메뉴 건너뛰기




Volumn 53, Issue , 2002, Pages 595-614

Rational approach to aids drug design through structural biology

Author keywords

[No Author keywords available]

Indexed keywords

A 77003; ABACAVIR; AG 1002; AG 1004; AMPRENAVIR; AMPRENAVIR PHOSPHATE; ANTIRETROVIRUS AGENT; ATAZANAVIR; DIDANOSINE; EMTRICITABINE; INDINAVIR; L 682 679; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; MOZENAVIR; NELFINAVIR; PEPSTATIN; PROTEINASE; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; RO 31 8558; SAQUINAVIR; STAVUDINE; TIPRANAVIR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZALCITABINE; ZIDOVUDINE;

EID: 0036176766     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.53.052901.131947     Document Type: Review
Times cited : (134)

References (106)
  • 3
    • 0033915678 scopus 로고    scopus 로고
    • Recent developments in structure-based drug design
    • (2000) J. Mol. Med. , vol.78 , pp. 269-281
    • Klebe, G.1
  • 11
    • 0032544311 scopus 로고    scopus 로고
    • Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: High level of similarity of the active site with other viral integrases
    • (1998) J. Mol. Biol. , vol.282 , pp. 359-368
    • Maignan, S.1    Guilloteau, J.P.2    Zhou-Liu, Q.3
  • 23
    • 0034011309 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 protease inhibitors: Therapeutic successes and failures, suppression and resistance
    • (2000) Pharmacol. Ther. , vol.86 , pp. 145-170
    • Swanstrom, R.1    Erona, J.2
  • 26
    • 0021846499 scopus 로고
    • Murine leukemia virus maturation: Protease region required for conversion from immature to mature form and for virus infectivity
    • (1985) Virology , vol.145 , pp. 280-292
    • Katoh, I.1    Yoshinaka, Y.2    Rein, A.3
  • 33
    • 0027742457 scopus 로고
    • Three-dimensional structure of a simian immunodeficiency virus protease/inhibitor complex. Implications for the design of human immunodeficiency virus type 1 and 2 protease inhibitors
    • (1993) Biochemistry , vol.32 , pp. 13054-13060
    • Zhao, B.1    Winborne, E.2    Minnich, M.D.3
  • 40
    • 0029782278 scopus 로고    scopus 로고
    • Solution conformations of KNI-272, a tripeptide HIV protease inhibitor designed on the basis of substrate transition state: Determined by NMR spectroscopy and simulated annealing calculations
    • (1996) Bioorg. Med. Chem. , vol.4 , pp. 1565-1572
    • Ohno, Y.1    Kiso, Y.2    Kobayashi, Y.3
  • 50
    • 0026503819 scopus 로고
    • Application of free energy simulations to the binding of a transition-state-analogue inhibitor to HIV protease
    • (1992) Protein Eng. , vol.5 , pp. 29-33
    • Tropsha, A.1    Hermans, J.2
  • 52
    • 0029844655 scopus 로고    scopus 로고
    • Free energy perturbation studies on binding of A-74704 and its diester analog to HIV-1 protease
    • (1996) Protein Eng. , vol.9 , pp. 767-771
    • Rao, B.G.1    Murcko, M.A.2
  • 53
    • 0029731556 scopus 로고    scopus 로고
    • Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials. Compensatory modulations of binding and activity
    • (1996) J. Biol. Chem. , vol.271 , pp. 31957-31963
    • Schock, H.B.1    Garsky, V.M.2    Kuo, L.C.3
  • 82
    • 0034519576 scopus 로고    scopus 로고
    • Amprenavir: A review of its clinical potential in patients with HIV infection
    • (2000) Drugs , vol.60 , pp. 1383-1410
    • Noble, S.1    Goa, K.L.2
  • 86
    • 0031849665 scopus 로고    scopus 로고
    • In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor
    • (1998) J. Virol. , vol.72 , pp. 7532-7541
    • Carrillo, A.1    Stewart, K.D.2    Sham, H.L.3
  • 90
    • 0031022510 scopus 로고    scopus 로고
    • Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV
    • (1997) J. Med. Chem. , vol.40 , pp. 181-191
    • Jadhav, P.K.1    Ala, P.2    Woerner, F.J.3
  • 91
    • 0030113025 scopus 로고    scopus 로고
    • Improved cyclic urea inhibitors of the HIV-1 protease: Synthesis, potency, resistance profile, human pharmacokinetics and X-ray crystal structure of DMP 450
    • (1996) Chem. Biol. , vol.3 , pp. 301-314
    • Hodge, C.N.1    Aldrich, P.2    Bacheler, L.T.3
  • 93
  • 103
    • 0032437454 scopus 로고    scopus 로고
    • The role of nonnucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection
    • (1998) Antiviral Res. , vol.38 , pp. 153-179
    • De Clercq, E.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.