High-speed screening and quantitative SAR analysis of human ABC transporter ABCG2 for molecular modeling of anticancer drugs to circumvent multidrug resistance

Mini-Reviews in Medicinal Chemistry

Volumn 7, Issue 10, 2007, Pages 1009-1018

  Saito, H ^a   Hirano, H ^a   Ishikawa, T ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

ABC transporter; ABCG2; BCRP; Camptothecin; High throughput screening; Irinotecan; Multidrug resistance; QSAR analysis

Indexed keywords

4 AMINOBUTYRIC ACID; 7 ETHYL 10 HYDROXYCAMPTOTHECIN; ABC TRANSPORTER; ACACETIN; ADRENALIN; ANTINEOPLASTIC AGENT; BREAST CANCER RESISTANCE PROTEIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; DOPAMINE; DOXORUBICIN; GENISTEIN; GLUTAMIC ACID; GLYCINE; GLYCOPROTEIN P; HEMATOPORPHYRIN; IRINOTECAN; KAEMPFEROL; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; NARINGENIN; NORADRENALIN; NOVOBIOCIN; PHEOPHORBIDE; PRAZOSIN; QUERCETIN; TACROLIMUS; TOPOTECAN; UNINDEXED DRUG;

BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CHROMOSOME 4Q; DRUG DESIGN; DRUG EFFICACY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SENSITIZATION; DRUG TRANSPORT; ENZYME INHIBITION; ENZYME STABILITY; GENE LOCATION; HUMAN; INHIBITION KINETICS; MALIGNANT NEOPLASTIC DISEASE; MOLECULAR MODEL; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM CHEMISTRY; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; MODELS, MOLECULAR; NEOPLASM PROTEINS; NEOPLASMS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 35048885972     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955707782110169     Document Type: Review

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