c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

Current Biology

Volumn 11, Issue 8, 2001, Pages 558-568

  Arnold, Isabel ^a   Watt, Fiona M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; EPIDERMIS CELL; GENE ACTIVATION; KERATINOCYTE; PROTEIN C MYC; STEM CELL; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 0035901594     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00154-3     Document Type: Article

References (38)

1. Epidermal stem cells: Markers, patterning and the control of stem cell fate
2. Out of Eden: Stem cells and their niches
3. Involvement of follicular stem cells in forming not only the follicle but also the epidermis
4. Morphogenesis and renewal of hair follicles from adult multipotent stem cells
5. Epidermal stem cells as targets for gene transfer
6. c-Myc promotes differentiation of human epidermal stem cells
7. The Myc/Max/Mad network and the transcriptional control of cell behavior
8. Action of c-Myc in vivo: Proliferation and apoptosis
9. Reversible activation of c-Myc in skin: Induction of a complex neoplastic phenotype by a single oncogenic lesion
10. Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis
11. The magical touch: Genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
12. A modified oestrogen receptor ligand binding domain as an improved switch for the regulation of heterologous proteins
13. Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice
14. Expression of keratins K6 and K16 in regenerating mouse epidermis is less restricted by cell replication than expression of K1 and K10
15. Cell growth: Downstream of Myc - To grow or to cycle?
16. Epithelial stem cells in vivo
17. Critical aspects of initiation, promotion, and progression in multistage epidermal carcinogenesis
18. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
19. The suprabasal expression of α6β4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis
20. The biology of hair follicles
21. Acidic and basic hair/nail ("hard") keratins: Their colocalization in upper cortical and cuticle cells of the human hair follicle and their relationship to "soft" keratins
22. Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5
23. The pharmacology and clinical uses of tamoxifen
24. The ornithine decarboxylase gene is a transcriptional target of c-Myc
25. Heterogeneity of ornithine decarboxylase expression in 12-O-tetradecanoylphorbol-13-acetate-treated mouse skin and in epidermal tumors
26. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin
27. c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin
28. Reversible tumorigenesis by MYC in hematopoietic lineages
29. Cell replacement in epidermis (keratopoiesis) via discrete units of proliferation
30. The Myc oncoprotein: A critical evaluation of transactivation and target gene regulation
31. Regulation of Myc and Mad during epidermal differentiation and HPV-associated tumorigenesis
32. Mad3 and Mad4: Novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation
33. Expression of the mad gene during cell differentiation in vivo and its inhibition of cell growth in vitro
34. Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes
35. Optimised retroviral infection of human epidermal keratinocytes: Long-term expression of transduced integrin gene following grafting on to SCID mice
36. Evidence that mirex promotes a unique population of epidermal cells that cannot by distinguished by their mutant Ha-ras genotype
37. Elimination of precipitates in Oil Red O fat stain by adding dextrin