Molecular mechanisms of activated T cell death in vivo

Current Opinion in Immunology

Volumn 14, Issue 3, 2002, Pages 354-359

  Hildeman, David A ^a,b   Zhu, Yanan ^b,c   Mitchell, Thomas C ^c,d   Appler, John ^a,b,c   Marrack, Philippa ^a,b,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CASPASE; CYTOKINE; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN; PROTEIN BCL 2; PROTEIN BCL 3; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN SPECIFICITY; APOPTOSIS; AUTOIMMUNITY; CELL DEATH; CELL SURVIVAL; HOMEOSTASIS; HUMAN; IMMUNE RESPONSE; MOLECULAR DYNAMICS; NONHUMAN; REVIEW; T LYMPHOCYTE ACTIVATION;

EID: 0036604897     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(02)00335-7     Document Type: Editorial

References (33)

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2. Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
3. Mature T lymphocyte apoptosis- immune regulation in a dynamic and unpredictable antigenic environment
4. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis
5. A single injection of Staphylococcus aureus enterotoxin B reduces autoimmunity in MRL/lpr mice
6. T-lymphocyte downregulation after acute viral infection is not dependent on CD95 (Fas) receptor-ligand interactions
7. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
8. IL-2 addiction: Withdrawal of growth factor activates a suicide program in dependent T cells
9. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes
10. Molecular steps of death receptor and mitochondrial pathways of apoptosis
11. Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection
12. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
13. TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia
14. Requirement for transforming growth factor beta 1 in controlling T cell apoptosis
15. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
16. Immune system dysfunction and autoimmune disease in mice lacking Emk (Par-1) protein kinase
17. Critical involvement of OX40 ligand signals in the T cell priming events during experimental autoimmune encephalomyelitis
18. Breaking the mitochondrial barrier
19. The Bcl-2 family and cell death regulation
20. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
21. BH3 only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
22. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues
23. Type I interferons keep activated T cells alive
24. Bystander virus infection prolongs activated T cell survival
25. Reactive oxygen species regulate activation-induced T cell apoptosis
26. T cell-specific loss of Pten leads to defects in central and peripheral tolerance
27. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
28. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
29. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy
30. NF-kappa B signals induce the expression of c-FLIP
31. Immunological adjuvants promote activated T cell survival via induction of Bcl-3
32. The proto-oncogene Bcl-3 encodes an I kappa B protein
33. An inverse relationship between T cell receptor affinity and antigen dose during CD4(+) T cell responses in vivo and in vitro