TNF receptor 1 (TNFR1) and CD95 are not required for T cell deletion after virus infection but contribute to peptide-induced deletion under limited conditions

European Journal of Immunology

Volumn 30, Issue 2, 2000, Pages 683-688

  Nguyen, Linh T ^a   McKall Faienza, Kim ^a   Zakarian, Arsen ^a   Speiser, Daniel E ^b   Mak, Tak W ^a,b   Ohashi, Pamela S ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

CD95; Cytotoxic T lymphocyte; Peripheral deletion; TCR transgenic; TNF receptor 1

Indexed keywords

CD8 ANTIGEN; FAS ANTIGEN; PEPTIDE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR; VIRUS ANTIGEN; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD95; ANTIGENS, VIRAL; APOPTOSIS; CYTOTOXICITY, IMMUNOLOGIC; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; T-LYMPHOCYTES;

EID: 0033956309     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200002)30:2<683::AID-IMMU683>3.0.CO;2-5     Document Type: Article

References (24)

1. Green, D. R. and Scott, D. W., Activation-induced apoptosis in lymphocytes. Curr. Opin. Immunol. 1994, 6: 476-487.
2. Lee, S. Y., Park, C. G. and Choi, Y., T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmatic domain in association with tumor necrosis factor receptor-associated factors. J. Exp. Med. 1996, 183: 669-674.
3. Nagata, S., Apoptosis by death factor. Cell 1997. 88: 355-365.
4. Ashkenazi, A. and Dixit, V. M., Apoptosis control by death and decoy receptors. Curr. Opin. Cell Biol. 1999. 11: 255-260.
5. Watanabe-Fukunaga, R., Brannan, C. I., Copeland, N. G., Jenkins, N. A. and Nagata, S., Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992. 356:314-317.
6. Nagata, S. and Suda, T., Fas and Fas ligand: lpr and gld mutations. Immunol. Today 1995. 16: 39-43.
7. Russell, J. H., Rush, B., Weaver, C. and Wang, R., Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA 1993, 90: 4409-4413.
8. Scott, D. E., Kisch, W. J. and Steinberg, A. D., Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice. J. Immunol. 1993. 150: 664-672.
9. Singer, G. G. and Abbas, A. K., The Fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1994. 1: 365-371.
10. Kurts, C., Heath, W. R., Kosaka, H., Miller, J. F. and Carbone, F. R., The peripheral deletion of autoreactive CD8+ T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1). J. Exp. Med. 1998. 188: 415-40.
11. Ehl, S., Hoffmann-Rohrer, U., Nagata, S., Hengartner, H. and Zinkernagel, R., Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo. J. Immunol. 1996. 156: 2357-2360.
12. + T cells after antigen challenge in the absence of Fas (CD95). Eur. J. Immunol. 1996. 26: 2903-2910.
13. + T cells. Int. Immunol. 1996. 8: 675-681.
14. Hsu, H., Shu, H. B., Pan, M. G. and Goeddel, D. V., TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996. 84: 299-311.
15. Varfolomeev, E. E., Boldin, M. P., Goncharov, T. M. and Wallach, D., A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and the Fas/AP01 : Proteins binding to the death domains of the two receptors also bind to each other. J. Exp. Med. 1996. 183: 1271-1275.
16. Zhou, T., Edwards III, C. K., Yang, P., Wang, Z., Bluethmann, H. and Mountz, J. D., Greatly accelerated lymphadenopathy and autoimmune disase in lpr mice lacking tumor necrosis factor receptor I. J. Immunol. 1996. 156: 2661-2665.
17. Zheng, L., Fisher, G., Miller, R. E., Peschon, J., Lynch, D. H. and Lenardo, M. J., Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995. 377: 348-351.
18. Sytwu, H.-K., Liblau, R. L. and McDevitt, H. O., The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice. Immunity 1996. 5: 17-30.
19. Speiser, D. E., Sebzda, E., Ohteki, T., Bachmann, M. F., Pfeffer, K., Mak, T. W. and Ohashi, P. S., Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo. Eur. J. Immunol. 1996. 26: 3055-3060.
20. Pircher, H., Bürki, K., Lang, R., Hengartner, H. and Zinkernagel, R., Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 1989. 342: 559-561.
21. Lenardo, M. J., Chan, F. K. M., Hornung, F., McFarland, H., Siegel, R., Wang, J. and Zheng, L., Mature T lymphocyte apoptosis - immune regulation in a dynamic and unpredictable environment. Annu. Rev. Immunol. 1999. 17: 221-253.
22. Kishimito, H., Surh, C. D. and Sprent, J., A role for Fas in negative selection of thymocytes in vivo. J. Exp. Med. 1998. 187: 1427-1438.
23. Alexander-Miller, M. A., Derby, M. A., Sarin, A., Henkart, P. A. and Berzofsky, J. A., Supraoptimal peptide-major histocompatibility complex causes a decreases in Bcl-2 levels and allows tumor necrosis factor α receptor II-mediated apoptosis of cytotoxic T lymphocytes. J. Exp. Med. 1998. 188: 1391-1399.
24. Sebzda, E., Kündig, T. M., Thomson, C. T., Aoki, K., Mak, S. Y., Mayer, J., Zamborelli, T. M., Nathenson, S. and Ohashi, P. S., Mature T cell reactivity altered by a peptide agonist that induces positive selection. J. Exp. Med. 1996. 183: 1093-1104.