Fusion of ETV6 to neurotrophin-3 receptor TRKC in acute myeloid leukemia with t(12;15)(p13;q25)

Blood

Volumn 93, Issue 4, 1999, Pages 1355-1363

  Eguchi, Mariko ^b   Eguchi Ishimae, Minenori ^b   Tojo, Arinobu ^b   Morishita, Kazuhiro ^b   Suzuki, Katsuyuki ^b   Sato, Yuko ^b   Kudoh, Shiori ^b   Tanaka, Kimio ^b   Setoyama, Misao ^b   Nagamura, Fumitaka ^b   Asano, Shigetaka ^b   Kamada, Nanao ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; CELL TRANSFORMATION; CHROMOSOME 12P; CHROMOSOME 15Q; CHROMOSOME TRANSLOCATION 12; CHROMOSOME TRANSLOCATION 15; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0033557864     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.4.1355.404k29_1355_1363     Document Type: Article

References (37)

1. Rabbitts TH: Chromosomal translocations in human cancer. Nature 372:143, 1994
2. Golub TR, Barker GF, Lovett M, Gilliland DG: Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell 77:307, 1994
3. Sato Y, Bohlander SK, Kobayashi H, Reshmi S. Suto Y, Davis EM, Espinosa R, Hoopes R, Montgomery KT, Kucherlapati RS, Le Beau MM, Rowley JD: Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6) is involved in only one half. Blood 90:4886, 1997
4. Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H, Marynen P: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of 1(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 90:2535, 1997
5. Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA: A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 278:1309, 1997
6. Buijs A, Sherr S, van Baal S, van Bezouw S, van der Plas D, Geurts van Kessel A, Riegman P, Lekanne Deprez R, Zwarthoff E, Hagemeijer A, Grosveld G: Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. Oncogene 10:1511, 1995
7. Peeters P, Wlodarska I, Baens M, Criel A, Selleslag D, Hagemeijer A, Van den Berghe H, Marynen P: Fusion of ETV6 to MDS1/EVI1 as a result of t(3;12)(q26;p13) in myeloproliferative disorders. Cancer Res 57:564, 1997
8. Rotnana SP, Mauchauffe M, Le Coniat M, Chumakov I, Le Paslier D, Berger R, Bernard OA: The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. Blood 85:3662, 1995
9. Golub TR, Barker GF, Bohlander SK, Hiebert SW, Ward DC, Bray-Ward P, Morgan E, Raimondi SC, Rowley JD, Gilliland DG: Fusion of the TEL gene on 12p13 to the AML1 gene on 21 q22 in acute lymphoblastic leukemia. Proc Natl Acad Sci USA 92:4917, 1995
10. Papadopoulos P, Ridge SA, Boucher CA, Stocking C, Wiedemann LM: The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res 55:34, 1995
11. Golub TR, Goga A, Barker GF, Afar DE, McLaughlin J, Bohlander SK, Rowley JD, Witte ON, Gilliland DG: Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol 16:4107, 1996
12. Suto Y, Sato Y, Smith SD, Rowley JD, Bohlander SK: A t(6;12)(q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line. Genes Chromosom Cancer 18:254, 1997
13. Delattre O, Zucman J, Plougastel B, Desmaze C, Melot T, Peter M, Kovar H, Joubert I, de Jong P, Rouleau G, Aurias A, Thomas G: Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359:162, 1992
14. Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN: A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1. Oncogene 10:1229, 1995
15. Zucman J, Melot T, Desmaze C, Ghysdael J, Plougastel B, Peter M, Zucker JM, Triche TJ, Sheer D, Turc-Carel C, Ambros P, Combaret V, Lenoir G, Aurias A, Thomas G, Delattre O: Combinatorial generation of variable fusion proteins in the Ewing family of tumours. EMBO J 12:4481, 1993
16. Setoyama M, Tojo A, Nagamura F, Asano S, Ishimae M, Eguchi M, Kamada N: A unique translocation of the TEL gene in a case of acute myelogenous leukemia with inv(12)(p13q15). Blood 92:1454, 1998
17. Mitelman F: An International System for Human Cytogenetic Nomenclature. Basel, Switzerland, S. Karger, 1995
18. Baens M, Peeters P, Guo C, Aerssens J, Marynen P: Genomic organization of TEL: The human ETS-variant gene 6. Genome Res 6:404, 1996
19. Bohlander SK, Espinosa R 3rd, Fernald AA, Rowley JD, Le Beau MM, Diaz MO: Sequence-independent amplification and labelling of yeast artificial chromosomes for fluorescence in situ hybridization. Cytogenet Cell Genet 65:108, 1994
20. Arif M, Tanaka K, Kumaravel TS, Eguchi M, Iwato K, Dohy H, Kamada N: Detection of residual host cells in sex-mismatched bone marrow transplantation in various hematological diseases by fluorescence in situ hybridization. Jpn J Cancer Res 88:420, 1997
21. Lamballe F, Klein R, Barbacid M: trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66:967, 1991
22. Chevalier S, Praloran V, Smith C, MacGrogan D, Ip NY, Yancopoulos GD, Brachet P, Pouplard A, Gascan H: Expression and functionality of the trkA proto-oncogene product/NGF receptor in undifferentiated hematopoietic cells. Blood 83:1479, 1994
23. Poirel H, Oury C, Carron C, Duprez E, Laabi Y, Tsapis A, Romana SP, Mauchauffe M, Le Coniat M, Berger R, Ghysdael J. Bernard OA: The TEL gene products: Nuclear phosphoproteins with DNA binding properties. Oncogene 14:349, 1997
24. Dechant G, Rodriguez-Tebar A, Kolbeck R, Barde YA: Specific high-affinity receptors for neurotrophin-3 on sympathetic neurons. J Neurosci 13:2610, 1993
25. Yamashiro DJ, Nakagawara A, Ikegaki N, Liu XG, Brodeur GM: Expression of TrkC in favorable human neuroblastomas. Oncogene 12:37, 1996
26. Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL: Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci USA 91:12867, 1994
27. Martin-Zanca D, Hughes SH, Barbacid M: A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature 319:743, 1986
28. Greco A, Miranda C, Pagliardini S, Fusetti L, Bongarzone I, Pierotti MA: Chromosome 1 rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid-specific TRK oncogenes. Genes Chromosom Cancer 19:112, 1997
29. Lugo TG, Pendergast AM, Muller AJ, Witte ON: Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 247:1079, 1990
30. Carroll M, Tomasson MH, Barker GF, Golub TR, Gilliland DG: The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc Natl Acad Sci USA 93:14845, 1996
31. Jousset C, Carron C, Boureux A, Quang CT, Oury C, DusanterFourt I, Charon M, Levin J, Bernard O, Ghysdael J: A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein. EMBO J 16:69, 1997
32. Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH: A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet 18:184, 1998
33. Lamballe F, Taoley P, Barbacid M: trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. EMBO J 12:3083, 1993
34. McGregor L, Baylin S, Griffin C, Hawkins A, Nelkin B: Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. Genomics 22:267, 1994
35. Tsoulfas P, Stephens R, Kaplan D, Parada L: TrkC isoforms with inserts in the kinase domain show impared signaling resposes. J Biol Chem 271:5691, 1996
36. Ichikawa H, Shimizu K, Hayashi Y, Ohki M: An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation. Cancer Res 54:2865, 1994
37. Baffa R, Negrini M, Schichman SA, Huebner K, Croce CM: Involvement of the ALL-1 gene in a solid tumor. Proc Natl Acad Sci USA 92:4922, 1995