On the Mechanism of Topoisomerase I Inhibition by Camptothecin: Evidence for Binding to an Enzyme-DNA Complex

Biochemistry

Volumn 28, Issue 11, 1989, Pages 4629-4638

  Hertzberg, Robert P ^a   Caranfa, Mary Jo ^a   Hecht, Sidney M ^a  

^a SmithKline Beecham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE;

ANIMAL CELL; CATTLE; DRUG DNA INTERACTION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL;

CAMPTOTHECIN; CATALYSIS; COLLODION; COPPER; DNA; DNA TOPOISOMERASES, TYPE I; DNA, SUPERHELICAL; DNA-BINDING PROTEINS; HYDROLYSIS; HYDROXYLATION; ORGANOMETALLIC COMPOUNDS; PLASMIDS; SUPPORT, U.S. GOV'T, P.H.S.; ULTRAVIOLET RAYS;

EID: 0024324205     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00437a018     Document Type: Article

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