Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate

Biochemistry

Volumn 37, Issue 39, 1998, Pages 13835-13845

  Ridky, Todd W ^a   Kikonyogo, Alexandra ^a   Leis, Jonathan ^a   Gulnik, Sergei ^b   Copeland, Terry ^b   Erickson, John ^b   Wlodawer, Alexander ^b   Kurinov, Igor ^c   Harrison, Robert W ^c   Weber, Irene T ^c  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; VIRUS ISOLATION;

AMINO ACID SUBSTITUTION; ASPARTIC ENDOPEPTIDASES; AVIAN SARCOMA VIRUSES; BINDING SITES; CAPSID; CATALYSIS; CRYSTALLIZATION; DRUG RESISTANCE, MICROBIAL; ENZYME ACTIVATION; HIV PROTEASE; HIV-1; HYDROLYSIS; MUTAGENESIS, SITE-DIRECTED; NUCLEOCAPSID PROTEINS; PEPTIDE FRAGMENTS; SUBSTRATE SPECIFICITY; VALINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RICE STRIPE VIRUS; RNA VIRUSES;

EID: 0032578505     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980612k     Document Type: Article

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