O6-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives

Japanese Journal of Cancer Research

Volumn 93, Issue 1, 2002, Pages 93-102

  Okamoto, Ryo ^a   Takano, Hiroshi ^a   Okamura, Tatsunori ^b   Park, Ji Seon ^a   Tanimoto, Keiji ^a   Sekikawa, Takashi ^c   Yamamoto, Wataru ^c   Sparreboom, Alex ^d   Verweij, Jaap ^d   Nishiyama, Masahiko ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^c SHOWA UNIVERSITY   (Japan)

^d ERASMUS MC CANCER INSTITUTE   (Netherlands)

Author keywords

CPT 11; Drug resistance; DX 8951f; MGMT

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DRUG METABOLITE; EXATECAN; IRINOTECAN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NIMUSTINE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DRUG ACTIVITY; DRUG RESISTANCE; DRUG SENSITIVITY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; WESTERN BLOTTING;

EID: 0036160987     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2002.tb01205.x     Document Type: Article

References (23)

1. Cellular determinants of sensitivity and resistance to camptothecins
2. The role of glucuronidation in 7-ethyl-10-hydroxy-camptothecin resistance in vitro
3. The current status of camptothecin analogues as anti-tumor agents
4. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo
5. DX-8951f, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant
6. Characterization of a human small-cell lung cancer cell line resistant to a new water-soluble camptothecin derivative, DX-8951f
7. An overview of the clinical pharmacology of topotecan
8. Topoisomerase I-mediated DNA damage and repair
9. 6-Alkylation of guanine induces topoisomerase I-DNA covalent complexes in vitro and in MNNG-treated cells
10. NADPH/quinone oxidoreductase is a priority target of glioblastoma chemotherapy
11. 6-Methylguanaine-DNA methytransferase is a critical determinant of cytotoxicity for DNA topoisomerase I inhibitors
12. Molecular targeting of mitomycin C chemotherapy
13. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma
14. Suppression of human colorectal carcinoma cell growth by wild-type p53
15. A multidrug resistance transporter from human MCF-7 breast cancer cells
16. 6-alkylguanine
17. 6-alkylguanine-DNA alkyltransferase activity in human cells and tumor tissues by restriction endonuclease inhibition
18. 6-benzylguanine combined with streptozocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity
19. A role of erythrocytes and serum proteins in the kinetic profile of total 9-amino-20(S)-camptothecin in human
20. 6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents
21. 6-methylguanine-DNA alkyltransferase
22. 6-alkylguanine-DNA alkyltransferase in protecting against cyclophosphamide-induced toxicity and mutagenicity
23. 6-arylmethylguanines