메뉴 건너뛰기




Volumn 40, Issue 6, 2007, Pages 442-452

Apoptotic signal transduction and T cell tolerance

Author keywords

Apoptosis; Autoimmunity; Costimulation; T cell; Thymus; Tolerance

Indexed keywords

APOPTOSIS INDUCING FACTOR; BIM PROTEIN; CASPASE 10; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CYTOCHROME C; ENDONUCLEASE G; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; FLICE INHIBITORY PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN KINASE ZAP 70; PROTEIN NOXA; PROTEIN P53; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE PROTEINASE OMI; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR 3; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 34548306413     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930701464962     Document Type: Review
Times cited : (38)

References (125)
  • 1
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J., Wyllie, A. and Currie, A. (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer, 26, pp. 239-257.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.1    Wyllie, A.2    Currie, A.3
  • 3
    • 0031918223 scopus 로고    scopus 로고
    • BCL-2 family: Regulators of cell death
    • Chao, DT and Korsmeyer, SJ (1998) BCL-2 family: Regulators of cell death. Annu Rev Immunol, 16, pp. 395-419.
    • (1998) Annu Rev Immunol , vol.16 , pp. 395-419
    • Chao, D.T.1    Korsmeyer, S.J.2
  • 5
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, DR and Reed, JC (1998) Mitochondria and apoptosis. Science, 281, pp. 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 6
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Nijhawan, D., Budihardjo, I., Srinivasula, SM, Ahmad, M., Alnemri, ES and Wang, X. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade. Cell, 91, pp. 479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Nijhawan, D.1    Budihardjo, I.2    Srinivasula, S.M.3    Ahmad, M.4    Alnemri, E.S.5    Wang, X.6
  • 7
    • 0029834497 scopus 로고    scopus 로고
    • CrmA expression in T lymphocytes of transgenic mice inhibits CD95 Fas/ APO-1-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease
    • Smith, K., Strasser, A. and Vaux, D. (1996) CrmA expression in T lymphocytes of transgenic mice inhibits CD95 Fas/APO-1-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease. EMBO J, 15, pp. 5167-5176.
    • (1996) EMBO J , vol.15 , pp. 5167-5176
    • Smith, K.1    Strasser, A.2    Vaux, D.3
  • 9
    • 0038320263 scopus 로고    scopus 로고
    • The signaling adaptors and pathways activated by TNF superfamily
    • Dempsey, PW, Doyle, SE, He, JQ and Cheng, G. (2003) The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev, 14, pp. 193-209.
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 193-209
    • Dempsey, P.W.1    Doyle, S.E.2    He, J.Q.3    Cheng, G.4
  • 10
    • 0030925774 scopus 로고    scopus 로고
    • FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
    • Medema, J., Scaffidi, C., Kischkel, F., Shevchenko, A., Mann, M., Krammer, P. and Peter, M. (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J, 16:10, pp. 2794-2804.
    • (1997) EMBO J , vol.16 , Issue.10 , pp. 2794-2804
    • Medema, J.1    Scaffidi, C.2    Kischkel, F.3    Shevchenko, A.4    Mann, M.5    Krammer, P.6    Peter, M.7
  • 11
    • 0042332033 scopus 로고    scopus 로고
    • The "fuzzy logic" of the death-inducing signaling complex in lymphocytes
    • Walsh, CM, Luhrs, KA and Arechiga, AF (2003) The "fuzzy logic" of the death-inducing signaling complex in lymphocytes. J Clin Immunol, 23, pp. 333-353.
    • (2003) J Clin Immunol , vol.23 , pp. 333-353
    • Walsh, C.M.1    Luhrs, K.A.2    Arechiga, A.F.3
  • 12
    • 0031615875 scopus 로고    scopus 로고
    • Autoproteolytic activation of pro-caspases by oligomerization
    • Yang, X., Chang, HY and Baltimore, D. (1998) Autoproteolytic activation of pro-caspases by oligomerization. Mol Cell, 1, pp. 319-325.
    • (1998) Mol Cell , vol.1 , pp. 319-325
    • Yang, X.1    Chang, H.Y.2    Baltimore, D.3
  • 14
    • 0032584149 scopus 로고    scopus 로고
    • Synthetic activation of caspases: Artificial death switches
    • MacCorkle, RA, Freeman, KW and Spencer, DM (1998) Synthetic activation of caspases: Artificial death switches. Proc Natl Acad Sci USA, 95, pp. 3655-3660.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3655-3660
    • MacCorkle, R.A.1    Freeman, K.W.2    Spencer, D.M.3
  • 15
    • 33645299092 scopus 로고    scopus 로고
    • Caspases at the crossroads of immune-cell life and death
    • Siegel, RM (2006) Caspases at the crossroads of immune-cell life and death. Nat Rev Immunol, 6, pp. 308-317.
    • (2006) Nat Rev Immunol , vol.6 , pp. 308-317
    • Siegel, R.M.1
  • 16
    • 0028795758 scopus 로고
    • Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
    • Dhein, J., Walczak, H., Baumler, C., Debatin, K. and Krammer, P. (1995) Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature, 373:6513, pp. 438-441.
    • (1995) Nature , vol.373 , Issue.6513 , pp. 438-441
    • Dhein, J.1    Walczak, H.2    Baumler, C.3    Debatin, K.4    Krammer, P.5
  • 18
    • 0028893078 scopus 로고
    • Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
    • Panka, D., Cui, H., Ettinger, R., el-Khatib, M., Sherr, D., Stanger, B. and Marshak-Rothstein, A. (1995) Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature, 373:6513, pp. 444-448.
    • (1995) Nature , vol.373 , Issue.6513 , pp. 444-448
    • Panka, D.1    Cui, H.2    Ettinger, R.3    el-Khatib, M.4    Sherr, D.5    Stanger, B.6    Marshak-Rothstein, A.7
  • 19
    • 0028983657 scopus 로고
    • Cell-autonomous Fas CD95 /Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
    • Brunner, T., Mogil, R., LaFace, D., Yoo, N., Mahboubi, A., Echeverri, F., Martin, S., Force, W., Lynch, D. and Ware, C. (1995) Cell-autonomous Fas CD95 /Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature, 373, pp. 441-444.
    • (1995) Nature , vol.373 , pp. 441-444
    • Brunner, T.1    Mogil, R.2    LaFace, D.3    Yoo, N.4    Mahboubi, A.5    Echeverri, F.6    Martin, S.7    Force, W.8    Lynch, D.9    Ware, C.10
  • 21
    • 1442359848 scopus 로고    scopus 로고
    • The interplay between the Bcl-2 family and death receptor-mediated apoptosis
    • Sprick, MR and Walczak, H. (2004) The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochim Biophys Acta, 1644, pp. 125-132.
    • (2004) Biochim Biophys Acta , vol.1644 , pp. 125-132
    • Sprick, M.R.1    Walczak, H.2
  • 22
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Zhu, H., Xu, CJ and Yuan, J. (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell, 94, pp. 491-501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Zhu, H.1    Xu, C.J.2    Yuan, J.3
  • 23
    • 0032555716 scopus 로고    scopus 로고
    • Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
    • Luo, X., Budihardjo, I., Zou, H., Slaughter, C. and Wang, X. (1998) Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell, 94, pp. 481-490.
    • (1998) Cell , vol.94 , pp. 481-490
    • Luo, X.1    Budihardjo, I.2    Zou, H.3    Slaughter, C.4    Wang, X.5
  • 24
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Fang, M. and Wang, X. (2000) Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell, 102, pp. 33-42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Fang, M.1    Wang, X.2
  • 25
    • 0034785591 scopus 로고    scopus 로고
    • A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
    • Suzuki, Y., Imai, Y., Nakayama, H., Takahashi, K., Takio, K. and Takahashi, R. (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell, 8, pp. 613-621.
    • (2001) Mol Cell , vol.8 , pp. 613-621
    • Suzuki, Y.1    Imai, Y.2    Nakayama, H.3    Takahashi, K.4    Takio, K.5    Takahashi, R.6
  • 26
    • 0029112253 scopus 로고
    • Induction of apoptosis in mature T cells by tumour necrosis factor
    • Zheng, L., Fisher, G., Miller, R., Peschon, J., Lynch, D. and Lenardo, M. (1995) Induction of apoptosis in mature T cells by tumour necrosis factor. Nature, 377:6547, pp. 348-351.
    • (1995) Nature , vol.377 , Issue.6547 , pp. 348-351
    • Zheng, L.1    Fisher, G.2    Miller, R.3    Peschon, J.4    Lynch, D.5    Lenardo, M.6
  • 28
    • 0035085627 scopus 로고    scopus 로고
    • Apoptotic and necrotic cell death induced by death domain receptors
    • Denecker, G., Vercammen, D., Declercq, W. and Vandenabeele, P. (2001) Apoptotic and necrotic cell death induced by death domain receptors. Cell Mol Life Sci, 58, pp. 356-370.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 356-370
    • Denecker, G.1    Vercammen, D.2    Declercq, W.3    Vandenabeele, P.4
  • 29
    • 14644390310 scopus 로고    scopus 로고
    • Molecular mechanisms of TNF-alpha-induced apoptosis in aging human T cell subsets
    • Gupta, S. and Gollapudi, S. (2005) Molecular mechanisms of TNF-alpha-induced apoptosis in aging human T cell subsets. Int J Biochem Cell Biol, 37, pp. 1034-1042.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1034-1042
    • Gupta, S.1    Gollapudi, S.2
  • 31
    • 33845199637 scopus 로고    scopus 로고
    • Perforin-mediated target-cell death and immune homeostasis
    • Voskoboinik, I., Smyth, MJ and Trapani, JA (2006) Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol, 6, pp. 940-952.
    • (2006) Nat Rev Immunol , vol.6 , pp. 940-952
    • Voskoboinik, I.1    Smyth, M.J.2    Trapani, J.A.3
  • 36
    • 33947194246 scopus 로고    scopus 로고
    • Differential survival of cytotoxic T cells and memory cell precursors
    • Zhang, M., Byrne, S., Liu, N., Wang, Y., Oxenius, A. and Ashton-Rickardt, PG (2007) Differential survival of cytotoxic T cells and memory cell precursors. J Immunol, 178, pp. 3483-3491.
    • (2007) J Immunol , vol.178 , pp. 3483-3491
    • Zhang, M.1    Byrne, S.2    Liu, N.3    Wang, Y.4    Oxenius, A.5    Ashton-Rickardt, P.G.6
  • 37
    • 0036631471 scopus 로고    scopus 로고
    • Selection and fine-tuning of the autoimmune T-cell repertoire
    • Anderton, SM and Wraith, DC (2002) Selection and fine-tuning of the autoimmune T-cell repertoire. Nat Rev Immunol, 2, pp. 487-498.
    • (2002) Nat Rev Immunol , vol.2 , pp. 487-498
    • Anderton, S.M.1    Wraith, D.C.2
  • 39
    • 0037383758 scopus 로고    scopus 로고
    • Aire regulates negative selection of organ-specific T cells
    • Liston, A., Lesage, S., Wilson, J., Peltonen, L. and Goodnow, CC (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol, 4, pp. 350-354.
    • (2003) Nat Immunol , vol.4 , pp. 350-354
    • Liston, A.1    Lesage, S.2    Wilson, J.3    Peltonen, L.4    Goodnow, C.C.5
  • 42
    • 2442567829 scopus 로고    scopus 로고
    • Back to central tolerance
    • Mathis, D. and Benoist, C. (2004) Back to central tolerance. Immunity, 20, pp. 509-516.
    • (2004) Immunity , vol.20 , pp. 509-516
    • Mathis, D.1    Benoist, C.2
  • 43
    • 2542482697 scopus 로고    scopus 로고
    • Control of T cell viability
    • Marrack, P. and Kappler, J. (2004) Control of T cell viability. Annu Rev Immunol, 22, pp. 765-787.
    • (2004) Annu Rev Immunol , vol.22 , pp. 765-787
    • Marrack, P.1    Kappler, J.2
  • 44
    • 22544460774 scopus 로고    scopus 로고
    • Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes
    • Bunin, A., Khwaja, FW and Kersh, GJ (2005) Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes. J Immunol, 175, pp. 1532-1539.
    • (2005) J Immunol , vol.175 , pp. 1532-1539
    • Bunin, A.1    Khwaja, F.W.2    Kersh, G.J.3
  • 45
    • 7444243152 scopus 로고    scopus 로고
    • Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
    • Harada, H., Quearry, B., Ruiz-Vela, A. and Korsmeyer, SJ (2004) Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci USA, 101, pp. 15313-15317.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15313-15317
    • Harada, H.1    Quearry, B.2    Ruiz-Vela, A.3    Korsmeyer, S.J.4
  • 46
    • 32044471627 scopus 로고    scopus 로고
    • Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim
    • [corrected]
    • Cante-Barrett, K., Gallo, EM, Winslow, MM and Crabtree, GR (2006) Thymocyte negative selection is mediated by protein kinase C- and Ca2+ -dependent transcriptional induction of bim [corrected]. J Immunol, 176, pp. 2299-2306.
    • (2006) J Immunol , vol.176 , pp. 2299-2306
    • Cante-Barrett, K.1    Gallo, E.M.2    Winslow, M.M.3    Crabtree, G.R.4
  • 48
    • 0036794390 scopus 로고    scopus 로고
    • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
    • Rathmell, JC, Lindsten, T., Zong, WX, Cinalli, RM and Thompson, CB (2002) Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol, 3, pp. 932-939.
    • (2002) Nat Immunol , vol.3 , pp. 932-939
    • Rathmell, J.C.1    Lindsten, T.2    Zong, W.X.3    Cinalli, R.M.4    Thompson, C.B.5
  • 49
    • 0028117306 scopus 로고
    • Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene
    • Strasser, A., Harris, AW, von Boehmer, H. and Cory, S. (1994) Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc Natl Acad Sci USA, 91, pp. 1376-1380.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 1376-1380
    • Strasser, A.1    Harris, A.W.2    von Boehmer, H.3    Cory, S.4
  • 50
    • 0028448483 scopus 로고
    • Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points
    • Linette, GP, Grusby, MJ, Hedrick, SM, Hansen, TH, Glimcher, LH and Korsmeyer, SJ (1994) Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity, 1, pp. 197-205.
    • (1994) Immunity , vol.1 , pp. 197-205
    • Linette, G.P.1    Grusby, M.J.2    Hedrick, S.M.3    Hansen, T.H.4    Glimcher, L.H.5    Korsmeyer, S.J.6
  • 52
    • 0030610288 scopus 로고    scopus 로고
    • BCL-XL-regulated apoptosis in T cell development
    • Chao, DT and Korsmeyer, SJ (1997) BCL-XL-regulated apoptosis in T cell development. Int Immunol, 9, pp. 1375-1384.
    • (1997) Int Immunol , vol.9 , pp. 1375-1384
    • Chao, D.T.1    Korsmeyer, S.J.2
  • 53
    • 0028970662 scopus 로고
    • Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
    • Grillot, DA, Merino, R. and Nunez, G. (1995) Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J Exp Med, 182, pp. 1973-1983.
    • (1995) J Exp Med , vol.182 , pp. 1973-1983
    • Grillot, D.A.1    Merino, R.2    Nunez, G.3
  • 54
    • 0031883138 scopus 로고    scopus 로고
    • TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection
    • Page, D., Roberts, E., Peschon, J. and Hedrick, S. (1998) TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. J Immunol, 160, pp. 120-133.
    • (1998) J Immunol , vol.160 , pp. 120-133
    • Page, D.1    Roberts, E.2    Peschon, J.3    Hedrick, S.4
  • 55
    • 0025873567 scopus 로고
    • Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice
    • Zhou, T., Bluethmann, H., Eldridge, J., Brockhaus, M., Berry, K. and Mountz, J. (1991) Abnormal thymocyte development and production of autoreactive T cells in T cell receptor transgenic autoimmune mice. J Immunol, 147:2, pp. 466-474.
    • (1991) J Immunol , vol.147 , Issue.2 , pp. 466-474
    • Zhou, T.1    Bluethmann, H.2    Eldridge, J.3    Brockhaus, M.4    Berry, K.5    Mountz, J.6
  • 57
    • 0031054632 scopus 로고    scopus 로고
    • Negative selection in the thymus includes semimature T cells
    • Kishimoto, H. and Sprent, J. (1997) Negative selection in the thymus includes semimature T cells. J Exp Med, 185:2, pp. 263-271.
    • (1997) J Exp Med , vol.185 , Issue.2 , pp. 263-271
    • Kishimoto, H.1    Sprent, J.2
  • 59
    • 0037342029 scopus 로고    scopus 로고
    • The suicide in the thymus, a twisted trail
    • Green, DR (2003) The suicide in the thymus, a twisted trail. Nat Immunol, 4, pp. 207-208.
    • (2003) Nat Immunol , vol.4 , pp. 207-208
    • Green, D.R.1
  • 61
    • 11844305926 scopus 로고    scopus 로고
    • Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice
    • Yue, HH, Diehl, GE and Winoto, A. (2005) Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ, 12, pp. 94-97.
    • (2005) Cell Death Differ , vol.12 , pp. 94-97
    • Yue, H.H.1    Diehl, G.E.2    Winoto, A.3
  • 62
    • 0034655149 scopus 로고    scopus 로고
    • Caspase enzyme activity is not essential for apoptosis during thymocyte development
    • Doerfler, P., Forbush, KA and Perlmutter, RM (2000) Caspase enzyme activity is not essential for apoptosis during thymocyte development. J Immunol, 164, pp. 4071-4079.
    • (2000) J Immunol , vol.164 , pp. 4071-4079
    • Doerfler, P.1    Forbush, K.A.2    Perlmutter, R.M.3
  • 63
    • 0028008513 scopus 로고
    • Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
    • Woronicz, JD, Calnan, B., Ngo, V. and Winoto, A. (1994) Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature, 367, pp. 277-281.
    • (1994) Nature , vol.367 , pp. 277-281
    • Woronicz, J.D.1    Calnan, B.2    Ngo, V.3    Winoto, A.4
  • 64
    • 0028807837 scopus 로고
    • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection
    • Calnan, BJ, Szychowski, S., Chan, FK, Cado, D. and Winoto, A. (1995) A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. Immunity, 3, pp. 273-282.
    • (1995) Immunity , vol.3 , pp. 273-282
    • Calnan, B.J.1    Szychowski, S.2    Chan, F.K.3    Cado, D.4    Winoto, A.5
  • 65
    • 0030977267 scopus 로고    scopus 로고
    • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
    • Cheng, LE, Chan, FK, Cado, D. and Winoto, A. (1997) Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J, 16, pp. 1865-1875.
    • (1997) EMBO J , vol.16 , pp. 1865-1875
    • Cheng, L.E.1    Chan, F.K.2    Cado, D.3    Winoto, A.4
  • 67
    • 0028178784 scopus 로고
    • T cell receptor antagonist peptides induce positive selection
    • Hogquist, K., Jameson, S., Heath, W., Howard, J., Bevan, M. and Carbone, F. (1994) T cell receptor antagonist peptides induce positive selection. Cell, 76, pp. 17-27.
    • (1994) Cell , vol.76 , pp. 17-27
    • Hogquist, K.1    Jameson, S.2    Heath, W.3    Howard, J.4    Bevan, M.5    Carbone, F.6
  • 68
    • 0029154410 scopus 로고
    • Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+T cells
    • Hogquist, K., Jameson, S. and Bevan, M. (1995) Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+T cells. Immunity, 3, pp. 79-86.
    • (1995) Immunity , vol.3 , pp. 79-86
    • Hogquist, K.1    Jameson, S.2    Bevan, M.3
  • 69
  • 70
    • 0034768532 scopus 로고    scopus 로고
    • Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65
    • Yablonski, D. and Weiss, A. (2001) Mechanisms of signaling by the hematopoietic-specific adaptor proteins, SLP-76 and LAT and their B cell counterpart, BLNK/SLP-65. Adv Immunol, 79, pp. 93-128.
    • (2001) Adv Immunol , vol.79 , pp. 93-128
    • Yablonski, D.1    Weiss, A.2
  • 74
    • 0035693742 scopus 로고    scopus 로고
    • CD28 as a molecular amplifier extending TCR ligation and signaling capabilities
    • Michel, F., Attal-Bonnefoy, G., Mangino, G., Mise-Omata, S. and Acuto, O. (2001) CD28 as a molecular amplifier extending TCR ligation and signaling capabilities. Immunity, 15, pp. 935-945.
    • (2001) Immunity , vol.15 , pp. 935-945
    • Michel, F.1    Attal-Bonnefoy, G.2    Mangino, G.3    Mise-Omata, S.4    Acuto, O.5
  • 75
    • 0141609073 scopus 로고    scopus 로고
    • Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity?
    • Croft, M. (2003) Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity?. Nat Rev Immunol, 3, pp. 609-620.
    • (2003) Nat Rev Immunol , vol.3 , pp. 609-620
    • Croft, M.1
  • 77
    • 31844446946 scopus 로고    scopus 로고
    • Regulation of CD4 T cell memory by OX40 (CD134)
    • Salek-Ardakani, S. and Croft, M. (2006) Regulation of CD4 T cell memory by OX40 (CD134). Vaccine, 24, pp. 872-883.
    • (2006) Vaccine , vol.24 , pp. 872-883
    • Salek-Ardakani, S.1    Croft, M.2
  • 78
    • 15244355148 scopus 로고    scopus 로고
    • Peripheral tolerance of CD8 T lymphocytes
    • Redmond, WL and Sherman, LA (2005) Peripheral tolerance of CD8 T lymphocytes. Immunity, 22, pp. 275-284.
    • (2005) Immunity , vol.22 , pp. 275-284
    • Redmond, W.L.1    Sherman, L.A.2
  • 79
    • 4043142982 scopus 로고    scopus 로고
    • E3 ligases in T cell anergy-turning immune responses into tolerance
    • Heissmeyer, V. and Rao, A. (2004) E3 ligases in T cell anergy-turning immune responses into tolerance. Sci STKE, 2004, p. pe29.
    • (2004) Sci STKE
    • Heissmeyer, V.1    Rao, A.2
  • 81
    • 0035920554 scopus 로고    scopus 로고
    • Requirement for transforming growth factor beta1 in controlling T cell apoptosis
    • Chen, W., Jin, W., Tian, H., Sicurello, P., Frank, M., Orenstein, JM and Wahl, SM (2001) Requirement for transforming growth factor beta1 in controlling T cell apoptosis. J Exp Med, 194, pp. 439-453.
    • (2001) J Exp Med , vol.194 , pp. 439-453
    • Chen, W.1    Jin, W.2    Tian, H.3    Sicurello, P.4    Frank, M.5    Orenstein, J.M.6    Wahl, S.M.7
  • 82
    • 0038171458 scopus 로고    scopus 로고
    • Activation-induced cell death in T cells
    • Green, DR, Droin, N. and Pinkoski, M. (2003) Activation-induced cell death in T cells. Immunol Rev, 193, pp. 70-81.
    • (2003) Immunol Rev , vol.193 , pp. 70-81
    • Green, D.R.1    Droin, N.2    Pinkoski, M.3
  • 83
    • 0033566826 scopus 로고    scopus 로고
    • Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+T cells
    • Kishimoto, H. and Sprent, J. (1999) Strong TCR ligation without costimulation causes rapid onset of Fas-dependent apoptosis of naive murine CD4+T cells. J Immunol, 163, pp. 1817-1826.
    • (1999) J Immunol , vol.163 , pp. 1817-1826
    • Kishimoto, H.1    Sprent, J.2
  • 84
    • 0028079746 scopus 로고
    • Delayed kinetics of T lymphocyte anergy and deletion in lpr mice
    • Mixter, PF, Russell, JQ and Budd, RC (1994) Delayed kinetics of T lymphocyte anergy and deletion in lpr mice. J Autoimmun, 7, pp. 697-710.
    • (1994) J Autoimmun , vol.7 , pp. 697-710
    • Mixter, P.F.1    Russell, J.Q.2    Budd, R.C.3
  • 85
    • 0027314703 scopus 로고
    • Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide
    • Russell, JH, Rush, B., Weaver, C. and Wang, R. (1993) Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc Natl Acad Sci USA, 90, pp. 4409-4413.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4409-4413
    • Russell, J.H.1    Rush, B.2    Weaver, C.3    Wang, R.4
  • 86
    • 0027284016 scopus 로고
    • Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells
    • Russell, JH and Wang, R. (1993) Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells. Eur J Immunol, 23, pp. 2379-2382.
    • (1993) Eur J Immunol , vol.23 , pp. 2379-2382
    • Russell, J.H.1    Wang, R.2
  • 87
    • 0028485743 scopus 로고
    • The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
    • Singer, G. and Abbas, A. (1994) The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity, 1, pp. 365-371.
    • (1994) Immunity , vol.1 , pp. 365-371
    • Singer, G.1    Abbas, A.2
  • 89
    • 0033954469 scopus 로고    scopus 로고
    • Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis
    • Suvannavejh, GC, Canto, MC Dal, Matis, LA and Miller, SD (2000) Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis. J Clin Invest, 105, pp. 223-231.
    • (2000) J Clin Invest , vol.105 , pp. 223-231
    • Suvannavejh, G.C.1    Canto, M.C.2    Dal Matis, L.A.3    Miller, S.D.4
  • 90
    • 1642444653 scopus 로고    scopus 로고
    • Cutting edge: Distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells
    • Kerstan, A. and Hunig, T. (2004) Cutting edge: Distinct TCR- and CD28-derived signals regulate CD95L, Bcl-xL, and the survival of primary T cells. J Immunol, 172, pp. 1341-1345.
    • (2004) J Immunol , vol.172 , pp. 1341-1345
    • Kerstan, A.1    Hunig, T.2
  • 91
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N. and Nagata, S. (1992) Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature, 356:6367, pp. 314-317.
    • (1992) Nature , vol.356 , Issue.6367 , pp. 314-317
    • Watanabe-Fukunaga, R.1    Brannan, C.2    Copeland, N.3    Jenkins, N.4    Nagata, S.5
  • 92
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand
    • Takahashi, T., Tanaka, M., Brannan, C., Jenkins, N., Copeland, N., Suda, T. and Nagata, S. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell, 76:6, pp. 969-976.
    • (1994) Cell , vol.76 , Issue.6 , pp. 969-976
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.3    Jenkins, N.4    Copeland, N.5    Suda, T.6    Nagata, S.7
  • 93
    • 0020567013 scopus 로고
    • Monoclonal IgM rheumatoid factors derived from arthritic MRL/Mp-lpr/lpr mice
    • Theofilopoulos, AN, Balderas, RS, Hang, L. and Dixon, FJ (1983) Monoclonal IgM rheumatoid factors derived from arthritic MRL/Mp-lpr/lpr mice. J Exp Med, 158, pp. 901-919.
    • (1983) J Exp Med , vol.158 , pp. 901-919
    • Theofilopoulos, A.N.1    Balderas, R.S.2    Hang, L.3    Dixon, F.J.4
  • 94
    • 0041519115 scopus 로고    scopus 로고
    • Molecular regulation of T lymphocyte homeostasis in the healthy and diseased immune system
    • Lenardo, MJ (2003) Molecular regulation of T lymphocyte homeostasis in the healthy and diseased immune system. Immunol Res, 27, pp. 387-398.
    • (2003) Immunol Res , vol.27 , pp. 387-398
    • Lenardo, M.J.1
  • 95
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis
    • Lenardo, MJ (1991) Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis. Nature, 353, pp. 858-861.
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 96
    • 0035496099 scopus 로고    scopus 로고
    • Regulation of lymphocyte proliferation and death by FLIP
    • Thome, M. and Tschopp, J. (2001) Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol, 1, pp. 50-58.
    • (2001) Nat Rev Immunol , vol.1 , pp. 50-58
    • Thome, M.1    Tschopp, J.2
  • 97
    • 0035866004 scopus 로고    scopus 로고
    • Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis
    • Semra, YK, Seidi, OA and Sharief, MK (2001) Overexpression of the apoptosis inhibitor FLIP in T cells correlates with disease activity in multiple sclerosis. J Neuroimmunol, 113, pp. 268-274.
    • (2001) J Neuroimmunol , vol.113 , pp. 268-274
    • Semra, Y.K.1    Seidi, O.A.2    Sharief, M.K.3
  • 98
    • 2542449195 scopus 로고    scopus 로고
    • T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis
    • Hao, Z., Hampel, B., Yagita, H. and Rajewsky, K. (2004) T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis. J Exp Med, 199, pp. 1355-1365.
    • (2004) J Exp Med , vol.199 , pp. 1355-1365
    • Hao, Z.1    Hampel, B.2    Yagita, H.3    Rajewsky, K.4
  • 99
    • 0030200829 scopus 로고    scopus 로고
    • The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice
    • Sytwu, H., Liblau, R. and McDevitt, H. (1996) The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity, 5:1, pp. 17-30.
    • (1996) Immunity , vol.5 , Issue.1 , pp. 17-30
    • Sytwu, H.1    Liblau, R.2    McDevitt, H.3
  • 100
    • 0033956309 scopus 로고    scopus 로고
    • TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions
    • Nguyen, LT, McKall-Faienza, K., Zakarian, A., Speiser, DE, Mak, TW and Ohashi, PS (2000) TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions. Eur J Immunol, 30, pp. 683-688.
    • (2000) Eur J Immunol , vol.30 , pp. 683-688
    • Nguyen, L.T.1    McKall-Faienza, K.2    Zakarian, A.3    Speiser, D.E.4    Mak, T.W.5    Ohashi, P.S.6
  • 101
    • 0031945015 scopus 로고    scopus 로고
    • Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells
    • Mariani, SM and Krammer, PH (1998) Surface expression of TRAIL/Apo-2 ligand in activated mouse T and B cells. Eur J Immunol, 28, pp. 1492-1498.
    • (1998) Eur J Immunol , vol.28 , pp. 1492-1498
    • Mariani, S.M.1    Krammer, P.H.2
  • 102
    • 0031974417 scopus 로고    scopus 로고
    • TRAIL/Apo-2-ligand-induced apoptosis in human T cells
    • Jeremias, I., Herr, I., Boehler, T. and Debatin, KM (1998) TRAIL/ Apo-2-ligand-induced apoptosis in human T cells. Eur J Immunol, 28, pp. 143-152.
    • (1998) Eur J Immunol , vol.28 , pp. 143-152
    • Jeremias, I.1    Herr, I.2    Boehler, T.3    Debatin, K.M.4
  • 103
    • 0034599757 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression
    • Song, K., Chen, Y., Goke, R., Wilmen, A., Seidel, C., Goke, A. and Hilliard, B. (2000) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression. J Exp Med, 191, pp. 1095-1104.
    • (2000) J Exp Med , vol.191 , pp. 1095-1104
    • Song, K.1    Chen, Y.2    Goke, R.3    Wilmen, A.4    Seidel, C.5    Goke, A.6    Hilliard, B.7
  • 104
    • 0024577093 scopus 로고
    • The V beta-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice
    • White, J., Herman, A., Pullen, A., Kubo, R., Kappler, J. and Marrack, P. (1989) The V beta-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice. Cell, 56, pp. 27-35.
    • (1989) Cell , vol.56 , pp. 27-35
    • White, J.1    Herman, A.2    Pullen, A.3    Kubo, R.4    Kappler, J.5    Marrack, P.6
  • 106
    • 0037037543 scopus 로고    scopus 로고
    • Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
    • Davey, GM, Kurts, C., Miller, JF, Bouillet, P., Strasser, A., Brooks, AG, Carbone, FR and Heath, WR (2002) Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim. J Exp Med, 196, pp. 947-955.
    • (2002) J Exp Med , vol.196 , pp. 947-955
    • Davey, G.M.1    Kurts, C.2    Miller, J.F.3    Bouillet, P.4    Strasser, A.5    Brooks, A.G.6    Carbone, F.R.7    Heath, W.R.8
  • 107
    • 0027319521 scopus 로고
    • p53 is required for radiation-induced apoptosis in mouse thymocytes
    • Lowe, SW, Schmitt, EM, Smith, SW, Osborne, BA and Jacks, T. (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature, 362, pp. 847-849.
    • (1993) Nature , vol.362 , pp. 847-849
    • Lowe, S.W.1    Schmitt, E.M.2    Smith, S.W.3    Osborne, B.A.4    Jacks, T.5
  • 109
    • 0035265686 scopus 로고    scopus 로고
    • PUMA a novel proapoptotic gene, is induced by p53
    • Nakano, K. and Vousden, KH (2001) PUMA a novel proapoptotic gene, is induced by p53. Mol Cell, 7, pp. 683-694.
    • (2001) Mol Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 111
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger, P. (2002) The danger model: A renewed sense of self. Science, 296, pp. 301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 113
    • 2442592788 scopus 로고    scopus 로고
    • Toll-like receptor ligands directly promote activated CD4+T cell survival
    • Gelman, AE, Zhang, J., Choi, Y. and Turka, LA (2004) Toll-like receptor ligands directly promote activated CD4+T cell survival. J Immunol, 172, pp. 6065-6073.
    • (2004) J Immunol , vol.172 , pp. 6065-6073
    • Gelman, A.E.1    Zhang, J.2    Choi, Y.3    Turka, L.A.4
  • 114
    • 7044224867 scopus 로고    scopus 로고
    • Regulatory CD4+T cells and the control of autoimmune disease
    • Wraith, DC, Nicolson, KS and Whitley, NT (2004) Regulatory CD4+T cells and the control of autoimmune disease. Curr Opin Immunol, 16, pp. 695-701.
    • (2004) Curr Opin Immunol , vol.16 , pp. 695-701
    • Wraith, D.C.1    Nicolson, K.S.2    Whitley, N.T.3
  • 116
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek, TR and Bayer, AL (2004) Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol, 4, pp. 665-674.
    • (2004) Nat Rev Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 117
    • 0033491981 scopus 로고    scopus 로고
    • Biology of the interleukin-2 receptor
    • Nelson, BH and Willerford, DM (1998) Biology of the interleukin-2 receptor. Adv Immunol, 70, pp. 1-81.
    • (1998) Adv Immunol , vol.70 , pp. 1-81
    • Nelson, B.H.1    Willerford, D.M.2
  • 118
    • 0031569514 scopus 로고    scopus 로고
    • Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor
    • Van Parijs, L., Biuckians, A., Ibragimov, A., Alt, FW, Willerford, DM and Abbas, AK (1997) Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor. J Immunol, 158, pp. 3738-3745.
    • (1997) J Immunol , vol.158 , pp. 3738-3745
    • Van Parijs, L.1    Biuckians, A.2    Ibragimov, A.3    Alt, F.W.4    Willerford, D.M.5    Abbas, A.K.6
  • 119
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • Refaeli, Y., Van Parijs, L., London, CA, Tschopp, J. and Abbas, AK (1998) Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity, 8, pp. 615-623.
    • (1998) Immunity , vol.8 , pp. 615-623
    • Refaeli, Y.1    Van Parijs, L.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 120
    • 0348047537 scopus 로고    scopus 로고
    • The main function of IL-2 is to promote the development of T regulatory cells
    • Malek, TR (2003) The main function of IL-2 is to promote the development of T regulatory cells. J Leukoc Biol, 74, pp. 961-965.
    • (2003) J Leukoc Biol , vol.74 , pp. 961-965
    • Malek, T.R.1
  • 121
    • 0242580058 scopus 로고    scopus 로고
    • Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/ 5B-deficient mice
    • Snow, JW, Abraham, N., Ma, MC, Herndier, BG, Pastuszak, AW and Goldsmith, MA (2003) Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice. J Immunol, 171, pp. 5042-5050.
    • (2003) J Immunol , vol.171 , pp. 5042-5050
    • Snow, J.W.1    Abraham, N.2    Ma, M.C.3    Herndier, B.G.4    Pastuszak, A.W.5    Goldsmith, M.A.6
  • 122
    • 33748522053 scopus 로고    scopus 로고
    • Clearance of apoptotic and necrotic cells and its immunological consequences
    • Krysko, DV, D'Herde, K. and Vandenabeele, P. (2006) Clearance of apoptotic and necrotic cells and its immunological consequences. Apoptosis, 11, pp. 1709-1726.
    • (2006) Apoptosis , vol.11 , pp. 1709-1726
    • Krysko, D.V.1    D'Herde, K.2    Vandenabeele, P.3
  • 123
    • 28544435485 scopus 로고    scopus 로고
    • Lysosomes and autophagy in cell death control
    • Kroemer, G. and Jaattela, M. (2005) Lysosomes and autophagy in cell death control. Nat Rev Cancer, 5, pp. 886-897.
    • (2005) Nat Rev Cancer , vol.5 , pp. 886-897
    • Kroemer, G.1    Jaattela, M.2
  • 125
    • 33846054490 scopus 로고    scopus 로고
    • Autoimmunity versus tolerance: Can dying cells tip the balance?
    • Viorritto, IC, Nikolov, NP and Siegel, RM (2007) Autoimmunity versus tolerance: Can dying cells tip the balance?. Clin Immunol, 122, pp. 125-134.
    • (2007) Clin Immunol , vol.122 , pp. 125-134
    • Viorritto, I.C.1    Nikolov, N.P.2    Siegel, R.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.