Brain distribution and efficacy as chemosensitizer of an oral formulation of PARP-1 inhibitor GPI 15427 in experimental models of CNS tumors.

International journal of oncology

Volumn 26, Issue 2, 2005, Pages 415-422

  Tentori, Lucio ^a   Leonetti, Carlo ^a   Scarsella, Marco ^a   Vergati, Matteo ^a   Xu, Weizheng ^a   Calvin, David ^a   Morgan, Lisa ^a   Tang, Zhaocheng ^a   Woznizk, Krystyna ^a   Alemu, Christina ^a   Hoover, Randall ^a   Lapidus, Rena ^a   Zhang, Jie ^a   Graziani, Grazia ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DACARBAZINE; DRUG DERIVATIVE; ENZYME INHIBITOR; GPI 15427; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ORGANIC COMPOUND; TEMOZOLOMIDE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD BRAIN BARRIER; BRAIN; C57BL MOUSE; CANCER TRANSPLANTATION; CELL CYCLE G2 PHASE; CENTRAL NERVOUS SYSTEM TUMOR; DISEASE MODEL; DRUG EFFECT; EXPERIMENTAL MELANOMA; FLOW CYTOMETRY; HUMAN; IC 50; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MOUSE; ORAL DRUG ADMINISTRATION; RAT; SPRAGUE DAWLEY RAT; TIME; TUMOR CELL LINE;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; BRAIN; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM NEOPLASMS; CHROMATOGRAPHY, LIQUID; DACARBAZINE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FLOW CYTOMETRY; G2 PHASE; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MASS SPECTROMETRY; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; ORGANIC CHEMICALS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

MLCS; MLOWN;

EID: 19444386117     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.26.2.415     Document Type: Article

References (0)