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Volumn 213, Issue 2, 2007, Pages 117-130

Sarcomas: Genetics, signalling, and cellular origins. Part 2: TET-independent fusion proteins and receptor tyrosine kinase mutations

Author keywords

Chromosomal translocations; Primary cells of orgin; Sarcoma; Signalling pathways

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; HYBRID PROTEIN; PLATELET DERIVED GROWTH FACTOR B; PROTEIN NTRK3; STEM CELL FACTOR RECEPTOR; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PAX3; TRANSCRIPTION FACTOR PAX7; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

EID: 35348997157     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2208     Document Type: Review
Times cited : (17)

References (140)
  • 1
    • 34548446433 scopus 로고    scopus 로고
    • Sarcomas: Genetics, signalling, and cellular origins. Part 1: The fellowship of TET
    • Riggi N, Cironi L, Suva M-L, Stamenkovic I. Sarcomas: genetics, signalling, and cellular origins. Part 1: The fellowship of TET. J Pathol 2007;213:4-20.
    • (2007) J Pathol , vol.213 , pp. 4-20
    • Riggi, N.1    Cironi, L.2    Suva, M.-L.3    Stamenkovic, I.4
  • 3
    • 0028364374 scopus 로고
    • Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma
    • Davis RJ, D'Cruz CM, Lovell MA, Biegel JA, Barr FG. Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma. Cancer Res 1994;54:2869-2872.
    • (1994) Cancer Res , vol.54 , pp. 2869-2872
    • Davis, R.J.1    D'Cruz, C.M.2    Lovell, M.A.3    Biegel, J.A.4    Barr, F.G.5
  • 4
    • 0028366153 scopus 로고
    • Pax: Genes for mice and men
    • Tremblay P, Gruss P. Pax: genes for mice and men. Pharmacol Ther 1994;61:205-226.
    • (1994) Pharmacol Ther , vol.61 , pp. 205-226
    • Tremblay, P.1    Gruss, P.2
  • 5
    • 0025875226 scopus 로고
    • Pax-3, a novel murine DNA binding protein expressed during early neurogenesis
    • Goulding MD, Chalepakis G, Deutsch U, Erselius JR, Gruss P. Pax-3, a novel murine DNA binding protein expressed during early neurogenesis. EMBO J 1991;10:1135-1147.
    • (1991) EMBO J , vol.10 , pp. 1135-1147
    • Goulding, M.D.1    Chalepakis, G.2    Deutsch, U.3    Erselius, J.R.4    Gruss, P.5
  • 7
    • 0032468024 scopus 로고    scopus 로고
    • The role of Pax3 and Pax7 in development and cancer
    • Mansouri A. The role of Pax3 and Pax7 in development and cancer. Crit Rev Oncog 1998;9:141-149.
    • (1998) Crit Rev Oncog , vol.9 , pp. 141-149
    • Mansouri, A.1
  • 8
    • 0035379646 scopus 로고    scopus 로고
    • Pax3 is essential for skeletal myogenesis and the expression of Six1 and Eya2
    • Ridgeway AG, Skerjanc IS. Pax3 is essential for skeletal myogenesis and the expression of Six1 and Eya2. J Biol Chem 2001;276:19033-19039.
    • (2001) J Biol Chem , vol.276 , pp. 19033-19039
    • Ridgeway, A.G.1    Skerjanc, I.S.2
  • 9
    • 0028356007 scopus 로고
    • PAX3 gene structure and mutations: Close analogies between Waardenburg syndrome and the Splotch mouse
    • Tassabehji M, Newton VE, Leverton K, Turnbull K, Seemanova E, Kunze J, et al. PAX3 gene structure and mutations: close analogies between Waardenburg syndrome and the Splotch mouse. Hum Mol Genet 1994;3:1069-1074.
    • (1994) Hum Mol Genet , vol.3 , pp. 1069-1074
    • Tassabehji, M.1    Newton, V.E.2    Leverton, K.3    Turnbull, K.4    Seemanova, E.5    Kunze, J.6
  • 10
    • 0026602124 scopus 로고
    • Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene
    • Tassabehji M, Read AP, Newton VE, Harris R, Balling R, Gruss P, et al. Waardenburg's syndrome patients have mutations in the human homologue of the Pax-3 paired box gene. Nature 1992;355:635-636.
    • (1992) Nature , vol.355 , pp. 635-636
    • Tassabehji, M.1    Read, A.P.2    Newton, V.E.3    Harris, R.4    Balling, R.5    Gruss, P.6
  • 12
    • 4444235631 scopus 로고    scopus 로고
    • Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification
    • Oustanina S, Hause G, Braun T. Pax7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification. EMBO J 2004;23:3430-3439.
    • (2004) EMBO J , vol.23 , pp. 3430-3439
    • Oustanina, S.1    Hause, G.2    Braun, T.3
  • 13
    • 0029867255 scopus 로고    scopus 로고
    • Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice
    • Mansouri A, Stoykova A, Torres M, Gruss P. Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice. Development 1996;122:831-838.
    • (1996) Development , vol.122 , pp. 831-838
    • Mansouri, A.1    Stoykova, A.2    Torres, M.3    Gruss, P.4
  • 14
    • 2342496712 scopus 로고    scopus 로고
    • FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
    • Accili D, Arden KC. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 2004;117:421-426.
    • (2004) Cell , vol.117 , pp. 421-426
    • Accili, D.1    Arden, K.C.2
  • 15
    • 12144290563 scopus 로고    scopus 로고
    • Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    • Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004;303:2011-2015.
    • (2004) Science , vol.303 , pp. 2011-2015
    • Brunet, A.1    Sweeney, L.B.2    Sturgill, J.F.3    Chua, K.F.4    Greer, P.L.5    Lin, Y.6
  • 16
    • 1342264308 scopus 로고    scopus 로고
    • Mammalian SIRT1 represses forkhead transcription factors
    • Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, et al. Mammalian SIRT1 represses forkhead transcription factors. Cell 2004;116:551-563.
    • (2004) Cell , vol.116 , pp. 551-563
    • Motta, M.C.1    Divecha, N.2    Lemieux, M.3    Kamel, C.4    Chen, D.5    Gu, W.6
  • 17
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 1999;286:1358-1362.
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 19
    • 2442440607 scopus 로고    scopus 로고
    • FoxO: Linking new signaling pathways
    • Arden KC. FoxO: linking new signaling pathways. Mol Cell 2004;14:416-418.
    • (2004) Mol Cell , vol.14 , pp. 416-418
    • Arden, K.C.1
  • 20
    • 0036723650 scopus 로고    scopus 로고
    • So CW, Cleary ML. MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol 2002;22:6542-6552.
    • So CW, Cleary ML. MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol 2002;22:6542-6552.
  • 21
    • 0037438589 scopus 로고    scopus 로고
    • Common mechanism for oncogenic activation of MLL by forkhead family proteins
    • So CW, Cleary ML. Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood 2003;101:633-639.
    • (2003) Blood , vol.101 , pp. 633-639
    • So, C.W.1    Cleary, M.L.2
  • 22
    • 0028881603 scopus 로고
    • The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3
    • Fredericks WJ, Galili N, Mukhopadhyay S, Rovera G, Bennicelli J, Barr FG, et al. The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. Mol Cell Biol 1995;15:1522-1535.
    • (1995) Mol Cell Biol , vol.15 , pp. 1522-1535
    • Fredericks, W.J.1    Galili, N.2    Mukhopadhyay, S.3    Rovera, G.4    Bennicelli, J.5    Barr, F.G.6
  • 23
    • 0033614967 scopus 로고    scopus 로고
    • PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma
    • Bennicelli JL, Advani S, Schafer BW, Barr FG. PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma. Oncogene 1999;18:4348-4356.
    • (1999) Oncogene , vol.18 , pp. 4348-4356
    • Bennicelli, J.L.1    Advani, S.2    Schafer, B.W.3    Barr, F.G.4
  • 24
    • 0033539498 scopus 로고    scopus 로고
    • cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene
    • Khan J, Bittner ML, Saal LH, Teichmann U, Azorsa DO, Gooden GC, et al. cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene. Proc Natl Acad Sci U S A 1999;96:13264-13269.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 13264-13269
    • Khan, J.1    Bittner, M.L.2    Saal, L.H.3    Teichmann, U.4    Azorsa, D.O.5    Gooden, G.C.6
  • 25
    • 0034853327 scopus 로고    scopus 로고
    • PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma
    • Anderson J, Ramsay A, Gould S, Pritchard-Jones K. PAX3-FKHR induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma. Am J Pathol 2001;159:1089-1096.
    • (2001) Am J Pathol , vol.159 , pp. 1089-1096
    • Anderson, J.1    Ramsay, A.2    Gould, S.3    Pritchard-Jones, K.4
  • 26
    • 16244385890 scopus 로고    scopus 로고
    • Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR
    • Begum S, Emani N, Cheung A, Wilkins O, Der S, Hamel PA. Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR. Oncogene 2005;24:1860-1872.
    • (2005) Oncogene , vol.24 , pp. 1860-1872
    • Begum, S.1    Emani, N.2    Cheung, A.3    Wilkins, O.4    Der, S.5    Hamel, P.A.6
  • 27
    • 4644310947 scopus 로고    scopus 로고
    • Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein
    • Xia SJ, Barr FG. Analysis of the transforming and growth suppressive activities of the PAX3-FKHR oncoprotein. Oncogene 2004;23:6864- 6871.
    • (2004) Oncogene , vol.23 , pp. 6864-6871
    • Xia, S.J.1    Barr, F.G.2
  • 28
    • 33746895755 scopus 로고    scopus 로고
    • Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas
    • Davicioni E, Finckenstein FG, Shahbazian V, Buckley JD, Triche TJ, Anderson MJ. Identification of a PAX-FKHR gene expression signature that defines molecular classes and determines the prognosis of alveolar rhabdomyosarcomas. Cancer Res 2006;66:6936-6946.
    • (2006) Cancer Res , vol.66 , pp. 6936-6946
    • Davicioni, E.1    Finckenstein, F.G.2    Shahbazian, V.3    Buckley, J.D.4    Triche, T.J.5    Anderson, M.J.6
  • 30
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 1995;376:768-771.
    • (1995) Nature , vol.376 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 32
    • 0032529257 scopus 로고    scopus 로고
    • Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma
    • Ginsberg JP, Davis RJ, Bennicelli JL, Nauta LE, Barr FG. Up-regulation of MET but not neural cell adhesion molecule expression by the PAX3-FKHR fusion protein in alveolar rhabdomyosarcoma. Cancer Res 1998;58:3542- 3546.
    • (1998) Cancer Res , vol.58 , pp. 3542-3546
    • Ginsberg, J.P.1    Davis, R.J.2    Bennicelli, J.L.3    Nauta, L.E.4    Barr, F.G.5
  • 33
    • 10744231064 scopus 로고    scopus 로고
    • Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy
    • Jankowski K, Kucia M, Wysoczynski M, Reca R, Zhao D, Trzyna E, et al. Both hepatocyte growth factor (HGF) and stromal-derived factor-1 regulate the metastatic behavior of human rhabdomyosarcoma cells, but only HGF enhances their resistance to radiochemotherapy. Cancer Res 2003;63:7926-7935.
    • (2003) Cancer Res , vol.63 , pp. 7926-7935
    • Jankowski, K.1    Kucia, M.2    Wysoczynski, M.3    Reca, R.4    Zhao, D.5    Trzyna, E.6
  • 34
    • 0035856010 scopus 로고    scopus 로고
    • Chemokines and the molecular basis of cancer metastasis
    • Murphy PM. Chemokines and the molecular basis of cancer metastasis. N Engl J Med 2001;345:833-835.
    • (2001) N Engl J Med , vol.345 , pp. 833-835
    • Murphy, P.M.1
  • 35
    • 0036786348 scopus 로고    scopus 로고
    • CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    • Libura J, Drukala J, Majka M, Tomescu O, Navenot JM, Kucia M, et al. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Blood 2002;100:2597-2606.
    • (2002) Blood , vol.100 , pp. 2597-2606
    • Libura, J.1    Drukala, J.2    Majka, M.3    Tomescu, O.4    Navenot, J.M.5    Kucia, M.6
  • 37
    • 0034622048 scopus 로고    scopus 로고
    • Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR
    • Margue CM, Bernasconi M, Barr FG, Schafer BW. Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene 2000;19:2921-2929.
    • (2000) Oncogene , vol.19 , pp. 2921-2929
    • Margue, C.M.1    Bernasconi, M.2    Barr, F.G.3    Schafer, B.W.4
  • 38
    • 0036605806 scopus 로고    scopus 로고
    • PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: A report from the children's oncology group
    • Sorensen PH, Lynch JC, Qualman SJ, Tirabosco R, Lim JF, Maurer HM, et al. PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. J Clin Oncol 2002;20:2672-2679.
    • (2002) J Clin Oncol , vol.20 , pp. 2672-2679
    • Sorensen, P.H.1    Lynch, J.C.2    Qualman, S.J.3    Tirabosco, R.4    Lim, J.F.5    Maurer, H.M.6
  • 39
    • 0036787919 scopus 로고    scopus 로고
    • PAX3-FKHR knock-in mice show developmental aberrations but do not develop tumors
    • Lagutina I, Conway SJ, Sublett J, Grosveld GC. PAX3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Mol Cell Biol 2002;22:7204-7216.
    • (2002) Mol Cell Biol , vol.22 , pp. 7204-7216
    • Lagutina, I.1    Conway, S.J.2    Sublett, J.3    Grosveld, G.C.4
  • 40
    • 7544243041 scopus 로고    scopus 로고
    • Alveolar rhabdomyosarcomas in conditional Pax3 : Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function
    • Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA. Capecchi MR. Alveolar rhabdomyosarcomas in conditional Pax3 : Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev 2004;18:2614-2626.
    • (2004) Genes Dev , vol.18 , pp. 2614-2626
    • Keller, C.1    Arenkiel, B.R.2    Coffin, C.M.3    El-Bardeesy, N.4    DePinho, R.A.5    Capecchi, M.R.6
  • 41
    • 0034703978 scopus 로고    scopus 로고
    • Dedifferentiation of mammalian myotubes induced by msx1
    • Odelberg SJ, Kollhoff A, Keating MT. Dedifferentiation of mammalian myotubes induced by msx1. Cell 2000;103:1099-1109.
    • (2000) Cell , vol.103 , pp. 1099-1109
    • Odelberg, S.J.1    Kollhoff, A.2    Keating, M.T.3
  • 42
    • 33748616037 scopus 로고    scopus 로고
    • A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR
    • Galindo RL, Allport JA, Olson EN. A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR. Proc Natl Acad Sci U S A 2006;103:13439-13444.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 13439-13444
    • Galindo, R.L.1    Allport, J.A.2    Olson, E.N.3
  • 43
    • 0345256334 scopus 로고    scopus 로고
    • Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers
    • Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH. Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers. Oncogene 2003;22:8156-8167.
    • (2003) Oncogene , vol.22 , pp. 8156-8167
    • Perani, M.1    Ingram, C.J.2    Cooper, C.S.3    Garrett, M.D.4    Goodwin, G.H.5
  • 44
    • 18544373716 scopus 로고    scopus 로고
    • SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones
    • Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, et al. SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. J Biol Chem 2002;277:5498-5505.
    • (2002) J Biol Chem , vol.277 , pp. 5498-5505
    • Kato, H.1    Tjernberg, A.2    Zhang, W.3    Krutchinsky, A.N.4    An, W.5    Takeuchi, T.6
  • 46
    • 0036806406 scopus 로고    scopus 로고
    • Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma
    • Sandberg AA, Bridge JA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Synovial sarcoma. Cancer Genet Cytogenet 2002;133:1-23.
    • (2002) Cancer Genet Cytogenet , vol.133 , pp. 1-23
    • Sandberg, A.A.1    Bridge, J.A.2
  • 47
    • 0034664804 scopus 로고    scopus 로고
    • p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion
    • Eid JE, Kung AL, Scully R, Livingston DM. p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. Cell 2000;102:839-848.
    • (2000) Cell , vol.102 , pp. 839-848
    • Eid, J.E.1    Kung, A.L.2    Scully, R.3    Livingston, D.M.4
  • 48
    • 0034978459 scopus 로고    scopus 로고
    • The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10
    • de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, et al. The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. Oncogene 2001;20:3281- 3289.
    • (2001) Oncogene , vol.20 , pp. 3281-3289
    • de Bruijn, D.R.1    dos Santos, N.R.2    Thijssen, J.3    Balemans, M.4    Debernardi, S.5    Linder, B.6
  • 49
    • 0033035247 scopus 로고    scopus 로고
    • Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus
    • Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, et al. Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. Hum Mol Genet 1999;8:585-591.
    • (1999) Hum Mol Genet , vol.8 , pp. 585-591
    • Thaete, C.1    Brett, D.2    Monaghan, P.3    Whitehouse, S.4    Rennie, G.5    Rayner, E.6
  • 50
    • 0030777332 scopus 로고    scopus 로고
    • The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies
    • Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G. The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. Hum Mol Genet 1997;6:1559-1564.
    • (1997) Hum Mol Genet , vol.6 , pp. 1559-1564
    • Brett, D.1    Whitehouse, S.2    Antonson, P.3    Shipley, J.4    Cooper, C.5    Goodwin, G.6
  • 51
    • 0033963941 scopus 로고    scopus 로고
    • SYT-SSX fusion proteins in synovial sarcomas: Detection and characterization with new antibodies
    • Hashimoto N, Araki N, Yoshikawa H, Myoui A, Matsumine A, Kaneko M, et al. SYT-SSX fusion proteins in synovial sarcomas: detection and characterization with new antibodies. Cancer Lett 2000;149:31-36.
    • (2000) Cancer Lett , vol.149 , pp. 31-36
    • Hashimoto, N.1    Araki, N.2    Yoshikawa, H.3    Myoui, A.4    Matsumine, A.5    Kaneko, M.6
  • 52
    • 0036645310 scopus 로고    scopus 로고
    • SYT-SSX is critical for cyclin D1 expression in synovial sarcoma cells: A gain of function of the t(X;18)(p11.2;q11.2) translocation
    • Xie Y, Skytting B, Nilsson G, Gasbarri A, Haslam K, Bartolazzi A, et al. SYT-SSX is critical for cyclin D1 expression in synovial sarcoma cells: a gain of function of the t(X;18)(p11.2;q11.2) translocation. Cancer Res 2002;62:3861-3867.
    • (2002) Cancer Res , vol.62 , pp. 3861-3867
    • Xie, Y.1    Skytting, B.2    Nilsson, G.3    Gasbarri, A.4    Haslam, K.5    Bartolazzi, A.6
  • 53
    • 18744385495 scopus 로고    scopus 로고
    • The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery
    • Xie Y, Skytting B, Nilsson G, Grimer RJ, Mangham CD, Fisher C, et al. The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery. Oncogene 2002;21:5791-5796.
    • (2002) Oncogene , vol.21 , pp. 5791-5796
    • Xie, Y.1    Skytting, B.2    Nilsson, G.3    Grimer, R.J.4    Mangham, C.D.5    Fisher, C.6
  • 54
    • 0035957396 scopus 로고    scopus 로고
    • Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha
    • Nagai M, Tanaka S, Tsuda M, Endo S, Kato H, Sonobe H, et al. Analysis of transforming activity of human synovial sarcoma-associated chimeric protein SYT-SSX1 bound to chromatin remodeling factor hBRM/hSNF2 alpha. Proc Natl Acad Sci U S A 2001;98:3843-3848.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 3843-3848
    • Nagai, M.1    Tanaka, S.2    Tsuda, M.3    Endo, S.4    Kato, H.5    Sonobe, H.6
  • 55
    • 0027230568 scopus 로고
    • Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation
    • May WA, Gishizky ML, Lessnick SL, Lunsford LB, Lewis BC, Delattre O, et al. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc Natl Acad Sci U S A 1993;90:5752-5756.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 5752-5756
    • May, W.A.1    Gishizky, M.L.2    Lessnick, S.L.3    Lunsford, L.B.4    Lewis, B.C.5    Delattre, O.6
  • 56
    • 0035839938 scopus 로고    scopus 로고
    • Biology of EWS/ETS fusions in Ewing's family tumors
    • Arvand A, Denny CT. Biology of EWS/ETS fusions in Ewing's family tumors. Oncogene 2001;20:5747-5754.
    • (2001) Oncogene , vol.20 , pp. 5747-5754
    • Arvand, A.1    Denny, C.T.2
  • 57
    • 0036840271 scopus 로고    scopus 로고
    • Expression profiling of synovial sarcoma by cDNA microarrays: Association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation
    • Allander SV, Illei PB, Chen Y, Antonescu CR, Bittner M, Ladanyi M, et al. Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. Am J Pathol 2002;161:1587-1595.
    • (2002) Am J Pathol , vol.161 , pp. 1587-1595
    • Allander, S.V.1    Illei, P.B.2    Chen, Y.3    Antonescu, C.R.4    Bittner, M.5    Ladanyi, M.6
  • 58
  • 60
    • 33244494390 scopus 로고    scopus 로고
    • IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1
    • Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S. IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Oncogene 2006;25:1042-1052.
    • (2006) Oncogene , vol.25 , pp. 1042-1052
    • Sun, Y.1    Gao, D.2    Liu, Y.3    Huang, J.4    Lessnick, S.5    Tanaka, S.6
  • 61
    • 28544439731 scopus 로고    scopus 로고
    • Induction of p21 (WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1
    • Tsuda M, Watanabe T, Seki T, Kimura T, Sawa H, Minami A, et al. Induction of p21 (WAF1/CIP1) by human synovial sarcoma-associated chimeric oncoprotein SYT-SSX1. Oncogene 2005;24:7984-7990.
    • (2005) Oncogene , vol.24 , pp. 7984-7990
    • Tsuda, M.1    Watanabe, T.2    Seki, T.3    Kimura, T.4    Sawa, H.5    Minami, A.6
  • 62
    • 0036560740 scopus 로고    scopus 로고
    • The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts
    • Lessnick SL, Dacwag CS, Golub TR. The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts. Cancer Cell 2002;1:393-401.
    • (2002) Cancer Cell , vol.1 , pp. 393-401
    • Lessnick, S.L.1    Dacwag, C.S.2    Golub, T.R.3
  • 63
    • 33846908242 scopus 로고    scopus 로고
    • The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma
    • Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, et al. The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma. Mol Cell Biol 2007;27:1348-1355.
    • (2007) Mol Cell Biol , vol.27 , pp. 1348-1355
    • Ishida, M.1    Miyamoto, M.2    Naitoh, S.3    Tatsuda, D.4    Hasegawa, T.5    Nemoto, T.6
  • 65
    • 0029875843 scopus 로고    scopus 로고
    • Translocation, t(17;22) (q22;q13), in dermatofibrosarcoma protuberans: A new tumor-associated chromosome rearrangement
    • Pedeutour F, Simon MP, Minoletti F, Barcelo G, Terrier-Lacombe MJ, Combemale P, et al. Translocation, t(17;22) (q22;q13), in dermatofibrosarcoma protuberans: a new tumor-associated chromosome rearrangement. Cytogenet Cell Genet 1996;72:171-174.
    • (1996) Cytogenet Cell Genet , vol.72 , pp. 171-174
    • Pedeutour, F.1    Simon, M.P.2    Minoletti, F.3    Barcelo, G.4    Terrier-Lacombe, M.J.5    Combemale, P.6
  • 66
    • 0029006919 scopus 로고
    • Ring 22 chromosomes in dermatofibrosarcoma protuberans are low-level amplifiers of chromosome 17 and 22 sequences
    • Pedeutour F, Simon MP, Minoletti F, Sozzi G, Pierotti MA, Hecht F, et al. Ring 22 chromosomes in dermatofibrosarcoma protuberans are low-level amplifiers of chromosome 17 and 22 sequences. Cancer Res 1995;55:2400-2403.
    • (1995) Cancer Res , vol.55 , pp. 2400-2403
    • Pedeutour, F.1    Simon, M.P.2    Minoletti, F.3    Sozzi, G.4    Pierotti, M.A.5    Hecht, F.6
  • 67
    • 0031012850 scopus 로고    scopus 로고
    • Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
    • Simon MP, Pedeutour F, Sirvent N, Grosgeorge J, Minoletti F, Coindre JM, et al. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nature Genet 1997;15:95-98.
    • (1997) Nature Genet , vol.15 , pp. 95-98
    • Simon, M.P.1    Pedeutour, F.2    Sirvent, N.3    Grosgeorge, J.4    Minoletti, F.5    Coindre, J.M.6
  • 68
    • 0037402488 scopus 로고    scopus 로고
    • Genetics of dermatofibrosarcoma protuberans family of tumors: From ring chromosomes to tyrosine kinase inhibitor treatment
    • Sirvent N, Maire G, Pedeutour F. Genetics of dermatofibrosarcoma protuberans family of tumors: from ring chromosomes to tyrosine kinase inhibitor treatment. Genes Chromosomes Cancer 2003;37:1-19.
    • (2003) Genes Chromosomes Cancer , vol.37 , pp. 1-19
    • Sirvent, N.1    Maire, G.2    Pedeutour, F.3
  • 69
    • 0030789557 scopus 로고    scopus 로고
    • The human type I collagen mutation database
    • Dalgleish R. The human type I collagen mutation database. Nucleic Acids Res 1997;25:181-187.
    • (1997) Nucleic Acids Res , vol.25 , pp. 181-187
    • Dalgleish, R.1
  • 70
    • 0020533055 scopus 로고
    • Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor
    • Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, et al. Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 1983;221:275-277.
    • (1983) Science , vol.221 , pp. 275-277
    • Doolittle, R.F.1    Hunkapiller, M.W.2    Hood, L.E.3    Devare, S.G.4    Robbins, K.C.5    Aaronson, S.A.6
  • 71
    • 0020640259 scopus 로고
    • Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
    • Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, et al. Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature 1983;304:35-39.
    • (1983) Nature , vol.304 , pp. 35-39
    • Waterfield, M.D.1    Scrace, G.T.2    Whittle, N.3    Stroobant, P.4    Johnsson, A.5    Wasteson, A.6
  • 72
    • 0032547385 scopus 로고    scopus 로고
    • Signal transduction via platelet-derived growth factor receptors
    • Heldin CH, Ostman A, Ronnstrand L. Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1998;1378:F79-F113.
    • (1998) Biochim Biophys Acta , vol.1378
    • Heldin, C.H.1    Ostman, A.2    Ronnstrand, L.3
  • 73
    • 0027537711 scopus 로고
    • Localization and functional analysis of DNase-I-hypersensitive sites in the human c-sis/PDGF-B gene transcription unit and its flanking regions
    • Dirks RP, Jansen HJ, Gerritsma J, Onnekink C, Bloemers HP. Localization and functional analysis of DNase-I-hypersensitive sites in the human c-sis/PDGF-B gene transcription unit and its flanking regions. Eur J Biochem 1993;211:509-519.
    • (1993) Eur J Biochem , vol.211 , pp. 509-519
    • Dirks, R.P.1    Jansen, H.J.2    Gerritsma, J.3    Onnekink, C.4    Bloemers, H.P.5
  • 74
    • 0001270324 scopus 로고
    • The 5′ untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor
    • Rao CD, Pech M, Robbins KC, Aaronson SA. The 5′ untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor. Mol Cell Biol 1988;8:284-292.
    • (1988) Mol Cell Biol , vol.8 , pp. 284-292
    • Rao, C.D.1    Pech, M.2    Robbins, K.C.3    Aaronson, S.A.4
  • 75
    • 0031661840 scopus 로고    scopus 로고
    • Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas
    • O'Brien KP, Seroussi E, Dal Cin P, Sciot R, Mandahl N, Fletcher JA, et al. Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer 1998;23:187- 193.
    • (1998) Genes Chromosomes Cancer , vol.23 , pp. 187-193
    • O'Brien, K.P.1    Seroussi, E.2    Dal Cin, P.3    Sciot, R.4    Mandahl, N.5    Fletcher, J.A.6
  • 76
    • 0035342499 scopus 로고    scopus 로고
    • Growth-inhibitory effect of STI571 on cells transformed by the COL1A1/PDGFB rearrangement
    • Greco A, Roccato E, Miranda C, Cleris L, Formelli F, Pierotti MA. Growth-inhibitory effect of STI571 on cells transformed by the COL1A1/PDGFB rearrangement. Int J Cancer 2001;92:354-360.
    • (2001) Int J Cancer , vol.92 , pp. 354-360
    • Greco, A.1    Roccato, E.2    Miranda, C.3    Cleris, L.4    Formelli, F.5    Pierotti, M.A.6
  • 77
    • 0037143794 scopus 로고    scopus 로고
    • Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans
    • Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR. Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer 2002;100:623-626.
    • (2002) Int J Cancer , vol.100 , pp. 623-626
    • Maki, R.G.1    Awan, R.A.2    Dixon, R.H.3    Jhanwar, S.4    Antonescu, C.R.5
  • 78
    • 0036727124 scopus 로고    scopus 로고
    • Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
    • Rubin BP, Schuetze SM, Eary JF, Norwood TH, Mirza S, Conrad EU, et al. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans. J Clin Oncol 2002;20:3586-3591.
    • (2002) J Clin Oncol , vol.20 , pp. 3586-3591
    • Rubin, B.P.1    Schuetze, S.M.2    Eary, J.F.3    Norwood, T.H.4    Mirza, S.5    Conrad, E.U.6
  • 79
    • 14144256775 scopus 로고    scopus 로고
    • Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225
    • McArthur GA, Demetri GD, van Oosterom A, Heinrich MC, Debiec-Rychter M, Corless CL, et al. Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib Target Exploration Consortium Study B2225. J Clin Oncol 2005;23:866-873.
    • (2005) J Clin Oncol , vol.23 , pp. 866-873
    • McArthur, G.A.1    Demetri, G.D.2    van Oosterom, A.3    Heinrich, M.C.4    Debiec-Rychter, M.5    Corless, C.L.6
  • 80
    • 17044431346 scopus 로고    scopus 로고
    • ETV6-NTRK3: A chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
    • Lannon CL, Sorensen PH. ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages. Semin Cancer Biol 2005;15:215-223.
    • (2005) Semin Cancer Biol , vol.15 , pp. 215-223
    • Lannon, C.L.1    Sorensen, P.H.2
  • 81
    • 0000418386 scopus 로고    scopus 로고
    • The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow
    • Wang LC, Swat W, Fujiwara Y, Davidson L, Visvader J, Kuo F, et al. The TEL/ETV6 gene is required specifically for hematopoiesis in the bone marrow. Genes Dev 1998;12:2392-2402.
    • (1998) Genes Dev , vol.12 , pp. 2392-2402
    • Wang, L.C.1    Swat, W.2    Fujiwara, Y.3    Davidson, L.4    Visvader, J.5    Kuo, F.6
  • 83
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, Gilliland DG. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 1994;77:307-316.
    • (1994) Cell , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3    Gilliland, D.G.4
  • 85
  • 86
    • 0032778537 scopus 로고    scopus 로고
    • The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): Molecular cloning of both reciprocal transcripts
    • Cazzaniga G, Tosi S, Aloisi A, Giudici G, Daniotti M, Pioltelli P, et al. The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. Blood 1999;94:4370-4373.
    • (1999) Blood , vol.94 , pp. 4370-4373
    • Cazzaniga, G.1    Tosi, S.2    Aloisi, A.3    Giudici, G.4    Daniotti, M.5    Pioltelli, P.6
  • 87
    • 0035577690 scopus 로고    scopus 로고
    • Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation
    • Yagasaki F, Wakao D, Yokoyama Y, Uchida Y, Murohashi I, Kayano H, et al. Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation. Cancer Res 2001;61:8371-8374.
    • (2001) Cancer Res , vol.61 , pp. 8371-8374
    • Yagasaki, F.1    Wakao, D.2    Yokoyama, Y.3    Uchida, Y.4    Murohashi, I.5    Kayano, H.6
  • 88
    • 0032717039 scopus 로고    scopus 로고
    • The role of chromosome translocations in leukemogenesis
    • Rowley JD. The role of chromosome translocations in leukemogenesis. Semin Hematol 1999;36:59-72.
    • (1999) Semin Hematol , vol.36 , pp. 59-72
    • Rowley, J.D.1
  • 89
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol 2000;10:381-391.
    • (2000) Curr Opin Neurobiol , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 90
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001;411:355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 92
    • 0032533497 scopus 로고    scopus 로고
    • ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma
    • Knezevich SR, Garnett MJ, Pysher TJ, Beckwith JB, Grundy PE, Sorensen PH. ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res 1998;58:5046-5048.
    • (1998) Cancer Res , vol.58 , pp. 5046-5048
    • Knezevich, S.R.1    Garnett, M.J.2    Pysher, T.J.3    Beckwith, J.B.4    Grundy, P.E.5    Sorensen, P.H.6
  • 93
    • 19044391610 scopus 로고    scopus 로고
    • Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma
    • Tognon C, Knezevich SR, Huntsman D, Roskelley CD, Melnyk N, Mathers JA, et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2002;2:367-376.
    • (2002) Cancer Cell , vol.2 , pp. 367-376
    • Tognon, C.1    Knezevich, S.R.2    Huntsman, D.3    Roskelley, C.D.4    Melnyk, N.5    Mathers, J.A.6
  • 94
    • 0033557864 scopus 로고    scopus 로고
    • Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25)
    • Eguchi M, Eguchi-Ishimae M, Tojo A, Morishita K, Suzuki K, Sato Y, et al. Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25). Blood 1999;93:1355-1363.
    • (1999) Blood , vol.93 , pp. 1355-1363
    • Eguchi, M.1    Eguchi-Ishimae, M.2    Tojo, A.3    Morishita, K.4    Suzuki, K.5    Sato, Y.6
  • 95
    • 0034677550 scopus 로고    scopus 로고
    • The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells
    • Wai DH, Knezevich SR, Lucas T, Jansen B, Kay RJ, Sorensen PH. The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. Oncogene 2000;19:906-915.
    • (2000) Oncogene , vol.19 , pp. 906-915
    • Wai, D.H.1    Knezevich, S.R.2    Lucas, T.3    Jansen, B.4    Kay, R.J.5    Sorensen, P.H.6
  • 96
    • 0035893926 scopus 로고    scopus 로고
    • The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation
    • Tognon C, Garnett M, Kenward E, Kay R, Morrison K, Sorensen PH. The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation. Cancer Res 2001;61:8909-8916.
    • (2001) Cancer Res , vol.61 , pp. 8909-8916
    • Tognon, C.1    Garnett, M.2    Kenward, E.3    Kay, R.4    Morrison, K.5    Sorensen, P.H.6
  • 97
    • 33644517220 scopus 로고    scopus 로고
    • The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase
    • Martin MJ, Melnyk N, Pollard M, Bowden M, Leong H, Podor TJ, et al. The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase. Mol Cell Biol 2006;26:1754-1769.
    • (2006) Mol Cell Biol , vol.26 , pp. 1754-1769
    • Martin, M.J.1    Melnyk, N.2    Pollard, M.3    Bowden, M.4    Leong, H.5    Podor, T.J.6
  • 98
    • 0037158897 scopus 로고    scopus 로고
    • ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation
    • Morrison KB, Tognon CE, Garnett MJ, Deal C, Sorensen PH. ETV6-NTRK3 transformation requires insulin-like growth factor 1 receptor signaling and is associated with constitutive IRS-1 tyrosine phosphorylation. Oncogene 2002;21:5684-5695.
    • (2002) Oncogene , vol.21 , pp. 5684-5695
    • Morrison, K.B.1    Tognon, C.E.2    Garnett, M.J.3    Deal, C.4    Sorensen, P.H.5
  • 99
    • 1342325439 scopus 로고    scopus 로고
    • A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: An essential interaction for transformation
    • Lannon CL, Martin MJ, Tognon CE, Jin W, Kim SJ, Sorensen PH. A highly conserved NTRK3 C-terminal sequence in the ETV6-NTRK3 oncoprotein binds the phosphotyrosine binding domain of insulin receptor substrate-1: an essential interaction for transformation. J Biol Chem 2004;279:6225-6234.
    • (2004) J Biol Chem , vol.279 , pp. 6225-6234
    • Lannon, C.L.1    Martin, M.J.2    Tognon, C.E.3    Jin, W.4    Kim, S.J.5    Sorensen, P.H.6
  • 100
    • 28044451534 scopus 로고    scopus 로고
    • The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor
    • Jin W, Kim BC, Tognon C, Lee HJ, Patel S, Lannon CL, et al. The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor. Proc Natl Acad Sci U S A 2005;102:16239-16244.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 16239-16244
    • Jin, W.1    Kim, B.C.2    Tognon, C.3    Lee, H.J.4    Patel, S.5    Lannon, C.L.6
  • 101
    • 0026490917 scopus 로고
    • Molecular genetic, cytogenetic, and immunohistochemical characterization of alveolar soft-part sarcoma. Implications for cell of origin
    • Cullinane C, Thorner PS, Greenberg ML, Kwan Y, Kumar M, Squire J. Molecular genetic, cytogenetic, and immunohistochemical characterization of alveolar soft-part sarcoma. Implications for cell of origin. Cancer 1992;70:2444-2450.
    • (1992) Cancer , vol.70 , pp. 2444-2450
    • Cullinane, C.1    Thorner, P.S.2    Greenberg, M.L.3    Kwan, Y.4    Kumar, M.5    Squire, J.6
  • 102
    • 0031661841 scopus 로고    scopus 로고
    • Alveolar soft-part sarcoma: Further evidence by FISH for the involvement of chromosome band 17q25
    • Heimann P, Devalck C, Debusscher C, Sariban E, Vamos E. Alveolar soft-part sarcoma: further evidence by FISH for the involvement of chromosome band 17q25. Genes Chromosomes Cancer 1998;23:194-197.
    • (1998) Genes Chromosomes Cancer , vol.23 , pp. 194-197
    • Heimann, P.1    Devalck, C.2    Debusscher, C.3    Sariban, E.4    Vamos, E.5
  • 103
    • 0035804224 scopus 로고    scopus 로고
    • The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25
    • Ladanyi M, Lui MY, Antonescu CR, Krause-Boehm A, Meindl A, Argani P, et al. The der(17)t(X;17)(p11;q25) of human alveolar soft part sarcoma fuses the TFE3 transcription factor gene to ASPL, a novel gene at 17q25. Oncogene 2001;20:48-57.
    • (2001) Oncogene , vol.20 , pp. 48-57
    • Ladanyi, M.1    Lui, M.Y.2    Antonescu, C.R.3    Krause-Boehm, A.4    Meindl, A.5    Argani, P.6
  • 104
    • 2342624068 scopus 로고    scopus 로고
    • Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains
    • Kuiper RP, Schepens M, Thijssen J, Schoenmakers EF, van Kessel AG. Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains. Nucleic Acids Res 2004;32:2315-2322.
    • (2004) Nucleic Acids Res , vol.32 , pp. 2315-2322
    • Kuiper, R.P.1    Schepens, M.2    Thijssen, J.3    Schoenmakers, E.F.4    van Kessel, A.G.5
  • 105
    • 0028883473 scopus 로고
    • TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription
    • Artandi SE, Merrell K, Avitahl N, Wong KK, Calame K. TFE3 contains two activation domains, one acidic and the other proline-rich, that synergistically activate transcription. Nucleic Acids Res 1995;23:3865-3871.
    • (1995) Nucleic Acids Res , vol.23 , pp. 3865-3871
    • Artandi, S.E.1    Merrell, K.2    Avitahl, N.3    Wong, K.K.4    Calame, K.5
  • 106
    • 0026079764 scopus 로고
    • A dominant negative form of transcription activator mTFE3 created by differential splicing
    • Roman C, Cohn L, Calame K. A dominant negative form of transcription activator mTFE3 created by differential splicing. Science 1991;254:94-97.
    • (1991) Science , vol.254 , pp. 94-97
    • Roman, C.1    Cohn, L.2    Calame, K.3
  • 107
    • 0010346928 scopus 로고    scopus 로고
    • Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: A distinctive tumor entity previously included among renal cell carcinomas of children and adolescents
    • Argani P, Antonescu CR, Illei PB, Lui MY, Timmons CF, Newbury R, et al. Primary renal neoplasms with the ASPL-TFE3 gene fusion of alveolar soft part sarcoma: a distinctive tumor entity previously included among renal cell carcinomas of children and adolescents. Am J Pathol 2001;159:179- 192.
    • (2001) Am J Pathol , vol.159 , pp. 179-192
    • Argani, P.1    Antonescu, C.R.2    Illei, P.B.3    Lui, M.Y.4    Timmons, C.F.5    Newbury, R.6
  • 108
    • 2142769869 scopus 로고    scopus 로고
    • Recent advances in pediatric renal neoplasia
    • Argani P, Ladanyi M. Recent advances in pediatric renal neoplasia. Adv Anat Pathol 2003;10:243-260.
    • (2003) Adv Anat Pathol , vol.10 , pp. 243-260
    • Argani, P.1    Ladanyi, M.2
  • 109
    • 19944433827 scopus 로고    scopus 로고
    • Renal carcinomas with the t(6;11)(p21;q12): Clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR
    • Argani P, Lae M, Hutchinson B, Reuter VE, Collins MH, Perentesis J, et al. Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol 2005;29:230-240.
    • (2005) Am J Surg Pathol , vol.29 , pp. 230-240
    • Argani, P.1    Lae, M.2    Hutchinson, B.3    Reuter, V.E.4    Collins, M.H.5    Perentesis, J.6
  • 110
    • 0037609538 scopus 로고    scopus 로고
    • Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation
    • Davis IJ, Hsi BL, Arroyo JD, Vargas SO, Yeh YA, Motyckova G, et al. Cloning of an alpha-TFEB fusion in renal tumors harboring the t(6;11)(p21;q13) chromosome translocation. Proc Natl Acad Sci U S A 2003;100:6051-6056.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6051-6056
    • Davis, I.J.1    Hsi, B.L.2    Arroyo, J.D.3    Vargas, S.O.4    Yeh, Y.A.5    Motyckova, G.6
  • 111
    • 33847066415 scopus 로고    scopus 로고
    • TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition
    • Tsuda M, Davis IJ, Argani P, Shukla N, McGill GG, Nagai M, et al. TFE3 fusions activate MET signaling by transcriptional up-regulation, defining another class of tumors as candidates for therapeutic MET inhibition. Cancer Res 2007;67:919-929.
    • (2007) Cancer Res , vol.67 , pp. 919-929
    • Tsuda, M.1    Davis, I.J.2    Argani, P.3    Shukla, N.4    McGill, G.G.5    Nagai, M.6
  • 112
    • 33751239762 scopus 로고    scopus 로고
    • Alveolar soft-part sarcoma: A review and update
    • Folpe AL, Deyrup AT. Alveolar soft-part sarcoma: a review and update. J Clin Pathol 2006;59:1127-1132.
    • (2006) J Clin Pathol , vol.59 , pp. 1127-1132
    • Folpe, A.L.1    Deyrup, A.T.2
  • 115
    • 4444319567 scopus 로고    scopus 로고
    • Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells
    • Armstrong F, Duplantier MM, Trempat P, Hieblot C, Lamant L, Espinos E, et al. Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells. Oncogene 2004;23:6071-6082.
    • (2004) Oncogene , vol.23 , pp. 6071-6082
    • Armstrong, F.1    Duplantier, M.M.2    Trempat, P.3    Hieblot, C.4    Lamant, L.5    Espinos, E.6
  • 117
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, lshiguro S, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3    Hashimoto, K.4    Nishida, T.5    lshiguro, S.6
  • 118
    • 0037405026 scopus 로고    scopus 로고
    • Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region
    • Chan PM, Ilangumaran S, La Rose J, Chakrabartty A, Rottapel R. Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region. Mol Cell Biol 2003;23:3067-3078.
    • (2003) Mol Cell Biol , vol.23 , pp. 3067-3078
    • Chan, P.M.1    Ilangumaran, S.2    La Rose, J.3    Chakrabartty, A.4    Rottapel, R.5
  • 119
    • 0028959163 scopus 로고
    • Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines
    • Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, et al. Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 1995;85:790-798.
    • (1995) Blood , vol.85 , pp. 790-798
    • Kitayama, H.1    Kanakura, Y.2    Furitsu, T.3    Tsujimura, T.4    Oritani, K.5    Ikeda, H.6
  • 120
    • 0033532190 scopus 로고    scopus 로고
    • Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region
    • Ma Y, Cunningham ME, Wang X, Ghosh I, Regan L, Longley BJ. Inhibition of spontaneous receptor phosphorylation by residues in a putative alpha-helix in the KIT intracellular juxtamembrane region. J Biol Chem 1999;274:13399-13402.
    • (1999) J Biol Chem , vol.274 , pp. 13399-13402
    • Ma, Y.1    Cunningham, M.E.2    Wang, X.3    Ghosh, I.4    Regan, L.5    Longley, B.J.6
  • 121
    • 0033883060 scopus 로고    scopus 로고
    • KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
    • Lux ML, Rubin BP, Biase TL, Chen CJ, Maclure T, Demetri G, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol 2000;156:791-795.
    • (2000) Am J Pathol , vol.156 , pp. 791-795
    • Lux, M.L.1    Rubin, B.P.2    Biase, T.L.3    Chen, C.J.4    Maclure, T.5    Demetri, G.6
  • 122
    • 0035890740 scopus 로고    scopus 로고
    • KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
    • Rubin BP, Singer S, Tsao C, Duensing A, Lux ML, Ruiz R, et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res 2001;61:8118-8121.
    • (2001) Cancer Res , vol.61 , pp. 8118-8121
    • Rubin, B.P.1    Singer, S.2    Tsao, C.3    Duensing, A.4    Lux, M.L.5    Ruiz, R.6
  • 124
    • 0033678402 scopus 로고    scopus 로고
    • Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors
    • Isozaki K, Terris B, Belghiti J, Schiffmann S, Hirota S, Vanderwinden JM. Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. Am J Pathol 2000;157:1581-1585.
    • (2000) Am J Pathol , vol.157 , pp. 1581-1585
    • Isozaki, K.1    Terris, B.2    Belghiti, J.3    Schiffmann, S.4    Hirota, S.5    Vanderwinden, J.M.6
  • 125
    • 0036240932 scopus 로고    scopus 로고
    • Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene
    • Hirota S, Nishida T, Isozaki K, Taniguchi M, Nishikawa K, Ohashi A, et al. Familial gastrointestinal stromal tumors associated with dysphagia and novel type germline mutation of KIT gene. Gastroenterology 2002;122:1493-1499.
    • (2002) Gastroenterology , vol.122 , pp. 1493-1499
    • Hirota, S.1    Nishida, T.2    Isozaki, K.3    Taniguchi, M.4    Nishikawa, K.5    Ohashi, A.6
  • 126
    • 0035397627 scopus 로고    scopus 로고
    • Chromosomal aberrations in malignant gastrointestinal stromal tumors: Correlation with c-KIT gene mutation
    • Debiec-Rychter M, Lasota J, Sarlomo-Rikala M, Kordek R, Miettinen M. Chromosomal aberrations in malignant gastrointestinal stromal tumors: correlation with c-KIT gene mutation. Cancer Genet Cytogenet 2001;128:24-30.
    • (2001) Cancer Genet Cytogenet , vol.128 , pp. 24-30
    • Debiec-Rychter, M.1    Lasota, J.2    Sarlomo-Rikala, M.3    Kordek, R.4    Miettinen, M.5
  • 127
    • 0034525682 scopus 로고    scopus 로고
    • Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor
    • Fukasawa T, Chong JM, Sakurai S, Koshiishi N, Ikeno R, Tanaka A, et al. Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor. Jpn J Cancer Res 2000;91:1241-1249.
    • (2000) Jpn J Cancer Res , vol.91 , pp. 1241-1249
    • Fukasawa, T.1    Chong, J.M.2    Sakurai, S.3    Koshiishi, N.4    Ikeno, R.5    Tanaka, A.6
  • 129
    • 0036303804 scopus 로고    scopus 로고
    • Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations
    • Heinrich MC, Rubin BP, Longley BJ, Fletcher JA. Biology and genetic aspects of gastrointestinal stromal tumors: KIT activation and cytogenetic alterations. Hum Pathol 2002;33:484-495.
    • (2002) Hum Pathol , vol.33 , pp. 484-495
    • Heinrich, M.C.1    Rubin, B.P.2    Longley, B.J.3    Fletcher, J.A.4
  • 130
    • 0034006759 scopus 로고    scopus 로고
    • High-resolution deletion mapping of chromosome 14 in stromal tumors of the gastrointestinal tract suggests two distinct tumor suppressor loci
    • El-Rifai W, Sarlomo-Rikala M, Andersson LC, Miettinen M, Knuutila S. High-resolution deletion mapping of chromosome 14 in stromal tumors of the gastrointestinal tract suggests two distinct tumor suppressor loci. Genes Chromosomes Cancer 2000;27:387-391.
    • (2000) Genes Chromosomes Cancer , vol.27 , pp. 387-391
    • El-Rifai, W.1    Sarlomo-Rikala, M.2    Andersson, L.C.3    Miettinen, M.4    Knuutila, S.5
  • 133
    • 0027241506 scopus 로고
    • Neuroectodermal differentiation of the gastrointestinal tumors in the Carney triad. An ultrastructural and immunohistochemical study
    • Perez-Atayde AR, Shamberger RC, Kozakewich HW. Neuroectodermal differentiation of the gastrointestinal tumors in the Carney triad. An ultrastructural and immunohistochemical study. Am J Surg Pathol 1993;17:706-714.
    • (1993) Am J Surg Pathol , vol.17 , pp. 706-714
    • Perez-Atayde, A.R.1    Shamberger, R.C.2    Kozakewich, H.W.3
  • 134
    • 0032950650 scopus 로고    scopus 로고
    • Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal
    • Sakurai S, Fukasawa T, Chong JM, Tanaka A, Fukayama M. Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal. Am J Pathol 1999;154:23-28.
    • (1999) Am J Pathol , vol.154 , pp. 23-28
    • Sakurai, S.1    Fukasawa, T.2    Chong, J.M.3    Tanaka, A.4    Fukayama, M.5
  • 135
    • 0035101531 scopus 로고    scopus 로고
    • Expression of the intermediate filament nestin in gastrointestinal stromal tumors and interstitial cells of Cajal
    • Tsujimura T, Makiishi-Shimobayashi C, Lundkvist J, Lendahl U, Nakasho K, Sugihara A, et al. Expression of the intermediate filament nestin in gastrointestinal stromal tumors and interstitial cells of Cajal. Am J Pathol 2001;158:817-823.
    • (2001) Am J Pathol , vol.158 , pp. 817-823
    • Tsujimura, T.1    Makiishi-Shimobayashi, C.2    Lundkvist, J.3    Lendahl, U.4    Nakasho, K.5    Sugihara, A.6
  • 136
  • 138
    • 33748059560 scopus 로고    scopus 로고
    • Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor
    • Rossi F, Ehlers I, Agosti V, Socci ND, Viale A, Sommer G, et al. Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor. Proc Natl Acad Sci U S A 2006;103:12843-12848.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12843-12848
    • Rossi, F.1    Ehlers, I.2    Agosti, V.3    Socci, N.D.4    Viale, A.5    Sommer, G.6
  • 139
    • 20344408300 scopus 로고    scopus 로고
    • Childhood solid tumours: A developmental disorder
    • Scotting PJ, Walker DA, Perilongo G. Childhood solid tumours: a developmental disorder. Nature Rev 2005;5:481-488.
    • (2005) Nature Rev , vol.5 , pp. 481-488
    • Scotting, P.J.1    Walker, D.A.2    Perilongo, G.3
  • 140
    • 33644560281 scopus 로고
    • Cancer stem cells: An old idea - a paradigm shift
    • discussion
    • Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res 2006;66:1883-1890; discussion 1891-1896.
    • (1891) Cancer Res 2006 , vol.66 , pp. 1883-1890
    • Wicha, M.S.1    Liu, S.2    Dontu, G.3


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