메뉴 건너뛰기




Volumn 43, Issue 2, 2004, Pages 83-95

Clinical Pharmacokinetics of Everolimus

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; AZITHROMYCIN; CORTICOSTEROID; CYCLOSPORIN A; CYTOCHROME P450; DRUG METABOLITE; ERYTHROMYCIN; EVEROLIMUS; FLUCONAZOLE; GELATIN; GLYCOPROTEIN P; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR ANTIBODY; ITRACONAZOLE; MYCOPHENOLIC ACID; PRAVASTATIN; PREDNISONE; RAPAMYCIN; RIFAMPICIN; TACROLIMUS;

EID: 1442283866     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200443020-00002     Document Type: Review
Times cited : (436)

References (72)
  • 1
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic: I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Tokyo
    • Vezina C, Kudelski A, Sehgal SN. Rapamycin (AY-22,989), a new antifungal antibiotic: I. taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975; 28: 721-6
    • (1975) J Antibiot , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 2
    • 0016713286 scopus 로고
    • Rapamycin (AY-22.98), a new antifugal antibiotic: II. Fermentation, isolation and characterization
    • Tokyo
    • Sehgal SN, Baker H, Vezina C. Rapamycin (AY-22.98), a new antifugal antibiotic: II. fermentation, isolation and characterization. J Antibiot (Tokyo) 1975; 28: 727-32
    • (1975) J Antibiot , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 3
    • 0024976525 scopus 로고
    • Rapamycin for immunosuppression in organ allografting
    • Calne RY, Kim S, Saaman A, et al. Rapamycin for immunosuppression in organ allografting. Lancet 1989; II: 227
    • (1989) Lancet , vol.2 , pp. 227
    • Calne, R.Y.1    Kim, S.2    Saaman, A.3
  • 4
    • 0031713649 scopus 로고    scopus 로고
    • The in vivo effect of rapamycin derivative SDZ RAD on lymphocyte proliferation
    • Boehler T, Waiser J, Budde K, et al. The in vivo effect of rapamycin derivative SDZ RAD on lymphocyte proliferation. Transplant Proc 1998; 30: 2195-7
    • (1998) Transplant Proc , vol.30 , pp. 2195-2197
    • Boehler, T.1    Waiser, J.2    Budde, K.3
  • 5
    • 0030832514 scopus 로고    scopus 로고
    • SDZ RAD, a new rapamycin derivative: Pharmacological properties in vitro and in vivo
    • Schuler W, Sedrani R, Cottens S, et al. SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo. Transplantation 1997; 64: 36-42
    • (1997) Transplantation , vol.64 , pp. 36-42
    • Schuler, W.1    Sedrani, R.2    Cottens, S.3
  • 6
    • 0032930567 scopus 로고    scopus 로고
    • Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats
    • Crowe A, Bruelisauer A, Duerr L, et al. Absorption and intestinal metabolism of SDZ-RAD and rapamycin in rats. Drug Metab Dispos 1999; 27: 627-32
    • (1999) Drug Metab Dispos , vol.27 , pp. 627-632
    • Crowe, A.1    Bruelisauer, A.2    Duerr, L.3
  • 7
    • 0001240467 scopus 로고
    • Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription
    • Krönke M, Leonard WJ, Depper JM, et al. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc Natl Acad Sci U S A 1984; 81: 5214-8
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 5214-5218
    • Krönke, M.1    Leonard, W.J.2    Depper, J.M.3
  • 8
    • 0027527305 scopus 로고
    • Cyclosporin A and FK506: Molecular mechanisms of immunosuppression and probes and transplantation biology
    • Bierer BE, Holländer G, Frumann D, et al. Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes and transplantation biology. Curr Opin Immunol 1993; 5: 763-73
    • (1993) Curr Opin Immunol , vol.5 , pp. 763-773
    • Bierer, B.E.1    Holländer, G.2    Frumann, D.3
  • 9
    • 0024833664 scopus 로고
    • Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation
    • Emmel EA, Verweij CL, Durand DB, et al. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation. Science 1989; 246: 1617-20
    • (1989) Science , vol.246 , pp. 1617-1620
    • Emmel, E.A.1    Verweij, C.L.2    Durand, D.B.3
  • 10
    • 0025099697 scopus 로고
    • Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin
    • Dumont FJ, Staruch MJ, Koprak SL, et al. Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin. J Immunol 1990; 144: 251-8
    • (1990) J Immunol , vol.144 , pp. 251-258
    • Dumont, F.J.1    Staruch, M.J.2    Koprak, S.L.3
  • 11
    • 0028825698 scopus 로고
    • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin
    • Lorenz MC, Heitman J. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J Biol Chem 1995; 270: 27531-7
    • (1995) J Biol Chem , vol.270 , pp. 27531-27537
    • Lorenz, M.C.1    Heitman, J.2
  • 12
    • 0028869086 scopus 로고
    • Rapamune (sirolimus, rapamycin): An overview and mechanism of action
    • Sehgal SN. Rapamune (sirolimus, rapamycin): an overview and mechanism of action. Ther Drug Monit 1995; 17: 660-5
    • (1995) Ther Drug Monit , vol.17 , pp. 660-665
    • Sehgal, S.N.1
  • 13
    • 0031833563 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: Immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling
    • Abraham RT. Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling. Curr Opin Immunol 1998; 10: 330-6
    • (1998) Curr Opin Immunol , vol.10 , pp. 330-336
    • Abraham, R.T.1
  • 15
    • 0026969189 scopus 로고
    • Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells
    • Terada N, Lucas JJ, Szepesi A, et al. Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells. Biochem Biophys Res Commun 1992; 186: 1315-21
    • (1992) Biochem Biophys Res Commun , vol.186 , pp. 1315-1321
    • Terada, N.1    Lucas, J.J.2    Szepesi, A.3
  • 16
    • 0026721092 scopus 로고
    • Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
    • Kuo CJ, Chung J, Fiorentino DF, et al. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992; 358: 70-3
    • (1992) Nature , vol.358 , pp. 70-73
    • Kuo, C.J.1    Chung, J.2    Fiorentino, D.F.3
  • 17
    • 0030272487 scopus 로고    scopus 로고
    • Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: Tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide
    • Brazelton T, Morris RE. Molecular mechanisms of action of new xenobiotic immunosuppressive drugs: tacrolimus (FK506), sirolimus (rapamycin), mycophenolate mofetil and leflunomide. Curr Opin Immunol 1996; 8: 710-20
    • (1996) Curr Opin Immunol , vol.8 , pp. 710-720
    • Brazelton, T.1    Morris, R.E.2
  • 19
    • 0031657020 scopus 로고    scopus 로고
    • Chemical modification of rapamycin: The discovery of SDZ RAD
    • Sedrani R, Cottens S, Kallen J, et al. Chemical modification of rapamycin: the discovery of SDZ RAD. Transplant Proc 1998; 30: 2192-4
    • (1998) Transplant Proc , vol.30 , pp. 2192-2194
    • Sedrani, R.1    Cottens, S.2    Kallen, J.3
  • 21
    • 0034654046 scopus 로고    scopus 로고
    • Oral efficacy of the macrolide immunosuppressant SDZ RAD and of cyclosporine microemulsion in cynomolgus monkey kidney allotransplantation
    • Schuurman H, Ringers J, Schuler W, et al. Oral efficacy of the macrolide immunosuppressant SDZ RAD and of cyclosporine microemulsion in cynomolgus monkey kidney allotransplantation. Transplantation 2000; 69: 737-42
    • (2000) Transplantation , vol.69 , pp. 737-742
    • Schuurman, H.1    Ringers, J.2    Schuler, W.3
  • 22
    • 0029827815 scopus 로고    scopus 로고
    • Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats
    • Stepkowski SM, Napoli KL, Wang ME, Qu X, et al. Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in rats. Transplantation 1996; 62: 986-94
    • (1996) Transplantation , vol.62 , pp. 986-994
    • Stepkowski, S.M.1    Napoli, K.L.2    Wang, M.E.3    Qu, X.4
  • 23
    • 0034650246 scopus 로고    scopus 로고
    • Combined immunosuppression with cyclosporine (Neoral) and SDZ RAD in non-human primate lung transplantation: Systemic pharmacokinetic-based trials to improve efficacy and tolerability
    • Hausen B, Ikonen T, Briffa N, et al. Combined immunosuppression with cyclosporine (Neoral) and SDZ RAD in non-human primate lung transplantation: systemic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation 2000; 69: 76-86
    • (2000) Transplantation , vol.69 , pp. 76-86
    • Hausen, B.1    Ikonen, T.2    Briffa, N.3
  • 24
    • 0032930815 scopus 로고    scopus 로고
    • Suppression of acute rejection in allogenic rat lung transplantation: A study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion formulation of cyclosporine
    • Hausen B, Boeke K, Berry G, et al. Suppression of acute rejection in allogenic rat lung transplantation: a study of the efficacy and pharmacokinetics of rapamycin derivative (SDZ RAD) used alone and in combination with a microemulsion formulation of cyclosporine. J Heart Lung Transplant 1999; 18: 150-9
    • (1999) J Heart Lung Transplant , vol.18 , pp. 150-159
    • Hausen, B.1    Boeke, K.2    Berry, G.3
  • 25
    • 0031024092 scopus 로고    scopus 로고
    • The synergistic effects of cyclosporine and sirolimus
    • Kahan BD. The synergistic effects of cyclosporine and sirolimus. Transplantation 1997; 63: 170
    • (1997) Transplantation , vol.63 , pp. 170
    • Kahan, B.D.1
  • 26
    • 0035958104 scopus 로고    scopus 로고
    • RAD in de novo renal transplantation: Comparison of three doses on the incidence and severity of acute rejection
    • Kahan BD, Kaplan B, Lorber MI, et al. RAD in de novo renal transplantation: comparison of three doses on the incidence and severity of acute rejection. Transplantation 2001; 71: 1400-6
    • (2001) Transplantation , vol.71 , pp. 1400-1406
    • Kahan, B.D.1    Kaplan, B.2    Lorber, M.I.3
  • 27
    • 0036176782 scopus 로고    scopus 로고
    • The future role of target of rapamycin inhibitors in renal transplantation
    • Schwarz C, Oberbauer R. The future role of target of rapamycin inhibitors in renal transplantation. Curr Opin Urol 2002; 12: 109-13
    • (2002) Curr Opin Urol , vol.12 , pp. 109-113
    • Schwarz, C.1    Oberbauer, R.2
  • 28
    • 0027958718 scopus 로고
    • Quantitative and temporal analysis of the cellular interaction of FK506 and rapamycin in T-lymphocytes
    • Dumont FJ, Kastner C, Iacovone Jr F, et al. Quantitative and temporal analysis of the cellular interaction of FK506 and rapamycin in T-lymphocytes. J Pharmacol Exp Ther 1994; 268: 32-41
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 32-41
    • Dumont, F.J.1    Kastner, C.2    Iacovone Jr., F.3
  • 29
    • 0000373660 scopus 로고    scopus 로고
    • One year results of a multicenter, open-label trial on safety and efficacy of Certican™ (RAD) used in combination with Simulect, corticosteroids, and full or reduced dose Neoral in renal transplantation
    • abstract 1335
    • Curtis J, Nashan B, Ponticelli C, et al. One year results of a multicenter, open-label trial on safety and efficacy of Certican™ (RAD) used in combination with Simulect, corticosteroids, and full or reduced dose Neoral in renal transplantation [abstract 1335]. Am J Transplant 2001; 1 Suppl.: 474
    • (2001) Am J Transplant , vol.1 , Issue.SUPPL. , pp. 474
    • Curtis, J.1    Nashan, B.2    Ponticelli, C.3
  • 30
    • 0034762375 scopus 로고    scopus 로고
    • Progress in the clinical application of immunosuppressive drugs in renal transplantation
    • Wilkinson A. Progress in the clinical application of immunosuppressive drugs in renal transplantation. Curr Opin Nephrol Hypertens 2001; 10: 763-70
    • (2001) Curr Opin Nephrol Hypertens , vol.10 , pp. 763-770
    • Wilkinson, A.1
  • 31
    • 0000576008 scopus 로고    scopus 로고
    • Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin
    • Segarra I, Brazelton TR, Guterman N, et al. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. J Chromatogr B Biomed Sci Appl 1998; 720: 179-87
    • (1998) J Chromatogr B Biomed Sci Appl , vol.720 , pp. 179-187
    • Segarra, I.1    Brazelton, T.R.2    Guterman, N.3
  • 32
    • 0037024124 scopus 로고    scopus 로고
    • Quantification and stability of everolimus (SDZ RAD) in human blood by high-performance liquid chromatography-electrospray tandem mass spectrometry
    • Salm P, Taylor PJ, Lynch SV, et al. Quantification and stability of everolimus (SDZ RAD) in human blood by high-performance liquid chromatography-electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci J Chromatogr B 2002; 772: 283-90
    • (2002) J Chromatogr B Analyt Technol Biomed Life Sci J Chromatogr B , vol.772 , pp. 283-290
    • Salm, P.1    Taylor, P.J.2    Lynch, S.V.3
  • 33
    • 0031777929 scopus 로고    scopus 로고
    • Automated simultaneous quantification of the immunosuppressants 40-O-(2-hydroxyethyl)rapamycin and cyclosporine in blood with electrospray-mass spectrometric detection
    • Vidal C, Kirchner GI, Wünsch G, et al. Automated simultaneous quantification of the immunosuppressants 40-O-(2-hydroxyethyl)rapamycin and cyclosporine in blood with electrospray-mass spectrometric detection. Clin Chem 1998; 44: 1275-82
    • (1998) Clin Chem , vol.44 , pp. 1275-1282
    • Vidal, C.1    Kirchner, G.I.2    Wünsch, G.3
  • 34
    • 0034746371 scopus 로고    scopus 로고
    • Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: Pharmacokinetics, exposure-response relationships, and influence on cyclosporin
    • Kovarik JM, Kahan BD, Kaplan B, et al. Longitudinal assessment of everolimus in de novo renal transplant recipients over the first post-transplant year: pharmacokinetics, exposure-response relationships, and influence on cyclosporin. Clin Pharmacol Ther 2001; 69: 48-56
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 48-56
    • Kovarik, J.M.1    Kahan, B.D.2    Kaplan, B.3
  • 35
    • 0033060549 scopus 로고    scopus 로고
    • LC/ESI-MS allows simultaneous and specific quantification of SDZ RAD and ciclosporin including their metabolites in human blood
    • Kirchner GI, Vidal C, Winkler M, et al. LC/ESI-MS allows simultaneous and specific quantification of SDZ RAD and ciclosporin including their metabolites in human blood. Ther Drug Monit 1999; 21: 116-22
    • (1999) Ther Drug Monit , vol.21 , pp. 116-122
    • Kirchner, G.I.1    Vidal, C.2    Winkler, M.3
  • 36
    • 0034306732 scopus 로고    scopus 로고
    • Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: Immunosuppressants
    • Christians U, Jacobsen W, Serkova N, et al. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl 2000; 748: 41-53
    • (2000) J Chromatogr B Biomed Sci Appl , vol.748 , pp. 41-53
    • Christians, U.1    Jacobsen, W.2    Serkova, N.3
  • 37
    • 0033791645 scopus 로고    scopus 로고
    • High-throughput analysis of everolimus (RAD001) and cyclosporin a (CsA) in whole blood by liquid chromatography/mass spectrometry using a semi-automated 96-well solid-phase extraction system
    • McMahon LM, Luo S, Hayes M, et al. High-throughput analysis of everolimus (RAD001) and cyclosporin A (CsA) in whole blood by liquid chromatography/mass spectrometry using a semi-automated 96-well solid-phase extraction system. Rapid Commun Mass Spectrom 2000; 14: 1965-71
    • (2000) Rapid Commun Mass Spectrom , vol.14 , pp. 1965-1971
    • McMahon, L.M.1    Luo, S.2    Hayes, M.3
  • 38
    • 0034962528 scopus 로고    scopus 로고
    • High-throughput semi-automated 96-well liquid/liquid extraction and liquid chromatography/mass spectrometric analysis of everolimus (RAD 001) and cyclosporin a (CsA) in whole blood
    • Brignol N, McMahon LM, Luo S, et al. High-throughput semi-automated 96-well liquid/liquid extraction and liquid chromatography/mass spectrometric analysis of everolimus (RAD 001) and cyclosporin A (CsA) in whole blood. Rapid Commun Mass Spectrom 2001; 15: 898-907
    • (2001) Rapid Commun Mass Spectrom , vol.15 , pp. 898-907
    • Brignol, N.1    McMahon, L.M.2    Luo, S.3
  • 39
    • 0036267333 scopus 로고    scopus 로고
    • Rapid liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin a in whole blood
    • Streit F, Armstrong VW, Oellerich M. Rapid liquid chromatography-tandem mass spectrometry routine method for simultaneous determination of sirolimus, everolimus, tacrolimus, and cyclosporin A in whole blood. Clin Chem 2002; 48: 955-8
    • (2002) Clin Chem , vol.48 , pp. 955-958
    • Streit, F.1    Armstrong, V.W.2    Oellerich, M.3
  • 40
    • 0036238215 scopus 로고    scopus 로고
    • Simultaneous quantification of sirolimus, everolimus, tacrolimus and cyclosporine by liquid chromatography-mass spectrometry (LC-MS)
    • Deters M, Kirchner G, Resch K, et al. Simultaneous quantification of sirolimus, everolimus, tacrolimus and cyclosporine by liquid chromatography-mass spectrometry (LC-MS). Clin Chem Lab Med 2002; 40: 285-92
    • (2002) Clin Chem Lab Med , vol.40 , pp. 285-292
    • Deters, M.1    Kirchner, G.2    Resch, K.3
  • 41
    • 0036014062 scopus 로고    scopus 로고
    • Effect of rifampin on apparent clearance of everolimus
    • Kovarik JM, Hartmann S, Figueiredo J, et al. Effect of rifampin on apparent clearance of everolimus. Ann Pharmacother 2002; 36: 981-5
    • (2002) Ann Pharmacother , vol.36 , pp. 981-985
    • Kovarik, J.M.1    Hartmann, S.2    Figueiredo, J.3
  • 42
    • 0032736334 scopus 로고    scopus 로고
    • Entry-into-human study with the novel immunosuppressant SDZ RAD in stable renal transplant recipients
    • Neumayer HH, Paradis K, Korn A, et al. Entry-into-human study with the novel immunosuppressant SDZ RAD in stable renal transplant recipients. Br J Clin Pharmacol 1999; 48: 694-703
    • (1999) Br J Clin Pharmacol , vol.48 , pp. 694-703
    • Neumayer, H.H.1    Paradis, K.2    Korn, A.3
  • 43
    • 0033610455 scopus 로고    scopus 로고
    • A phase I study of a 4-week course of SDZ RAD (RAD) in quiescent cyclosporin-prednisone-treated renal transplant recipients
    • Kahan BD, Wong RL, Carter C, et al. A phase I study of a 4-week course of SDZ RAD (RAD) in quiescent cyclosporin-prednisone-treated renal transplant recipients. Transplantation 1999; 68: 1100-6
    • (1999) Transplantation , vol.68 , pp. 1100-1106
    • Kahan, B.D.1    Wong, R.L.2    Carter, C.3
  • 44
    • 0035862975 scopus 로고    scopus 로고
    • Pharmacokinetics and tolerability of 40-O-[2-hydroxyethyl]rapamycin in de novo liver transplant recipients
    • Levy GA, Grant D, Paradis K, et al. Pharmacokinetics and tolerability of 40-O-[2-hydroxyethyl]rapamycin in de novo liver transplant recipients. Transplantation 2001; 71: 160-3
    • (2001) Transplantation , vol.71 , pp. 160-163
    • Levy, G.A.1    Grant, D.2    Paradis, K.3
  • 45
    • 0035112208 scopus 로고    scopus 로고
    • RAD in stable lung and heart/lung transplant recipients; safety, tolerability, pharmacokinetics, and impact of cystic fibrosis
    • Doyle RL, Hertz MI, Dunitz JM, et al. RAD in stable lung and heart/lung transplant recipients; safety, tolerability, pharmacokinetics, and impact of cystic fibrosis. J Heart Lung Transplant 2001; 20: 330-9
    • (2001) J Heart Lung Transplant , vol.20 , pp. 330-339
    • Doyle, R.L.1    Hertz, M.I.2    Dunitz, J.M.3
  • 46
    • 0029867449 scopus 로고    scopus 로고
    • Inhibition by rapamycin of P-glycoprotein 170-mediated export from normal lymphocytes
    • Yacyshyn BR, Bowen-Yacyshyn MB, Pilarski LM. Inhibition by rapamycin of P-glycoprotein 170-mediated export from normal lymphocytes. Scand J Immunol 1996; 43: 449-55
    • (1996) Scand J Immunol , vol.43 , pp. 449-455
    • Yacyshyn, B.R.1    Bowen-Yacyshyn, M.B.2    Pilarski, L.M.3
  • 47
    • 0031786057 scopus 로고    scopus 로고
    • In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: Comparison with rapamycin
    • Crowe A, Lemaire M. In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with rapamycin. Pharm Res 1998; 15: 1666-72
    • (1998) Pharm Res , vol.15 , pp. 1666-1672
    • Crowe, A.1    Lemaire, M.2
  • 48
    • 0031863355 scopus 로고    scopus 로고
    • Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine
    • Lampen A, Zhang Y, Hackbarth I, et al. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther 1998; 285: 1104-12
    • (1998) J Pharmacol Exp Ther , vol.285 , pp. 1104-1112
    • Lampen, A.1    Zhang, Y.2    Hackbarth, I.3
  • 49
    • 0034834765 scopus 로고    scopus 로고
    • Population pharmacokinetics of everolimus in de novo renal transplant patients: Impact of ethnicity and comedications
    • Kovarik JM, Hsu CH, McMahon L, et al. Population pharmacokinetics of everolimus in de novo renal transplant patients: impact of ethnicity and comedications. Clin Pharmacol Ther 2001; 70: 247-54
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 247-254
    • Kovarik, J.M.1    Hsu, C.H.2    McMahon, L.3
  • 50
    • 0025688396 scopus 로고
    • Altered pharmacokinetics of cyclosporin in heart-lung transplant recipients with cystic fibrosis
    • Tan KKC, Hue KL, Strickland SE, et al. Altered pharmacokinetics of cyclosporin in heart-lung transplant recipients with cystic fibrosis. Ther Drug Monit 1990; 12: 520-4
    • (1990) Ther Drug Monit , vol.12 , pp. 520-524
    • Tan, K.K.C.1    Hue, K.L.2    Strickland, S.E.3
  • 51
    • 0035215119 scopus 로고    scopus 로고
    • Influence of hepatic impairment on everolimus pharmacokinetics: Implications for dose adjustment
    • Kovarik JM, Sabia HD, Figueiredo J, et al. Influence of hepatic impairment on everolimus pharmacokinetics: implications for dose adjustment. Clin Pharmacol Ther 2001; 70: 425-30
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 425-430
    • Kovarik, J.M.1    Sabia, H.D.2    Figueiredo, J.3
  • 52
    • 0033932343 scopus 로고    scopus 로고
    • Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: Interaction with cyclosporine
    • Serkova N, Hausen B, Berry GJ, et al. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. J Pharmacol Exp Ther 2000; 294: 323-32
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 323-332
    • Serkova, N.1    Hausen, B.2    Berry, G.J.3
  • 53
    • 0035082180 scopus 로고    scopus 로고
    • Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD
    • Jacobsen W, Serkova N, Hausen B, et al. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplant Proc 2001; 33: 514-5
    • (2001) Transplant Proc , vol.33 , pp. 514-515
    • Jacobsen, W.1    Serkova, N.2    Hausen, B.3
  • 54
    • 0034835020 scopus 로고    scopus 로고
    • Current immunosuppressant regimens: Considerations for critical care
    • Kahan BD, Koch SM. Current immunosuppressant regimens: considerations for critical care. Curr Opin Crit Care 2001; 7: 242-50
    • (2001) Curr Opin Crit Care , vol.7 , pp. 242-250
    • Kahan, B.D.1    Koch, S.M.2
  • 55
    • 0031008434 scopus 로고    scopus 로고
    • Pharmacokinetics of sirolimus in stable renal transplant patients after multiple oral dose administration
    • Zimmerman J, Kahan BD. Pharmacokinetics of sirolimus in stable renal transplant patients after multiple oral dose administration. J Clin Pharmacol 1997; 37: 405-15
    • (1997) J Clin Pharmacol , vol.37 , pp. 405-415
    • Zimmerman, J.1    Kahan, B.D.2
  • 56
    • 0033729567 scopus 로고    scopus 로고
    • Pharmacokinetics of SDZ RAD and cyclosporin including their metabolites in seven kidney graft patients after the first dose of SDZ RAD
    • Kirchner GI, Winkler M, Mueller L, et al. Pharmacokinetics of SDZ RAD and cyclosporin including their metabolites in seven kidney graft patients after the first dose of SDZ RAD. Br J Clin Pharmacol 2000; 50: 449-54
    • (2000) Br J Clin Pharmacol , vol.50 , pp. 449-454
    • Kirchner, G.I.1    Winkler, M.2    Mueller, L.3
  • 57
    • 0036755344 scopus 로고    scopus 로고
    • Long-term pharmacokinetics of the metabolites of everolimus (SDZ RAD) and cyclosporine in renal transplant recipients
    • Kirchner GI, Mueller L, Winkler M, et al. Long-term pharmacokinetics of the metabolites of everolimus (SDZ RAD) and cyclosporine in renal transplant recipients. Transplant Proc 2002; 34: 2233-4
    • (2002) Transplant Proc , vol.34 , pp. 2233-2234
    • Kirchner, G.I.1    Mueller, L.2    Winkler, M.3
  • 58
    • 0036138190 scopus 로고    scopus 로고
    • Differential influence of two cyclosporine formulations on everolimus pharmacokinetics: A clinically relevant pharmacokinetic interaction
    • Kovarik JM, Kalbag J, Figueiredo J, et al. Differential influence of two cyclosporine formulations on everolimus pharmacokinetics: a clinically relevant pharmacokinetic interaction. J Clin Pharmacol 2002; 42: 95-9
    • (2002) J Clin Pharmacol , vol.42 , pp. 95-99
    • Kovarik, J.M.1    Kalbag, J.2    Figueiredo, J.3
  • 59
    • 0032232418 scopus 로고    scopus 로고
    • Structural elucidation by electrospray mass spectrometry: An approach to the in vitro metabolism of the macrolide immuno-suppressant SDZ RAD
    • Vidal C, Kirchner GI, Sewing KF. Structural elucidation by electrospray mass spectrometry: an approach to the in vitro metabolism of the macrolide immuno-suppressant SDZ RAD. J Am Soc Mass Spectrom 1998; 9: 1267-74
    • (1998) J Am Soc Mass Spectrom , vol.9 , pp. 1267-1274
    • Vidal, C.1    Kirchner, G.I.2    Sewing, K.F.3
  • 60
    • 0034477611 scopus 로고    scopus 로고
    • Identification of a new metabolite of macrolide immunosuppressant, like rapamycin and SDZ RAD, using high performance liquid chromatography and electrospray tandem mass spectrometry
    • Hallensleben K, Raida M, Habermehl G. Identification of a new metabolite of macrolide immunosuppressant, like rapamycin and SDZ RAD, using high performance liquid chromatography and electrospray tandem mass spectrometry. J Am Soc Mass Spectrom 2000; 11: 516-25
    • (2000) J Am Soc Mass Spectrom , vol.11 , pp. 516-525
    • Hallensleben, K.1    Raida, M.2    Habermehl, G.3
  • 61
    • 0343775809 scopus 로고    scopus 로고
    • Isolation from pig liver microsomes, identification by tandem mass spectrometry and in vitro immunosuppressive activity of an SDZ-RAD 17,18,19,20,21,22-tris-epoxide
    • Lhoest GJ, Gougnard TY, Verbeeck RK, et al. Isolation from pig liver microsomes, identification by tandem mass spectrometry and in vitro immunosuppressive activity of an SDZ-RAD 17,18,19,20,21,22-tris-epoxide. J Mass Spectrom 2000; 35: 454-60
    • (2000) J Mass Spectrom , vol.35 , pp. 454-460
    • Lhoest, G.J.1    Gougnard, T.Y.2    Verbeeck, R.K.3
  • 62
    • 0034853228 scopus 로고    scopus 로고
    • In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry
    • Lhoest G, Hertsens R, Verbeeck RK, et al. In vitro immunosuppressive activity of tacrolimus dihydrodiol precursors obtained by chemical oxidation and identification of a new metabolite of SDZ-RAD by electrospray and electrospray-linked scan mass spectrometry. J Mass Spectrom 2001; 36: 889-901
    • (2001) J Mass Spectrom , vol.36 , pp. 889-901
    • Lhoest, G.1    Hertsens, R.2    Verbeeck, R.K.3
  • 63
    • 0036246092 scopus 로고    scopus 로고
    • Single-dose pharmacokinetics and tolerability of everolimus in stable pediatric renal transplant patients
    • Van Damme-Lombaerts R, Webb NAY, Hoyer PF, et al. Single-dose pharmacokinetics and tolerability of everolimus in stable pediatric renal transplant patients. Pediatr Transplant 2002; 6: 147-52
    • (2002) Pediatr Transplant , vol.6 , pp. 147-152
    • Van Damme-Lombaerts, R.1    Webb, N.A.Y.2    Hoyer, P.F.3
  • 64
    • 0034810020 scopus 로고    scopus 로고
    • Safety and efficacy of TOR inhibitors in pediatric renal transplant recipients
    • Ettenger RB, Grimm EM. Safety and efficacy of TOR inhibitors in pediatric renal transplant recipients. Am J Kidney Dis 2001; 38 (4 Suppl. 2): S22-8
    • (2001) Am J Kidney Dis , vol.38 , Issue.4 SUPPL. 2
    • Ettenger, R.B.1    Grimm, E.M.2
  • 65
    • 10744220571 scopus 로고    scopus 로고
    • Everolimus in pediatric de novo renal transplant patients
    • Hoyer PF, Ettenger R, Kovarik JM, et al. Everolimus in pediatric de novo renal transplant patients. Transplantation 2003; 75: 2082-5
    • (2003) Transplantation , vol.75 , pp. 2082-2085
    • Hoyer, P.F.1    Ettenger, R.2    Kovarik, J.M.3
  • 66
    • 0037302058 scopus 로고    scopus 로고
    • Clinical development of an everolimus pediatric formulation: Relative bioavailability, food effect, and steady-state pharmacokinetics
    • Kovarik JM, Noe A, Berthier S, et al. Clinical development of an everolimus pediatric formulation: relative bioavailability, food effect, and steady-state pharmacokinetics. J Clin Pharmacol 2003; 43: 141-7
    • (2003) J Clin Pharmacol , vol.43 , pp. 141-147
    • Kovarik, J.M.1    Noe, A.2    Berthier, S.3
  • 67
    • 0036157484 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic assessments of HMG-CoA reductase inhibitors when coadministered with everolimus
    • Kovarik JM, Hartmann S, Hubert M, et al. Pharmacokinetic and pharmacodynamic assessments of HMG-CoA reductase inhibitors when coadministered with everolimus. J Clin Pharmacol 2002; 42: 222-8
    • (2002) J Clin Pharmacol , vol.42 , pp. 222-228
    • Kovarik, J.M.1    Hartmann, S.2    Hubert, M.3
  • 68
    • 0036151699 scopus 로고    scopus 로고
    • Effect of food on everolimus absorption: Quantification in healthy subjects and a confirmatory screening in patients with renal transplants
    • Kovarik JM, Hartmann S, Figueiredo J, et al. Effect of food on everolimus absorption: quantification in healthy subjects and a confirmatory screening in patients with renal transplants. Pharmacotherapy 2002; 22: 154-9
    • (2002) Pharmacotherapy , vol.22 , pp. 154-159
    • Kovarik, J.M.1    Hartmann, S.2    Figueiredo, J.3
  • 69
    • 0037181426 scopus 로고    scopus 로고
    • Exposure-response relationships for everolimus in de novo kidney transplantation: Defining a therapeutic range
    • Kovarik JM, Kaplan B, Tedesco Silva H, et al. Exposure-response relationships for everolimus in de novo kidney transplantation: defining a therapeutic range. Transplantation 2002; 73: 920-5
    • (2002) Transplantation , vol.73 , pp. 920-925
    • Kovarik, J.M.1    Kaplan, B.2    Tedesco Silva, H.3
  • 70
    • 0036146486 scopus 로고    scopus 로고
    • Early clinical experience with a novel rapamycin derivative
    • Nashan B. Early clinical experience with a novel rapamycin derivative. Ther Drug Monit 2002; 24: 53-8
    • (2002) Ther Drug Monit , vol.24 , pp. 53-58
    • Nashan, B.1
  • 71
    • 0035671844 scopus 로고    scopus 로고
    • The role of Certican (Everolimus, RAD) in the many pathways of chronic rejection
    • Nashan B. The role of Certican (Everolimus, RAD) in the many pathways of chronic rejection. Transplant Proc 2001; 33: 3215-20
    • (2001) Transplant Proc , vol.33 , pp. 3215-3220
    • Nashan, B.1
  • 72
    • 0035679176 scopus 로고    scopus 로고
    • The evolving role of TOR inhibitors for individualizing posttransplant immunosuppression
    • Lorber MI, Basadonna GP, Friedman AL, et al. The evolving role of TOR inhibitors for individualizing posttransplant immunosuppression. Transplant Proc 2001; 33: 3075-7
    • (2001) Transplant Proc , vol.33 , pp. 3075-3077
    • Lorber, M.I.1    Basadonna, G.P.2    Friedman, A.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.