MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

Molecular and Cellular Biology

Volumn 22, Issue 18, 2002, Pages 6542-6552

  So, Chi Wai ^a   Cleary, Michael L ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; NEUROTROPHIN RECEPTOR; PROTEIN TYROSINE KINASE; THREONINE;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CELL POLARITY; CONTROLLED STUDY; ENDOSOME; EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN TARGETING; SEQUENCE HOMOLOGY;

3T3 CELLS; ANIMALS; APOPTOSIS; CELL LINE; CELL LINE, TRANSFORMED; COS CELLS; DNA; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENES, DOMINANT; GLUTATHIONE TRANSFERASE; HUMANS; MICE; MUTATION; MYELOID PROGENITOR CELLS; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; PHENOTYPE; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENES; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 0036723650     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.18.6542-6552.2002     Document Type: Article

References (62)

1. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily
2. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
3. Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma
4. PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma
5. Mechanism for transcriptional gain of function resulting from chromosomal translocation in alveolar rhabdomyosarcoma
6. Wild-type PAX3 protein and the PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma contain potent, structurally distinct transcriptional activation domains
7. Cloning and characterization of AFX, the gene that fuses to MLL in acute leukemias with a t(X;11)(q13:q23)
8. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
9. The capacity of polyomavirus enhancer binding protein 2αB (AML1/Cbfa2) to stimulate polyomavirus DNA replication is related to its affinity for the nuclear matrix
10. Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARα and NPM-RARα
11. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
12. Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma
13. KIP1
14. MLL rearrangements in haematological malignancies: Lessons from clinical and biological studies
15. A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL
16. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
17. Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene
18. Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9
19. The AML1/ETO fusion protein blocks transactivation of the GM-CSF promoter by AML1B
20. Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma
21. Deregulation of c-myc by leukemogenic MLL fusion proteins
22. Synergistic activation of transcription by the mutant and wild-type minimal transcriptional activation domain of VP16
23. CBP/p300 in cell growth, transformation, and development
24. Functions of mammalian Polycomb group and trithorax group related genes
25. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
26. Mammalian trithorax and polycomb-group homologues are antagonistic regulators of homeotic development
27. AF6q21, a novel partner of the MLL gene in t(6;11)(q21;q23), defines a forkhead transcriptional factor subfamily
28. The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx
29. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
30. Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
31. Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways
32. A genetic analysis of PAX3-FKHR, the oncogene of alveolar rhabdomyosarcoma
33. Direct control of the Forkhead transcription factor AFX by protein kinase B
34. The oncogenic potential of the Pax3-FKHR fusion protein requires the Pax3 homeodomain recognition helix but not the Pax3 paired-box DNA binding domain
35. Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia
36. Immortalization and leukemic transformation of a myetomonocytic precursor by retrovirally transduced HRX-ENL
37. AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML
38. The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis
39. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein
40. DNA rearrangements and altered transcripts of the MLL gene in a human T-ALL cell line Karpas 45 with a t(X;11) (q13;q23) translocation
41. kip1
42. The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation
43. DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
44. PMLRAR homodimers: Distinct DNA binding properties and heteromeric interactions with RXR
45. Analysis of the molecular genetics of acute promyelocytic leukemia in mouse models
46. ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells
47. A vector for expressing GAL4(1-147) fusions in mammalian cells
48. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond
49. The oncoprotein Tax binds the SRC-1-interacting domain of CBP/p300 to mediate transcriptional activation
50. The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX
51. The impact of differential binding of wild-type RARα, PML-, PLZF-, and NPM-RARα fusion proteins towards transcriptional co-activator, RIP-140, on retinoic acid responses in acute promyelocytic leukemia
52. The interaction between EEN and Abi, two MLL fusion partners, and synaptojanin and dynamin: Implications for leukacmogenesis
53. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
54. The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
55. The AML1/ETO(MTG8) and AML1/Evi-1 leukemia-associated chimeric oncoproteins accumulate PEBP2beta(CBF-beta) in the nucleus more efficiently than wild-type AML1
56. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
57. Binding of p53 to the KIX domain of CREB binding protein. A potential link to human T-cell leukemia virus, type I-associated leukemo-genesis
58. The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation
59. Interaction of the pRB-family proteins with factors containing paired-like homeodomains
60. MLL repression domain interacts with histone deacetylases
61. MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis
62. Altered Hox expression and segmental identity in Mll-mutant mice