KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors

American Journal of Pathology

Volumn 156, Issue 3, 2000, Pages 791-795

  Lux, Marcia L ^a,c   Rubin, Brian P ^a,c   Biase, Tara L ^a,c   Chen, Chang Jie ^a,c   Maclure, Timothy ^a,c   Demetri, George ^b,c   Xiao, Sheng ^a,c   Singer, Samuel ^a,b,c   Fletcher, Christopher D M ^a,b,c   Fletcher, Jonathan A ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STEM CELL FACTOR; TYROSINE KINASE RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; EXON; GASTROINTESTINAL TUMOR; GENE ACTIVATION; GENE MUTATION; HUMAN; HUMAN TISSUE; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS;

EID: 0033883060     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64946-2     Document Type: Article

References (26)

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8. Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3
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14. KIT mutation portends poor prognosis in gastrointestinal stromal/smooth muscle tumors
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17. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
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19. Full activation of MEN2B mutant RET by an additional MEN2A mutation or by ligand GDNF stimulation
20. Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain
21. FGFR activation in skeletal disorders: Too much of a good thing
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26. Expression of Kit in neurofibromin-deficient human Schwann cells: Role in Schwann cell hyperplasia associated with type 1 neurofibromatosis