Poly ADP-ribosylation: A DNA break signal mechanism

Molecular and Cellular Biochemistry

Volumn 193, Issue 1-2, 1999, Pages 5-11

  Althaus, Felix R ^a   Kleczowska, Hanna E ^a   Malanga, Maria ^a   Müntener, Cedric R ^a   Pleschke, Jutta M ^a   Ebner, Maria ^b   Auer, Bernhard ^b  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

MARCKS protein; P53 protein; PARP knockout mice; Poly(ADP ribose) binding proteins; Poly(ADP ribose)polymerase

Indexed keywords

ACTIN BINDING PROTEIN; BINDING PROTEIN; CYTOSKELETON PROTEIN; DNA; MARCKS PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYMER; PROTEIN P53; SIGNAL PEPTIDE;

AMINO ACID SEQUENCE; APOPTOSIS; BINDING SITE; CELL SURVIVAL; CONFERENCE PAPER; DNA NICK TRANSLATION; DNA STRAND BREAKAGE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENOTOXICITY; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; SISTER CHROMATID EXCHANGE; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 0032939088     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-1-4419-8740-2_1     Document Type: Conference Paper

References (28)

1. Wang ZQ, Auer B, Stingl L, Berghammer H, Haidacher D, Schweiger M, Wagner EF: Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev 9: 509-520, 1997
2. Ménissier-de Murcia J, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Marks M, Oliver FJ, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G: Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 94: 7303-7307, 1997
3. Schreiber V, Hunting D, Trucco C, Gowans B, Grunwald D, de Murcia G, Ménissier-de Murcia J: Dominant-negative mutant of human poly(ADP-ribose)polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage. Proc Natl Acad Sci USA 92: 4753-4757, 1995
4. Lindahl T, Satoh MS, Poirier GG, Klungland A: Posttranslational modification of poly(ADP-ribose)polymerase induced by DNA strand breaks. Trends Biochem Sci 20: 405-411, 1995
5. Althaus FR: Role of poly(ADP-ribose)polymerase in base excision repair. In: J.D. Hickson (ed) Base Excision Repair of DNA Damage. Springer/Landes Bioscience, Austin TX, 1997, pp. 169-181
6. Althaus FR: Poly ADP-ribosylation: A histone shuttle mechanism in DNA excision repair. J Cell Sci 102: 663-670, 1992
7. Mathis G, Althaus FR: Uncoupling of DNA excision repair and nucleosomal unfolding in poly (ADP-ribose)-depleted mammalian cells. Carcinogenesis 13: 135-138, 1990
8. Reed M, Woelker B, Wang P, Anderson MA, Tegtmeyer P: The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc Natl Acad Sci USA 92: 9455-9459, 1995
9. Jackson SP, Jeggo PA: DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK. Trends Biochem Sci 20: 412-415, 1995
10. De Murcia G, Ménissier-de Murcia J: Poly(ADP-ribose)polymerase: A molecular nick sensor. Trends Biochem Sci 19: 172-176, 1994
11. Bargonetti J, Friedman PN, Kern SE, Vogelstein B, Prives C: Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65: 1083-1091, 1991
12. Niewolik D, Vojtesek B, Kovarik J: p53-derived from human tumour cell lines and containing distinct point mutations can be activated to bind its consensus target sequence. Oncogene 10: 881-890, 1995
13. Malanga M, Bachmann S, Panzeter PL, Zweifel B, Althaus FR: Poly(ADP-ribose) quantification at the fentomol level in mammalian cells. Anal Biochem 228: 245-251, 1995
14. Kaiser P, Auer B, Schweiger M: Inhibition of cell proliferation in Saccharomyces cerevisiae by expression of human NAD-ADP-ribosyltransferase requires the DNA binding domain ('zinc finger'). Mol Gen Genet 232: 231-239, 1992
15. Panzeter PL, Zweifel B, Malanga M, Waser SH, Richard MC, Althaus FR: Targeting of histone tails by poly(ADP-ribose). J Biol Chem 268: 17662-17664, 1993
16. Jayaraman L, Prives C: Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81: 1021-1029, 1995
17. Panzeter P, Realini C, Althaus FR: Noncovalent interactions of poly(adenosine diphosphate ribose) with histones. Biochemistry 31: 1379-1385, 1992
18. Malanga M, Pleschke JM, Kleczowska HE, Althaus FR: Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions. J Biol Chem 273: 11839-11843, 1998
19. Bakalkin G, Selivanova G, Yakovleva T, Kiseleva E, Kashuba E, Magnusson KP, Szekely L, Klein G, Terenius L, Wiman KG: p53 binds single-stranded DNA ends through the C-terminal domain and internal DNA segments via the middle domain. Nucleic Acids Res 23: 362-369, 1995
20. Aderem AA: The MARCKS brothers: A family of protein kinase C substrates. Cell 71: 713-716, 1992
21. Hartwig JH, Thelen M, Rosen A, Janmey PA, Naim AC, Aderem AA: MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature 356: 618-622, 1992
22. Shin I, Kam Y, Ha KS, Kang K, Joe CO: Inhibition of the phosphorylation of a myristoylated alanine-rich C kinase substrate by methyl methanesulfonate in cultured MH 3T3 cells. Mutat Res 351: 163-171, 1996
23. Li X, Coffino P: Identification of a region of p53 that confers lability. J Biol Chem 271: 4447-4451, 1996
24. Althaus FR, Richter C: ADP-ribosylation of proteins. Mol Biol Biochem Biophys 37: 1-125, 1987
25. Kleczkowska HE, Althaus FR: Response of human keratinocytes to extremely low concentrations of N-methyl-N′-nitro-N-nitrosoguanidine. Mutat Res 367: 151-159, 1996
26. Wesierska-Gadek J, Bugajaska-Schretter A, Cemi C: ADP-ribosylation of p53 tumor suppressor protein: Mutant but not wild-type p53 is modified. J Cell Biochem 62: 90-101, 1996
27. Mendoza-Alvarez H, Alvarez-Gonzalez R: Poly(ADP-ribose) polymerase is a catalytic dimer and the automodification reaction is intermolecular. J Biol Chem 268: 22575-22580, 1993
28. Panzeter P L, Althaus FR: DNA strand break-mediated partitioning of poly(ADP-ribose)polymerase function. Biochemistry 33: 9600-9605, 1994