. Dallas, M.H., Varnum-Finney, B., Delaney, C., Kato, K. & Bernstein, I.D. Density of the Notch ligand Delta1 determines generation of B and T-cell precursors from hematopoietic stem cells. J. Exp. Med. 201, 1361-1366 (2005).
39. Terwey, T.H. et al. CC chemokine receptor 2 is required for CD8-induced graft-versus-host disease. Blood 106, 3322-3330 (2005).
40. Schmaltz, C. et al. Differential use of Fas ligand and perforin cytotoxic pathways by donor T-cells in graft-versus-host disease and graft-versus- leukemia effect. Blood 97, 2886-2895 (2001).
41. 7 integrin) is an important homing integrin on alloreactive T-cells in the development of intestinal graft-versus-host disease. Blood 103, 1542-1547 (2004).