Zonated expression of cytokines in rat liver: Effect of chronic ethanol and the cytochrome P450 2E1 inhibitor, chlormethiazole

Hepatology

Volumn 27, Issue 5, 1998, Pages 1304-1310

  Fang, Che ^a   Lindros, Kai O ^b   Badger, Thomas M ^c   Ronis, Martin J J ^c   Ingelman Sundberg, Magnus ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOMETHIAZOLE; CYTOCHROME P450 INHIBITOR; CYTOCHROME P450 ISOENZYME; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SYNTHESIS; HEPATITIS; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; CHLORMETHIAZOLE; CYTOCHROME P-450 CYP2E1; CYTOKINES; ETHANOL; GENE EXPRESSION; INTERLEUKIN-1; INTERLEUKINS; LIVER; LIVER DISEASES, ALCOHOLIC; MALE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031971248     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510270516     Document Type: Article

References (11)

1. Hansen J, Cherwitz DL, Allen JI. The role of tumor necrosis factor-aα in acute endotoxin-induced hepatotoxicity in ethanol-fed rats. HEPATOLOGY 1994;20:461-475.
2. Ingelman-Sundberg M, Ronis MJJ, Lindros KO, Eliasson E, Zhukov A. Ethanol-inducible cytochrome P4502E1: regulation, enzymology and molecular biology. Alcohol Alcohol 1994;(Suppl 2):133S-141S.
3. Alcolado R, Arthur MJP, Iredale JP. Pathogenesis of liver fibrosis. Clin Sci 1997;92:103-112.
4. Arnon R, Esposti SD, Zern MA. Molecular biological aspects of alcohol-induced liver disease. Alcohol Clin Exp Res 1995;19:247-256.
5. Lands WEM. Cellular signals in alcohol-induced liver injury: a review. Alcohol Clin Exp Res 1995;19:928-938.
6. Lindros KO. Alcoholic liver disease: pathobiological aspects. J Hepatol 1995;23(Suppl 1):7S-15S.
7. Nanji AA, Tsukamoto H, French SW. Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease. Exp Mol Pathol 1989;51:141-148.
8. Nanji AA, Zhao S, Sadrzadeh SMH, Waxman DJ. Use of reverse transcription-polymerase chain reaction to evaluate in vivo cytokine gene expression in rats fed ethanol for long periods. HEPATOLOGY 1994;19:1483-1487.
9. Martomez F, Abril ER, Earnest DL, Watson RR. Ethanol and cytokine secretion. Alcohol 1992;9:455-458.
10. Degli ES, Frizell E, He Q, Abraham A, French SW, Zern MA. Improved rat model of alcoholic liver disease: omega-3 fatty acids (ω3FAs) plus ethanol administration. HEPATOLOGY 1991;14:132.
11. Kamimura S, Tsukamoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. HEPATOLOGY 1995;21:1304-1309.