Hepatitis B virus X protein sensitizes UV-induced apoptosis by transcriptional transactivation of Fas ligand gene expression

IUBMB Life

Volumn 57, Issue 9, 2005, Pages 651-658

  Kim, Sang Yong ^a   Kim, Jeong Ki ^a   Kim, Hye Jin ^a   Ahn, Jeong Keun ^a  

^a Chungnam National University   (South Korea)

Author keywords

Apoptosis; FasL; HBV X protein (HBx); Transactivation

Indexed keywords

DNA FRAGMENT; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; MESSENGER RNA; MUTANT PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS X PROTEIN;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DNA DETERMINATION; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; MICROBIOLOGICAL EXAMINATION; MOLECULAR MECHANICS; PROMOTER REGION; SENSITIZATION; TRANSACTIVATION; ULTRAVIOLET RADIATION;

APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; CHLORAMPHENICOL O-ACETYLTRANSFERASE; FAS LIGAND PROTEIN; GENES, REPORTER; HEPATOCYTES; HUMANS; LIGANDS; LIVER NEOPLASMS; MEMBRANE GLYCOPROTEINS; RNA, SMALL INTERFERING; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTORS; ULTRAVIOLET RAYS;

HEPATITIS B VIRUS;

EID: 27444447839     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540500239697     Document Type: Article

References (38)

1. Nita, M. E., Alves, V. A., Carrilho, F. J., Ono-Nita, S. K., Mello, E. S., and Gama-Rodrigues, J. J. (2002) Molecular aspects of hepatic carcinogenesis. Rev. Inst. M ed. Trop. Sao Paulo 44, 39-48.
2. Tiollais, P., Pourcel, C., and Dejean, A. (1985) The hepatitis B virus. Nature 317, 489-495.
3. Klein, N. P., Bouchard, M. J., Wang, L. H., Kobarg, C., and Schneider, R. J. (1999) Src kinases involved in hepatitis B virus replication. Embo J. 18, 5019-5027.
4. Bouchard, M. J., Wang, L. H., and Schneider, R. J. (2001) Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science 294, 2376-2378.
5. Rossner, M. T. (1992) Review: Hepatitis B virus X-gene product: A promiscuous transcriptional activator. J. Med. Virol. 36, 101-117.
6. Cromlish, J. A. (1996) Hepatitis B virus-induced hepatocellular carcinoma: Possible roles for HBx. Trends Microbiol. 4, 270-274.
7. Ahn, J. Y., Chung, E. Y., Kwun, H. J., and Jang, K. L. (2001) Transcriptional repression of p21(waf1) promoter by hepatitis B virus X protein via a p53-independent pathway. Gene 275, 163-168.
8. Yoo, Y. D., Ueda, H., Park, K., Flanders, K. C., Lee, Y. I., Jay, G., and Kim, S. J. (1996) Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis. J. Clin. Invest. 97, 388-395.
9. Menzo, S., Clementi, M., Alfani, E., Bagnarelli, P., Iacovacci, S., Manzin, A., Dandri, M., Natoli, G., Levrero, M., and Carloni, G. (1993) Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product. Virology 196, 878-882.
10. Twu, J. S., and Robinson, W. S. (1989) Hepatitis B virus X gene can transactivate heterologous viral sequences. Proc. Natl. Acad. Sci. USA 86, 2046-2050.
11. Maguire, H. F., Hoeffler, J. P., and Siddiqui, A. (1991) HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science 252, 842-844.
12. Qadri, I., Maguire, H. F., and Siddiqui, A. (1995) Hepatitis B virus transactivator protein X interacts with the TATA- binding protein. Proc. Natl. Acad. Sci. USA 92, 1003-1007.
13. Seto, E., Mitchell, P. J., and Yen, T. S. (1990) Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature 344, 72-74.
14. Benn, J., and Schneider, R. J. (1994) Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl. Acad. Sci. USA 91, 10350-10354.
15. Cross, J. C., Wen, P., and Rutter, W. J. (1993) Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proc. Natl. Acad. Sci. USA 90, 8078-8082.
16. Kekule, A. S., Lauer, U., Weiss, L., Luber, B., and Hofschneider, P. H. (1993) Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361, 742-745.
17. Natoli, G., Avantaggiati, M. L., Chirillo, P., Puri, P. L., Ianni, A., Balsano, C., and Levrero, M. (1994) Ras- and Raf-dependent activation of c-jun transcriptional activity by the hepatitis B virus transactivator pX. Oncogene 9, 2837-2843.
18. Kim, H., Lee, H., and Yun, Y. (1998) X-gene product of hepatitis B virus induces apoptosis in liver cells. J. Biol. Chem. 273, 381-385.
19. Bontron, S., Lin-Marq, N., and Strubin, M. (2002) Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2. J. Biol. Chem. 277, 38847-38854.
20. Terradillos, O., de La Coste, A., Pollicino, T., Neuveut, C., Sitterlin, D., Lecoeur, H., Gougeon, M. L., Kahn, A., and Buendia, M. A. (2002) The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver. Oncogene 21, 377-386.
21. Shih, W. L., Kuo, M. L., Chuang, S. E., Cheng, A. L., and Doong, S. L. (2000) Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidy-linositol 3- kinase pathway. J. Biol. Chem. 275, 25858-25864.
22. Wang, X. W., Gibson, M. K., Vermeulen, W., Yeh, H., Forrester, K., Sturzbecher, H. W., Hoeijmakers, J. H., and Harris, C. C. (1995) Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Res. 55, 6012-6016.
23. Gottlob, K., Fulco, M., Levrero, M., and Graessmann, A. (1998) The hepatitis B virus HBx protein inhibits caspase 3 activity. J. Biol. Chem. 273, 33347-33353.
24. Rehemtulla, A., Hamilton, C. A., Chinnaiyan, A. M., and Dixit, V. M. (1997) Ultraviolet radiation-induced apoptosis is mediated by activation of CD- 95 (Fas/APO-1). J. Biol. Chem. 272, 25783-25786.
25. Galle, P. R., Hofmann, W. J., Walczak, H., Schaller, H., Otto, G., Stremmel, W., Krammer, P. H., and Runkel, L. (1995) Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage. J. Exp. Med. 182, 1223-1230.
26. Kim, Y. K., Junn, E., Park, I., Lee, Y., Kang, C., and Ahn, J. K. (1999) Repression of hepatitis B virus X gene expression by hammerhead ribozymes. Biochem. Biophys. Res. Commun. 257, 759-765.
27. Mittelstadt, P. R., and Ashwell, J. D. (1998) Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mol. Cell Biol. 18, 3744-3751.
28. Wada, N., Matsumura, M., Ohba, Y., Kobayashi, N., Takizawa, T., and Nakanishi, Y. (1995) Transcription stimulation of the Fas-encoding gene by nuclear factor for interleukin-6 expression upon influenza virus infection. J. Biol. Chem. 270, 18007-18012.
29. Kuprash, D. V., Udalova, I. A., Turetskaya, R. L., Kwiatkowski, D., Rice, N. R., and Nedospasov, S. A. (1999) Similarities and differences between human and murine TNF promoters in their response to lipopolysaccharide. J. Immunol. 162, 4045-4052.
30. Newton, K., Harris, A. W., Bath, M. L., Smith, K. G., and Strasser, A. (1998) A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. Embo J. 17, 706-718.
31. Park, A., and Baichwal, V. R. (1996) Systematic mutational analysis of the death domain of the tumor necrosis factor receptor 1-associated protein TRADD. J. Biol. Chem. 271, 9858-9862.
32. Schwartz, L. M., and Osborne, B. A. (1995) Cell death. Methods Cell Biol. 46, xv-xviii.
33. Burton, K. (1956) A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 62, 315-323.
34. McConkey, D. J., Hartzell, P., Jondal, M., and Orrenius, S. (1989) Inhibition of DNA fragmentation in thymocytes and isolated thymocyte nuclei by agents that stimulate protein kinase C. J. Biol. Chem. 264, 13399-13402.
35. Eara-Pezzi, E., Armesilla, A. E., Majano, P. E., Redondo, J. M., and Eopez-Cabrera, M. (1998) The hepatitis B virus X protein activates nuclear factor of activated T cells (NF-AT) by a cyclosporin A-sensitive pathway. Embo J. 17, 7066-7077.
36. Su, F., and Schneider, R. J. (1997) Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc. Natl. Acad. Sci. USA 94, 8744-8749.
37. Andrisani, O. M., and Barnabas, S. (1999) The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review). Int. J. Oncol. 15, 373-379.
38. Bergametti, F., Prigent, S., Euber, B., Benoit, A., Tiollais, P., Sarasin, A., and Transy, C. (1999) The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines. Oncogene 18, 2860-2871.