Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells

Journal of Cell Biology

Volumn 154, Issue 6, 2001, Pages 1197-1208

  Tuma, Pamela L ^a   Nyasae, Lydia K ^a   Backer, Jonathan M ^b   Hubbard, Ann L ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Endocytosis; Hepatocytes; Phosphoinositides; Polarity; Transcytosis

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN VPS34P; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CATALYSIS; CELL POLARITY; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; LIVER CELL; LIVER LYSOSOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RECYCLING; REGULATORY MECHANISM;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; ANTIBODIES, MONOCLONAL; CELL MEMBRANE; CELL POLARITY; ENDOCYTOSIS; ENDOSOMES; EPITHELIAL CELLS; LIVER; LYSOSOMES; MEMBRANE PROTEINS; MICROINJECTIONS; PROTEINS; RATS; TUMOR CELLS, CULTURED; VACUOLES; VESICULAR TRANSPORT PROTEINS;

EID: 0035904227     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200105138     Document Type: Article

References (45)

1. Phosphoinositide 3-kinases and the regulation of vesicular trafficking
2. Newly synthesized hepatocyte PM proteins are transported in cranscytotic vesicles in the bile duct-ligared rat
3. Immunoadsorption of hepatic vesicles carting newly synthesized dipeptldyl pepridase IV and polymeric IgA receptor
4. Endocyrosis in filter-grown Madin-Darby Canine Kidney cells
5. Role for phosphatidylinosirol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells
6. Wortmannin inhibits transcytosis of dimeric IgA by the polymeric immunoglobulln receptor
7. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
8. Receptor-mediated endocytosis of epidermal growth factor by rat hepatocytes: Receptor pathway
9. Phosphoinositide kinases
10. Convergence of the apical and basolateral endocytic pathways at apical late endosomes in absorptive cells of suckling rat ileum in vivo
11. Endogenous syntaxins 2, 3, and 4 exhibit distinct but overlapping patterns of expression at the hepatocyte PM
12. Actin microfilaments play a critical role in endocytosis at the apical but not the basolateral surface of polarized epithelial cells
13. Wortmannin, an inhibitor of phosphoinositide 3-kinase, inhibits transcytosis in polarized epithelial cells
14. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
15. A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole
16. Specific requirement for the p85-p110α phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells
17. Phorbol myristate acetate selectively stimulates apical endocytosis via protein kisnase C in polarized MDCK cells
18. WIF-B cells: An in vitro model for studies of hepatocyte polarity
19. Apical PM proteins and endolyn-78 travel through a subapical compartment in polarized WIF-B hepatocytes
20. Inhibition of apical but not basolateral endocytosis of ricin and folate in Caco-2 cells by cytochalasin D
21. Microinjection, of the SH2 domain of the 85-kilodalton subunit of phosphatidylinositol 3-kinase inhibits insulin-induced DNA synthesis and c-fos expression
22. Post-Golgi biosynthetic trafficking
23. Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells
24. Sorting of membrane and fluid at the apical pole of polarized Madin Darby Canine Kidney cells
25. Effect of calmodulin antagonists on endocytosis and intracellular transport of ricin in polarized MDCK cells
26. Oligomeric complexes link rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13
27. Phosphoinositide 3-kinase lipid products regulate ATP-dependent transport by sister of P-glycoprotein coprotein and multidrug resistance associated protein 2 in bile canalicular membrane vesicles
28. Characterization of p150, an adaptor protein for the human phosphatidyl inositol (Ptd-Ins) 3-kinase
29. Meeting of the apical and basolateral endocytic pathways of the Madin-Darby Canine Kidney cell in late endosomes
30. Identification of an early endosomal protein regulated by phosphatidylinositol 3-kinase
31. Apical endocyrosis in rat hepatocytes in situ involves clathrin, traverses a sub-apical compartment, and leads to lysosomes
32. The effect of wortmannin on the localisation of lysosomal type 1 integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocyric parhway
33. Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins
34. An improved rat hepatoma hybrid cell line. Generation and comparison with its hepatoma relatives and hepatocytes in vivo
35. Phosphoinositide 3-kinases and membrane traffic
36. The effects of cytochalasin D and phorbol myristate acetate on the apical endocytosis of ricin in polarised Caco-2 cells
37. Distinct roles for p110α and hVPS34 phosphatidylinosirol 3′-kinases in vesicular trafficking, regulation of the actin cytoskeleton, and mitogenesis
38. FYVE-finger proteins-effectors of an inositol lipid
39. The hepatocyte surface: Dynamic polarity
40. Evidence of apical endocytosis in polarized hepatic cells: Phosphoinositide 3-kinase inhibitors lead to the lysosomal accumulation of resident apical plasma membrane proteins
41. Acidification of lysosomes and endosomes
42. A human phosphatidylinositol 3-kinase complex related to yeast Vps34p-Vps15p protein sorting system
43. Receptor-mediated endocytosis of asialoglycoproteins by rat liver hepatocytes: Biochemical characterization of the endosomal compartments
44. Phosphoinositide signaling and turnover: Ptd-Ins(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities
45. Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85