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Volumn 13, Issue 21, 2007, Pages 6252-6256

Targeting poly(ADP-ribose) polymerase: A two-armed strategy for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ABT 888; AG 014699; ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; CEP 6800; CISPLATIN; DOUBLE STRANDED DNA; GP 21016; GPI 15427; GPI 21016; INO 1001; IRINOTECAN; KU 0059436; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; QUINAZOLINE DERIVATIVE; SINGLE STRANDED DNA; TEMOZOLOMIDE; UNCLASSIFIED DRUG;

EID: 35948968410     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-0617     Document Type: Article
Times cited : (51)

References (55)
  • 1
    • 0002160618 scopus 로고
    • Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
    • Chambon P, Weil J, Mandel P. Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem Biophys Res Commun 1963;11:39.
    • (1963) Biochem Biophys Res Commun , vol.11 , pp. 39
    • Chambon, P.1    Weil, J.2    Mandel, P.3
  • 2
    • 0036447366 scopus 로고    scopus 로고
    • Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors
    • Tentori L, Portarena I, Graziani G. Potential clinical applications of poly(ADP-ribose) polymerase (PARP) inhibitors. Pharmacol Res 2002;45:73-85.
    • (2002) Pharmacol Res , vol.45 , pp. 73-85
    • Tentori, L.1    Portarena, I.2    Graziani, G.3
  • 3
    • 19444362951 scopus 로고    scopus 로고
    • Clinical perspectives of PARP inhibitors
    • Graziani G, Szabo C. Clinical perspectives of PARP inhibitors. Pharmacol Res 2005;52:109-18.
    • (2005) Pharmacol Res , vol.52 , pp. 109-118
    • Graziani, G.1    Szabo, C.2
  • 4
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 5
    • 0036270993 scopus 로고    scopus 로고
    • DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: Fail-safe protection against carcinogenesis
    • Bernstein C, Bernstein H, Payne CM, Garewal H. DNA repair/pro-apoptotic dual-role proteins in five major DNA repair pathways: fail-safe protection against carcinogenesis. Mutat Res 2002;511:145-78.
    • (2002) Mutat Res , vol.511 , pp. 145-178
    • Bernstein, C.1    Bernstein, H.2    Payne, C.M.3    Garewal, H.4
  • 8
    • 0033001635 scopus 로고    scopus 로고
    • Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions
    • D'Silva I, Pelletier JD, Lagueux J, et al. Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. Biochim Biophys Acta 1999;1430:119-26.
    • (1999) Biochim Biophys Acta , vol.1430 , pp. 119-126
    • D'Silva, I.1    Pelletier, J.D.2    Lagueux, J.3
  • 9
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • Audebert M, Salles B, Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 2004;279:55117-26.
    • (2004) J Biol Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 10
    • 30744469845 scopus 로고    scopus 로고
    • Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway
    • Audebert M, Salles B, Weinfeld M, Calsou P. Involvement of polynucleotide kinase in a poly(ADP-ribose) polymerase-1-dependent DNA double-strand breaks rejoining pathway. J Mol Biol 2006;356:257-65.
    • (2006) J Mol Biol , vol.356 , pp. 257-265
    • Audebert, M.1    Salles, B.2    Weinfeld, M.3    Calsou, P.4
  • 11
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • Wang M, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G. PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res 2006;34:6170- 82.
    • (2006) Nucleic Acids Res , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Rosidi, B.3    Zhang, L.4    Wang, H.5    Iliakis, G.6
  • 12
  • 13
    • 0035425899 scopus 로고    scopus 로고
    • Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism
    • Davidovic L, Vodenicharov M, Affar EB, Poirier GG. Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res 2001;268:7-13.
    • (2001) Exp Cell Res , vol.268 , pp. 7-13
    • Davidovic, L.1    Vodenicharov, M.2    Affar, E.B.3    Poirier, G.G.4
  • 14
    • 0032917607 scopus 로고    scopus 로고
    • Function of poly(ADP-ribose) polymerase in response to DNA damage: Gene-disruption study in mice
    • Masutani M, Nozaki T, Nishiyama E, et al. Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice. Mol Cell Biochem 1999;193:149-52.
    • (1999) Mol Cell Biochem , vol.193 , pp. 149-152
    • Masutani, M.1    Nozaki, T.2    Nishiyama, E.3
  • 16
    • 0026507413 scopus 로고
    • Role of poly(ADP-ribose) formation in DNA repair
    • Satoh MS, Lindahl T. Role of poly(ADP-ribose) formation in DNA repair. Nature 1992;356:356 -8.
    • (1992) Nature , vol.356 , pp. 356-358
    • Satoh, M.S.1    Lindahl, T.2
  • 17
    • 0027486183 scopus 로고    scopus 로고
    • The carboxy-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli large scale purification and characterization
    • Simonin F. The carboxy-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli large scale purification and characterization. J Biol Chem1993;268:13454-61.
    • J Biol Chem1993;268 , pp. 13454-13461
    • Simonin, F.1
  • 18
    • 0018990986 scopus 로고
    • Novel inhibitors of poly(ADP-ribose) synthetase
    • Purnell MR, Whish WJD. Novel inhibitors of poly(ADP-ribose) synthetase. Biochem J 1980;185:775-7.
    • (1980) Biochem J , vol.185 , pp. 775-777
    • Purnell, M.R.1    Whish, W.J.D.2
  • 19
    • 0032539957 scopus 로고    scopus 로고
    • + binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling
    • + binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling. Biochemistry 1998;37:3893-900.
    • (1998) Biochemistry , vol.37 , pp. 3893-3900
    • Ruf, A.1    deMurcia, G.2    Schulz, G.E.3
  • 20
    • 0037038322 scopus 로고    scopus 로고
    • Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: Design, synthesis, and X-ray cocrystal structure
    • Canan Koch SS, Thoresen LH, Tikhe JG, et al. Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure. J Med Chem 2002;45:4961-74.
    • (2002) J Med Chem , vol.45 , pp. 4961-4974
    • Canan Koch, S.S.1    Thoresen, L.H.2    Tikhe, J.G.3
  • 21
    • 0037448385 scopus 로고    scopus 로고
    • Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors
    • Skalitzky DJ, Marakovits JT, Maegley KA, et al. Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem 2003;46:210-3.
    • (2003) J Med Chem , vol.46 , pp. 210-213
    • Skalitzky, D.J.1    Marakovits, J.T.2    Maegley, K.A.3
  • 22
    • 6044250300 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase
    • Tikhe JG, Webber SE, Hostomsky Z, et al. Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase. J Med Chem 2004;47:5467-81.
    • (2004) J Med Chem , vol.47 , pp. 5467-5481
    • Tikhe, J.G.1    Webber, S.E.2    Hostomsky, Z.3
  • 23
    • 0037239590 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors
    • Southan GJ, Szabo C. Poly(ADP-ribose) polymerase inhibitors. Curr Med Chem 2003;10:321-40.
    • (2003) Curr Med Chem , vol.10 , pp. 321-340
    • Southan, G.J.1    Szabo, C.2
  • 24
    • 0028793846 scopus 로고
    • Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP)
    • Griffin RJ, Pemberton LC, Rhodes D, et al. Novel potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). Anticancer Drug Des 1995;10:507-14.
    • (1995) Anticancer Drug Des , vol.10 , pp. 507-514
    • Griffin, R.J.1    Pemberton, L.C.2    Rhodes, D.3
  • 25
    • 0025902273 scopus 로고
    • Endogenous mutagens and the causes of aging and cancer
    • Ames BN, Gold LS. Endogenous mutagens and the causes of aging and cancer. Mutat Res 1991;250:3-16.
    • (1991) Mutat Res , vol.250 , pp. 3-16
    • Ames, B.N.1    Gold, L.S.2
  • 26
    • 0033815382 scopus 로고    scopus 로고
    • Review of mammalian DNA repair and translational implications
    • Hansen K, Kelly M. Review of mammalian DNA repair and translational implications. J Pharmacol Exp Ther 2000;295:1-9.
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 1-9
    • Hansen, K.1    Kelly, M.2
  • 28
    • 0031844311 scopus 로고    scopus 로고
    • XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
    • Masson M, Niedergang C, Schreiber V, Muller S, Menissier-de Murcia J, de Murcia G. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol 1998;18:3563-71.
    • (1998) Mol Cell Biol , vol.18 , pp. 3563-3571
    • Masson, M.1    Niedergang, C.2    Schreiber, V.3    Muller, S.4    Menissier-de Murcia, J.5    de Murcia, G.6
  • 29
    • 0018906390 scopus 로고
    • (ADP-ribose) n participates in DNA excision repair
    • Durkacz B, Omidiji O, Gray D, Shall S. (ADP-ribose) n participates in DNA excision repair. Nature 1980;283:593-6.
    • (1980) Nature , vol.283 , pp. 593-596
    • Durkacz, B.1    Omidiji, O.2    Gray, D.3    Shall, S.4
  • 30
    • 33646183367 scopus 로고    scopus 로고
    • DNA damage responses and their many interactions with the replication fork
    • Andreassen P, Ho G, D'Andrea A. DNA damage responses and their many interactions with the replication fork. Carcinogenesis 2006;27:883-92.
    • (2006) Carcinogenesis , vol.27 , pp. 883-892
    • Andreassen, P.1    Ho, G.2    D'Andrea, A.3
  • 31
    • 0031762817 scopus 로고    scopus 로고
    • Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064
    • Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br J Cancer 1998;78:1269-77.
    • (1998) Br J Cancer , vol.78 , pp. 1269-1277
    • Bowman, K.J.1    White, A.2    Golding, B.T.3    Griffin, R.J.4    Curtin, N.J.5
  • 32
    • 12444276597 scopus 로고    scopus 로고
    • Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies
    • Calabrese CR, Batey MA, Thomas HD, et al. Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res 2003;9:2711-8.
    • (2003) Clin Cancer Res , vol.9 , pp. 2711-2718
    • Calabrese, C.R.1    Batey, M.A.2    Thomas, H.D.3
  • 33
    • 0242588748 scopus 로고    scopus 로고
    • Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor
    • Miknyoczki SJ, Jones-Bolin S, Pritchard S, et al. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol Cancer Ther 2003;2 :371-82.
    • (2003) Mol Cancer Ther , vol.2 , pp. 371-382
    • Miknyoczki, S.J.1    Jones-Bolin, S.2    Pritchard, S.3
  • 34
    • 19444375973 scopus 로고    scopus 로고
    • Chemopotentiation by PARP inhibitors in cancer therapy
    • Tentori L, Graziani G. Chemopotentiation by PARP inhibitors in cancer therapy. Pharmacol Res 2005;52:25-33.
    • (2005) Pharmacol Res , vol.52 , pp. 25-33
    • Tentori, L.1    Graziani, G.2
  • 35
    • 17244375049 scopus 로고    scopus 로고
    • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
    • Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005;434:913-7.
    • (2005) Nature , vol.434 , pp. 913-917
    • Bryant, H.E.1    Schultz, N.2    Thomas, H.D.3
  • 36
    • 33746100822 scopus 로고    scopus 로고
    • Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer
    • Tutt AN, Lord CJ, McCabe N, et al. Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Cold Spring Harb Symp Quant Biol 2005;70:139-48.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 139-148
    • Tutt, A.N.1    Lord, C.J.2    McCabe, N.3
  • 37
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005;205:275-92.
    • (2005) J Pathol , vol.205 , pp. 275-292
    • Longley, D.B.1    Johnston, P.G.2
  • 38
    • 0035902108 scopus 로고    scopus 로고
    • Genone maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. Genone maintenance mechanisms for preventing cancer. Nature 2001;411:360-74.
    • (2001) Nature , vol.411 , pp. 360-374
    • Hoeijmakers, J.H.1
  • 39
    • 0028826231 scopus 로고
    • Potentiation of temozolomide-induced cytotoxicity: A comparative study of the biological effects of poly(-ADP-ribose) polymerase inhibitors
    • Boulton S, Pemberton LC, Porteous JK, et al. Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(-ADP-ribose) polymerase inhibitors. Br J Cancer 1995;72:849-56.
    • (1995) Br J Cancer , vol.72 , pp. 849-856
    • Boulton, S.1    Pemberton, L.C.2    Porteous, J.K.3
  • 40
    • 0033941729 scopus 로고    scopus 로고
    • Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines
    • Delaney CA, Wang LZ, Kyle S, et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin Cancer Res 2000;6:2860-7.
    • (2000) Clin Cancer Res , vol.6 , pp. 2860-2867
    • Delaney, C.A.1    Wang, L.Z.2    Kyle, S.3
  • 41
    • 10744233684 scopus 로고    scopus 로고
    • Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
    • Tentori L, Leonetti C, Scarsella M, et al. Systemic administration of GPI 15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin Cancer Res 2003;9:5370-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 5370-5379
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3
  • 42
    • 33644675410 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft
    • Cheng CL, Johnson SP, Keir ST, et al. Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft. Mol Cancer Ther 2005;4:1364-8.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1364-1368
    • Cheng, C.L.1    Johnson, S.P.2    Keir, S.T.3
  • 43
    • 28544451260 scopus 로고    scopus 로고
    • First in human phase I trial of the PARP inhibitor AG-014699 with temozolomide (TMZ) in patients (pts) with advanced solid tumors
    • Plummer R, Middleton M, Wilson R, et al. First in human phase I trial of the PARP inhibitor AG-014699 with temozolomide (TMZ) in patients (pts) with advanced solid tumors. J Clin Oncol 2005;23:208S.
    • (2005) J Clin Oncol , vol.23
    • Plummer, R.1    Middleton, M.2    Wilson, R.3
  • 44
    • 35148894301 scopus 로고    scopus 로고
    • First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM)
    • Plummer R, Lorigan P, Evans J, et al. First and final report of a phase II study of the poly(ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM). J Clin Oncol 2006;24:8013.
    • (2006) J Clin Oncol , vol.24 , pp. 8013
    • Plummer, R.1    Lorigan, P.2    Evans, J.3
  • 45
    • 12144291692 scopus 로고    scopus 로고
    • Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide
    • Hegi ME, Diserens AC, Godard S, et al. Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. Clin Cancer Res 2004;10:1871- 4.
    • (2004) Clin Cancer Res , vol.10 , pp. 1871-1874
    • Hegi, M.E.1    Diserens, A.C.2    Godard, S.3
  • 46
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352:997-1003.
    • (2005) N Engl J Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 47
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987-96.
    • (2005) N Engl J Med , vol.352 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    van den Bent, M.J.3
  • 48
    • 19444386117 scopus 로고    scopus 로고
    • Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors
    • Tentori L, Leonetti C, Scarsella M, et al. Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors. Int J Oncol 2005;26:415-22.
    • (2005) Int J Oncol , vol.26 , pp. 415-422
    • Tentori, L.1    Leonetti, C.2    Scarsella, M.3
  • 49
    • 0036793612 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells
    • Tentori L, Portarena I, Torino F, Scerrati M, Navarra P, Graziani G. Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells. Glia 2002;40:44-54.
    • (2002) Glia , vol.40 , pp. 44-54
    • Tentori, L.1    Portarena, I.2    Torino, F.3    Scerrati, M.4    Navarra, P.5    Graziani, G.6
  • 50
    • 10744226451 scopus 로고    scopus 로고
    • Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
    • Calabrese CR, Almassy R, Barton S, et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. J Natl Cancer Inst 2004;96:56-67.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 56-67
    • Calabrese, C.R.1    Almassy, R.2    Barton, S.3
  • 51
    • 34249024488 scopus 로고    scopus 로고
    • Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of a small molecule inhibitor of poly ADP-ribose polymerase (PARP), KU-0059436 (Ku) in patients (p) with advanced tumours
    • Fong P, Spicer J, Reade S, et al. Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of a small molecule inhibitor of poly ADP-ribose polymerase (PARP), KU-0059436 (Ku) in patients (p) with advanced tumours. J Clin Oncol 2006;24:3022.
    • (2006) J Clin Oncol , vol.24 , pp. 3022
    • Fong, P.1    Spicer, J.2    Reade, S.3
  • 52
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
    • McCabe N, Turner NC, Lord CJ, et al. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res 2006;66:8109-15.
    • (2006) Cancer Res , vol.66 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3
  • 53
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of BRCA-ness in sporadic cancer
    • Turner N, Tutt A, Ashworth A. Hallmarks of BRCA-ness in sporadic cancer. Nat Rev Cancer 2004;4:814-9.
    • (2004) Nat Rev Cancer , vol.4 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 54
    • 33745876586 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase in cancer
    • Plummer ER. Inhibition of poly(ADP-ribose) polymerase in cancer. Curr Opin Pharmacol 2006;6:364-8.
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 364-368
    • Plummer, E.R.1
  • 55
    • 33947380240 scopus 로고    scopus 로고
    • Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology
    • Ratman K, Low J. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. Clin Cancer Res 2007;13:1383-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 1383-1388
    • Ratman, K.1    Low, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.