-
1
-
-
0002160618
-
Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme
-
Chambon P, Weill JD, Mandel P. Nicotinamide mononucleotide activation of a new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. Biochem Biophys Res Commun 1963;11:39-43.
-
(1963)
Biochem Biophys Res Commun
, vol.11
, pp. 39-43
-
-
Chambon, P.1
Weill, J.D.2
Mandel, P.3
-
2
-
-
27644577665
-
In silico characterization of the family of PARP-like poly(ADP-ribosyl) transferases (pARTs)
-
Otto H, Reche PA, Bazan F, Dittmar K, Haag F, Koch-Nolte F. In silico characterization of the family of PARP-like poly(ADP-ribosyl) transferases (pARTs). BMC Genomics 2005;6:139.
-
(2005)
BMC Genomics
, vol.6
, pp. 139
-
-
Otto, H.1
Reche, P.A.2
Bazan, F.3
Dittmar, K.4
Haag, F.5
Koch-Nolte, F.6
-
3
-
-
0040984333
-
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
-
de Murcia JM, Niedergang C, Trucco C, et al. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A 1997;94:7303-7.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 7303-7307
-
-
de Murcia, J.M.1
Niedergang, C.2
Trucco, C.3
-
4
-
-
0034109623
-
The response of Parp knockout mice against DNA damaging agents
-
Masutani M, Nozaki T, Nakamoto K, et al. The response of Parp knockout mice against DNA damaging agents. Mutat Res 2000;462:159-66.
-
(2000)
Mutat Res
, vol.462
, pp. 159-166
-
-
Masutani, M.1
Nozaki, T.2
Nakamoto, K.3
-
5
-
-
0028922462
-
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease
-
Wang ZQ, Auer B, Stingl L, et al. Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 1995; 9:509-20.
-
(1995)
Genes Dev
, vol.9
, pp. 509-520
-
-
Wang, Z.Q.1
Auer, B.2
Stingl, L.3
-
6
-
-
0038219534
-
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse
-
de Murcia JM, Ricoul M, Tartier L, et al. Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J 2003;22:2255-63.
-
(2003)
EMBO J
, vol.22
, pp. 2255-2263
-
-
de Murcia, J.M.1
Ricoul, M.2
Tartier, L.3
-
7
-
-
0033580856
-
PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase
-
Ame JC, Rolli V, Schreiber V, et al. PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 1999;274:17860-8.
-
(1999)
J Biol Chem
, vol.274
, pp. 17860-17868
-
-
Ame, J.C.1
Rolli, V.2
Schreiber, V.3
-
8
-
-
0037151051
-
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1
-
Schreiber V, Ame JC, Dolle P, et al. Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem 2002;277:23028-36.
-
(2002)
J Biol Chem
, vol.277
, pp. 23028-23036
-
-
Schreiber, V.1
Ame, J.C.2
Dolle, P.3
-
9
-
-
0033135769
-
A human poly(ADP-ribose) polymerase gene family (ADPRTL): CDNA cloning of two novel poly(ADP-ribose) polymerase homologues
-
Johansson M. A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. Genomics 1999;57:442-5.
-
(1999)
Genomics
, vol.57
, pp. 442-445
-
-
Johansson, M.1
-
10
-
-
0037067317
-
Mediation of poly(ADP-ribose) polymerase-1 -dependent cell death by apoptosis-inducing factor
-
Yu SW, Wang H, Poitras MF, et al. Mediation of poly(ADP-ribose) polymerase-1 -dependent cell death by apoptosis-inducing factor. Science 2002; 297:259-63.
-
(2002)
Science
, vol.297
, pp. 259-263
-
-
Yu, S.W.1
Wang, H.2
Poitras, M.F.3
-
11
-
-
33744475759
-
Control of AlF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage
-
Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P. Control of AlF-mediated cell death by the functional interplay of SIRT1 and PARP-1 in response to DNA damage. Cell Cycle 2006;5:873-7.
-
(2006)
Cell Cycle
, vol.5
, pp. 873-877
-
-
Kolthur-Seetharam, U.1
Dantzer, F.2
McBurney, M.W.3
de Murcia, G.4
Sassone-Corsi, P.5
-
12
-
-
0034760530
-
Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: Implications for apoptosis
-
D'Amours D, Sallmann FR, Dixit VM, Poirier GG. Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J Cell Sci 2001;114:3771-8.
-
(2001)
J Cell Sci
, vol.114
, pp. 3771-3778
-
-
D'Amours, D.1
Sallmann, F.R.2
Dixit, V.M.3
Poirier, G.G.4
-
13
-
-
18544384491
-
Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: Where and when?
-
Bonicalzi ME, Haince JF, Droit A, Poirier GG. Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when? Cell Mol Life Sci 2005;62:739-50.
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 739-750
-
-
Bonicalzi, M.E.1
Haince, J.F.2
Droit, A.3
Poirier, G.G.4
-
14
-
-
0021339860
-
ADP-ribosyl protein lyase. Purification, properties, and identification of the product
-
Oka J, Ueda K, Hayaishi O, Komura H, Nakanishi K. ADP-ribosyl protein lyase. Purification, properties, and identification of the product. J Biol Chem 1984;259: 986-95.
-
(1984)
J Biol Chem
, vol.259
, pp. 986-995
-
-
Oka, J.1
Ueda, K.2
Hayaishi, O.3
Komura, H.4
Nakanishi, K.5
-
15
-
-
0344875495
-
Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination
-
Schultz N, Lopez E, Saleh-Gohari N, Helleday T. Poly(ADP-ribose) polymerase (PARP-1) has a controlling role in homologous recombination. Nucleic Acids Res 2003;31:4959-64.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 4959-4964
-
-
Schultz, N.1
Lopez, E.2
Saleh-Gohari, N.3
Helleday, T.4
-
16
-
-
2342524565
-
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks
-
Yang YG, Cortes U, Patnaik S, Jasin M, Wang ZQ. Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene 2004;23:3872-82.
-
(2004)
Oncogene
, vol.23
, pp. 3872-3882
-
-
Yang, Y.G.1
Cortes, U.2
Patnaik, S.3
Jasin, M.4
Wang, Z.Q.5
-
17
-
-
0032486256
-
Stimulation of the DNA-dependent protein kinase by poly(-ADP-ribose) polymerase
-
Ruscetti T, Lehnert BE, Halbrook J, et al. Stimulation of the DNA-dependent protein kinase by poly(-ADP-ribose) polymerase. J Biol Chem 1998;273: 14461-7.
-
(1998)
J Biol Chem
, vol.273
, pp. 14461-14467
-
-
Ruscetti, T.1
Lehnert, B.E.2
Halbrook, J.3
-
18
-
-
0033575278
-
Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences
-
Galande S, Kohwi-Shigematsu T. Poly(ADP-ribose) polymerase and Ku autoantigen form a complex and synergistically bind to matrix attachment sequences. J Biol Chem 1999;274:20521-8.
-
(1999)
J Biol Chem
, vol.274
, pp. 20521-20528
-
-
Galande, S.1
Kohwi-Shigematsu, T.2
-
19
-
-
0036894745
-
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation
-
Tong WM, Cortes U, Hande MP, et al. Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res 2002;62:6990-6.
-
(2002)
Cancer Res
, vol.62
, pp. 6990-6996
-
-
Tong, W.M.1
Cortes, U.2
Hande, M.P.3
-
20
-
-
33645532464
-
Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
-
Bryant HE, Helleday T. Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res 2006;34:1685-91.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1685-1691
-
-
Bryant, H.E.1
Helleday, T.2
-
21
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005;434:917-21.
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
-
22
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant HE, Schultz N, Thomas HD, et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005;434:913-7.
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
-
23
-
-
28544433970
-
Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy
-
Hay T, Jenkins H, Sansom OJ, Martin NM, Smith GC, Clarke AR. Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy. Cancer Res 2005;65:10145-8.
-
(2005)
Cancer Res
, vol.65
, pp. 10145-10148
-
-
Hay, T.1
Jenkins, H.2
Sansom, O.J.3
Martin, N.M.4
Smith, G.C.5
Clarke, A.R.6
-
24
-
-
11244280890
-
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
-
Audebert M, Salles B, Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem 2004;279:55117-26.
-
(2004)
J Biol Chem
, vol.279
, pp. 55117-55126
-
-
Audebert, M.1
Salles, B.2
Calsou, P.3
-
25
-
-
3242891383
-
PARP-1, PARP-2, and ATM in the DNA damage response: Functional synergy in mouse development
-
Huber A, Bai P, de Murcia JM, de Murcia G. PARP-1, PARP-2, and ATM in the DNA damage response: functional synergy in mouse development. DNA Repair (Amst) 2004;3:1103-8.
-
(2004)
DNA Repair (Amst)
, vol.3
, pp. 1103-1108
-
-
Huber, A.1
Bai, P.2
de Murcia, J.M.3
de Murcia, G.4
-
26
-
-
0025770287
-
Enhanced expression of poly (ADP-ribose) synthetase gene in malignant lymphoma
-
Tomoda T, Kurashige T, Moriki T, Yamamoto H, Fujimoto S, Taniguchi T. Enhanced expression of poly (ADP-ribose) synthetase gene in malignant lymphoma. Am J Hematol 1991;37:223-7.
-
(1991)
Am J Hematol
, vol.37
, pp. 223-227
-
-
Tomoda, T.1
Kurashige, T.2
Moriki, T.3
Yamamoto, H.4
Fujimoto, S.5
Taniguchi, T.6
-
27
-
-
0035029463
-
Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma
-
Shiobara M, Miyazaki M, Ito H, et al. Enhanced polyadenosine diphosphate-ribosylation in cirrhotic liver and carcinoma tissues in patients with hepatocellular carcinoma. J Gastroenterol Hepatol 2001;16:338-44.
-
(2001)
J Gastroenterol Hepatol
, vol.16
, pp. 338-344
-
-
Shiobara, M.1
Miyazaki, M.2
Ito, H.3
-
28
-
-
0019788529
-
Poly(ADP-ribose) synthesis in human cervical cancer cell-diagnostic cytological usefulness
-
Fukushima M, Kuzuya K, Ota K, Ikai K. Poly(ADP-ribose) synthesis in human cervical cancer cell-diagnostic cytological usefulness. Cancer Lett 1981;14:227-36.
-
(1981)
Cancer Lett
, vol.14
, pp. 227-236
-
-
Fukushima, M.1
Kuzuya, K.2
Ota, K.3
Ikai, K.4
-
29
-
-
0025013226
-
New targets for cancer chemotherapypoly(ADP-ribosylation) processing and polyisoprene metabolism
-
Alderson T. New targets for cancer chemotherapypoly(ADP-ribosylation) processing and polyisoprene metabolism. Biol Rev Camb Philos Soc 1990;65: 623-41.
-
(1990)
Biol Rev Camb Philos Soc
, vol.65
, pp. 623-641
-
-
Alderson, T.1
-
30
-
-
0019151522
-
ADP-ribosylation of nuclear proteins in normal lymphocytes and in low-grade malignant non-Hodgkin lymphoma cells
-
Wielckens K, Garbrecht M, Kittler M, Hilz H. ADP-ribosylation of nuclear proteins in normal lymphocytes and in low-grade malignant non-Hodgkin lymphoma cells. Eur J Biochem 1980;104:279-87.
-
(1980)
Eur J Biochem
, vol.104
, pp. 279-287
-
-
Wielckens, K.1
Garbrecht, M.2
Kittler, M.3
Hilz, H.4
-
31
-
-
0018149712
-
Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes
-
Berger NA, Adams JW, Sikorski GW, Petzold SJ, Shearer WT. Synthesis of DNA and poly(adenosine diphosphate ribose) in normal and chronic lymphocytic leukemia lymphocytes. J Clin Invest 1978;62:111-8.
-
(1978)
J Clin Invest
, vol.62
, pp. 111-118
-
-
Berger, N.A.1
Adams, J.W.2
Sikorski, G.W.3
Petzold, S.J.4
Shearer, W.T.5
-
32
-
-
0020621890
-
Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers
-
Hirai K, Ueda K, Hayaishi O. Aberration of poly(adenosine diphosphate-ribose) metabolism in human colon adenomatous polyps and cancers. Cancer Res 1983;43:3441-6.
-
(1983)
Cancer Res
, vol.43
, pp. 3441-3446
-
-
Hirai, K.1
Ueda, K.2
Hayaishi, O.3
-
33
-
-
33744952644
-
In prostate cancer cells the interaction of C/EBPα with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage
-
Yin H, Glass J. In prostate cancer cells the interaction of C/EBPα with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage. J Biol Chem 2006;281:11496-505.
-
(2006)
J Biol Chem
, vol.281
, pp. 11496-11505
-
-
Yin, H.1
Glass, J.2
-
34
-
-
33745288540
-
Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis
-
Martin-Oliva D, Aguilar-Quesada R, O'Valle F, et al. Inhibition of poly(ADP-ribose) polymerase modulates tumor-related gene expression, including hypoxia-inducible factor-1 activation, during skin carcinogenesis. Cancer Res 2006;66:5744-56.
-
(2006)
Cancer Res
, vol.66
, pp. 5744-5756
-
-
Martin-Oliva, D.1
Aguilar-Quesada, R.2
O'Valle, F.3
-
35
-
-
10644234769
-
The role of hypoxia-induced factors in tumor progression
-
Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 2004;9 Suppl 5:10-7.
-
(2004)
Oncologist
, vol.9
, Issue.SUPPL. 5
, pp. 10-17
-
-
Vaupel, P.1
-
37
-
-
0015244123
-
Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5′-methyl nicotinamide
-
Clark JB, Ferris GM, Pinder S. Inhibition of nuclear NAD nucleosidase and poly ADP-ribose polymerase activity from rat liver by nicotinamide and 5′-methyl nicotinamide. Biochim Biophys Acta 1971;238:82-5.
-
(1971)
Biochim Biophys Acta
, vol.238
, pp. 82-85
-
-
Clark, J.B.1
Ferris, G.M.2
Pinder, S.3
-
38
-
-
0024554229
-
Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo
-
Rankin PW, Jacobson EL, Benjamin RC, Moss J, Jacobson MK. Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo. J Biol Chem 1989;264:4312-7.
-
(1989)
J Biol Chem
, vol.264
, pp. 4312-4317
-
-
Rankin, P.W.1
Jacobson, E.L.2
Benjamin, R.C.3
Moss, J.4
Jacobson, M.K.5
-
39
-
-
12444276597
-
Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies
-
Calabrese CR, Batey MA, Thomas HD, et al. Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies. Clin Cancer Res 2003;9:2711-8.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2711-2718
-
-
Calabrese, C.R.1
Batey, M.A.2
Thomas, H.D.3
-
40
-
-
30344446655
-
Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors
-
Tao M, Park CH, Bihovsky R, et al. Synthesis and structure-activity relationships of novel poly(ADP-ribose) polymerase-1 inhibitors. Bioorg Med Chem Lett 2006;16:938-42.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 938-942
-
-
Tao, M.1
Park, C.H.2
Bihovsky, R.3
-
41
-
-
20244389572
-
Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase
-
Loh VM, Jr., Cockcroft XL, Dillon KJ, et al. Phthalazinones. Part 1: the design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase. Bioorg Med Chem Lett 2005;15:2235-8.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 2235-2238
-
-
Loh Jr., V.M.1
Cockcroft, X.L.2
Dillon, K.J.3
-
42
-
-
30344439130
-
Phthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase
-
Cockcroft XL, Dillon KJ, Dixon L, et al. Phthalazinones 2: optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase. Bioorg Med Chem Lett 2006;16:1040-4.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 1040-1044
-
-
Cockcroft, X.L.1
Dillon, K.J.2
Dixon, L.3
-
43
-
-
0037239590
-
Poly(ADP-ribose) polymerase inhibitors
-
Southan GJ, Szabo C. Poly(ADP-ribose) polymerase inhibitors. Curr Med Chem 2003;10:321-40.
-
(2003)
Curr Med Chem
, vol.10
, pp. 321-340
-
-
Southan, G.J.1
Szabo, C.2
-
44
-
-
0034733694
-
Base excision repair in yeast and mammals
-
Memisoglu A, Samson L. Base excision repair in yeast and mammals. Mutat Res 2000;451:39-51.
-
(2000)
Mutat Res
, vol.451
, pp. 39-51
-
-
Memisoglu, A.1
Samson, L.2
-
45
-
-
10744233628
-
Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells
-
Curtin NJ, Wang LZ, Yiakouvaki A, et al. Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. Clin Cancer Res 2004;10:881-9.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 881-889
-
-
Curtin, N.J.1
Wang, L.Z.2
Yiakouvaki, A.3
-
46
-
-
0242588748
-
Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor
-
Miknyoczki SJ, Jones-Bolin S, Pritchard S, et al. Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor. Mol Cancer Ther 2003;2:371-82.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 371-382
-
-
Miknyoczki, S.J.1
Jones-Bolin, S.2
Pritchard, S.3
-
47
-
-
33746154897
-
Poly(-ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells
-
Nguewa PA, Fuertes MA, Cepeda V, et al. Poly(-ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells. Med Chem 2006;2:47-53.
-
(2006)
Med Chem
, vol.2
, pp. 47-53
-
-
Nguewa, P.A.1
Fuertes, M.A.2
Cepeda, V.3
-
48
-
-
0037220314
-
Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor
-
Tentori L, Portarena I, Barbarino M, et al. Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor. Mol Pharmacol 2003;63:192-202.
-
(2003)
Mol Pharmacol
, vol.63
, pp. 192-202
-
-
Tentori, L.1
Portarena, I.2
Barbarino, M.3
-
49
-
-
10744226451
-
Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361
-
Calabrese CR, Almassy R, Barton S, et al. Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361. J Natl Cancer Inst 2004;96:56-67.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 56-67
-
-
Calabrese, C.R.1
Almassy, R.2
Barton, S.3
-
50
-
-
0031762817
-
Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064
-
Bowman KJ, White A, Golding BT, Griffin RJ, Curtin NJ. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br J Cancer 1998;78:1269-77.
-
(1998)
Br J Cancer
, vol.78
, pp. 1269-1277
-
-
Bowman, K.J.1
White, A.2
Golding, B.T.3
Griffin, R.J.4
Curtin, N.J.5
-
51
-
-
0942300650
-
PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation
-
Chalmers A, Johnston P, Woodcock M, Joiner M, Marples B. PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation. Int J Radiat Oncol Biol Phys 2004;58:410-9.
-
(2004)
Int J Radiat Oncol Biol Phys
, vol.58
, pp. 410-419
-
-
Chalmers, A.1
Johnston, P.2
Woodcock, M.3
Joiner, M.4
Marples, B.5
-
52
-
-
33645469913
-
Radiosensitization by the poly (ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis
-
Noel G, Godon C, Fernet M, Giocanti N, Megnin-Chanet F, Favaudon V. Radiosensitization by the poly (ADP-ribose) polymerase inhibitor 4-amino-1,8-naphthalimide is specific of the S phase of the cell cycle and involves arrest of DNA synthesis. Mol Cancer Ther 2006;5:564-74.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 564-574
-
-
Noel, G.1
Godon, C.2
Fernet, M.3
Giocanti, N.4
Megnin-Chanet, F.5
Favaudon, V.6
-
53
-
-
1242271229
-
Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase
-
Brock WA, Milas L, Bergh S, Lo R, Szabo C, Mason KA. Radiosensitization of human and rodent cell lines by INO-1001, a novel inhibitor of poly(ADP-ribose) polymerase. Cancer Lett 2004;205:155-60.
-
(2004)
Cancer Lett
, vol.205
, pp. 155-160
-
-
Brock, W.A.1
Milas, L.2
Bergh, S.3
Lo, R.4
Szabo, C.5
Mason, K.A.6
-
54
-
-
0033637826
-
Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation
-
Fernet M, Ponette V, Deniaud-Alexandre E, et al. Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation. Int J Radiat Biol 2000;76:1621-9.
-
(2000)
Int J Radiat Biol
, vol.76
, pp. 1621-1629
-
-
Fernet, M.1
Ponette, V.2
Deniaud-Alexandre, E.3
-
55
-
-
0141619287
-
Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1
-
Veuger SJ, Curtin NJ, Richardson CJ, Smith GC, Durkacz BW. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res 2003;63:6008-15.
-
(2003)
Cancer Res
, vol.63
, pp. 6008-6015
-
-
Veuger, S.J.1
Curtin, N.J.2
Richardson, C.J.3
Smith, G.C.4
Durkacz, B.W.5
-
56
-
-
0032938458
-
Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage
-
Boulton S, Kyle S, Durkacz BW. Interactive effects of inhibitors of poly(ADP-ribose) polymerase and DNA-dependent protein kinase on cellular responses to DNA damage. Carcinogenesis 1999;20:199-203.
-
(1999)
Carcinogenesis
, vol.20
, pp. 199-203
-
-
Boulton, S.1
Kyle, S.2
Durkacz, B.W.3
-
57
-
-
25144432400
-
Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition
-
Gallmeier E, Kern SE. Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition. Cancer Biol Ther 2005;4:703-6.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 703-706
-
-
Gallmeier, E.1
Kern, S.E.2
-
58
-
-
27744568392
-
BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: An issue of potency
-
McCabe N, Lord CJ, Tutt AN, Martin NM, Smith GC, Ashworth A. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly (ADP-ribose) polymerase: an issue of potency. Cancer Biol Ther 2005;4:934-6.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 934-936
-
-
McCabe, N.1
Lord, C.J.2
Tutt, A.N.3
Martin, N.M.4
Smith, G.C.5
Ashworth, A.6
-
59
-
-
33748073782
-
Targeting the double-strand DNA break repair pathway as a therapeutic strategy
-
Lord CJ, Garrett MD, Ashworth A. Targeting the double-strand DNA break repair pathway as a therapeutic strategy. Clin Cancer Res 2006;12: 4463-8.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4463-4468
-
-
Lord, C.J.1
Garrett, M.D.2
Ashworth, A.3
-
60
-
-
28544451260
-
First in human phase I trial of the PARP inhibitor AG-014699 with temozolomide (TMZ) in patients (pts) with advanced solid tumors
-
Plummer R, Middleton M, Wilson R, et al. First in human phase I trial of the PARP inhibitor AG-014699 with temozolomide (TMZ) in patients (pts) with advanced solid tumors. Proc Am Soc Clin Oncol 2005; 24:A3065.
-
(2005)
Proc Am Soc Clin Oncol
, vol.24
-
-
Plummer, R.1
Middleton, M.2
Wilson, R.3
-
61
-
-
33947384930
-
Population pharmacokinetic/ pharmacodynamic (PK/PD) modeling of AG-014447, a poly(ADP-ribose)polymerase (PARP) inhibitor, in cancer patients (pts)
-
Sam WJ, Amantea M, Houk B, et al. Population pharmacokinetic/ pharmacodynamic (PK/PD) modeling of AG-014447, a poly(ADP-ribose)polymerase (PARP) inhibitor, in cancer patients (pts). Proc Am Assoc Cancer Res 2006;47:A2914.
-
(2006)
Proc Am Assoc Cancer Res
, vol.47
-
-
Sam, W.J.1
Amantea, M.2
Houk, B.3
-
62
-
-
35148894301
-
First and final report of a phase II study of the poly (ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM)
-
Plummer R, Lorigan P, Evans J, et al. First and final report of a phase II study of the poly (ADP-ribose) polymerase (PARP) inhibitor, AG014699, in combination with temozolomide (TMZ) in patients with metastatic malignant melanoma (MM). Proc Am Soc Clin Oncol 2006;25:A8013.
-
(2006)
Proc Am Soc Clin Oncol
, vol.25
-
-
Plummer, R.1
Lorigan, P.2
Evans, J.3
-
63
-
-
34249024488
-
Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of a small molecule inhibitor of poly ADP-ribose polymerase (PARP), KU-0059436 (Ku) in patients (p) with advanced tumours
-
Fong PC, Spicer J, Reade S, et al. Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of a small molecule inhibitor of poly ADP-ribose polymerase (PARP), KU-0059436 (Ku) in patients (p) with advanced tumours. Proc Am Soc Clin Oncol 2006;25:A3022.
-
(2006)
Proc Am Soc Clin Oncol
, vol.25
-
-
Fong, P.C.1
Spicer, J.2
Reade, S.3
-
64
-
-
33947413472
-
Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of an oral small molecule inhibitor of poly ADP-ribose polymerase (PARP), Ku in patients (p) with advanced tumors
-
de Bono JS, Fong PC, Boss D, et al. Phase I pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of an oral small molecule inhibitor of poly ADP-ribose polymerase (PARP), Ku in patients (p) with advanced tumors. Prague (Czech Republic): 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics; 2006. p. 153.
-
(2006)
Prague (Czech Republic): 18th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
, pp. 153
-
-
de Bono, J.S.1
Fong, P.C.2
Boss, D.3
-
65
-
-
33846504444
-
Compressing drug development timelines in oncology using phase '0' trials
-
Kummar S, Kinders RJ, Rubinstein L, et al. Compressing drug development timelines in oncology using phase '0' trials. Nature Reviews: Cancer 2007;7: 131-9.
-
(2007)
Nature Reviews: Cancer
, vol.7
, pp. 131-139
-
-
Kummar, S.1
Kinders, R.J.2
Rubinstein, L.3
-
66
-
-
35148872024
-
Evaluation of tolerability, safety, and pharmacokinetics of INO-1001 plus temozolomide (TMZ) in patients with unresectable stage III/IV melanoma
-
Proc Am Soc Clin Oncol
-
Wang C, Bedikian A, Kim K, Papadopoulos N, Hwu W, Hwu P. Evaluation of tolerability, safety, and pharmacokinetics of INO-1001 plus temozolomide (TMZ) in patients with unresectable stage III/IV melanoma. Proc Am Soc Clin Oncol 2006;. Proc Am Soc Clin Oncol 2006;25:A12015.
-
(2006)
Proc Am Soc Clin Oncol
, vol.25
-
-
Wang, C.1
Bedikian, A.2
Kim, K.3
Papadopoulos, N.4
Hwu, W.5
Hwu, P.6
-
67
-
-
33947379595
-
PARP inhibitors enhance the effect of cisplatin against tumors and ameliorate cisplatin-induced neuropathy
-
Lapidus RG, Xu W, Spicer E, Hoover R, Zhang J. PARP inhibitors enhance the effect of cisplatin against tumors and ameliorate cisplatin-induced neuropathy. Proc Am Assoc Cancer Res 2006;47:A2141.
-
(2006)
Proc Am Assoc Cancer Res
, vol.47
-
-
Lapidus, R.G.1
Xu, W.2
Spicer, E.3
Hoover, R.4
Zhang, J.5
-
68
-
-
10744233684
-
Systemic administration of GPI15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma
-
Tentori L, Leonetti C, Scarsella M, et al. Systemic administration of GPI15427, a novel poly(ADP-ribose) polymerase-1 inhibitor, increases the antitumor activity of temozolomide against intracranial melanoma, glioma, lymphoma. Clin Cancer Res 2003;9:5370-9.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5370-5379
-
-
Tentori, L.1
Leonetti, C.2
Scarsella, M.3
-
69
-
-
0037087592
-
BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity
-
Racz I, Tory K, Gallyas F, Jr., et al. BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity. Biochem Pharmacol 2002;63:1099-111.
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 1099-1111
-
-
Racz, I.1
Tory, K.2
Gallyas Jr., F.3
-
70
-
-
33644861815
-
Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure
-
Pacher P, Liaudet L, Mabley JG, Cziraki A, Hasko G, Szabo C. Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure. Int J Mol Med 2006;17:369-75.
-
(2006)
Int J Mol Med
, vol.17
, pp. 369-375
-
-
Pacher, P.1
Liaudet, L.2
Mabley, J.G.3
Cziraki, A.4
Hasko, G.5
Szabo, C.6
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