Liver toxicity and apoptosis: Role of TGF-β1, cytochrome c and the apoptosome

Toxicology Letters

Volumn 120, Issue 1-3, 2001, Pages 307-315

  Cain, Kelvin ^a   Freathy, Caroline ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Apoptosis; Apoptosome; Caspases; Hepatocyte; TGF 1

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CASPASE 9; CELL PROTEIN; CYTOCHROME C; FAS ANTIGEN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

APOPTOSIS; CELL DEATH; CELL MEMBRANE; CELL ORGANELLE; CONFERENCE PAPER; ENZYME ACTIVATION; HUMAN; LIVER CELL; LIVER SIZE; LIVER TOXICITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; STRESS;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASES; CYTOCHROME C GROUP; ENZYME ACTIVATION; HEPATOCYTES; HUMANS; MOLECULAR WEIGHT; PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0035977898     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(01)00283-1     Document Type: Conference Paper

References (38)

1. Mads and Smads in TGFβ signalling
2. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis
3. Growth, regression and cell death in rat liver as related to tissue levels of the hepatomitogen cyproterone acetate
4. A cleavage-site-directed inhibitor of interleukin 1 beta-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes
5. Caspase activation involves the formation of the aposome, a large (similar to 700 kDa) caspase-activating complex
6. Apaf-1 oligomerizes into biologically active ∼700-kDa and inactive ∼1.4-MDa apoptosome complexes
7. ICE-Like protease (caspase) is involved in transforming growth factor beta 1-mediated apoptosis in FaO rat hepatoma cell line
8. Involvement of an ICE-like protease in Fas-mediated apoptosis
9. Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane
10. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas
11. Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration
12. 1 induces apoptosis in rat Fao hepatoma cells via cytochrome c release and oligomerization of apaf-1 to form a ∼700-kd apoptosome caspase processing complex
13. Induction of apoptosis by transforming growth-factor-beta-1 in the rat hepatoma-cell line McA-RH7777 - A possible association with tissue transglutaminase expression
14. Mitochondria and apoptosis
15. Transforming growth factor beta 1 potently activates CPP32-like proteases in human hepatoma cells
16. Processing/activation of CPP32-like proteases is involved in transforming growth factor β1-induced apoptosis in rat hepatocytes
17. Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics
18. In vitro apoptosis in the human hepatoma-cell line induced by transforming growth factor-beta-1
19. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
20. Liver regeneration
21. Induction of apoptosis in cultured-hepatocytes and in the regressing liver by transforming growth factor-beta-1 occurs without activation of an endonuclease
22. Induction of apoptosis in cultured-hepatocytes and in regressing liver by transforming growth factor-beta-1
23. Apoptosis is induced by transforming growth-factor-beta-1 within 5 hours in regressing liver without significant fragmentation of the DNA
24. Lethal effect of the anti-Fas antibody in mice
25. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
26. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1)
27. The transforming growth factor β1-inducible transcription factor, TIEG1, mediates apoptosis through oxidative stress
28. Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
29. Caspase-9 and APAF-1 form an active holoenzyme
30. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
31. Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor β in fetal rat hepatocytes in primary culture
32. Apoptosis and multistage carcinogenesis in rat liver
33. The significance of cell death by apoptosis in hepatobilliary disease
34. 2+ accumulation and early DNA fragmentation with cell death
35. Activation of caspase-8 in transforming growth factor-beta-induced apoptosis of human hepatoma cells
36. Caspases: Enemies within
37. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
38. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9