-
1
-
-
0025048205
-
Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell cell lung cancer cells
-
Smith, P. J., Morgan, S. A., Fox, M. E., and Watson, J. V. Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell cell lung cancer cells. Biochem. Pharmacol., 40: 2069-2078, 1990.
-
(1990)
Biochem. Pharmacol.
, vol.40
, pp. 2069-2078
-
-
Smith, P.J.1
Morgan, S.A.2
Fox, M.E.3
Watson, J.V.4
-
2
-
-
0028822554
-
Comparison of aza-anthracenedione-induced DNA damage and cytotoxicity in experimental tumor cells
-
Hazlehurst, L. A., Krapcho, A. P., and Hacker, M. P. Comparison of aza-anthracenedione-induced DNA damage and cytotoxicity in experimental tumor cells. Biochem. Pharmacol., 50: 1087-1094, 1995.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 1087-1094
-
-
Hazlehurst, L.A.1
Krapcho, A.P.2
Hacker, M.P.3
-
3
-
-
0019349401
-
Interactions of a new antitumor agent. 1,4-dihydroxy-5,8-bis[2-[(2-hydroxyethyl)amino]ethyl]-amino-9,10-anthracenedione in nucleic acids
-
Kapuscinski, J., Darzynkiewicz, Z., Tranganos, F., and Melamed, M. R. Interactions of a new antitumor agent. 1,4-dihydroxy-5,8-bis[(2-[(2-hydroxyethyl)amino]ethyl]-amino-9,10- anthracenedione in nucleic acids. Biochem. Pharmacol., 30: 231-240, 1981.
-
(1981)
Biochem. Pharmacol.
, vol.30
, pp. 231-240
-
-
Kapuscinski, J.1
Darzynkiewicz, Z.2
Tranganos, F.3
Melamed, M.R.4
-
4
-
-
0024329202
-
Biochemical characteristics and physiological significance of major DNA topoisomerases
-
Sutcliffe, J. A., Gootz, T. D., and Barret, J. F. Biochemical characteristics and physiological significance of major DNA topoisomerases. Antimicrob. Agents Chemother., 33: 2027-2033, 1989.
-
(1989)
Antimicrob. Agents Chemother.
, vol.33
, pp. 2027-2033
-
-
Sutcliffe, J.A.1
Gootz, T.D.2
Barret, J.F.3
-
5
-
-
0023897681
-
Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone
-
Dalton, W. S., Cress, A. E., Alberts, D. S., and Trent, J. M. Cytogenetic and phenotypic analysis of a human colon carcinoma cell line resistant to mitoxantrone. Cancer Res., 48: 1882-1888, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 1882-1888
-
-
Dalton, W.S.1
Cress, A.E.2
Alberts, D.S.3
Trent, J.M.4
-
6
-
-
0025733402
-
Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line
-
Taylor, C. W., Dalton, W. S., Parrish, M. C., Gleason, M. C., Bellamy, W. T., Thompson, F. H., Roe, D. J., and Trent, J. M. Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line. Br. J. Cancer, 63: 923-929, 1991.
-
(1991)
Br. J. Cancer
, vol.63
, pp. 923-929
-
-
Taylor, C.W.1
Dalton, W.S.2
Parrish, M.C.3
Gleason, M.C.4
Bellamy, W.T.5
Thompson, F.H.6
Roe, D.J.7
Trent, J.M.8
-
7
-
-
0028239105
-
Analysis of MRP mRNA in mitoxantrone-selected, multidrug-resistant human tumor cells
-
Futscher, B. W., Ahbaszadegan, M. R., Domann, F., and Dalton, W. S. Analysis of MRP mRNA in mitoxantrone-selected, multidrug-resistant human tumor cells. Biochem. Pharmacol., 47: 1601-1606, 1994.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 1601-1606
-
-
Futscher, B.W.1
Ahbaszadegan, M.R.2
Domann, F.3
Dalton, W.S.4
-
8
-
-
0026496549
-
Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells
-
Nakagawa, M., Schneider, E., Dixon, K. H., Horton, J., Kelley, K., Marrow, C., and Cowan, K. H. Reduced intracellular drug accumulation in the absence of P-glycoprotein (mdr1) overexpression in mitoxantrone-resistant human MCF-7 breast cancer cells. Cancer Res., 52: 6175-6181, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 6175-6181
-
-
Nakagawa, M.1
Schneider, E.2
Dixon, K.H.3
Horton, J.4
Kelley, K.5
Marrow, C.6
Cowan, K.H.7
-
9
-
-
0024353128
-
Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression
-
Harker, G. W., Slade, D. L., Dalton, W. S., Meltzer, P. S., and Trent, J. M. Multidrug resistance in mitoxantrone-selected HL-60 leukemia cells in the absence of P-glycoprotein overexpression. Cancer Res., 49: 4542-4549, 1989.
-
(1989)
Cancer Res.
, vol.49
, pp. 4542-4549
-
-
Harker, G.W.1
Slade, D.L.2
Dalton, W.S.3
Meltzer, P.S.4
Trent, J.M.5
-
10
-
-
0028819988
-
Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to truncated topoisomerase IIα messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone
-
Harker, W. G., Slade, D. L., Parr, R. L., and Holguin, M. H. Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to truncated topoisomerase IIα messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone. Cancer Res., 55: 4962-4971, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 4962-4971
-
-
Harker, W.G.1
Slade, D.L.2
Parr, R.L.3
Holguin, M.H.4
-
11
-
-
0024511372
-
Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: Association with levels of drug resistance and drug accumulation
-
Dalton, W. S., Grogan, T. M., Rybski, J. A., Scheper, R. J., Richter, L., Kailey, J., Broxterman, H. J., Pinedo, H. M., and Salmon, S. Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with levels of drug resistance and drug accumulation. Blood, 73: 747-752, 1989.
-
(1989)
Blood
, vol.73
, pp. 747-752
-
-
Dalton, W.S.1
Grogan, T.M.2
Rybski, J.A.3
Scheper, R.J.4
Richter, L.5
Kailey, J.6
Broxterman, H.J.7
Pinedo, H.M.8
Salmon, S.9
-
12
-
-
84965822602
-
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
-
Alley, M. C., Scudiero, D. A., Monks, A., Hursey, M. L., Czerwinski, M. J., Fine, D. L., Mayo, J. G., Shoemaker, R. H., and Boyd, M. R. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res., 48: 589-601, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 589-601
-
-
Alley, M.C.1
Scudiero, D.A.2
Monks, A.3
Hursey, M.L.4
Czerwinski, M.J.5
Fine, D.L.6
Mayo, J.G.7
Shoemaker, R.H.8
Boyd, M.R.9
-
13
-
-
0022477546
-
Proliferation dependence of topoisomerase II mediated drug action
-
Sullivan, D. M., Glisson, B. S., Hodges, P. K., Smallwood-Kentro, S., and Ross W. E. Proliferation dependence of topoisomerase II mediated drug action. Biochemistry, 25: 2248-2256, 1986.
-
(1986)
Biochemistry
, vol.25
, pp. 2248-2256
-
-
Sullivan, D.M.1
Glisson, B.S.2
Hodges, P.K.3
Smallwood-Kentro, S.4
Ross, W.E.5
-
14
-
-
0026723072
-
DNA topoisomerase II immunostaining in human leukemia amd rhabdomysarcoma cell lines and their responses to topoisomerase II inhibitors
-
Wolverton, J. S., Danks, M. K., Grazen, B., and Beck, W. T. DNA topoisomerase II immunostaining in human leukemia amd rhabdomysarcoma cell lines and their responses to topoisomerase II inhibitors. Cancer Res., 52: 4248-4253, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 4248-4253
-
-
Wolverton, J.S.1
Danks, M.K.2
Grazen, B.3
Beck, W.T.4
-
15
-
-
0028135485
-
Subcellular distribution of the α and β topoisomerase II-DNA complexes stabilized by VM-26
-
Danks, M. K., Qui, J., Captapano, C. V., Schmidt, C. A., Beck, W. T., and Fernandes, D. J. Subcellular distribution of the α and β topoisomerase II-DNA complexes stabilized by VM-26. Biochem. Pharmacol., 48: 1785-1795, 1994.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 1785-1795
-
-
Danks, M.K.1
Qui, J.2
Captapano, C.V.3
Schmidt, C.A.4
Beck, W.T.5
Fernandes, D.J.6
-
16
-
-
0025677217
-
Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamyein selection: Decreased anthracycline uptake precedes increased P-glycoprotein expression
-
Slapak, C. A., Daniel, J. C., and Levy, S. B. Sequential emergence of distinct resistance phenotypes in murine erythroleukemia cells under adriamyein selection: decreased anthracycline uptake precedes increased P-glycoprotein expression. Cancer Res., 50: 7895-7901, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 7895-7901
-
-
Slapak, C.A.1
Daniel, J.C.2
Levy, S.B.3
-
17
-
-
0030962278
-
Vesicular anthracycline accumulation in doxorubicin-selected U-937 cells: Participation of lysosomes
-
Hurwitz, S. J., Terashima, M., Mizunuma, N., and Slapak, C. A. Vesicular anthracycline accumulation in doxorubicin-selected U-937 cells: participation of lysosomes. Blood, 89: 3745-3754, 1997.
-
(1997)
Blood
, vol.89
, pp. 3745-3754
-
-
Hurwitz, S.J.1
Terashima, M.2
Mizunuma, N.3
Slapak, C.A.4
-
18
-
-
0028081258
-
Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells
-
Slapak, C. A., Mizunuma, N., and Kufe, D. W. Expression of the multidrug resistance associated protein and P-glycoprotein in doxorubicin-selected human myeloid leukemia cells. Blood, 84: 3113-3121, 1994.
-
(1994)
Blood
, vol.84
, pp. 3113-3121
-
-
Slapak, C.A.1
Mizunuma, N.2
Kufe, D.W.3
-
19
-
-
0029091756
-
Cross-resistance to camptothecin analoques in a mitoxantrone-resistant breast carcinoma cell line is not due to DNa topoisomerase I alterations
-
Yang, C. J., Horton, J. K., Cowan, K. H., and Schneider, E. Cross-resistance to camptothecin analoques in a mitoxantrone-resistant breast carcinoma cell line is not due to DNA topoisomerase I alterations. Cancer Res., 55: 4004-4009, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 4004-4009
-
-
Yang, C.J.1
Horton, J.K.2
Cowan, K.H.3
Schneider, E.4
-
20
-
-
0025175599
-
Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257
-
Dietel, M., Arps, H., Lage, H., and Niendorf, A. Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257. Cancer Res., 50: 6100-6106, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 6100-6106
-
-
Dietel, M.1
Arps, H.2
Lage, H.3
Niendorf, A.4
-
21
-
-
0026714604
-
Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts
-
Slapak, C. A., Lecerf, J-M., Daniel, J. C., and Levy, S. B. Energy-dependent accumulation of daunorubicin into subcellular compartments of human leukemia cells and cytoplasts. J. Biol. Chem., 267: 10638-10644, 1992.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 10638-10644
-
-
Slapak, C.A.1
Lecerf, J.-M.2
Daniel, J.C.3
Levy, S.B.4
-
22
-
-
0025991596
-
Early multidrug resistance, defined by changes in intracellular doxoruhicin distrihution, independent of P-glycoprotein
-
Schuurhuis, G. J., Broxterman, H. J., de Lange, J. H. M., Pinedo, H. M., van Heijningen, T. H. M., Kuiper, C. M., Scheffer, G. L., Scheper, R. J., van Kalken, C. K., Baak, J. P. A., and Lankelma, J. Early multidrug resistance, defined by changes in intracellular doxoruhicin distrihution, independent of P-glycoprotein. Br. J. Cancer. 64: 857-861, 1991.
-
(1991)
Br. J. Cancer.
, vol.64
, pp. 857-861
-
-
Schuurhuis, G.J.1
Broxterman, H.J.2
De Lange, J.H.M.3
Pinedo, H.M.4
Van Heijningen, T.H.M.5
Kuiper, C.M.6
Scheffer, G.L.7
Scheper, R.J.8
Van Kalken, C.K.9
Baak, J.P.A.10
Lankelma, J.11
-
23
-
-
0030476060
-
Evidence for cytoplasmic P-glycoproiein location associated with increasing niultidrug resistance to chemosensitizers
-
Abbaszadegan, M. R., Cress, A. E., Futscher, B. W., Bellamy, W. T., and Dalton, W. S. Evidence for cytoplasmic P-glycoproiein location associated with increasing niultidrug resistance to chemosensitizers. Cancer Res., 56: 5435-5442, 1996.
-
(1996)
Cancer Res.
, vol.56
, pp. 5435-5442
-
-
Abbaszadegan, M.R.1
Cress, A.E.2
Futscher, B.W.3
Bellamy, W.T.4
Dalton, W.S.5
-
24
-
-
0028908472
-
4 sub-lines with increasing adriamycin resistance
-
4 sub-lines with increasing adriamycin resistance. Int. J. Cancer, 61: 375-380, 1995.
-
(1995)
Int. J. Cancer
, vol.61
, pp. 375-380
-
-
Versantvoort, C.H.1
Withoff, S.2
Broxterntan, H.J.3
Kuiper, C.M.4
Scheper, R.J.5
Mulder, N.H.6
De Vries, E.G.7
-
25
-
-
0029889369
-
Verapamil suppresses the emergence of P-glycoprotein-mediated multi-drug resistance
-
Futscher, B. W., Gleason-Guzman, M., Meltzer, P. S., Sullivan, D. M., Folley, N. E., Bellamy, W. T., and Dalton, W. S. Verapamil suppresses the emergence of P-glycoprotein-mediated multi-drug resistance. Int. J. Cancer. 66: 520-525, 1996.
-
(1996)
Int. J. Cancer
, vol.66
, pp. 520-525
-
-
Futscher, B.W.1
Gleason-Guzman, M.2
Meltzer, P.S.3
Sullivan, D.M.4
Folley, N.E.5
Bellamy, W.T.6
Dalton, W.S.7
-
26
-
-
0025941508
-
Mitoxantrone resistance in HL-60 leukemia cells: Reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II β isoform
-
Harker, G. W., Slade, D. L., Drake, F. H., and Parr, R. L. Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II β isoform. Biochemistry, 30: 9953-9961, 1991.
-
(1991)
Biochemistry
, vol.30
, pp. 9953-9961
-
-
Harker, G.W.1
Slade, D.L.2
Drake, F.H.3
Parr, R.L.4
-
27
-
-
0026343071
-
Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line
-
Webb, C. D., Latham, M. D., Lock, R. B., and Sullivan, D. M. Attenuated topoisomerase II content directly correlates with a low level of drug resistance in a Chinese hamster ovary cell line. Cancer Res., 51: 6543-6549, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 6543-6549
-
-
Webb, C.D.1
Latham, M.D.2
Lock, R.B.3
Sullivan, D.M.4
-
28
-
-
0025901097
-
Expression of a mutant topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide
-
Bugg, B. Y., Danks, M. K., Beck, W. T., and Suttle, D. P. Expression of a mutant topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide. Proc. Natl. Acad. Sci. USA, 88: 7654-7658, 1991.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 7654-7658
-
-
Bugg, B.Y.1
Danks, M.K.2
Beck, W.T.3
Suttle, D.P.4
-
29
-
-
0030912109
-
Two COOH-terminal truncated cytoplasmic forms of topoisomerase II in a VP-16-selected lung cancer cell line result from partial gene deletion and alternative splicing
-
Yu, Q., Mirski, S. E., Sparks, K. E., and Cole, S. P. Two COOH-terminal truncated cytoplasmic forms of topoisomerase II in a VP-16-selected lung cancer cell line result from partial gene deletion and alternative splicing. Biochemistry, 36: 5868-5877, 1997.
-
(1997)
Biochemistry
, vol.36
, pp. 5868-5877
-
-
Yu, Q.1
Mirski, S.E.2
Sparks, K.E.3
Cole, S.P.4
-
30
-
-
0029006931
-
1 160,000 topoisomerase IIα is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line
-
1 160,000 topoisomerase IIα is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line. Cancer Res., 55: 2129-2134, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 2129-2134
-
-
Mirski, S.E.1
Cole, S.P.2
-
31
-
-
0028091270
-
Altered subcellular distribution of topoisomerase II α in a drug-resistant human small cell lung cancer cell line
-
Feldhoff, P. W., Mirski, S. E., Cole, S. P., and Sullivan. D. M. Altered subcellular distribution of topoisomerase II α in a drug-resistant human small cell lung cancer cell line. Cancer Res., 54: 756-762, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 756-762
-
-
Feldhoff, P.W.1
Mirski, S.E.2
Cole, S.P.3
Sullivan, D.M.4
-
32
-
-
0030774826
-
1492 in the COOH-terminal region of topoisomerase IIα in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization
-
1492 in the COOH-terminal region of topoisomerase IIα in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization. Cancer Res., 57: 4451-4454, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 4451-4454
-
-
Wessel, I.1
Jenson, P.B.2
Falck, J.3
Mirski, S.E.4
Cole, S.P.5
Sehested, M.6
-
33
-
-
0028985942
-
Alterations in the topoisomerase IIα gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNa topoisomerase II β enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line
-
Harker, W. G., Slade, L. D., Parr, R. L., Feldhoff, P. W., Sullivan, D. M., and Holquin, M. H. Alterations in the topoisomerase IIα gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II β enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line. Cancer Res., 55: 1707-1716, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 1707-1716
-
-
Harker, W.G.1
Slade, L.D.2
Parr, R.L.3
Feldhoff, P.W.4
Sullivan, D.M.5
Holquin, M.H.6
-
34
-
-
0026048306
-
Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells
-
Friche, E., Danks, M. K., Schmidt, C. A., and Beck, W. T. Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells. Cancer Res., 51: 4213-4218, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 4213-4218
-
-
Friche, E.1
Danks, M.K.2
Schmidt, C.A.3
Beck, W.T.4
-
35
-
-
0027274736
-
Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia
-
List, A. F., Spier, C., Greer, J., Wolf, S., Hutter, S., Dorr, R., Salmon, S., Futscher, B., Baier, M., and Dalton, W. Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. J. Clin. Oncol., II: 1652-1660, 1993.
-
(1993)
J. Clin. Oncol.
, vol.2
, pp. 1652-1660
-
-
List, A.F.1
Spier, C.2
Greer, J.3
Wolf, S.4
Hutter, S.5
Dorr, R.6
Salmon, S.7
Futscher, B.8
Baier, M.9
Dalton, W.10
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