Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 6, 1997, Pages 2243-2248

  Shao, Wei ^a,c   Everitt, Lorraine ^a,d   Manchester, Marianne ^a,e   Loeb, Daniel D ^a,b,f   Hutchison III, Clyde A ^b   Swanstrom, Ronald ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BINDING SITES; GLYCINE; HIV PROTEASE; HIV-1; ISOLEUCINE; KINETICS; METHIONINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PHENYLALANINE; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SOLVENTS; VALINE;

BACTERIA (MICROORGANISMS); FELIS CATUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030910583     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.6.2243     Document Type: Article

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