Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells

World Journal of Gastroenterology

Volumn 13, Issue 37, 2007, Pages 4960-4966

  McVicker, Benita L ^a,b   Tuma, Dean J ^a,b   Casey, Carol A ^a,b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Caspase; Ethanol; Fas receptor; Hepatoma hybrid cells

Indexed keywords

ALCOHOL; CYTOCHROME P450 2E1; CYTOKINE; FAS ANTIGEN; FAS LIGAND; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; APOPTOSIS; CELL CULTURE; CELL DAMAGE; CELL HYBRIDIZATION; CELL POLARITY; CELL SURVIVAL; CLINICAL FEATURE; DISEASE COURSE; FATALITY; HEPATOMEGALY; HUMAN; LIVER CELL; LIVER CIRRHOSIS; LIVER INJURY; MOLECULAR DYNAMICS; NONHUMAN; OXIDATIVE STRESS; REVIEW; SYMPTOMATOLOGY;

EID: 34848876971     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i37.4960     Document Type: Review

References (73)

1. Dufour MC, Stinson FS, Caces MF. Trends in cirrhosis morbidity and mortality: United States, 1979-1988. Semin Liver Dis 1993; 13: 109-125
2. French SW. Ethanol and hepatocellular injury. Clin Lab Med 1996; 16: 289-306
3. Malliard ME, Sorrell MF, Volentine GD, Tuma DJ. Impaired plasma membrane glycoprotien assembly in the liver following acute ethanol administration. Biochem and Biophys Res Commun 1984; 123: 951-958
4. Sorrell MF, Nauss JM, Donohue TM Jr, Tuma DJ. Effects of chronic ethanol administration on hepatic glycoprotein secretion in the rat. Gastroenterology 1983; 84: 580-586
5. Sorrell MK, Tuma DJ. Hypothesis: alcoholic liver injury and the covalent binding of acetaldehyde. Alcohol Clinical and Exp Res 1985; 9: 306-309
6. Wu D, Cederbaum AI. Expression of cytochrome P4502E1 in rat fetal hepatocyte culture. Mol Pharmacol 1996; 49: 802-807
7. Hoek JB, Pastorino JG. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 2002; 27: 63-68
8. McClain CJ, Barve S, Deaciuc I, Kugelmas M, Hill D. Cytokines in alcoholic liver disease. Semin Liver Dis 1999; 19: 205-219
9. Valente M, Calabrese F. Liver and apoptosis. Ital J Gastroenterol Hepatol 1999; 31: 73-77
10. Kanzler S, Galle PR. Apoptosis and the liver. Semin Cancer Biol 2000; 10: 173-184
11. Deaciuc IV, Fortunato F, D'Souza NB, Hill DB, Schmidt J, Lee EY, McClain CJ. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res 1999; 23: 349-356
12. Baroni GS, Marucci L, Benedetti A, Mancini R, Jezequel AM, Orlandi F. Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver. J Hepatol 1994; 20: 508-513
13. Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, Gores GJ. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J Hepatol 2001; 34: 248-253
14. Benedetti A, Brunelli E, Risicato R, Cilluffo T, Jezequel AM, Orlandi F. Subcellular changes and apoptosis induced by ethanol in rat liver. J Hepatol 1988; 6: 137-143
15. Yacoub LK, Fogt F, Griniuviene B, Nanji AA. Apoptosis and bcl-2 protein expression in experimental alcoholic liver disease in the rat. Alcohol Clin Exp Res 1995; 19: 854-859
16. Kerr JFR, Winterford CM, Harmon BV. Morphological Criteria for Identifying Apoptosis. Cell Biology: A Laboratory Handbook: Academic Press Inc, 1994: 319-329
17. Cohen JJ. Apoptosis. Immunol Today 1993; 14: 126-130
18. Gerschenson LE, Rotello RJ. Apoptosis: a different type of cell death. FASEB J 1992; 6: 2450-2455
19. Ryter SW, Kim HP, Hoetzel A, Park JW, Nakahira K, Wang X, Choi AMK. Mechanisms of cell death in oxidative stress. Antioxid Redox Signal 2007; 9: 49-89
20. Castillo T, Koop DR, Kamimura S, Triadafilopoulos G, Tsukamoto H. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Hepatology 1992; 16: 992-996
21. Diehl AM. Cytokine regulation of liver injury and repair. Immunol Rev 2000; 174: 160-171
22. Luster MI, Simeonova PP, Gallucci R, Matheson J. Tumor necrosis factor alpha and toxicology. Crit Rev Toxicol 1999; 29: 491-511
23. Jaeschke H, Gores GJ, Cederbatun AI, Hinson JA, Pessayre D, Lemasters JJ. Mechanisms of hepatotoxicity. Toxicol Sci 2002; 65: 166-176
24. Castaneda F, Kinne RK. Apoptosis induced in HepG2 cells by short exposure to millimolar concentrations of ethanol involves the Fas-receptor pathway. J Cancer Res Clin Oncol 2001; 127: 418-424
25. Wu D, Cederbaum AI. Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem 1996; 271: 23914-23919
26. Chen Q, Galleano M, Cederbaum AI. Cytotoxicity and apoptosis produced by arachidonic acid in Hep G2 cells overexpressing human cytochrome P4502E1. J Biol Chem 1997; 272: 14532-14541
27. Neuman MG. Apoptosis in diseases of the liver. Crit Rev Clin Lab Sci 2001; 38: 109-166
28. Katz GG, Shear NH, Malkiewicz IM, Valentino K, Neuman MG. Signaling for ethanol-induced apoptosis and repair in vitro. Clin Biochem 2001; 34: 219-227
29. Fernandez-Checa JC, Yi JR, Garcia Ruiz C, Ookhtens M, Kaplowitz N. Plasma membrane and mitochondrial transport of hepatic reduced glutathione. Semin Liver Dis 1996; 16: 147-158
30. Mari M, Bai J, Cederbaum AI. Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria. Free Radic Biol Med 2002; 32: 73-83
31. Coll O, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC. Sensitivity of the 2-oxoglutarate carTier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology 2003; 38: 692-702
32. Cameron RG, Neuman MG. Novel morphologic findings in alcoholic liver disease. Clin Biochem 1999; 32: 579-584
33. Pastorino JG, Hoek JB. Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology 2000; 31: 1141-1152
34. Colantoni A, Idilman R, De Maria N, La Paglia N, Belmonte J, Wezeman F, Emanuele N, Van Thiel DH, Kovacs EJ, Emanuele MA. Hepatic apoptosis and proliferation in male and female rats fed alcohol: role of cytokines. Alcohol Clin Exp Res 2003; 27: 1184-1189
35. Fernandez-Checa JC, Colell A, Garcia-Ruiz C. S-Adenosyl-L-methionine and mitochondrial reduced glutathione depletion in alcoholic liver disease. Alcohol 2002; 27: 179-183
36. Massague J. The transforming growth factor-beta family. Annu Rev Cell Biol 1990; 6: 597-641
37. Border WA, Noble NA. Transforming growth factor beta in tissue fibrosis. N Engl J Med 1994; 331: 1286-1292
38. Fang C, Lindros KO, Badger TM, Ronis MJ, Ingelman-Sundberg M. Zonated expression of cytokines in rat liver: effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole. Hepatology 1998; 27: 1304-1310
39. Kamimura S, Sohda T, Shijo H, Takeshima M, Sugyo S, Okumura M. Hepatic fibrosis in rats fed a liquid diet with ethanol and carbonyl iron. Int Hepatol Commun 1995; 3: 70-76
40. Sanchez A, Alvarez AM, Benito M, Fabregat I. Apoptosis induced by transforming growth factor-beta in fetal hepatocyte primary cultures: involvement of reactive oxygen intermediates. J Biol Chem 1996; 271: 7416-7422
41. Franklin CC, Rosenfeld-Franklin ME, White C, Kavanagh TJ, Fausto N. TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms. FASEB J 2003; 17: 1535-1537
42. Albright CD, Borgman C, Craciunescu CN. Activation of a caspase-dependent oxidative damage response mediates TGFbeta1 apoptosis in rat hepatocytes. Exp Mol Pathol 2003; 74: 256-261
43. Cain K, Freathy C. Liver toxicity and apoptosis: role of TGF-beta1, cytochrome c and the apoptosome. Toxicol Lett 2001; 120: 307-315
44. Yoon JH, Gores GJ. Death receptor-mediated apoptosis and the liver. J Hepatol 2002; 37: 400-410
45. Taieb J, Mathurin P, Poynard T, Gougerot-Pocidalo MA, Chollet-Martin S. Raised plasma soluble Fas and Fas-ligand in alcoholic liver disease. Lancet 1998; 351: 1930-1931
46. Nagata S, Golstein P. The Fas death factor. Science 1995; 267: 1449-1456
47. Deaciuc IV, Fortunato F, D'Souza NB, Hill DB, Schmidt J, Lee EY, McClain CJ. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and lipopolysaccharide. Alcohol Clin Exp Res 1999; 23: 349-356
48. Zhou Z, Sun X, Kang YJ. Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 2001; 159: 329-338
49. Higuchi H, Kurose I, Kato S, Miura S, Ishii H. Ethanol-induced apoptosis and oxidative stress in hepatocytes. Alcholism Clinical and Exp Res 1996; 9: 340-346
50. Adachi M, Higuchi H, Miura S, Azuma T, Inokuchi S, Saito H, Kato S, Ishii H. Bax interacts with the voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. Am J Physiol Gastrointest Liver Physiol 2004; 287: G695-G705
51. Minana JB, Gomez-Cambronero L, Lloret A, Pallardo FV, Del Olmo J, Escudero A, Rodrigo JM, Pelliin A, Vina JR, Vina J, Sastre J. Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology 2002; 35: 1205-1214
52. Higuchi H, Adachi M, Miura S, Gores GJ, Ishii H. The mitochondrial permeability transition contributes to acute ethanol-induced apoptosis in rat hepatocytes. Hepatology 2001; 34: 320-328
53. Kim SY, Kim JK, Kim HJ, Ahn JK. Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression. IUBMB Life 2005; 57: 651-658
54. Wu D, Cederbaum AI. Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol 2005; 207: 70-76
55. Cederbaum AI, Wu D, Mari M, Bai J. CYP2E1-dependent toxicity and oxidative stress in HepG2 cells. Free Radic Biol Med 2001; 31: 1539-1543
56. Wu D, Cederbaum AI. Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1. Alcohol Clin Exp Res 1999; 23: 67-76
57. Wu D, Cederbaum AI. Ethanol and arachidonic acid produce toxicity in hepatocytes from pyrazole-treated rats with high levels of CYP2E1. Mol Cell Biochem 2000; 204: 157-167
58. Albano E. Alcohol, oxidative stress and free radical damage. Proc Nutr Soc 2006; 65: 278-290
59. Zhuge J, Cederbatun AI. Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. Free Radic Biol Med 2006; 40: 63-74
60. Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial glutathione: hepatocellular survival-death switch. J Gastroenterol Hepatol 2006; 21 Suppl 3: S3-S6
61. Luedde T, Trautwein LT. Intracellular survival pathways in the liver. Liver Int 2006; 26: 1163-1174
62. Donohue TM, Osna NA, Clemens DL. Recombinant Hep G2 cells that express alcohol dehydrogenase and cytochrome P450 2E1 as a model of ethanol-elicited cytotoxicity. Int J Biochem Cell Biol 2006; 38: 92-101
63. Pani G, Fusco S, Colavitti R, Borrello S, Maggiano N, Cravero AA, Farre SM, Galeotti T, Koch OR. Abrogation of hepatocyte apoptosis and early appearance of liver dysplasia in ethanol-fed p53-deficient mice. Biochem Biophys Res Commun 2004; 325: 97-100
64. Yeon JE, Califano S, Xu J, Wands JR, De La Monte SM. Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Hepatology 2003; 38: 703-714
65. Ihrke G, Neufeld EB, Meads T, Shanks MR, Cassio D, Laurent M, Schroer TA, Pagano RE, Hubbard AL. WIF-B cells: an in vitro model for studies of hepatocyte polarity. J Cell Biol 1993; 123: 1761-1775
66. Cassio D, Hamon-Benais C, Guerin M, Lecoq O. Hybrid cell lines constitute a potential reservoir of polarized cells: isolation and study of highly differentiated hepatoma-derived hybrid cells able to form functional bile canaliculi in vitro. J Cell Biol 1991; 115: 1397-1408
67. Schaffert CS, Todero SL, McVicker BL, Tuma PL, Sorrell MF, Tuma DJ. WIF-B cells as a model for alcohol-induced hepatocyte injury. Biochem Pharmacol 2004; 67: 2167-2174
68. Decaens C, Rodriguez P, Bouchaud C, Cassio D. Establishment of hepatic cell polarity in the rat hepatoma-human fibroblast hybrid WIF-B9. A biphasic phenomenon going from a simple epithelial polarized phenotype to an hepatic polarized one. J Cell Sci 1996; 109: 1623-1635
69. Bender V, Bravo P, Decaens C, Cassio D. The structural and functional polarity of the hepatic human/rat hybrid WIF-B is a stable and dominant trait. Hepatology 1999; 30: 1002-1010
70. Bravo P, Bender V, Cassio D. Efficient in vitro vectorial transport of a fluorescent conjugated bile acid analogue by polarized hepatic hybrid WIF-B and WIF-B9 cells. Hepatology 1998; 27: 576-583
71. Tuma PL, Nyasae LK, Backer JM, Hubbard AL. Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells. J Cell Biol 2001; 154: 1197-1208
72. Tuma PL, Nyasae LK, Hubbard AL. Nonpolarized cells selectively sort apical proteins from cell surface to a novel compartrnent, but lack apical retention mechanisms. Mol Biol Cell 2002; 13: 3400-3415
73. McVicker BL, Tuma DJ, Kubik JL, Tuma PL, Casey CA. Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway. Alcohol Clin Exp Res 2006; 30: 1906-1915