-
1
-
-
0026666519
-
Cleavage of bovine brain microtubule associated protein 2 by human immunodeficiency virus proteinase
-
A.M. Ainsztein and D.L. Punch (1992) Cleavage of bovine brain microtubule associated protein 2 by human immunodeficiency virus proteinase. J. Neurochem. 59 874-880.
-
(1992)
J. Neurochem.
, vol.59
, pp. 874-880
-
-
Ainsztein, A.M.1
Punch, D.L.2
-
2
-
-
0031027901
-
Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors
-
P.J. Ala, E.E. Huston, R.M. Klabe, D.D. McCabe, J.L. Duke, B.D. Korant, R.J. Deloskey, P.Y.S. Lam, C.N. Hodge and C.H. Chang (1997) Molecular basis of HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with cyclic urea inhibitors. Biochemistry 36 1573-1580.
-
(1997)
Biochemistry
, vol.36
, pp. 1573-1580
-
-
Ala, P.J.1
Huston, E.E.2
Klabe, R.M.3
McCabe, D.D.4
Duke, J.L.5
Korant, B.D.6
Deloskey, R.J.7
Lam, P.Y.S.8
Hodge, C.N.9
Chang, C.H.10
-
3
-
-
0029665574
-
A p6Pol protease fusion protein is present in mature particles of human immunodeficiency virus type 1
-
N. Almog, R. Roller, G. Arad, L. Passi-Even, M.A. Wainberg and M. Kotler (1996) A p6Pol protease fusion protein is present in mature particles of human immunodeficiency virus type 1. J. Virol. 70 7228-7232.
-
(1996)
J. Virol.
, vol.70
, pp. 7228-7232
-
-
Almog, N.1
Roller, R.2
Arad, G.3
Passi-Even, L.4
Wainberg, M.A.5
Kotler, M.6
-
4
-
-
0029644939
-
Structure of HIV-1 protease with KNI 272, a tight binding transition state analog containing allophenylnorstatine
-
E.T. Baldwin, T.N. Bhat, S. Gulnik, B. Liu, I.A. Topol, Y. Kiso, T. Mimoto, H. Mitsuya and J.W. Erickson (1995) Structure of HIV-1 protease with KNI 272, a tight binding transition state analog containing allophenylnorstatine. Structure 3 581-590.
-
(1995)
Structure
, vol.3
, pp. 581-590
-
-
Baldwin, E.T.1
Bhat, T.N.2
Gulnik, S.3
Liu, B.4
Topol, I.A.5
Kiso, Y.6
Mimoto, T.7
Mitsuya, H.8
Erickson, J.W.9
-
5
-
-
0028945211
-
Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase
-
E.T. Baldwin, T.N. Bhat, B. Liu, N. Pattabiraman and J.W. Erickson (1995) Structural basis of drug resistance for the V82A mutant of HIV-1 proteinase. Nature Struct. Biol. 2 244-249.
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 244-249
-
-
Baldwin, E.T.1
Bhat, T.N.2
Liu, B.3
Pattabiraman, N.4
Erickson, J.W.5
-
6
-
-
0030905238
-
Structure-based thermodynamic analysis of HIV-1 protease inhibitors
-
J.S. Bardi, I. Luque and E. Freire (1997) Structure-based thermodynamic analysis of HIV-1 protease inhibitors. Biochemistry 36 6588-6596.
-
(1997)
Biochemistry
, vol.36
, pp. 6588-6596
-
-
Bardi, J.S.1
Luque, I.2
Freire, E.3
-
7
-
-
0030007802
-
Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within Gag/Pol polyprotein: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1
-
K.A. Barrie, E.E. Perez, S.L. Lamers, W.G. Farmerie, B.M. Dunn, J.W. Sleasman and M.M. Goodenow (1996) Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within Gag/Pol polyprotein: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1. Virology 219 407-416.
-
(1996)
Virology
, vol.219
, pp. 407-416
-
-
Barrie, K.A.1
Perez, E.E.2
Lamers, S.L.3
Farmerie, W.G.4
Dunn, B.M.5
Sleasman, J.W.6
Goodenow, M.M.7
-
8
-
-
0034284978
-
Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development
-
Z.Q. Beck, L. Hervio, P.E. Dawson, J.H. Elder and E.L. Madison (2000) Identification of efficiently cleaved substrates for HIV-1 protease using a phage display library and use in inhibitor development. Jpn J. Cancer Chemother. 274 391-401.
-
(2000)
Jpn J. Cancer Chemother.
, vol.274
, pp. 391-401
-
-
Beck, Z.Q.1
Hervio, L.2
Dawson, P.E.3
Elder, J.H.4
Madison, E.L.5
-
9
-
-
0027494364
-
Rapid, sensitive and efficient HPLC assays for HIV-1 proteinase
-
R. Betageri, J.L. Hopkins, D. Thibeault, M.J. Emmanuel, G.C. Chow, M.T. Skoog, P. de Dreu and K.A. Cohen (1993) Rapid, sensitive and efficient HPLC assays for HIV-1 proteinase. J. Biochem. Biophys. Methods 27 191-197.
-
(1993)
J. Biochem. Biophys. Methods
, vol.27
, pp. 191-197
-
-
Betageri, R.1
Hopkins, J.L.2
Thibeault, D.3
Emmanuel, M.J.4
Chow, G.C.5
Skoog, M.T.6
de Dreu, P.7
Cohen, K.A.8
-
10
-
-
0028483655
-
Crystal structure of a tethered dimer of HIV-1 proteinase complexed with an inhibitor
-
T.N. Bhat, E.T. Baldwin, B. Liu, Y.S. Cheng and J.W. Erickson (1994) Crystal structure of a tethered dimer of HIV-1 proteinase complexed with an inhibitor. Nature Struct. Biol. 1 552-556.
-
(1994)
Nature Struct. Biol.
, vol.1
, pp. 552-556
-
-
Bhat, T.N.1
Baldwin, E.T.2
Liu, B.3
Cheng, Y.S.4
Erickson, J.W.5
-
11
-
-
0029071231
-
X ray structure of a tethered dimer for HIV-1 protease
-
T.N. Bhat, E.T. Baldwin, B. Liu, Y.S. Cheng and J.W. Erickson (1995) X ray structure of a tethered dimer for HIV-1 protease. Adv. Exp. Med. Biol. 362 439-444.
-
(1995)
Adv. Exp. Med. Biol.
, vol.362
, pp. 439-444
-
-
Bhat, T.N.1
Baldwin, E.T.2
Liu, B.3
Cheng, Y.S.4
Erickson, J.W.5
-
12
-
-
0026044822
-
Analysis of subsite preferences of HIV-1 proteinase using MA/CA junction peptides substituted at the P3–P1′ positions
-
A. Billich and G. Winkler (1991) Analysis of subsite preferences of HIV-1 proteinase using MA/CA junction peptides substituted at the P3–P1′ positions. Arch. Biochem. Biophys. 290 186-190.
-
(1991)
Arch. Biochem. Biophys.
, vol.290
, pp. 186-190
-
-
Billich, A.1
Winkler, G.2
-
13
-
-
0025130997
-
The 3D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS
-
T.L. Blundell, R. Lapatto, A.F. Wilderspin, A.M. Hemmings, P.M. Hobart, D.E. Danley and P.J. Whittle (1990) The 3D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS. Trends Biochem. Sci. 15 425-430.
-
(1990)
Trends Biochem. Sci.
, vol.15
, pp. 425-430
-
-
Blundell, T.L.1
Lapatto, R.2
Wilderspin, A.F.3
Hemmings, A.M.4
Hobart, P.M.5
Danley, D.E.6
Whittle, P.J.7
-
14
-
-
0028268676
-
A structural role for arginine in protein: multiple hydrogen bonds to backbone carbonyl oxygens
-
C.L. Borders Jr., J.A. Broadwater, P.A. Bekeny, J.E. Salmon, A.S. Lee, A.M. Eldridge and V.B. Pert (1994) A structural role for arginine in protein: multiple hydrogen bonds to backbone carbonyl oxygens. Protein Sci. 3 541-548.
-
(1994)
Protein Sci.
, vol.3
, pp. 541-548
-
-
Borders, C.L.1
Broadwater, J.A.2
Bekeny, P.A.3
Salmon, J.E.4
Lee, A.S.5
Eldridge, A.M.6
Pert, V.B.7
-
15
-
-
0001351236
-
Effect of substrate residues on the P2′ preference of retroviral proteinases
-
P. Boross, P. Bagossi, T.D. Copeland, S. Oroszlan, J.M. Louis and J. Tözsér (1999) Effect of substrate residues on the P2′ preference of retroviral proteinases. Eur. J. Biochem. 264 921-929.
-
(1999)
Eur. J. Biochem.
, vol.264
, pp. 921-929
-
-
Boross, P.1
Bagossi, P.2
Copeland, T.D.3
Oroszlan, S.4
Louis, J.M.5
Tözsér, J.6
-
16
-
-
0031015224
-
Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease
-
A.A. Bukovsky, T. Dorfman, A. Weimann and H.G. Gottlinger (1997) Nef association with human immunodeficiency virus type 1 virions and cleavage by the viral protease. J. Virol. 71 1013-1018.
-
(1997)
J. Virol.
, vol.71
, pp. 1013-1018
-
-
Bukovsky, A.A.1
Dorfman, T.2
Weimann, A.3
Gottlinger, H.G.4
-
17
-
-
0033951838
-
Design of dimerization inhibitors of HIV-1 aspartic proteinase: a computer-based combinatorial approach
-
A. Caflisch, H.J. Schramm and M. Karplus (2000) Design of dimerization inhibitors of HIV-1 aspartic proteinase: a computer-based combinatorial approach. J. Comput. Aided Mol. Design 14 161-179.
-
(2000)
J. Comput. Aided Mol. Design
, vol.14
, pp. 161-179
-
-
Caflisch, A.1
Schramm, H.J.2
Karplus, M.3
-
18
-
-
0031762518
-
Artificial neural network method for predicting HIV protease cleavage sites in protein
-
Y.D. Cai, H. Yu and K.C. Chou (1998) Artificial neural network method for predicting HIV protease cleavage sites in protein. J. Protein Chem. 17 607-615.
-
(1998)
J. Protein Chem.
, vol.17
, pp. 607-615
-
-
Cai, Y.D.1
Yu, H.2
Chou, K.C.3
-
19
-
-
0028240335
-
Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus 1 proteases
-
C.E. Cameron, T.W. Ridky, S. Shulenin, J. Leis, I.T. Weber, T. Copeland, A. Wlodawer, H. Burstein, D. Bizub-Bender and A.M. Skalka (1994) Mutational analysis of the substrate binding pockets of the Rous sarcoma virus and human immunodeficiency virus 1 proteases. J. Biol. Chem. 269 11170-11177.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 11170-11177
-
-
Cameron, C.E.1
Ridky, T.W.2
Shulenin, S.3
Leis, J.4
Weber, I.T.5
Copeland, T.6
Wlodawer, A.7
Burstein, H.8
Bizub-Bender, D.9
Skalka, A.M.10
-
20
-
-
0035112594
-
Extended nucleocapsid protein is cleaved from the Gag-Pol precursor of human immunodeficiency virus type 1
-
N. Chen, A. Morag, N. Almog, I. Blumenzweig, O. Dreazin and M. Kotler (2001) Extended nucleocapsid protein is cleaved from the Gag-Pol precursor of human immunodeficiency virus type 1. J. Gen. Virol. 82 581-590.
-
(2001)
J. Gen. Virol.
, vol.82
, pp. 581-590
-
-
Chen, N.1
Morag, A.2
Almog, N.3
Blumenzweig, I.4
Dreazin, O.5
Kotler, M.6
-
21
-
-
0027943157
-
Crystal structure at 1.9 Å resolution of human immunodeficiency virus (HIV) II protease complexed with L-735 524, an orally bioavailable inhibitor of the HIV proteases
-
Z. Chen, Y. Li, E. Chen, D. Hall, P. Darke, C. Culberson, J.A. Shafer and L.A. Kuo (1994) Crystal structure at 1.9 Å resolution of human immunodeficiency virus (HIV) II protease complexed with L-735 524, an orally bioavailable inhibitor of the HIV proteases. J. Biol. Chem. 269 26344-26348.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 26344-26348
-
-
Chen, Z.1
Li, Y.2
Chen, E.3
Hall, D.4
Darke, P.5
Culberson, C.6
Shafer, J.A.7
Kuo, L.A.8
-
22
-
-
0029131607
-
Three dimensional structure of a mutant HIV-1 protease displaying cross resistance to all protease inhibitors in clinical trials
-
Z. Chen, Y. Li, H. Schock, D. Hall, E. Chen and L.A. Kuo (1995) Three dimensional structure of a mutant HIV-1 protease displaying cross resistance to all protease inhibitors in clinical trials. J. Biol. Chem. 270 21433-21436.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 21433-21436
-
-
Chen, Z.1
Li, Y.2
Schock, H.3
Hall, D.4
Chen, E.5
Kuo, L.A.6
-
23
-
-
0025248435
-
High level synthesis of recombinant HIV-1 protease and the recovery of active enzyme from inclusion bodies
-
Y.S.E. Cheng, M.H. McGowan, C.A. Kettner, J.V. Schloss, S. Erickson-Viitanen and F.H. Yin (1990) High level synthesis of recombinant HIV-1 protease and the recovery of active enzyme from inclusion bodies. Gene 87 243-248.
-
(1990)
Gene
, vol.87
, pp. 243-248
-
-
Cheng, Y.S.E.1
McGowan, M.H.2
Kettner, C.A.3
Schloss, J.V.4
Erickson-Viitanen, S.5
Yin, F.H.6
-
24
-
-
0025641617
-
Stability and activity of human immunodeficiency virus protease comparison of the natural dimer with a homologous, single chain tethered dimer
-
Y.S.E. Cheng, F.H. Yin, S. Foundling, D. Blomstrom and C.A. Kettner (1990) Stability and activity of human immunodeficiency virus protease comparison of the natural dimer with a homologous, single chain tethered dimer. Proc. Natl. Acad. Sci. USA 87 9660-9664.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 9660-9664
-
-
Cheng, Y.S.E.1
Yin, F.H.2
Foundling, S.3
Blomstrom, D.4
Kettner, C.A.5
-
25
-
-
0030027067
-
Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method
-
K.C. Chou, A.G. Tomasselli, I.M. Reardon and R.L. Heinrikson (1996) Predicting human immunodeficiency virus protease cleavage sites in proteins by a discriminant function method. Proteins 24 51-72.
-
(1996)
Proteins
, vol.24
, pp. 51-72
-
-
Chou, K.C.1
Tomasselli, A.G.2
Reardon, I.M.3
Heinrikson, R.L.4
-
26
-
-
0028345852
-
Proteolytic processing mechanisms of a miniprecursor of the aspartic protease of human immunodeficiency virus type 1
-
E. Co, G. Koelsch, Y.Z. Lin, E. Ido, J.A. Hartsuck and J. Tang (1994) Proteolytic processing mechanisms of a miniprecursor of the aspartic protease of human immunodeficiency virus type 1. Biochemistry 33 1248-1254.
-
(1994)
Biochemistry
, vol.33
, pp. 1248-1254
-
-
Co, E.1
Koelsch, G.2
Lin, Y.Z.3
Ido, E.4
Hartsuck, J.A.5
Tang, J.6
-
27
-
-
0028958868
-
Rap opening in HIV-1 protease simulated by ‘activated’ molecular dynamics
-
J.R. Collins, S.K. Burt and J.W. Erickson (1995) Rap opening in HIV-1 protease simulated by ‘activated’ molecular dynamics. Nature Struct. Biol. 2 334-338.
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 334-338
-
-
Collins, J.R.1
Burt, S.K.2
Erickson, J.W.3
-
28
-
-
0028943992
-
in vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
-
J.H. Condra, W.A. Schleif, O.M. Blahy, L.J. Gabryelski, D.J. Graham, J.C. Quintero, A. Rhodes, H.L. Robins, E. Roth, M. Shivaprakash, T. Yang, J.A. Chodakewitz, P.J. Deutsch, R.Y. Leavitt, F.E. Massari, J.W. Mellors, K.E. Squires, R.T. Steigbigel, H. Teppler and E.A. Emini (1995) in vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 374 569-571.
-
(1995)
Nature
, vol.374
, pp. 569-571
-
-
Condra, J.H.1
Schleif, W.A.2
Blahy, O.M.3
Gabryelski, L.J.4
Graham, D.J.5
Quintero, J.C.6
Rhodes, A.7
Robins, H.L.8
Roth, E.9
Shivaprakash, M.10
Yang, T.11
Chodakewitz, J.A.12
Deutsch, P.J.13
Leavitt, R.Y.14
Massari, F.E.15
Mellors, J.W.16
Squires, K.E.17
Steigbigel, R.T.18
Teppler, H.19
Emini, E.A.20
more..
-
29
-
-
0026347525
-
Scintillation proximity enzyme assay. A rapid and novel assay technique applied to HIV proteinase
-
N.D. Cook, R.A. Jessop, P.S. Robinson, A.D. Richards and J. Kay (1991) Scintillation proximity enzyme assay. A rapid and novel assay technique applied to HIV proteinase. Adv. Exp. Med. Biol. 306 525-528.
-
(1991)
Adv. Exp. Med. Biol.
, vol.306
, pp. 525-528
-
-
Cook, N.D.1
Jessop, R.A.2
Robinson, P.S.3
Richards, A.D.4
Kay, J.5
-
30
-
-
0025296462
-
Substitution of proline with pipecolic acid at the scissile bond converts a peptide substrate of HIV proteinase into a selective inhibitor
-
T.D. Copeland, E.M. Wondrak, J. Tözsér, M.M. Roberts and S. Oroszlan (1990) Substitution of proline with pipecolic acid at the scissile bond converts a peptide substrate of HIV proteinase into a selective inhibitor. Biochem. Biophys. Res. Commun. 169 310-314.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.169
, pp. 310-314
-
-
Copeland, T.D.1
Wondrak, E.M.2
Tözsér, J.3
Roberts, M.M.4
Oroszlan, S.5
-
31
-
-
0030858617
-
Pol gene diversity of five human immunodeficiency virus type 1 subtypes: evidence for naturally occurring mutations that contribute to drug resistance, limited recombination patterns, and common ancestry for subtypes B and D
-
M. Cornelissen, R. van den Burg, F. Zorgdrager, V. Lukashov and J. Goudsmit (1997) Pol gene diversity of five human immunodeficiency virus type 1 subtypes: evidence for naturally occurring mutations that contribute to drug resistance, limited recombination patterns, and common ancestry for subtypes B and D. J. Virol. 71 6348-6358.
-
(1997)
J. Virol.
, vol.71
, pp. 6348-6358
-
-
Cornelissen, M.1
van den Burg, R.2
Zorgdrager, F.3
Lukashov, V.4
Goudsmit, J.5
-
32
-
-
0035163687
-
Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir
-
H.C.F. Cote, Z.L. Brumme and P.R. Harrigan (2001) Human immunodeficiency virus type 1 protease cleavage site mutations associated with protease inhibitor cross-resistance selected by indinavir, ritonavir, and/or saquinavir. J. Virol. 75 589-594.
-
(2001)
J. Virol.
, vol.75
, pp. 589-594
-
-
Cote, H.C.F.1
Brumme, Z.L.2
Harrigan, P.R.3
-
33
-
-
0024834718
-
Crystallizable HIV-1 protease derived from expression of the viral pol gene in Escherichia coli
-
D.E. Danley, K.F. Geoghegan, K.G. Scheld, S.E. Lee, J.R. Merson, S.J. Hawrylik, G.A. Rickett, M.J. Ammirati and P.M. Hobart (1989) Crystallizable HIV-1 protease derived from expression of the viral pol gene in Escherichia coli. Biochem. Biophys. Res. Commun. 165 1043-1050.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.165
, pp. 1043-1050
-
-
Danley, D.E.1
Geoghegan, K.F.2
Scheld, K.G.3
Lee, S.E.4
Merson, J.R.5
Hawrylik, S.J.6
Rickett, G.A.7
Ammirati, M.J.8
Hobart, P.M.9
-
34
-
-
0024286275
-
HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins
-
P.L. Darke, R.F. Nutt, S.F. Brady, V.M. Garsky, T.M. Ciccarone, C.T. Leu, P.K. Lumma, R.M. Freidinger, D.F. Veber and I.S. Sigal (1988) HIV-1 protease specificity of peptide cleavage is sufficient for processing of gag and pol polyproteins. Biochem. Biophys. Res. Commun. 156 297-303.
-
(1988)
Biochem. Biophys. Res. Commun.
, vol.156
, pp. 297-303
-
-
Darke, P.L.1
Nutt, R.F.2
Brady, S.F.3
Garsky, V.M.4
Ciccarone, T.M.5
Leu, C.T.6
Lumma, P.K.7
Freidinger, R.M.8
Veber, D.F.9
Sigal, I.S.10
-
35
-
-
0035951768
-
Interaction of a novel inhibitor from an extremophilic Bacillus sp with HIV-1 protease- implications for the mechanism of inactivation
-
C. Dash and M. Rao (2001) Interaction of a novel inhibitor from an extremophilic Bacillus sp with HIV-1 protease- implications for the mechanism of inactivation. J. Biol. Chem. 276 2487-2493.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 2487-2493
-
-
Dash, C.1
Rao, M.2
-
36
-
-
0034658382
-
Bioluminescence detection of proteolytic bond cleavage by using recombinant aequorin
-
S.K. Deo, J.D. Lewis and S. Daunert (2000) Bioluminescence detection of proteolytic bond cleavage by using recombinant aequorin. Anal. Biochem. 281 87-94.
-
(2000)
Anal. Biochem.
, vol.281
, pp. 87-94
-
-
Deo, S.K.1
Lewis, J.D.2
Daunert, S.3
-
37
-
-
0022498061
-
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of hTLV-III/LAV
-
F. di Marzo Veronese, T.D. Copeland, A.L. DeVico, R. Rahman, S. Oroszlan, R.C. Gallo and M.G. Sarngadharan (1986) Characterization of highly immunogenic p66/p51 as the reverse transcriptase of hTLV-III/LAV. Science 231 1289-1291.
-
(1986)
Science
, vol.231
, pp. 1289-1291
-
-
di Marzo Veronese, F.1
Copeland, T.D.2
DeVico, A.L.3
Rahman, R.4
Oroszlan, S.5
Gallo, R.C.6
Sarngadharan, M.G.7
-
38
-
-
0027969994
-
L 735 524 the design of a potent and orally bioavailable HIV protease inhibitor
-
B.D. Dorsey, R.B. Levin, S.L. McDaniel, J.P. Vacca, J.P. Guare, P.L. Darke, J.A. Zugay, E.A. Emini, W.A. Schleif, J.C. Quintero, J.H. Lin, I.-W. Chen, M.K.M.D. Holloway, P. Fitzgerald, M.G. Axel, D. Ostovic, P.S. Anderson and J.R. Huff (1994) L 735 524 the design of a potent and orally bioavailable HIV protease inhibitor. J. Med. Chem. 37 3443-3451.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 3443-3451
-
-
Dorsey, B.D.1
Levin, R.B.2
McDaniel, S.L.3
Vacca, J.P.4
Guare, J.P.5
Darke, P.L.6
Zugay, J.A.7
Emini, E.A.8
Schleif, W.A.9
Quintero, J.C.10
Lin, J.H.11
Chen, I.-W.12
Holloway, M.K.M.D.13
Fitzgerald, P.14
Axel, M.G.15
Ostovic, D.16
Anderson, P.S.17
Huff, J.R.18
-
39
-
-
0031015475
-
Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors
-
L. Doyon, D. Thibeault, G. Mckercher, L. Pilote and D. Lamarre (1997) Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J. Virol. 71 1089-1096.
-
(1997)
J. Virol.
, vol.71
, pp. 1089-1096
-
-
Doyon, L.1
Thibeault, D.2
Mckercher, G.3
Pilote, L.4
Lamarre, D.5
-
41
-
-
0024784403
-
Cleavage of HIV-1 gag polyprotein synthesized in vitro sequential cleavage by the viral protease
-
S. Erickson-Viitanen, J. Manfredi, P. Viitanen, D.E. Tribe, R. Tritch, C.A. Hutchison III, D.D. Loeb and R. Swanstrom (1989) Cleavage of HIV-1 gag polyprotein synthesized in vitro sequential cleavage by the viral protease. AIDS Res. Hum. Retroviruses 5 577-591.
-
(1989)
AIDS Res. Hum. Retroviruses
, vol.5
, pp. 577-591
-
-
Erickson-Viitanen, S.1
Manfredi, J.2
Viitanen, P.3
Tribe, D.E.4
Tritch, R.5
Hutchison, C.A.6
Loeb, D.D.7
Swanstrom, R.8
-
42
-
-
0030870159
-
Kinetic properties of saquinavir-resistant mutants of human immunodeficiency virus type 1 protease and their implications in drug resistance in vivo
-
J. Ermolieff, X.L. Lin and J. Tang (1997) Kinetic properties of saquinavir-resistant mutants of human immunodeficiency virus type 1 protease and their implications in drug resistance in vivo. Biochemistry 36 12364-12370.
-
(1997)
Biochemistry
, vol.36
, pp. 12364-12370
-
-
Ermolieff, J.1
Lin, X.L.2
Tang, J.3
-
43
-
-
0026440861
-
An ultrasensitive human immunodeficiency virus type 1 protease radioimmuno rate assay with a potential for monitoring blood levels of protease inhibitors in acquired immunodeficiency disease syndrome patients
-
D.B. Evans, A.F. Vosters, T.J. McQuade and S.K. Sharma (1992) An ultrasensitive human immunodeficiency virus type 1 protease radioimmuno rate assay with a potential for monitoring blood levels of protease inhibitors in acquired immunodeficiency disease syndrome patients. Anal. Biochem. 206 192-288.
-
(1992)
Anal. Biochem.
, vol.206
, pp. 192-288
-
-
Evans, D.B.1
Vosters, A.F.2
McQuade, T.J.3
Sharma, S.K.4
-
44
-
-
0025108755
-
Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl pepstatin at 2.0 Å resolution
-
P.M.D. Fitzgerald, B.M. McKeever, J.F. VanMiddlesworth, J.P. Springer, J.C. Heimbach, C.T. Leu, W.K. Herber, R.A.F. Dixon and P.L. Darke (1990) Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl pepstatin at 2.0 Å resolution. J. Biol. Chem. 265 14209-14219.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 14209-14219
-
-
Fitzgerald, P.M.D.1
McKeever, B.M.2
VanMiddlesworth, J.F.3
Springer, J.P.4
Heimbach, J.C.5
Leu, C.T.6
Herber, W.K.7
Dixon, R.A.F.8
Darke, P.L.9
-
45
-
-
0026803394
-
PCR amplification of HIV-1 proteinase sequences directly from lab isolates allows determination of five conserved domains
-
G. Fontenot, K. Johnston, J.C. Cohen, W.R. Gallaher, J. Robinson and R.B. Luftig (1992) PCR amplification of HIV-1 proteinase sequences directly from lab isolates allows determination of five conserved domains. Virology 190 1-10.
-
(1992)
Virology
, vol.190
, pp. 1-10
-
-
Fontenot, G.1
Johnston, K.2
Cohen, J.C.3
Gallaher, W.R.4
Robinson, J.5
Luftig, R.B.6
-
46
-
-
0027999147
-
A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease
-
J. Freund, R. Kellner, J. Konvalinka, V. Wolber, H.G. Kräusslich and H.R. Kalbitzer (1994) A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease. Eur. J. Biochem. 223 589-593.
-
(1994)
Eur. J. Biochem.
, vol.223
, pp. 589-593
-
-
Freund, J.1
Kellner, R.2
Konvalinka, J.3
Wolber, V.4
Kräusslich, H.G.5
Kalbitzer, H.R.6
-
47
-
-
0028869561
-
Cleavage of recombinant and cell derived human immunodeficiency virus 1 (HIV-1) Nef protein by HIV-1 protease
-
K. Gaedigk-Nitschko, A. Schon, G. Wachinger, V. Erfle and B. Kohleisen (1995) Cleavage of recombinant and cell derived human immunodeficiency virus 1 (HIV-1) Nef protein by HIV-1 protease. FEBS Lett. 357 275-278.
-
(1995)
FEBS Lett.
, vol.357
, pp. 275-278
-
-
Gaedigk-Nitschko, K.1
Schon, A.2
Wachinger, G.3
Erfle, V.4
Kohleisen, B.5
-
48
-
-
0026102613
-
High yield purification of HIV-1 proteinase expressed by a synthetic gene in Escherichia coli
-
L. Goobar, U.H. Danielson, P. Brodin, T. Grundstrom, B. Oberg and E. Norrby (1991) High yield purification of HIV-1 proteinase expressed by a synthetic gene in Escherichia coli. Protein Expr. Purif. 2 15-23.
-
(1991)
Protein Expr. Purif.
, vol.2
, pp. 15-23
-
-
Goobar, L.1
Danielson, U.H.2
Brodin, P.3
Grundstrom, T.4
Oberg, B.5
Norrby, E.6
-
49
-
-
0036056291
-
Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease
-
M.M. Goodenow, G. Bloom, S.L. Rose, S.M. Pomeroy, P.O. O'Brien, E.E. Perez, J.W. Sleasman and B.M. Dunn (2002) Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease. Virology 292 137-149.
-
(2002)
Virology
, vol.292
, pp. 137-149
-
-
Goodenow, M.M.1
Bloom, G.2
Rose, S.L.3
Pomeroy, S.M.4
O'Brien, P.O.5
Perez, E.E.6
Sleasman, J.W.7
Dunn, B.M.8
-
50
-
-
0026344674
-
The three dimensional x ray crystal structure of HIV-1 protease complexed with a hydroxyethylene inhibitor
-
B.J. Graves, M.H. Hatada, J.K. Miller, M.C. Graves, S. Roy, C.M. Cook, A. Krohn, J.A. Martin and N.A. Roberts (1991) The three dimensional x ray crystal structure of HIV-1 protease complexed with a hydroxyethylene inhibitor. Adv. Exp. Med. Biol. 306 455-460.
-
(1991)
Adv. Exp. Med. Biol.
, vol.306
, pp. 455-460
-
-
Graves, B.J.1
Hatada, M.H.2
Miller, J.K.3
Graves, M.C.4
Roy, S.5
Cook, C.M.6
Krohn, A.7
Martin, J.A.8
Roberts, N.A.9
-
51
-
-
84884846178
-
Expression and characterization of human immunodeficiency virus-1 protease
-
V. Kostka (Eds), Berlin: Walter de Gruyter
-
M.C. Graves, J.J. Lim, M.A. Zicopoulos, T.J. Stoller, M.C. Miedel, Y.-C.E. Pan, W. Danho and C.M. Nalin (1989) Expression and characterization of human immunodeficiency virus-1 protease. V. Kostka (Eds) Proteases of Retroviruses Berlin: Walter de Gruyter 83-92.
-
(1989)
Proteases of Retroviruses
, pp. 83-92
-
-
Graves, M.C.1
Lim, J.J.2
Zicopoulos, M.A.3
Stoller, T.J.4
Miedel, M.C.5
Pan, Y.-C.E.6
Danho, W.7
Nalin, C.M.8
-
52
-
-
0025278597
-
Identification of a human immunodeficiency virus-1 protease cleavage site within the 66 000 Dalton subunit of reverse transcriptase
-
M.C. Graves, M.C. Meidel, Y.C. Pan, M. Manneberg, H.W. Lahm and F. Gruninger-Leitch (1990) Identification of a human immunodeficiency virus-1 protease cleavage site within the 66 000 Dalton subunit of reverse transcriptase. Biochem. Biophys. Res. Commun. 168 30-36.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.168
, pp. 30-36
-
-
Graves, M.C.1
Meidel, M.C.2
Pan, Y.C.3
Manneberg, M.4
Lahm, H.W.5
Gruninger-Leitch, F.6
-
53
-
-
0028297112
-
Application of the three dimensional structures of protein target molecules in structure based drug design
-
J. Greer, J.W. Erickson, J.J. Baldwin and M.D. Varney (1994) Application of the three dimensional structures of protein target molecules in structure based drug design. J. Med. Chem. 37 1035-1054.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 1035-1054
-
-
Greer, J.1
Erickson, J.W.2
Baldwin, J.J.3
Varney, M.D.4
-
54
-
-
0026721254
-
Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing hydrophobic*hydrophobic or aromatic*pro cleavage sites
-
J.H. Griffiths, L.H. Phylip, J. Konvalinka, P. Strop, A. Gustchina, A. Wlodawer, R.J. Davenport, R. Briggs, B.M. Dunn and J. Kay (1992) Different requirements for productive interaction between the active site of HIV-1 proteinase and substrates containing hydrophobic*hydrophobic or aromatic*pro cleavage sites. Biochemistry 31 5193-5200.
-
(1992)
Biochemistry
, vol.31
, pp. 5193-5200
-
-
Griffiths, J.H.1
Phylip, L.H.2
Konvalinka, J.3
Strop, P.4
Gustchina, A.5
Wlodawer, A.6
Davenport, R.J.7
Briggs, R.8
Dunn, B.M.9
Kay, J.10
-
55
-
-
0024388250
-
HIV-1 protease mutagenesis of asparagine 88 indicates a domain required for dimer formation
-
C. Guenet, R.A. Leppik, J.T. Pelton, K. Moelling, W. Lovenberg and B.A. Harris (1989) HIV-1 protease mutagenesis of asparagine 88 indicates a domain required for dimer formation. Eur. J. Pharmacol. 172 443-451.
-
(1989)
Eur. J. Pharmacol.
, vol.172
, pp. 443-451
-
-
Guenet, C.1
Leppik, R.A.2
Pelton, J.T.3
Moelling, K.4
Lovenberg, W.5
Harris, B.A.6
-
56
-
-
0029151345
-
Kinetic characterization and cross resistance patterns of HIV-1 protease mutants selected under drug pressure
-
S.V. Gulnik, L.I. Suvorov, B.S. Liu, B. Yu, B. Anderson, H. Mitsuya and J.W. Erickson (1995) Kinetic characterization and cross resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry 34 9282-9287.
-
(1995)
Biochemistry
, vol.34
, pp. 9282-9287
-
-
Gulnik, S.V.1
Suvorov, L.I.2
Liu, B.S.3
Yu, B.4
Anderson, B.5
Mitsuya, H.6
Erickson, J.W.7
-
57
-
-
0029346901
-
Large scale production of HIV-1 protease from Escherichia coli using selective extraction and membrane fractionation
-
M.E. Gustafson, K.D. Junger, B.A. Foy, J.A. Baez, B.F. Bishop, S.H. Rangwala, M.L. Michener, R.M. Leimgruber, K.A. Houseman, R.A. Mueller, B.K. Matthews, P.O. Olins, R.W. Grabner and A. Hershman (1995) Large scale production of HIV-1 protease from Escherichia coli using selective extraction and membrane fractionation. Protein Expr. Purif. 6 512-518.
-
(1995)
Protein Expr. Purif.
, vol.6
, pp. 512-518
-
-
Gustafson, M.E.1
Junger, K.D.2
Foy, B.A.3
Baez, J.A.4
Bishop, B.F.5
Rangwala, S.H.6
Michener, M.L.7
Leimgruber, R.M.8
Houseman, K.A.9
Mueller, R.A.10
Matthews, B.K.11
Olins, P.O.12
Grabner, R.W.13
Hershman, A.14
-
58
-
-
0025122828
-
Comparison of inhibitor binding in HIV-1 protease and in nonviral aspartic protease: the role of the flap
-
A. Gustchina and I.T. Weber (1990) Comparison of inhibitor binding in HIV-1 protease and in nonviral aspartic protease: the role of the flap. FEBS Lett. 269 269-272.
-
(1990)
FEBS Lett.
, vol.269
, pp. 269-272
-
-
Gustchina, A.1
Weber, I.T.2
-
59
-
-
0028180528
-
Energy calculations and analysis of HIV-1 protease inhibitor crystal structures
-
A. Gustchina, C. Sansom, M. Prevost, J. Richelle, S.Y. Wodak, A. Wlodawer and I.T. Weber (1994) Energy calculations and analysis of HIV-1 protease inhibitor crystal structures. Protein Eng. 7 309-317.
-
(1994)
Protein Eng.
, vol.7
, pp. 309-317
-
-
Gustchina, A.1
Sansom, C.2
Prevost, M.3
Richelle, J.4
Wodak, S.Y.5
Wlodawer, A.6
Weber, I.T.7
-
60
-
-
0025221847
-
Domain communication in the dynamical structure of human immunodeficiency virus 1 protease
-
W.J. Harte, S. Swaminathan, M.M. Mansuri, J.C. Martin, I.E. Rosenberg and D.L. Beveridge (1990) Domain communication in the dynamical structure of human immunodeficiency virus 1 protease. Proc. Natl. Acad. Sci. USA 87 8864-8868.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 8864-8868
-
-
Harte, W.J.1
Swaminathan, S.2
Mansuri, M.M.3
Martin, J.C.4
Rosenberg, I.E.5
Beveridge, D.L.6
-
61
-
-
0024430994
-
Affinity purification of the HIV-1 protease
-
J.C. Heimbach, V.M. Garsky, S.R. Michelson, R.A.F. Dixon, I.S. Sigal and P.L. Darke (1989) Affinity purification of the HIV-1 protease. Biochem. Biophys. Res. Commun. 164 955-960.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.164
, pp. 955-960
-
-
Heimbach, J.C.1
Garsky, V.M.2
Michelson, S.R.3
Dixon, R.A.F.4
Sigal, I.S.5
Darke, P.L.6
-
62
-
-
0001538414
-
Analysis of proteins and peptides purified from sucrose gradient banded HTLV-III
-
D. Bolognesi (Eds), New York: Alan R. Liss
-
L.E. Henderson, T.D. Copeland, R.C. Sowder, A.M. Schultz and S. Oroszlan (1988) Analysis of proteins and peptides purified from sucrose gradient banded HTLV-III. D. Bolognesi (Eds) Human Retroviruses, Cancer, and AIDS: Approaches to Prevention and Therapy New York: Alan R. Liss 135-147.
-
(1988)
Human Retroviruses, Cancer, and AIDS: Approaches to Prevention and Therapy
, pp. 135-147
-
-
Henderson, L.E.1
Copeland, T.D.2
Sowder, R.C.3
Schultz, A.M.4
Oroszlan, S.5
-
63
-
-
0028874048
-
Rapid turnover of plasma virions and CD3 lymphocytes in HIV-1 infection
-
D.D. Ho, A.U. Neumann, A.S. Perelson, L.J. Chen and M. Markowitz (1995) Rapid turnover of plasma virions and CD3 lymphocytes in HIV-1 infection. Nature 373 123-126.
-
(1995)
Nature
, vol.373
, pp. 123-126
-
-
Ho, D.D.1
Neumann, A.U.2
Perelson, A.S.3
Chen, L.J.4
Markowitz, M.5
-
64
-
-
0028726636
-
Chemical synthesis of the aspartic proteinase from human immunodeficiency virus (HIV)
-
P.J. Hoeprich (1994) Chemical synthesis of the aspartic proteinase from human immunodeficiency virus (HIV). Methods Mol. Biol. 36 287-304.
-
(1994)
Methods Mol. Biol.
, vol.36
, pp. 287-304
-
-
Hoeprich, P.J.1
-
65
-
-
0026329721
-
Human immunodeficiency virus type 1 protease microinjected into cultured human skin fibroblasts cleaves vimentin and affects cytoskeletal and nuclear architecture
-
B. Höner, R.L. Shoeman and P. Traub (1991) Human immunodeficiency virus type 1 protease microinjected into cultured human skin fibroblasts cleaves vimentin and affects cytoskeletal and nuclear architecture. J. Cell Sci. 100 799-807.
-
(1991)
J. Cell Sci.
, vol.100
, pp. 799-807
-
-
Höner, B.1
Shoeman, R.L.2
Traub, P.3
-
66
-
-
0026683252
-
Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease
-
B. Höner, R.L. Shoeman and P. Traub (1992) Degradation of cytoskeletal proteins by the human immunodeficiency virus type 1 protease. Cell Biol. Int. Rep. 16 603-612.
-
(1992)
Cell Biol. Int. Rep.
, vol.16
, pp. 603-612
-
-
Höner, B.1
Shoeman, R.L.2
Traub, P.3
-
67
-
-
0029775232
-
Crystal structures of complexes of a peptidic inhibitor with wild type and two mutant HIV-1 proteases
-
L. Hong, A. Treharne, J.A. Hartsuck, S. Foundling and J. Tang (1996) Crystal structures of complexes of a peptidic inhibitor with wild type and two mutant HIV-1 proteases. Biochemistry 35 10627-10633.
-
(1996)
Biochemistry
, vol.35
, pp. 10627-10633
-
-
Hong, L.1
Treharne, A.2
Hartsuck, J.A.3
Foundling, S.4
Tang, J.5
-
68
-
-
0031915558
-
Active-site mobility in human immunodeficiency virus type 1 protease as demonstrated by crystal structure of A28S mutant
-
L. Hong, J.A. Hartsuck, S. Foundling, J. Ermolieff and J. Tang (1998) Active-site mobility in human immunodeficiency virus type 1 protease as demonstrated by crystal structure of A28S mutant. Protein Sci. 7 300-305.
-
(1998)
Protein Sci.
, vol.7
, pp. 300-305
-
-
Hong, L.1
Hartsuck, J.A.2
Foundling, S.3
Ermolieff, J.4
Tang, J.5
-
69
-
-
0029101203
-
A check on rational drug design crystal structure of a complex of human immunodeficiency virus type 1 protease with a novel gamma turn mimetic inhibitor
-
S.S. Hoog, B. Zhao, E. Winborne, S. Fisher, D.W. Green, R.L. DesJarlais, K.A. Newlander, J.F. Callahan, M.L. Moore, W.F. Huffman and S.S. Abdel-Meguid (1995) A check on rational drug design crystal structure of a complex of human immunodeficiency virus type 1 protease with a novel gamma turn mimetic inhibitor. J. Med. Chem. 38 3246-3252.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 3246-3252
-
-
Hoog, S.S.1
Zhao, B.2
Winborne, E.3
Fisher, S.4
Green, D.W.5
DesJarlais, R.L.6
Newlander, K.A.7
Callahan, J.F.8
Moore, M.L.9
Huffman, W.F.10
Abdel-Meguid, S.S.11
-
70
-
-
0024371552
-
High level expression of self processed HIV-1 protease in Escherichia coli using a synthetic gene
-
Z. Hostomsky, K. Appelt and R.C. Ogden (1989) High level expression of self processed HIV-1 protease in Escherichia coli using a synthetic gene. Biochem. Biophys. Res. Commun. 161 1056-1063.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.161
, pp. 1056-1063
-
-
Hostomsky, Z.1
Appelt, K.2
Ogden, R.C.3
-
71
-
-
0027160646
-
Large scale purification and refolding of HIV-1 protease from Escherichia coli inclusion bodies
-
J.O. Hui, A.G. Tomasselli, I.M. Reardon, J.M. Lull, D.P. Brunner, C.S. Tomich and R.L. Heinrikson (1993) Large scale purification and refolding of HIV-1 protease from Escherichia coli inclusion bodies. J. Protein Chem. 12 323-327.
-
(1993)
J. Protein Chem.
, vol.12
, pp. 323-327
-
-
Hui, J.O.1
Tomasselli, A.G.2
Reardon, I.M.3
Lull, J.M.4
Brunner, D.P.5
Tomich, C.S.6
Heinrikson, R.L.7
-
72
-
-
0025122798
-
A radiometric assay for HIV-1 protease
-
L.J. Hyland, B.D. Dayton, M.L. Moore, A.Y.L. Shu, J.R. Heys and T.D. Meek (1990) A radiometric assay for HIV-1 protease. Anal. Biochem. 188 408-415.
-
(1990)
Anal. Biochem.
, vol.188
, pp. 408-415
-
-
Hyland, L.J.1
Dayton, B.D.2
Moore, M.L.3
Shu, A.Y.L.4
Heys, J.R.5
Meek, T.D.6
-
73
-
-
0033200247
-
Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function
-
R. Ishima, D.I. Freedberg, Y.X. Wang, J.M. Louis and D.A. Torchia (1999) Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function. Structure 7 1047-1055.
-
(1999)
Structure
, vol.7
, pp. 1047-1055
-
-
Ishima, R.1
Freedberg, D.I.2
Wang, Y.X.3
Louis, J.M.4
Torchia, D.A.5
-
74
-
-
0028843163
-
Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31 8959
-
H. Jacobsen, K. Yasargil, D.L. Winslow, J.C. Craig, A. Krohn, I.B. Duncan and J. Mous (1995) Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31 8959. Virology 206 527-534.
-
(1995)
Virology
, vol.206
, pp. 527-534
-
-
Jacobsen, H.1
Yasargil, K.2
Winslow, D.L.3
Craig, J.C.4
Krohn, A.5
Duncan, I.B.6
Mous, J.7
-
75
-
-
0025829331
-
Structure at 2.5 Å resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene based inhibitor
-
M. Jaskolski, A.G. Tomasselli, T.K. Sawyer, D.G. Staples, R.L. Heinrikson, J. Schneider, S.B.H. Kent and A. Wlodawer (1991) Structure at 2.5 Å resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene based inhibitor. Biochemistry 30 1600-1609.
-
(1991)
Biochemistry
, vol.30
, pp. 1600-1609
-
-
Jaskolski, M.1
Tomasselli, A.G.2
Sawyer, T.K.3
Staples, D.G.4
Heinrikson, R.L.5
Schneider, J.6
Kent, S.B.H.7
Wlodawer, A.8
-
76
-
-
0027989743
-
X ray crystallographic studies of a series of penicillin derived asymmetric inhibitors of HIV-1 protease
-
H. Jhoti, O.M. Singh, M.P. Weir, R. Cooke, P. Murray-Rust and A. Wonacott (1994) X ray crystallographic studies of a series of penicillin derived asymmetric inhibitors of HIV-1 protease. Biochemistry 33 8417-8427.
-
(1994)
Biochemistry
, vol.33
, pp. 8417-8427
-
-
Jhoti, H.1
Singh, O.M.2
Weir, M.P.3
Cooke, R.4
Murray-Rust, P.5
Wonacott, A.6
-
77
-
-
0035173377
-
Human immunodeficiency virus reverse transcriptase and protease sequence database: an expanded data model integrating natural language text and sequence analysis programs
-
R. Kantor, R. Machekano, M.J. Gonzalez, K. Dupnik, J.M. Schapiro and R.W. Shafer (2001) Human immunodeficiency virus reverse transcriptase and protease sequence database: an expanded data model integrating natural language text and sequence analysis programs. Nucleic Acids Res. 29 296-299.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 296-299
-
-
Kantor, R.1
Machekano, R.2
Gonzalez, M.J.3
Dupnik, K.4
Schapiro, J.M.5
Shafer, R.W.6
-
78
-
-
0027158754
-
Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles
-
A.H. Kaplan, J.A. Zack, M. Knigge, DA. Paul, D.J. Kempf, D.W. Norbeck and R. Swanstrom (1993) Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles. J. Virol. 67 4050-4055.
-
(1993)
J. Virol.
, vol.67
, pp. 4050-4055
-
-
Kaplan, A.H.1
Zack, J.A.2
Knigge, M.3
Paul, D.A.4
Kempf, D.J.5
Norbeck, D.W.6
Swanstrom, R.7
-
79
-
-
0028286025
-
Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease
-
A.H. Kaplan, S.S. Michael, R.F. Wehbie, M.S. Knigge, D.A. Paul, L. Everitt, D.J. Kempf, D.W. Norbeck, J.W. Erickson and R. Swanstrom (1994) Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease. Proc. Natl. Acad. Sci. USA 91 5597-5601.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 5597-5601
-
-
Kaplan, A.H.1
Michael, S.S.2
Wehbie, R.F.3
Knigge, M.S.4
Paul, D.A.5
Everitt, L.6
Kempf, D.J.7
Norbeck, D.W.8
Erickson, J.W.9
Swanstrom, R.10
-
80
-
-
0027932364
-
The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency
-
A.H. Kaplan, M. Manchester and R. Swanstrom (1994) The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency. J. Virol. 68 6782-6786.
-
(1994)
J. Virol.
, vol.68
, pp. 6782-6786
-
-
Kaplan, A.H.1
Manchester, M.2
Swanstrom, R.3
-
81
-
-
0029793658
-
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication
-
A.H. Kaplan, M. Manchester, T. Smith, Y.L. Yang and R. Swanstrom (1996) Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication. J. Virol. 70 5840-5844.
-
(1996)
J. Virol.
, vol.70
, pp. 5840-5844
-
-
Kaplan, A.H.1
Manchester, M.2
Smith, T.3
Yang, Y.L.4
Swanstrom, R.5
-
82
-
-
0029065021
-
HIV-1 protease specificity derived from a complex mixture of synthetic substrates
-
D.B. Kassel, M.D. Green, R.S. Wehbie, R. Swanstrom and J. Berman (1995) HIV-1 protease specificity derived from a complex mixture of synthetic substrates. Anal. Biochem. 228 259-266.
-
(1995)
Anal. Biochem.
, vol.228
, pp. 259-266
-
-
Kassel, D.B.1
Green, M.D.2
Wehbie, R.S.3
Swanstrom, R.4
Berman, J.5
-
83
-
-
0028968902
-
ABT 538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans
-
D.J. Kempf, K.C. Marsh, J.F. Denissen, E. McDonald, S. Vasavanonda, C.A. Flentge, B.E. Green, L. Fino, C.H. Park, X.P. Kong, N.E. Wideburg, A. Saldivar, L. Ruiz, W.M. Kati, H.L. Shaw, T. Robins, K.D. Stewart, A. Hsu, J.J. Plattner, J.M. Leonard and D.W. Norbeck (1995) ABT 538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc. Natl. Acad. Sci. USA 92 2484-2488.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 2484-2488
-
-
Kempf, D.J.1
Marsh, K.C.2
Denissen, J.F.3
McDonald, E.4
Vasavanonda, S.5
Flentge, C.A.6
Green, B.E.7
Fino, L.8
Park, C.H.9
Kong, X.P.10
Wideburg, N.E.11
Saldivar, A.12
Ruiz, L.13
Kati, W.M.14
Shaw, H.L.15
Robins, T.16
Stewart, K.D.17
Hsu, A.18
Plattner, J.J.19
Leonard, J.M.20
Norbeck, D.W.21
more..
-
84
-
-
0025358371
-
Sub site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV-1
-
J. Konvalinka, P. Strop, J. Velek, V. Cerna, V. Kostka, L.H. Phylip, A.D. Richards, B.M. Dunn and J. Kay (1990) Sub site preferences of the aspartic proteinase from the human immunodeficiency virus, HIV-1. FEBS Lett. 268 35-38.
-
(1990)
FEBS Lett.
, vol.268
, pp. 35-38
-
-
Konvalinka, J.1
Strop, P.2
Velek, J.3
Cerna, V.4
Kostka, V.5
Phylip, L.H.6
Richards, A.D.7
Dunn, B.M.8
Kay, J.9
-
85
-
-
0026757343
-
Human immunodeficiency virus type 1 ga g-protease fusion proteins are enzymatically active
-
M. Kotler, G. Arad and S.H. Hughes (1992) Human immunodeficiency virus type 1 ga g-protease fusion proteins are enzymatically active. J. Virol. 66 6781-6783.
-
(1992)
J. Virol.
, vol.66
, pp. 6781-6783
-
-
Kotler, M.1
Arad, G.2
Hughes, S.H.3
-
86
-
-
15844378825
-
Extensive polymorphisms observed in HIV-1 clade B protease gene using high density oligonucleotide arrays
-
M.J. Kozal, N. Shah, N.P. Shen, R. Yang, R. Fucini, T.C. Merigan, D.D. Richman, D. Morris, E.R. Hubbell, M. Chee and T.R. Gingeras (1996) Extensive polymorphisms observed in HIV-1 clade B protease gene using high density oligonucleotide arrays. Nature Med. 2 753-759.
-
(1996)
Nature Med.
, vol.2
, pp. 753-759
-
-
Kozal, M.J.1
Shah, N.2
Shen, N.P.3
Yang, R.4
Fucini, R.5
Merigan, T.C.6
Richman, D.D.7
Morris, D.8
Hubbell, E.R.9
Chee, M.10
Gingeras, T.R.11
-
87
-
-
0028693604
-
Synthetic approaches to continuous assays of retroviral proteases
-
G.A. Krafft and G.T. Wang (1994) Synthetic approaches to continuous assays of retroviral proteases. Methods Enzymol. 2A 70-86.
-
(1994)
Methods Enzymol.
, vol.2A
, pp. 70-86
-
-
Krafft, G.A.1
Wang, G.T.2
-
88
-
-
1542502945
-
Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides
-
H.G. Kräusslich, R.H. Ingraham, M.T. Skoog, E. Wimmer, P.V. Pallai and C.A. Carter (1989) Activity of purified biosynthetic proteinase of human immunodeficiency virus on natural substrates and synthetic peptides. Proc. Natl. Acad. Sci. USA 86 807-811.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 807-811
-
-
Kräusslich, H.G.1
Ingraham, R.H.2
Skoog, M.T.3
Wimmer, E.4
Pallai, P.V.5
Carter, C.A.6
-
89
-
-
20244373125
-
X ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes
-
R. Lapatto, T. Blundell, A. Hemmings, J. Overington, A. Wilderspin, S. Wood, J. Merson, P.J. Whittle, D.E. Danley, K.F. Geoghegan, S.J. Hawrylik, S.E. Lee, K.G. Scheld and P.M. Hobart (1989) X ray analysis of HIV-1 proteinase at 2.7 Å resolution confirms structural homology among retroviral enzymes. Nature 342 299-302.
-
(1989)
Nature
, vol.342
, pp. 299-302
-
-
Lapatto, R.1
Blundell, T.2
Hemmings, A.3
Overington, J.4
Wilderspin, A.5
Wood, S.6
Merson, J.7
Whittle, P.J.8
Danley, D.E.9
Geoghegan, K.F.10
Hawrylik, S.J.11
Lee, S.E.12
Scheld, K.G.13
Hobart, P.M.14
-
90
-
-
9044230526
-
In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor resistant variants in untreated subjects
-
W.J. Lech, G. Wang, Y.L. Yang, Y. Chee, K. Dorman, D. McCrae, L.C. Lazzeroni, J.W. Erickson, J.S. Sinsheimer and A.H. Kaplan (1996) In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor resistant variants in untreated subjects. J. Virol. 70 2038-2043.
-
(1996)
J. Virol.
, vol.70
, pp. 2038-2043
-
-
Lech, W.J.1
Wang, G.2
Yang, Y.L.3
Chee, Y.4
Dorman, K.5
McCrae, D.6
Lazzeroni, L.C.7
Erickson, J.W.8
Sinsheimer, J.S.9
Kaplan, A.H.10
-
91
-
-
0023019732
-
Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus
-
M.M. Lightfoote, J.E. Coligan, T.M. Folks, A.S. Fauci, M.A. Martin and S. Venkatesan (1986) Structural characterization of reverse transcriptase and endonuclease polypeptides of the acquired immunodeficiency syndrome retrovirus. J. Virol. 60 771-775.
-
(1986)
J. Virol.
, vol.60
, pp. 771-775
-
-
Lightfoote, M.M.1
Coligan, J.E.2
Folks, T.M.3
Fauci, A.S.4
Martin, M.A.5
Venkatesan, S.6
-
92
-
-
0028927329
-
Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease relationship to drug resistance
-
Y. Lin, X. Lin, L. Hong, S. Foundling, R.L. Heinrikson, S. Thaisrivongs, W. Leelamanit, D. Raterman, M. Shah, B.M. Dunn and J. Tang (1995) Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease relationship to drug resistance. Biochemistry 34 1143-1152.
-
(1995)
Biochemistry
, vol.34
, pp. 1143-1152
-
-
Lin, Y.1
Lin, X.2
Hong, L.3
Foundling, S.4
Heinrikson, R.L.5
Thaisrivongs, S.6
Leelamanit, W.7
Raterman, D.8
Shah, M.9
Dunn, B.M.10
Tang, J.11
-
93
-
-
0030598997
-
A combined quantum/classical molecular dynamics study of the catalytic mechanism of HIV protease
-
H. Liu, F. Muller Plathe and W.F. van Gunsteren (1996) A combined quantum/classical molecular dynamics study of the catalytic mechanism of HIV protease. J. Mol. Biol. 261 454-469.
-
(1996)
J. Mol. Biol.
, vol.261
, pp. 454-469
-
-
Liu, H.1
Muller Plathe, F.2
van Gunsteren, W.F.3
-
94
-
-
0024406911
-
Complete mutagenesis of the HIV-1 protease
-
D.D. Loeb, R. Swanstrom, L. Everitt, M. Manchester, S.E. Stamper and C.A. Hutchison III (1989) Complete mutagenesis of the HIV-1 protease. Nature 340 397-400.
-
(1989)
Nature
, vol.340
, pp. 397-400
-
-
Loeb, D.D.1
Swanstrom, R.2
Everitt, L.3
Manchester, M.4
Stamper, S.E.5
Hutchison, C.A.6
-
95
-
-
0024434658
-
Substitution mutations of the highly conserved arginine 87 of HIV-1 protease result in loss of proteolytic activity
-
J.M. Louis, C.A.D. Smith, E. Wondrak, P.T. Mora and S. Oroszlan (1989) Substitution mutations of the highly conserved arginine 87 of HIV-1 protease result in loss of proteolytic activity. Biochem. Biophys. Res. Commun. 164 30-38.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.164
, pp. 30-38
-
-
Louis, J.M.1
Smith, C.A.D.2
Wondrak, E.3
Mora, P.T.4
Oroszlan, S.5
-
96
-
-
0027936212
-
Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag Pol polyprotein
-
J.M. Louis, N.T. Nashed, K.D. Parris, A.R. Kimmel and D.M. Jerina (1994) Kinetics and mechanism of autoprocessing of human immunodeficiency virus type 1 protease from an analog of the Gag Pol polyprotein. Proc. Natl. Acad. Sci. USA 91 7970-7974.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7970-7974
-
-
Louis, J.M.1
Nashed, N.T.2
Parris, K.D.3
Kimmel, A.R.4
Jerina, D.M.5
-
97
-
-
0032562202
-
Hydrophilic peptides derived from the transframe region of gag-pol inhibit the HIV-1 protease
-
J.M. Louis, F. Dyda, N.T. Nashed, A.R. Kimmel and D.R. Davies (1998) Hydrophilic peptides derived from the transframe region of gag-pol inhibit the HIV-1 protease. Biochemistry 37 2105-2110.
-
(1998)
Biochemistry
, vol.37
, pp. 2105-2110
-
-
Louis, J.M.1
Dyda, F.2
Nashed, N.T.3
Kimmel, A.R.4
Davies, D.R.5
-
98
-
-
17444392445
-
Autoprocessing of HIV-1 protease is tightly coupled to protein folding
-
J.M. Louis, G.M. Clore and A.M. Gronenborn (1999) Autoprocessing of HIV-1 protease is tightly coupled to protein folding. Nature Struct. Biol. 6 868-875.
-
(1999)
Nature Struct. Biol.
, vol.6
, pp. 868-875
-
-
Louis, J.M.1
Clore, G.M.2
Gronenborn, A.M.3
-
99
-
-
0028267575
-
Viral interactions with the host cell cytoskeleton: the role of retroviral proteases
-
R.B. Luftig and L.D. Lupo (1994) Viral interactions with the host cell cytoskeleton: the role of retroviral proteases. Trends Microbiol. 2 178-182.
-
(1994)
Trends Microbiol.
, vol.2
, pp. 178-182
-
-
Luftig, R.B.1
Lupo, L.D.2
-
100
-
-
0032574705
-
Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis
-
I. Luque, M.J. Todd, J. Gomez, N. Semo and E. Freire (1998) Molecular basis of resistance to HIV-1 protease inhibition: a plausible hypothesis. Biochemistry 37 5791-5797.
-
(1998)
Biochemistry
, vol.37
, pp. 5791-5797
-
-
Luque, I.1
Todd, M.J.2
Gomez, J.3
Semo, N.4
Freire, E.5
-
101
-
-
0035370444
-
Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes
-
B. Mahalingam, J.M. Louis, J. Hung, R.W. Harrision and I.T. Weber (2001) Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes. Proteins 43 455-464.
-
(2001)
Proteins
, vol.43
, pp. 455-464
-
-
Mahalingam, B.1
Louis, J.M.2
Hung, J.3
Harrision, R.W.4
Weber, I.T.5
-
102
-
-
0036643501
-
Combining mutations in HIV-1 protease to understand mechanisms of resistance
-
B. Mahalingam, P. Boross, Y.-F. Wang, J.M. Louis, C.C. Fischer, J. Tözsér, R.W. Harrison and I.T. Weber (2002) Combining mutations in HIV-1 protease to understand mechanisms of resistance. Proteins 48 107-116.
-
(2002)
Proteins
, vol.48
, pp. 107-116
-
-
Mahalingam, B.1
Boross, P.2
Wang, Y.-F.3
Louis, J.M.4
Fischer, C.C.5
Tözsér, J.6
Harrison, R.W.7
Weber, I.T.8
-
103
-
-
0025195961
-
Substitutions at the P2′ site of gag p17 p24 affect cleavage efficiency by HIV-1 protease
-
N. Margolin, W. Heath, E. Osborne, M. Lai and C. Vlahos (1990) Substitutions at the P2′ site of gag p17 p24 affect cleavage efficiency by HIV-1 protease. Biochem. Biophys. Res. Commun. 167 554-560.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.167
, pp. 554-560
-
-
Margolin, N.1
Heath, W.2
Osborne, E.3
Lai, M.4
Vlahos, C.5
-
105
-
-
0028854676
-
Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT 538, a novel protease inhibitor
-
M. Markowitz, H. Mo, D.J. Kempf, D.W. Norbeck, T.N. Bhat, J.W. Erickson and D.D. Ho (1995) Selection and analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT 538, a novel protease inhibitor. J. Virol. 69 701-706.
-
(1995)
J. Virol.
, vol.69
, pp. 701-706
-
-
Markowitz, M.1
Mo, H.2
Kempf, D.J.3
Norbeck, D.W.4
Bhat, T.N.5
Erickson, J.W.6
Ho, D.D.7
-
106
-
-
0025099455
-
Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer
-
E. Matayoshi, G.T. Wang, G.A. Krafft and J.W. Erickson (1990) Novel fluorogenic substrates for assaying retroviral proteases by resonance energy transfer. Science 247 954-958.
-
(1990)
Science
, vol.247
, pp. 954-958
-
-
Matayoshi, E.1
Wang, G.T.2
Krafft, G.A.3
Erickson, J.W.4
-
107
-
-
0028105957
-
The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties
-
A.M. Mildner, D.J. Rothrock, J.W. Leone, C.A. Bannow, J.M. Lull, I.M. Reardon, J.L. Sarcich, W.J. Howe, C.S.C. Tomich, C.W. Smith, R.L. Heinrikson and A.G. Tomasselli (1994) The HIV-1 protease as enzyme and substrate: mutagenesis of autolysis sites and generation of a stable mutant with retained kinetic properties. Biochemistry 33 9405-9413.
-
(1994)
Biochemistry
, vol.33
, pp. 9405-9413
-
-
Mildner, A.M.1
Rothrock, D.J.2
Leone, J.W.3
Bannow, C.A.4
Lull, J.M.5
Reardon, I.M.6
Sarcich, J.L.7
Howe, W.J.8
Tomich, C.S.C.9
Smith, C.W.10
Heinrikson, R.L.11
Tomasselli, A.G.12
-
108
-
-
0024344021
-
Structure of complex of synthetic HIV-1 protease with a substrate based inhibitor at 2.3 Å resolution
-
M. Miller, J. Schneider, B.K. Sathyanarayana, M.V. Toth, G.R. Marshall, L. Clawson, L. Selk, S.B.H. Kent and A. Wlodawer (1989) Structure of complex of synthetic HIV-1 protease with a substrate based inhibitor at 2.3 Å resolution. Science 246 1149-1152.
-
(1989)
Science
, vol.246
, pp. 1149-1152
-
-
Miller, M.1
Schneider, J.2
Sathyanarayana, B.K.3
Toth, M.V.4
Marshall, G.R.5
Clawson, L.6
Selk, L.7
Kent, S.B.H.8
Wlodawer, A.9
-
109
-
-
0026686436
-
Total chemical synthesis of a D enzyme the enantiomers of HIV-1 protease show reciprocal chiral substrate specificity
-
R.C. Milton, S.C. Milton and S.B.H. Kent (1992) Total chemical synthesis of a D enzyme the enantiomers of HIV-1 protease show reciprocal chiral substrate specificity. Science 256 1445-1448.
-
(1992)
Science
, vol.256
, pp. 1445-1448
-
-
Milton, R.C.1
Milton, S.C.2
Kent, S.B.H.3
-
110
-
-
15444377672
-
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
-
A. Molla, M. Korneyeva, Q. Gao, S. Vasavanonda, P.J. Schipper, H.M. Mo, M. Markowitz, T. Chernyavskiy, P. Niu, N. Lyons, A. Hsu, G.R. Granneman, D.D. Ho, C.A.B. Boucher, J.M. Leonard, D.W. Norbeck and D.J. Kempf (1996) Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nature Med. 2 760-766.
-
(1996)
Nature Med.
, vol.2
, pp. 760-766
-
-
Molla, A.1
Korneyeva, M.2
Gao, Q.3
Vasavanonda, S.4
Schipper, P.J.5
Mo, H.M.6
Markowitz, M.7
Chernyavskiy, T.8
Niu, P.9
Lyons, N.10
Hsu, A.11
Granneman, G.R.12
Ho, D.D.13
Boucher, C.A.B.14
Leonard, J.M.15
Norbeck, D.W.16
Kempf, D.J.17
-
111
-
-
0028911958
-
A side chain at position 48 of the human immunodeficiency virus type 1 protease flap provides an additional specificity determinant
-
M.D. Moody, S.C. Pettit, W. Shao, L. Everitt, D.D. Loeb, C.A. Hutchison III and R. Swanstrom (1995) A side chain at position 48 of the human immunodeficiency virus type 1 protease flap provides an additional specificity determinant. Virology 207 475-485.
-
(1995)
Virology
, vol.207
, pp. 475-485
-
-
Moody, M.D.1
Pettit, S.C.2
Shao, W.3
Everitt, L.4
Loeb, D.D.5
Hutchison, C.A.6
Swanstrom, R.7
-
112
-
-
0026474757
-
The crystal structures at 2.2 Å resolution of hydroxyethylene based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations
-
K.H. Murthy, E.L. Winborne, M.D. Minnich, J.S. Culp and C. Debouck (1992) The crystal structures at 2.2 Å resolution of hydroxyethylene based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. J. Biol. Chem. 267 22770-22778.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 22770-22778
-
-
Murthy, K.H.1
Winborne, E.L.2
Minnich, M.D.3
Culp, J.S.4
Debouck, C.5
-
113
-
-
0024448019
-
Continuous spectrophotometric assay for retroviral proteases of HIV-1 and AMV
-
N.T. Nashed, J.M. Louis, J.M. Sayer, E.M. Wondrak, P.T. Mora, S. Oroszlan and D.M. Jerina (1989) Continuous spectrophotometric assay for retroviral proteases of HIV-1 and AMV. Biochem. Biophys. Res. Commun. 163 1079-1085.
-
(1989)
Biochem. Biophys. Res. Commun.
, vol.163
, pp. 1079-1085
-
-
Nashed, N.T.1
Louis, J.M.2
Sayer, J.M.3
Wondrak, E.M.4
Mora, P.T.5
Oroszlan, S.6
Jerina, D.M.7
-
114
-
-
0028921302
-
Flexibility and function in HIV-1 protease (see comments)
-
L.K. Nicholson, T. Yamazaki, D.A. Torchia, S. Grzesiek, A. Bax, S.J. Stahl, J.D. Kaufman, P.T. Wingfield, P.Y.S. Lam, P.K. Jadhav, C.N. Hodge, P.J. Domaille and C.-H. Chang (1995) Flexibility and function in HIV-1 protease (see comments). Nature Struct. Biol. 2 274-280.
-
(1995)
Nature Struct. Biol.
, vol.2
, pp. 274-280
-
-
Nicholson, L.K.1
Yamazaki, T.2
Torchia, D.A.3
Grzesiek, S.4
Bax, A.5
Stahl, S.J.6
Kaufman, J.D.7
Wingfield, P.T.8
Lam, P.Y.S.9
Jadhav, P.K.10
Hodge, C.N.11
Domaille, P.J.12
Chang, C.-H.13
-
115
-
-
0026094799
-
Fibronectin is a non-viral substrate for the HIV proteinase
-
M. Oswald and K. von der Helm (1991) Fibronectin is a non-viral substrate for the HIV proteinase. FEBS Lett. 292 298-300.
-
(1991)
FEBS Lett.
, vol.292
, pp. 298-300
-
-
Oswald, M.1
von der Helm, K.2
-
116
-
-
0027219220
-
In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C 2 symmetrical inhibitors of HIV type 1 protease
-
M.J. Otto, S. Garber, D.L. Winslow, C.D. Reid, P. Aldrich, P.K. Jadhav, C.E. Patterson, C.E. Hodge and Y.N. Cheng (1993) In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C 2 symmetrical inhibitors of HIV type 1 protease. Proc. Natl. Acad. Sci. USA 90 7543-7547.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 7543-7547
-
-
Otto, M.J.1
Garber, S.2
Winslow, D.L.3
Reid, C.D.4
Aldrich, P.5
Jadhav, P.K.6
Patterson, C.E.7
Hodge, C.E.8
Cheng, Y.N.9
-
117
-
-
0025728270
-
Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1
-
K. Partin, G. Zybarth, L. Ehrlich, M. DeCrombrugghe, E. Wimmer and C. Carter (1991) Deletion of sequences upstream of the proteinase improves the proteolytic processing of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 88 4776-4780.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 4776-4780
-
-
Partin, K.1
Zybarth, G.2
Ehrlich, L.3
DeCrombrugghe, M.4
Wimmer, E.5
Carter, C.6
-
118
-
-
0029147294
-
Automation of a high performance liquid chromatography based enzyme assay evaluation of inhibition constants for human immunodeficiency virus 1 protease inhibitors
-
S. Pazhanisamy, C.M. Stuver and D.J. Livingston (1995) Automation of a high performance liquid chromatography based enzyme assay evaluation of inhibition constants for human immunodeficiency virus 1 protease inhibitors. Anal. Biochem. 229 48-53.
-
(1995)
Anal. Biochem.
, vol.229
, pp. 48-53
-
-
Pazhanisamy, S.1
Stuver, C.M.2
Livingston, D.J.3
-
119
-
-
0029896360
-
Kinetic characterization of human immunodeficiency virus type 1 protease resistant variants
-
S. Pazhanisamy, C.M. Stuver, A.B. Cullinan, N. Margolin, B.G. Rao and D.J. Livingston (1996) Kinetic characterization of human immunodeficiency virus type 1 protease resistant variants. J. Biol. Chem. 271 17979-17985.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 17979-17985
-
-
Pazhanisamy, S.1
Stuver, C.M.2
Cullinan, A.B.3
Margolin, N.4
Rao, B.G.5
Livingston, D.J.6
-
120
-
-
0023189868
-
A structural model for the retroviral proteases
-
L.H. Pearl and W.R. Taylor (1987) A structural model for the retroviral proteases. Nature 329 351-354.
-
(1987)
Nature
, vol.329
, pp. 351-354
-
-
Pearl, L.H.1
Taylor, W.R.2
-
121
-
-
0024523801
-
Possible role of sme groups in the structure and function of HIV-1 protease as revealed by molecular modeling studies
-
I.V. Pechik, A.E. Gustchina, N.S. Andreeva and A.A. Fedorov (1989) Possible role of sme groups in the structure and function of HIV-1 protease as revealed by molecular modeling studies. FEBS Lett. 247 118-122.
-
(1989)
FEBS Lett.
, vol.247
, pp. 118-122
-
-
Pechik, I.V.1
Gustchina, A.E.2
Andreeva, N.S.3
Fedorov, A.A.4
-
122
-
-
0028992812
-
Increase in fluorescence upon the hydrolysis of tyrosine peptide: application to proteinase assays
-
A.G. Peranteau, P. Kuzmic, Y. Angell, C. Garcia-Echeverria and D.H. Rich (1995) Increase in fluorescence upon the hydrolysis of tyrosine peptide: application to proteinase assays. Anal. Biochem. 227 242-245.
-
(1995)
Anal. Biochem.
, vol.227
, pp. 242-245
-
-
Peranteau, A.G.1
Kuzmic, P.2
Angell, Y.3
Garcia-Echeverria, C.4
Rich, D.H.5
-
123
-
-
0031942021
-
The regulation of sequential processing of HIV-1 gag by the viral protease
-
S.C. Pettit, N. Sheng, R. Tritch, S. Erickson-Viitanen and R. Swanstrom (1998) The regulation of sequential processing of HIV-1 gag by the viral protease. Adv. Exp. Med. Biol. 436 15-25.
-
(1998)
Adv. Exp. Med. Biol.
, vol.436
, pp. 15-25
-
-
Pettit, S.C.1
Sheng, N.2
Tritch, R.3
Erickson-Viitanen, S.4
Swanstrom, R.5
-
124
-
-
0025005515
-
Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases
-
L.H. Phylip, A.D. Richards, J. Kay, J. Konvalinka, P. Strop, I. Bláha, J. Velek, V. Kostka, A.J. Ritchie, A.V. Broadhurst, W.G. Farmerie, P.E. Scarborough and B.M. Dunn (1990) Hydrolysis of synthetic chromogenic substrates by HIV-1 and HIV-2 proteinases. Biochem. Biophys. Res. Commun. 171 439-444.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.171
, pp. 439-444
-
-
Phylip, L.H.1
Richards, A.D.2
Kay, J.3
Konvalinka, J.4
Strop, P.5
Bláha, I.6
Velek, J.7
Kostka, V.8
Ritchie, A.J.9
Broadhurst, A.V.10
Farmerie, W.G.11
Scarborough, P.E.12
Dunn, B.M.13
-
125
-
-
0026620457
-
Intrinsic activity of precursor forms of HIV-1 proteinase
-
L.H. Phylip, J.S. Mills, B.F. Parten, B.M. Dunn and J. Kay (1992) Intrinsic activity of precursor forms of HIV-1 proteinase. FEBS Lett. 314 449-454.
-
(1992)
FEBS Lett.
, vol.314
, pp. 449-454
-
-
Phylip, L.H.1
Mills, J.S.2
Parten, B.F.3
Dunn, B.M.4
Kay, J.5
-
126
-
-
0026345896
-
A cumulative specificity model for proteases from human immunodeficiency virus types 1 and 2, inferred from statistical analysis of an extended substrate data base
-
R.A. Poorman, A.G. Tomasselli, R.L. Heinrikson and F.J. Kezdy (1991) A cumulative specificity model for proteases from human immunodeficiency virus types 1 and 2, inferred from statistical analysis of an extended substrate data base. J. Biol. Chem. 266 14554-14561.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14554-14561
-
-
Poorman, R.A.1
Tomasselli, A.G.2
Heinrikson, R.L.3
Kezdy, F.J.4
-
127
-
-
0035909104
-
Effectors of HIV-1 protease peptidolytic activity
-
D.J.T. Porter, M.H. Hanlon, L.H. Carter, D.P. Danger and E.S. Furfine (2001) Effectors of HIV-1 protease peptidolytic activity. Biochemistry 40 11131-11139.
-
(2001)
Biochemistry
, vol.40
, pp. 11131-11139
-
-
Porter, D.J.T.1
Hanlon, M.H.2
Carter, L.H.3
Danger, D.P.4
Furfine, E.S.5
-
128
-
-
0034283345
-
How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease
-
M. Prabu-Jeyabalan, E. Nalivaika and C.A. Schiffer (2000) How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease. J. Mol. Biol. 301 1207-1220.
-
(2000)
J. Mol. Biol.
, vol.301
, pp. 1207-1220
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.2
Schiffer, C.A.3
-
129
-
-
0036121219
-
Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
-
M. Prabu-Jeyabalan, E. Nalivaika and C.A. Schiffer (2002) Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes. Structure 10 369-381.
-
(2002)
Structure
, vol.10
, pp. 369-381
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.2
Schiffer, C.A.3
-
130
-
-
0029644476
-
Comparative analysis of the X ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor
-
J.P. Priestle, A. Fassler, J. Rosel, M. Blomley, P. Strop and M.G. Grutter (1995) Comparative analysis of the X ray structures of HIV-1 and HIV-2 proteases in complex with CGP 53820, a novel pseudosymmetric inhibitor. Structure 3 381-389.
-
(1995)
Structure
, vol.3
, pp. 381-389
-
-
Priestle, J.P.1
Fassler, A.2
Rosel, J.3
Blomley, M.4
Strop, P.5
Grutter, M.G.6
-
131
-
-
0021912920
-
Complete nucleotide sequence of the AIDS virus, HTLV-III
-
L. Ratner, W. Haseltine, R. Patarca, K.J. Livak, B. Starcich, S.F. Josephs, E.R. Dorna, J.A. Rafalski, E.A. Whitehorn, K. Baumeister, L. Ivanoff, S.R. Petteway, M.L. Pearson, J.A. Lauttenberger, T.S. Papas, J. Ghrayeb, N.T. Chang, R.C. Gallo and F. Wong-Staal (1985) Complete nucleotide sequence of the AIDS virus, HTLV-III. Nature 313 277-285.
-
(1985)
Nature
, vol.313
, pp. 277-285
-
-
Ratner, L.1
Haseltine, W.2
Patarca, R.3
Livak, K.J.4
Starcich, B.5
Josephs, S.F.6
Dorna, E.R.7
Rafalski, J.A.8
Whitehorn, E.A.9
Baumeister, K.10
Ivanoff, L.11
Petteway, S.R.12
Pearson, M.L.13
Lauttenberger, J.A.14
Papas, T.S.15
Ghrayeb, J.16
Chang, N.T.17
Gallo, R.C.18
Wong-Staal, F.19
-
132
-
-
0024558304
-
Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases
-
A.D. Richards, R. Roberts, B.M. Dunn, M.C. Graves and J. Kay (1989) Effective blocking of HIV-1 proteinase activity by characteristic inhibitors of aspartic proteinases. FEBS Lett. 247 113-117.
-
(1989)
FEBS Lett.
, vol.247
, pp. 113-117
-
-
Richards, A.D.1
Roberts, R.2
Dunn, B.M.3
Graves, M.C.4
Kay, J.5
-
133
-
-
0025274362
-
Sensitive, soluble chromogenic substrates for HIV-1 proteinase
-
A.D. Richards, L.H. Phylip, W.G. Farmerie, P.E. Scarborough, A. Alvarez, B.M. Dunn, P.H. Hirel, J. Konvalinka, P. Strop, L. Pavlickova, V. Kostka and J. Kay (1990) Sensitive, soluble chromogenic substrates for HIV-1 proteinase. J. Biol. Chem. 265 7733-7736.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 7733-7736
-
-
Richards, A.D.1
Phylip, L.H.2
Farmerie, W.G.3
Scarborough, P.E.4
Alvarez, A.5
Dunn, B.M.6
Hirel, P.H.7
Konvalinka, J.8
Strop, P.9
Pavlickova, L.10
Kostka, V.11
Kay, J.12
-
134
-
-
0032127391
-
Reaction path and free energy calculations of the transition between alternate conformations of HIV-1 protease
-
S.W. Rick, J.W. Erickson and J.W. Burt (1998) Reaction path and free energy calculations of the transition between alternate conformations of HIV-1 protease. Proteins 32 7-16.
-
(1998)
Proteins
, vol.32
, pp. 7-16
-
-
Rick, S.W.1
Erickson, J.W.2
Burt, J.W.3
-
135
-
-
0029563229
-
Development of drug resistance to HIV-1 protease inhibitors
-
T.W. Ridky and J. Leis (1995) Development of drug resistance to HIV-1 protease inhibitors. J. Biol. Chem. 270 29621-29623.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29621-29623
-
-
Ridky, T.W.1
Leis, J.2
-
136
-
-
0032578505
-
Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate
-
T.W. Ridky, A. Kikonyogo, J. Leis, S. Gulnik, T. Copeland, J. Erickson, A. Wlodawer, I. Kurinov, R.W. Harrison and I.T. Weber (1998) Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate. Biochemistry 37 13835-13845.
-
(1998)
Biochemistry
, vol.37
, pp. 13835-13845
-
-
Ridky, T.W.1
Kikonyogo, A.2
Leis, J.3
Gulnik, S.4
Copeland, T.5
Erickson, J.6
Wlodawer, A.7
Kurinov, I.8
Harrison, R.W.9
Weber, I.T.10
-
137
-
-
0024990072
-
Affinity purification of HIV-1 and HIV-2 proteases from recombinant E. coli strains using pepstatin agarose
-
J. Rittenhouse, M.C. Turon, R.J. Helfrich, K.S. Albrecht, D. Weigl, R.L. Simmer, F. Mordini, J. Erickson and W.E. Kohlbrenner (1990) Affinity purification of HIV-1 and HIV-2 proteases from recombinant E. coli strains using pepstatin agarose. Biochem. Biophys. Res. Commun. 171 60-66.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.171
, pp. 60-66
-
-
Rittenhouse, J.1
Turon, M.C.2
Helfrich, R.J.3
Albrecht, K.S.4
Weigl, D.5
Simmer, R.L.6
Mordini, F.7
Erickson, J.8
Kohlbrenner, W.E.9
-
138
-
-
0025854741
-
Processing of the precursor of NF B by the HIV-1 protease during acute infection
-
Y. Rivière, V. Blank, P. Kourilsky and A. Israel (1991) Processing of the precursor of NF B by the HIV-1 protease during acute infection. Nature 350 625-626.
-
(1991)
Nature
, vol.350
, pp. 625-626
-
-
Rivière, Y.1
Blank, V.2
Kourilsky, P.3
Israel, A.4
-
139
-
-
0025268321
-
Rational design of peptide based HIV proteinase inhibitors
-
N.A. Roberts, J.A. Martin, D. Kinchington, A.V. Broadhurst, J.C. Craig, I.B. Duncan, S.A. Galpin, B.K. Handa, J. Kay, A. Kröhn, R.W. Lambert, J.H. Merrett, J.S. Mills, K.E.B. Parkes, S. Redshaw, A.J. Ritchie, D.L. Taylor, G.J. Thomas and P.J. Machin (1990) Rational design of peptide based HIV proteinase inhibitors. Science 248 358-361.
-
(1990)
Science
, vol.248
, pp. 358-361
-
-
Roberts, N.A.1
Martin, J.A.2
Kinchington, D.3
Broadhurst, A.V.4
Craig, J.C.5
Duncan, I.B.6
Galpin, S.A.7
Handa, B.K.8
Kay, J.9
Kröhn, A.10
Lambert, R.W.11
Merrett, J.H.12
Mills, J.S.13
Parkes, K.E.B.14
Redshaw, S.15
Ritchie, A.J.16
Taylor, D.L.17
Thomas, G.J.18
Machin, P.J.19
-
140
-
-
0029814481
-
Three dimensional structures of HIV-1 and SIV protease product complexes
-
R.B. Rose, C.S. Craik, N.L. Douglas and R.M. Stroud (1996) Three dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry 35 12933-12944.
-
(1996)
Biochemistry
, vol.35
, pp. 12933-12944
-
-
Rose, R.B.1
Craik, C.S.2
Douglas, N.L.3
Stroud, R.M.4
-
141
-
-
0029869305
-
Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors
-
R.E. Rose, Y.F. Gong, J.A. Greytok, C.M. Bechtold, B.J. Terry, B.S. Robinson, M. Alam, R.J. Colonno and P.F. Lin (1996) Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors. Proc. Natl. Acad. Sci. USA 93 1648-1653.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1648-1653
-
-
Rose, R.E.1
Gong, Y.F.2
Greytok, J.A.3
Bechtold, C.M.4
Terry, B.J.5
Robinson, B.S.6
Alam, M.7
Colonno, R.J.8
Lin, P.F.9
-
142
-
-
0032562224
-
Domain flexibility in retroviral proteases – structural implications for drug resistant mutations
-
R.B. Rose, C.S. Craik and R.M. Stroud (1998) Domain flexibility in retroviral proteases – structural implications for drug resistant mutations. Biochemistry 37 2607-2621.
-
(1998)
Biochemistry
, vol.37
, pp. 2607-2621
-
-
Rose, R.B.1
Craik, C.S.2
Stroud, R.M.3
-
143
-
-
0033573903
-
Coevolutionary analysis of resistance-evading peptidomimetic inhibitors of HIV-1 protease
-
C.D. Rosin, R.K. Belew, G.M. Morris, A.J. Olson and D.S. Good-sell (1999) Coevolutionary analysis of resistance-evading peptidomimetic inhibitors of HIV-1 protease. Proc. Natl. Acad. Sci. USA 96 1369-1374.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1369-1374
-
-
Rosin, C.D.1
Belew, R.K.2
Morris, G.M.3
Olson, A.J.4
Good-sell, D.S.5
-
144
-
-
0025835082
-
Maturation of human immunodeficiency virus particles assembled from the gag precursor protein requires in situ processing by gag-pol protease
-
E.K. Ross, T.R. Fuerst, J.M. Orenstein, T. O'Neill, M.A. Martin and S. Venkatesan (1991) Maturation of human immunodeficiency virus particles assembled from the gag precursor protein requires in situ processing by gag-pol protease. AIDS Res. Hum. Retroviruses 7 475-483.
-
(1991)
AIDS Res. Hum. Retroviruses
, vol.7
, pp. 475-483
-
-
Ross, E.K.1
Fuerst, T.R.2
Orenstein, J.M.3
O'Neill, T.4
Martin, M.A.5
Venkatesan, S.6
-
145
-
-
0027185772
-
Structure of a non peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure based drug design
-
E. Rutenber, E.B. Fauman, R.J. Keenan, S. Fong, P.S. Furth, P.R. Ortiz de Montellano, E. Meng, I.D. Kuntz, D.L. DeCamp, R. Salto, J.R. Rosé, C.C. Craik and R.M. Stroud (1993) Structure of a non peptide inhibitor complexed with HIV-1 protease. Developing a cycle of structure based drug design. J. Biol. Chem. 268 15343-15346.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15343-15346
-
-
Rutenber, E.1
Fauman, E.B.2
Keenan, R.J.3
Fong, S.4
Furth, P.S.5
Ortiz de Montellano, P.R.6
Meng, E.7
Kuntz, I.D.8
DeCamp, D.L.9
Salto, R.10
Rosé, J.R.11
Craik, C.C.12
Stroud, R.M.13
-
146
-
-
0021914933
-
Nucleotide sequence and expression of an AIDS associated retrovirus (ARV-2)
-
R. Sanchez-Pescador, M.D. Power, P.J. Barr, K.S. Steimer, M.M. Stempien, S.L. Brown-Shimer, W.W. Gee, A. Renard, A. Randolph, J.A. Levy, D. Dino and P.A. Luciw (1985) Nucleotide sequence and expression of an AIDS associated retrovirus (ARV-2). Science 227 4686-4849.
-
(1985)
Science
, vol.227
, pp. 4686-4849
-
-
Sanchez-Pescador, R.1
Power, M.D.2
Barr, P.J.3
Steimer, K.S.4
Stempien, M.M.5
Brown-Shimer, S.L.6
Gee, W.W.7
Renard, A.8
Randolph, A.9
Levy, J.A.10
Dino, D.11
Luciw, P.A.12
-
147
-
-
0028302946
-
Human immunodeficiency virus type 1 protease inhibitor: evaluation of resistance engendered by amino acid substitutions in the enzyme's substrate binding site
-
V.V. Sardana, A.J. Schlabach, P. Graham, B.L. Bush, J.H. Condra, J.C. Culberson, L. Gotlib, D.J. Graham, N.E. Kohl, R.L. LaFemina, C.L. Schneider, B.S. Wolanski, J.A. Wolfgang and E.A. Emini (1994) Human immunodeficiency virus type 1 protease inhibitor: evaluation of resistance engendered by amino acid substitutions in the enzyme's substrate binding site. Biochemistry 33 2004-2010.
-
(1994)
Biochemistry
, vol.33
, pp. 2004-2010
-
-
Sardana, V.V.1
Schlabach, A.J.2
Graham, P.3
Bush, B.L.4
Condra, J.H.5
Culberson, J.C.6
Gotlib, L.7
Graham, D.J.8
Kohl, N.E.9
LaFemina, R.L.10
Schneider, C.L.11
Wolanski, B.S.12
Wolfgang, J.A.13
Emini, E.A.14
-
148
-
-
0023714070
-
Enzymatic activity of a synthetic 99 residue protein corresponding to the putative HIV-1 protease
-
J. Schneider and S.B.H. Kent (1988) Enzymatic activity of a synthetic 99 residue protein corresponding to the putative HIV-1 protease. Cell 54 363-368.
-
(1988)
Cell
, vol.54
, pp. 363-368
-
-
Schneider, J.1
Kent, S.B.H.2
-
149
-
-
0001650127
-
Human immunodeficiency virus has an aspartic type protease that can be inhibited by pepstatin A
-
S. Seelmeier, H. Schmidt, V. Turk and K. von der Helm (1988) Human immunodeficiency virus has an aspartic type protease that can be inhibited by pepstatin A. Proc. Natl. Acad. Sci. USA 85 6612-6616.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 6612-6616
-
-
Seelmeier, S.1
Schmidt, H.2
Turk, V.3
von der Helm, K.4
-
150
-
-
0342321950
-
Examining methods for calculations of binding free energies: LRA, LIE, PDLD-LRA, and PDLD/S-LRA calculations of ligands binding to an HIV protease
-
Y.Y. Sham, Z.T. Chu, H. Tao and A. Warshel (2000) Examining methods for calculations of binding free energies: LRA, LIE, PDLD-LRA, and PDLD/S-LRA calculations of ligands binding to an HIV protease. Proteins 39 393-407.
-
(2000)
Proteins
, vol.39
, pp. 393-407
-
-
Sham, Y.Y.1
Chu, Z.T.2
Tao, H.3
Warshel, A.4
-
151
-
-
0030910583
-
Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants
-
W. Shao, L. Everitt, M. Manchester, D.D. Loeb, C.A. Hutchison and R. Swanstrom (1997) Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants. Proc. Natl. Acad. Sci. USA 94 2243-2248.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2243-2248
-
-
Shao, W.1
Everitt, L.2
Manchester, M.3
Loeb, D.D.4
Hutchison, C.A.5
Swanstrom, R.6
-
152
-
-
0025088659
-
Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein
-
R.L. Shoeman, B. Höner, T.J. Stoller, C. Kesselmeier, M.C. Miedel, P. Traub and M.C. Graves (1990) Human immunodeficiency virus type 1 protease cleaves the intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein. Proc. Natl. Acad. Sci. USA 87 6336-6340.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 6336-6340
-
-
Shoeman, R.L.1
Höner, B.2
Stoller, T.J.3
Kesselmeier, C.4
Miedel, M.C.5
Traub, P.6
Graves, M.C.7
-
153
-
-
0027529843
-
Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin
-
R.L. Shoeman, C. Sachse, B. Höner, E. Mothes, M. Kaufmann and P. Traub (1993) Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin. Am. J. Pathol. 142 221-230.
-
(1993)
Am. J. Pathol.
, vol.142
, pp. 221-230
-
-
Shoeman, R.L.1
Sachse, C.2
Höner, B.3
Mothes, E.4
Kaufmann, M.5
Traub, P.6
-
154
-
-
0029045640
-
Molecular dynamics of HIV-1 protease in complex with a difluoroketone containing inhibitor implications for the catalytic mechanism
-
A.M. Silva, R.E. Cachau, E.T. Baldwin, S. Gulnik, H.L. Sham and J.W. Erickson (1995) Molecular dynamics of HIV-1 protease in complex with a difluoroketone containing inhibitor implications for the catalytic mechanism. Adv. Exp. Med. Biol. 362 451-454.
-
(1995)
Adv. Exp. Med. Biol.
, vol.362
, pp. 451-454
-
-
Silva, A.M.1
Cachau, R.E.2
Baldwin, E.T.3
Gulnik, S.4
Sham, H.L.5
Erickson, J.W.6
-
155
-
-
0028708269
-
Expression systems for retroviral proteases
-
J. Stebbins and C. Debouck (1994) Expression systems for retroviral proteases. Methods Enzymol. 241 13-16.
-
(1994)
Methods Enzymol.
, vol.241
, pp. 13-16
-
-
Stebbins, J.1
Debouck, C.2
-
156
-
-
0036643507
-
Evolutionary analysis of HIV-1 protease inhibitors: Methods for design of inhibitors that evade resistance
-
D. Stoffler, M.F. Sanner, G.M. Morris, A.J. Olson and D.S. Good-sell (2002) Evolutionary analysis of HIV-1 protease inhibitors: Methods for design of inhibitors that evade resistance. Proteins 48 63-74.
-
(2002)
Proteins
, vol.48
, pp. 63-74
-
-
Stoffler, D.1
Sanner, M.F.2
Morris, G.M.3
Olson, A.J.4
Good-sell, D.S.5
-
157
-
-
0036280264
-
X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease
-
V. Stoll, W.Y. Qin, K.D. Stewart, C. Jakob, C. Park, K. Walter, R.L. Simmer, R. Helfrich, D. Bussiere, J. Kao, D. Kempf, H.L. Sham and D.W. Norbeck (2002) X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease. Bioorg. Med. Chem. 10 2803-2806.
-
(2002)
Bioorg. Med. Chem.
, vol.10
, pp. 2803-2806
-
-
Stoll, V.1
Qin, W.Y.2
Stewart, K.D.3
Jakob, C.4
Park, C.5
Walter, K.6
Simmer, R.L.7
Helfrich, R.8
Bussiere, D.9
Kao, J.10
Kempf, D.11
Sham, H.L.12
Norbeck, D.W.13
-
158
-
-
0025225682
-
X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate based hydroxyethylamine inhibitor
-
A.L. Swain, M.M. Miller, J. Green, D.H. Rich, J. Schneider, S.B.H. Kent and A. Wlodawer (1990) X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate based hydroxyethylamine inhibitor. Proc. Natl. Acad. Sci. USA 87 8805-8809.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 8805-8809
-
-
Swain, A.L.1
Miller, M.M.2
Green, J.3
Rich, D.H.4
Schneider, J.5
Kent, S.B.H.6
Wlodawer, A.7
-
159
-
-
0034011309
-
Human immunodeficiency virus type-1 protease inhibitors: therapeutic successes and failures, suppression and resistance
-
R. Swanstrom and J. Eron (2000) Human immunodeficiency virus type-1 protease inhibitors: therapeutic successes and failures, suppression and resistance. Pharmacol. Ther. 86 145-170.
-
(2000)
Pharmacol. Ther.
, vol.86
, pp. 145-170
-
-
Swanstrom, R.1
Eron, J.2
-
160
-
-
0028239370
-
Protein structure modelling from remote sequence similarity
-
W.R. Taylor (1994) Protein structure modelling from remote sequence similarity. J. Biotechnol. 35 281-291.
-
(1994)
J. Biotechnol.
, vol.35
, pp. 281-291
-
-
Taylor, W.R.1
-
161
-
-
0027081927
-
Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene containing inhibitor: comparisons with molecular modeling
-
N. Thanki, J.K. Rao, S.I. Foundling, W.J. Howe, J.B. Moon, J.O. Hui, A.G. Tomasselli, R.L. Heinrikson, S. Thaisrivongs and A. Wlodawer (1992) Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene containing inhibitor: comparisons with molecular modeling. Protein Sci. 1 1061-1072.
-
(1992)
Protein Sci.
, vol.1
, pp. 1061-1072
-
-
Thanki, N.1
Rao, J.K.2
Foundling, S.I.3
Howe, W.J.4
Moon, J.B.5
Hui, J.O.6
Tomasselli, A.G.7
Heinrikson, R.L.8
Thaisrivongs, S.9
Wlodawer, A.10
-
162
-
-
0029133978
-
Cross resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors
-
M. Tisdale, R.E. Myers, B. Maschera, N.R. Parry, N.M. Oliver and E.D. Blair (1995) Cross resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors. Antimicrob. Agents Chemother. 39 1704-1710.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 1704-1710
-
-
Tisdale, M.1
Myers, R.E.2
Maschera, B.3
Parry, N.R.4
Oliver, N.M.5
Blair, E.D.6
-
163
-
-
0034601808
-
Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant
-
M.J. Todd, I. Luque, A. Velbzques-Campoy and E. Freire (2000) Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant. Biochemistry 39 11876-11883.
-
(2000)
Biochemistry
, vol.39
, pp. 11876-11883
-
-
Todd, M.J.1
Luque, I.2
Velbzques-Campoy, A.3
Freire, E.4
-
164
-
-
0029052114
-
Specificity of retroviral protease: an analysis of viral and nonviral protein substrates
-
A.G. Tomasselli and R.L. Heinrikson (1994) Specificity of retroviral protease: an analysis of viral and nonviral protein substrates. Methods Enzymol. 241 279-301.
-
(1994)
Methods Enzymol.
, vol.241
, pp. 279-301
-
-
Tomasselli, A.G.1
Heinrikson, R.L.2
-
165
-
-
0025313396
-
Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates
-
A.G. Tomasselli, J.O. Hui, T.K. Sawyer, D.J. Staples, C.A. Bannow, I.M. Reardon, V.K. Chaudhary, C.M. Fryling, I. Pastan, D.J. Fitzgerald and R.L. Heinrikson (1990) Proteases from human immunodeficiency virus and avian myeloblastosis virus show distinct specificities in hydrolysis of multidomain protein substrates. J. Virol. 64 3157-3161.
-
(1990)
J. Virol.
, vol.64
, pp. 3157-3161
-
-
Tomasselli, A.G.1
Hui, J.O.2
Sawyer, T.K.3
Staples, D.J.4
Bannow, C.A.5
Reardon, I.M.6
Chaudhary, V.K.7
Fryling, C.M.8
Pastan, I.9
Fitzgerald, D.J.10
Heinrikson, R.L.11
-
166
-
-
0025101652
-
Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus 1 protease
-
A.G. Tomasselli, J.O. Hui, T.K. Sawyer, D.J. Staples, D.J. FitzGerald, V.K. Chaudhary, I. Pastan and R.L. Heinrikson (1990) Interdomain hydrolysis of a truncated Pseudomonas exotoxin by the human immunodeficiency virus 1 protease. J. Biol. Chem. 265 408-413.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 408-413
-
-
Tomasselli, A.G.1
Hui, J.O.2
Sawyer, T.K.3
Staples, D.J.4
FitzGerald, D.J.5
Chaudhary, V.K.6
Pastan, I.7
Heinrikson, R.L.8
-
167
-
-
0025143121
-
Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2
-
A.G. Tomasselli, J.O. Hui, T.K. Sawyer, D.J. Staples, C.A. Bannow, I.M. Reardon, W.J. Howe, D.L. DeCamp, C.S. Craik and R.L. Heinrikson (1990) Specificity and inhibition of proteases from human immunodeficiency viruses 1 and 2. J. Biol. Chem. 265 14675-14683.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 14675-14683
-
-
Tomasselli, A.G.1
Hui, J.O.2
Sawyer, T.K.3
Staples, D.J.4
Bannow, C.A.5
Reardon, I.M.6
Howe, W.J.7
DeCamp, D.L.8
Craik, C.S.9
Heinrikson, R.L.10
-
168
-
-
0025858972
-
Calcium free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2
-
A.G. Tomasselli, W.J. Howe, J.O. Hui, T.K. Sawyer, I.M. Reardon, D.L. DeCamp, C.S. Craik and R.L. Heinrikson (1991) Calcium free calmodulin is a substrate of proteases from human immunodeficiency viruses 1 and 2. Proteins 10 1-9.
-
(1991)
Proteins
, vol.10
, pp. 1-9
-
-
Tomasselli, A.G.1
Howe, W.J.2
Hui, J.O.3
Sawyer, T.K.4
Reardon, I.M.5
DeCamp, D.L.6
Craik, C.S.7
Heinrikson, R.L.8
-
169
-
-
0026327505
-
Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus
-
A.G. Tomasselli, J.O. Hui, L. Adams, J. Chosay, D.D. Lowery, B. Greenberg, A. Yem, M.R. Deibel Jr., H.A. Zurcher-Neely and R.L. Heinrikson (1991) Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. J. Biol. Chem. 266 14548-14553.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 14548-14553
-
-
Tomasselli, A.G.1
Hui, J.O.2
Adams, L.3
Chosay, J.4
Lowery, D.D.5
Greenberg, B.6
Yem, A.7
Deibel, M.R.8
Zurcher-Neely, H.A.9
Heinrikson, R.L.10
-
170
-
-
0027524696
-
Human immunodeficiency virus type 1 reverse transcriptase and ribonuclease H as substrates of the viral protease
-
A.G. Tomasselli, J.L. Sarcich, L.J. Barrett, I.M. Reardon, W.J. Howe, D.B. Evans, S.K. Sharma and R.L. Heinrikson (1993) Human immunodeficiency virus type 1 reverse transcriptase and ribonuclease H as substrates of the viral protease. Protein Sci. 2 2167-2176.
-
(1993)
Protein Sci.
, vol.2
, pp. 2167-2176
-
-
Tomasselli, A.G.1
Sarcich, J.L.2
Barrett, L.J.3
Reardon, I.M.4
Howe, W.J.5
Evans, D.B.6
Sharma, S.K.7
Heinrikson, R.L.8
-
171
-
-
0025347075
-
Chromophoric peptide substrates for the spectrophotometric assay of HIV-1 protease
-
T.A. Tomaszek, V.W. Magaard, H.G. Bryan, M.L. Moore and T.D. Meek (1990) Chromophoric peptide substrates for the spectrophotometric assay of HIV-1 protease. Biochem. Biophys. Res. Commun. 168 274-280.
-
(1990)
Biochem. Biophys. Res. Commun.
, vol.168
, pp. 274-280
-
-
Tomaszek, T.A.1
Magaard, V.W.2
Bryan, H.G.3
Moore, M.L.4
Meek, T.D.5
-
172
-
-
0025663423
-
A simple, continuous fluorometric assay for HIV protease
-
M.V. Toth and G.R. Marshall (1990) A simple, continuous fluorometric assay for HIV protease. Int. J. Pept. Protein Res. 36 544-550.
-
(1990)
Int. J. Pept. Protein Res.
, vol.36
, pp. 544-550
-
-
Toth, M.V.1
Marshall, G.R.2
-
173
-
-
0025980395
-
Comparison of the HIV-1 and HIV 2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins
-
J. Tözsér, I. Bláha, T.D. Copeland, E.M. Wondrak and S. Oroszlan (1991) Comparison of the HIV-1 and HIV 2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins. FEBS Lett. 281 77-80.
-
(1991)
FEBS Lett.
, vol.281
, pp. 77-80
-
-
Tözsér, J.1
Bláha, I.2
Copeland, T.D.3
Wondrak, E.M.4
Oroszlan, S.5
-
174
-
-
0025924419
-
Studies on the role of the S4 substrate binding site of HIV proteinases
-
J. Tözsér, A. Gustchina, I.T. Weber, I. Bl' aha, E.M. Wondrak and S. Oroszlan (1991) Studies on the role of the S4 substrate binding site of HIV proteinases. FEBS Lett. 279 356-360.
-
(1991)
FEBS Lett.
, vol.279
, pp. 356-360
-
-
Tözsér, J.1
Gustchina, A.2
Weber, I.T.3
Bl' aha, I.4
Wondrak, E.M.5
Oroszlan, S.6
-
175
-
-
0026639427
-
Kinetic and modeling studies of S3 S3′ subsites of HIV proteinases
-
J. Tözsér, I.T. Weber, A. Gustchina, I. Bl' aha, T.D. Copeland, J.M. Louis and S. Oroszlan (1992) Kinetic and modeling studies of S3 S3′ subsites of HIV proteinases. Biochemistry 31 4793-4800.
-
(1992)
Biochemistry
, vol.31
, pp. 4793-4800
-
-
Tözsér, J.1
Weber, I.T.2
Gustchina, A.3
Bl' aha, I.4
Copeland, T.D.5
Louis, J.M.6
Oroszlan, S.7
-
176
-
-
1842407760
-
Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity
-
J. Tözsér, P. Bagossi, I.T. Weber, J.M. Louis, T.D. Copeland and S. Oroszlan (1997) Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity. J. Biol. Chem. 272 16807-16814.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16807-16814
-
-
Tözsér, J.1
Bagossi, P.2
Weber, I.T.3
Louis, J.M.4
Copeland, T.D.5
Oroszlan, S.6
-
177
-
-
0030610548
-
Conformational selectivity of HIV-1 protease cleavage of X-Pro peptide bonds and its implications
-
J.E. Vance, D.A. Leblanc, P. Wingfield and R.E. London (1997) Conformational selectivity of HIV-1 protease cleavage of X-Pro peptide bonds and its implications. J. Biol. Chem. 272 15603-15606.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 15603-15606
-
-
Vance, J.E.1
Leblanc, D.A.2
Wingfield, P.3
London, R.E.4
-
178
-
-
0027931684
-
Crystal structure based design and synthesis of novel C terminal inhibitors of HIV protease
-
M.D. Varney, K. Appelt, V. Kalish, M.R. Reddy, J. Tatlock, C.L. Palmer, W.H. Romines, B.W. Wu and L. Musick (1994) Crystal structure based design and synthesis of novel C terminal inhibitors of HIV protease. J. Med. Chem. 37 2274-2284.
-
(1994)
J. Med. Chem.
, vol.37
, pp. 2274-2284
-
-
Varney, M.D.1
Appelt, K.2
Kalish, V.3
Reddy, M.R.4
Tatlock, J.5
Palmer, C.L.6
Romines, W.H.7
Wu, B.W.8
Musick, L.9
-
179
-
-
0030593188
-
New database (letter)
-
J. Vondrasek and A. Wlodawer (1996) New database (letter). Science 272 337-338.
-
(1996)
Science
, vol.272
, pp. 337-338
-
-
Vondrasek, J.1
Wlodawer, A.2
-
182
-
-
0022005974
-
Nucleotide sequence of the AIDS virus, LAV
-
S. Wain-Hobson, P. Sonigo, O. Danos, S. Cole and M. Alizon (1985) Nucleotide sequence of the AIDS virus, LAV. Cell 40 9-17.
-
(1985)
Cell
, vol.40
, pp. 9-17
-
-
Wain-Hobson, S.1
Sonigo, P.2
Danos, O.3
Cole, S.4
Alizon, M.5
-
183
-
-
0025039810
-
Proteolytic cleavage of microtubule associated proteins by retroviral proteinases
-
M. Wallin, J. Deinum, L. Goobar and U.H. Danielson (1990) Proteolytic cleavage of microtubule associated proteins by retroviral proteinases. J. Gen. Virol. 71 1985-1991.
-
(1990)
J. Gen. Virol.
, vol.71
, pp. 1985-1991
-
-
Wallin, M.1
Deinum, J.2
Goobar, L.3
Danielson, U.H.4
-
184
-
-
0029822931
-
Mapping hydration water molecules in the HIV-1 protease/DMP323 complex in solution by NMR spectroscopy
-
Y.X. Wang, D.I. Freedberg, S. Grzesiek, D.A. Torchia, P.T. Wingfield, J.D. Kaufman, S.J. Stahl, C.H. Chang and C.N. Hodge (1996) Mapping hydration water molecules in the HIV-1 protease/DMP323 complex in solution by NMR spectroscopy. Biochemistry 35 12694-12704.
-
(1996)
Biochemistry
, vol.35
, pp. 12694-12704
-
-
Wang, Y.X.1
Freedberg, D.I.2
Grzesiek, S.3
Torchia, D.A.4
Wingfield, P.T.5
Kaufman, J.D.6
Stahl, S.J.7
Chang, C.H.8
Hodge, C.N.9
-
185
-
-
0026319605
-
Modeling of structure of human immunodeficiency virus 1 protease with substrate based on crystal structure of Rous sarcoma virus protease
-
I.T. Weber (1991) Modeling of structure of human immunodeficiency virus 1 protease with substrate based on crystal structure of Rous sarcoma virus protease. Methods Enzymol. 202 727-741.
-
(1991)
Methods Enzymol.
, vol.202
, pp. 727-741
-
-
Weber, I.T.1
-
186
-
-
0024581802
-
Molecular modeling of the HIV-1 protease and its substrate binding site
-
I.T. Weber, M. Miller, M. Jaskolski, J. Leis, A.M. Skalka and A. Wlodawer (1989) Molecular modeling of the HIV-1 protease and its substrate binding site. Science 243 928-931.
-
(1989)
Science
, vol.243
, pp. 928-931
-
-
Weber, I.T.1
Miller, M.2
Jaskolski, M.3
Leis, J.4
Skalka, A.M.5
Wlodawer, A.6
-
187
-
-
0030669385
-
Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate – interactions with frequently occurring glutamic acid residue at P2′ position of substrate
-
I.T. Weber, J. Wu, J. Adomat, R.W. Harrison, A.R. Kimmel, E.M. Wondrak and J.M. Louis (1997) Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate – interactions with frequently occurring glutamic acid residue at P2′ position of substrate. Eur. J. Biochem. 249 523-530.
-
(1997)
Eur. J. Biochem.
, vol.249
, pp. 523-530
-
-
Weber, I.T.1
Wu, J.2
Adomat, J.3
Harrison, R.W.4
Kimmel, A.R.5
Wondrak, E.M.6
Louis, J.M.7
-
188
-
-
0029975546
-
Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase
-
R. Welker, H. Kottler, H.R. Kalbitzer and H.G. Kräusslich (1996) Human immunodeficiency virus type 1 Nef protein is incorporated into virus particles and specifically cleaved by the viral proteinase. Virology 219 228-236.
-
(1996)
Virology
, vol.219
, pp. 228-236
-
-
Welker, R.1
Kottler, H.2
Kalbitzer, H.R.3
Kräusslich, H.G.4
-
189
-
-
0030938867
-
Escape mutants of HIV-1 proteinase: enzymatic efficiency and susceptibility to inhibition
-
S.I. Wilson, L.H. Phylip, J.S. Mills, S.V. Gulnik, J.W. Erickson, B.M. Dunn and J. Kay (1997) Escape mutants of HIV-1 proteinase: enzymatic efficiency and susceptibility to inhibition. Biochim. Biophys. Acta 1339 113-125.
-
(1997)
Biochim. Biophys. Acta
, vol.1339
, pp. 113-125
-
-
Wilson, S.I.1
Phylip, L.H.2
Mills, J.S.3
Gulnik, S.V.4
Erickson, J.W.5
Dunn, B.M.6
Kay, J.7
-
190
-
-
0036176766
-
Rational approach to AIDS drug design through structural biology
-
A. Wlodawer (2002) Rational approach to AIDS drug design through structural biology. Annu. Rev. Med. 53 595-614.
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 595-614
-
-
Wlodawer, A.1
-
191
-
-
0027218692
-
Structure based inhibitors of HIV-1 protease
-
A. Wlodawer and J.W. Erickson (1993) Structure based inhibitors of HIV-1 protease. Annu. Rev. Biochem. 62 543-585.
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 543-585
-
-
Wlodawer, A.1
Erickson, J.W.2
-
192
-
-
0034615571
-
Structural and biochemical studies of retroviral proteases
-
A. Wlodawer and A. Gustchina (2000) Structural and biochemical studies of retroviral proteases. Biochim. Biophys. Acta 1477 16-34.
-
(2000)
Biochim. Biophys. Acta
, vol.1477
, pp. 16-34
-
-
Wlodawer, A.1
Gustchina, A.2
-
193
-
-
0024412506
-
Conserved folding in retroviral protease: crystal structure of a synthetic HIV-1 protease
-
A. Wlodawer, M. Miller, M. Jaskolski, B.K. Sathyanarayana, E. Baldwin, I.T. Weber, L.M. Selk, L. Clawson, J. Schneider and S.B.H. Kent (1989) Conserved folding in retroviral protease: crystal structure of a synthetic HIV-1 protease. Science 245 616-621.
-
(1989)
Science
, vol.245
, pp. 616-621
-
-
Wlodawer, A.1
Miller, M.2
Jaskolski, M.3
Sathyanarayana, B.K.4
Baldwin, E.5
Weber, I.T.6
Selk, L.M.7
Clawson, L.8
Schneider, J.9
Kent, S.B.H.10
-
194
-
-
0029833678
-
Influence of flanking sequences on the dimer stability of human immunodeficiency virus type 1 protease
-
E.M. Wondrak and J.M. Louis (1996) Influence of flanking sequences on the dimer stability of human immunodeficiency virus type 1 protease. Biochemistry 35 12957-12962.
-
(1996)
Biochemistry
, vol.35
, pp. 12957-12962
-
-
Wondrak, E.M.1
Louis, J.M.2
-
195
-
-
0030066643
-
A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation
-
E.M. Wondrak, N.T. Nashed, M.T. Haber, D.M. Jerina and J.M. Louis (1996) A transient precursor of the HIV-1 protease. Isolation, characterization, and kinetics of maturation. J. Biol. Chem. 271 4477-4481.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 4477-4481
-
-
Wondrak, E.M.1
Nashed, N.T.2
Haber, M.T.3
Jerina, D.M.4
Louis, J.M.5
-
197
-
-
0030969462
-
Targeting the dimerization interface of HIV-1 protease – inhibition with cross-linked interfacial peptides
-
R. Zutshi, J. Franciskovich, M. Shultz, B. Schweitzer, P. Biship, M. Wilson and J. Chmielewski (1997) Targeting the dimerization interface of HIV-1 protease – inhibition with cross-linked interfacial peptides. J. Am. Chem. Soc. 119 4841-4845.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 4841-4845
-
-
Zutshi, R.1
Franciskovich, J.2
Shultz, M.3
Schweitzer, B.4
Biship, P.5
Wilson, M.6
Chmielewski, J.7
-
198
-
-
0029013602
-
Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag Pol influence PR autoprocessing
-
G. Zybarth and C. Carter (1995) Domains upstream of the protease (PR) in human immunodeficiency virus type 1 Gag Pol influence PR autoprocessing. J. Virol. 69 3878-3884.
-
(1995)
J. Virol.
, vol.69
, pp. 3878-3884
-
-
Zybarth, G.1
Carter, C.2
-
199
-
-
0027957918
-
Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain
-
G. Zybarth, H.G. Kräusslich, K. Partin and C. Carter (1994) Proteolytic activity of novel human immunodeficiency virus type 1 proteinase proteins from a precursor with a blocking mutation at the N terminus of the PR domain. J. Virol. 68 240-250.
-
(1994)
J. Virol.
, vol.68
, pp. 240-250
-
-
Zybarth, G.1
Kräusslich, H.G.2
Partin, K.3
Carter, C.4
|